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Identifier: 15678439

GI number: 15678439

Start: 345892

End: 347709

Strand: Direct

Name: Not Available

Synonym: MTH411

Alternate gene names: 15678439

Gene position: 345892-347709 (Clockwise)

Preceding gene: 15678438

Following gene: 15678441

Centisome position: 19.75

GC content: 55.01

Gene sequence:

>1818_bases
ATGGGATGTGAATGCAGCTCATGTTCCCCATCAGGGAATGGTAATGAAATACTGGTTATGGCAGCATCGGCAGCACTCCT
TGCAGCAGGGATCCTCCTTGACCTCCAGGGAAGCATGATATCAGTTCCCCTCCTCATTGCAGCGGTTGTAGCTGCAGGAT
ACAGGATATTCCCGGCAGCAGTCAGGTCAGTACTCAGGGGCCACTTCACGGTGCACGTGCTCATACTCATCGCAGTCATC
GGTGCCATCGCACTGGGTGACTACACTGAAGCGGCCCTCGTGACCGTCCTCTACCACATAGCAGAGTACCTCGAGGAGTA
TGCCCACAGAAGATCACACAGATCCGTGGAATCCCTCATAAAACTCAGGCCCAGAACCGCGAGGGTCCTTGATGGAGGGG
AGAGGATCATGGGGGTCGAGGATGTTGAGGAAGGAAGCACAATAGGGATAAAACCAGGGGAGACGGTACCCCTCGATGGA
ACCGTTAAATCGGGGACCTCACAGGTTGACCAGTCCAGCATAACAGGTGAGTCCCTCCCTGTTACCGTGGGGGAGGGTGA
CCAGGTATTTGCAGGTACACAGAACCTTGACGGGTACCTGGAGGTTAAGGTCACAAGGACCTCCGAGGCGACCGTACTCG
CAGGTGTCATTGAAACGGTCAGGAGATCTGCTCTCAGGAGGTCCAGGAGGGAGAGATTCATTGAACGCTTCGCATCAATC
TACACACCCACGGTAACTGGTCTTGCAGCCCTCACAGCACTCATACCGGTACTCACCGGAGGCGACCCCCTCACATGGAT
ATACAGGGCCCTGGTGCTGCTGGTCATCTCATGCCCATGCGCACTCCTCATATCAACACCGGTCGCCATGGTCTCGGGAA
TGACAGCTGCGGCCGGGAGGGGAATCCTCATCAAAGGTTCAGAGTTCCTGGAGAAGATGGCCTCCACCGGATGCATCATA
TTCGATAAGACAGGGACCCTCACCGAGGGAAGACCAGAGGTGATTGCTGTTGAACCGGAGGAGAGGAGGGATGAGATACT
CAGAATAGCAGCATCCCTTGAGAGGAAATCCGGACACCCCATCGCAGAGGCCATAGTGAACTCATACAGTGGCAGAACAG
TGGACGTGACAGACTTCAGGTCCATCCCGGGGAGGGGTGTCTCAGGTTACATAGAGGGTGTGAGGTACACCCTTGGAAGC
CCGGAAACTGGAGGTGGGAATCCAGATAGAGGTACGGAGGTTCAGCTAACAGGACCGGAGGGTGTTATAGGCGTCATAAG
ACTCAGGGACAGCATCAGGAAATCCGCAGGGAGGATCACAGGGAGGCTCAGGGAGCGGGGTATCGGTACTCTGATGCTCA
CCGGTGACACTGAGGACTCTGCAGCGGCGGTGGCTGCTGAGATCGGTGCTGAAAGATACCGTGGGGGCCTGCTGCCAGAG
GATAAGATGAGGATAATACGTGAACTGAGCTCCAGGAAGATCACGGTGATGGTGGGGGATGGTGTTAACGATGCACCGGC
ACTTGCAGCGGCGGATGTGGGTATAGCCATGGGTGTCAGGGGATCGGACGTGGCCATTGAAACCGCAGATATAACCCTGG
TGGAGGATGACCTTGAAAGGATAGATGAGCTCATTGACATCAGCAGGAGAACCATGGATATCATCAGGGTTAACACAGGG
TTAACCGTTGCAGTGAAGCTTTCCCTGGCTGTTCTCTCTGTCGCTGGCCTCGTACCACTATGGGTTGCTGTTGCAGTGGG
TGATATGGGCCTTTCCCTTTTTGTTATAACAAACAGTCTGCTCCTTGCGAGGTTCTAG

Upstream 100 bases:

>100_bases
GTTCAGAGTCTCACCTGGGTCATATCTCAGCACAATATTAAGAAACATTTATATGATATGAACACACATGAATGTGTATT
CATATGTTCAGGTGAATCCT

Downstream 100 bases:

>100_bases
TAACGGTGTTATAACAAACAGTCTGCTCCTTGCGAGGTTCCGGTGTCAGTAAGAACCCCTTAAATTAATTTTAAATCCTA
AAAAAAAAATAAAATGGTGG

Product: cadmium efflux ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MGCECSSCSPSGNGNEILVMAASAALLAAGILLDLQGSMISVPLLIAAVVAAGYRIFPAAVRSVLRGHFTVHVLILIAVI
GAIALGDYTEAALVTVLYHIAEYLEEYAHRRSHRSVESLIKLRPRTARVLDGGERIMGVEDVEEGSTIGIKPGETVPLDG
TVKSGTSQVDQSSITGESLPVTVGEGDQVFAGTQNLDGYLEVKVTRTSEATVLAGVIETVRRSALRRSRRERFIERFASI
YTPTVTGLAALTALIPVLTGGDPLTWIYRALVLLVISCPCALLISTPVAMVSGMTAAAGRGILIKGSEFLEKMASTGCII
FDKTGTLTEGRPEVIAVEPEERRDEILRIAASLERKSGHPIAEAIVNSYSGRTVDVTDFRSIPGRGVSGYIEGVRYTLGS
PETGGGNPDRGTEVQLTGPEGVIGVIRLRDSIRKSAGRITGRLRERGIGTLMLTGDTEDSAAAVAAEIGAERYRGGLLPE
DKMRIIRELSSRKITVMVGDGVNDAPALAAADVGIAMGVRGSDVAIETADITLVEDDLERIDELIDISRRTMDIIRVNTG
LTVAVKLSLAVLSVAGLVPLWVAVAVGDMGLSLFVITNSLLLARF

Sequences:

>Translated_605_residues
MGCECSSCSPSGNGNEILVMAASAALLAAGILLDLQGSMISVPLLIAAVVAAGYRIFPAAVRSVLRGHFTVHVLILIAVI
GAIALGDYTEAALVTVLYHIAEYLEEYAHRRSHRSVESLIKLRPRTARVLDGGERIMGVEDVEEGSTIGIKPGETVPLDG
TVKSGTSQVDQSSITGESLPVTVGEGDQVFAGTQNLDGYLEVKVTRTSEATVLAGVIETVRRSALRRSRRERFIERFASI
YTPTVTGLAALTALIPVLTGGDPLTWIYRALVLLVISCPCALLISTPVAMVSGMTAAAGRGILIKGSEFLEKMASTGCII
FDKTGTLTEGRPEVIAVEPEERRDEILRIAASLERKSGHPIAEAIVNSYSGRTVDVTDFRSIPGRGVSGYIEGVRYTLGS
PETGGGNPDRGTEVQLTGPEGVIGVIRLRDSIRKSAGRITGRLRERGIGTLMLTGDTEDSAAAVAAEIGAERYRGGLLPE
DKMRIIRELSSRKITVMVGDGVNDAPALAAADVGIAMGVRGSDVAIETADITLVEDDLERIDELIDISRRTMDIIRVNTG
LTVAVKLSLAVLSVAGLVPLWVAVAVGDMGLSLFVITNSLLLARF
>Mature_604_residues
GCECSSCSPSGNGNEILVMAASAALLAAGILLDLQGSMISVPLLIAAVVAAGYRIFPAAVRSVLRGHFTVHVLILIAVIG
AIALGDYTEAALVTVLYHIAEYLEEYAHRRSHRSVESLIKLRPRTARVLDGGERIMGVEDVEEGSTIGIKPGETVPLDGT
VKSGTSQVDQSSITGESLPVTVGEGDQVFAGTQNLDGYLEVKVTRTSEATVLAGVIETVRRSALRRSRRERFIERFASIY
TPTVTGLAALTALIPVLTGGDPLTWIYRALVLLVISCPCALLISTPVAMVSGMTAAAGRGILIKGSEFLEKMASTGCIIF
DKTGTLTEGRPEVIAVEPEERRDEILRIAASLERKSGHPIAEAIVNSYSGRTVDVTDFRSIPGRGVSGYIEGVRYTLGSP
ETGGGNPDRGTEVQLTGPEGVIGVIRLRDSIRKSAGRITGRLRERGIGTLMLTGDTEDSAAAVAAEIGAERYRGGLLPED
KMRIIRELSSRKITVMVGDGVNDAPALAAADVGIAMGVRGSDVAIETADITLVEDDLERIDELIDISRRTMDIIRVNTGL
TVAVKLSLAVLSVAGLVPLWVAVAVGDMGLSLFVITNSLLLARF

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=628, Percent_Identity=27.2292993630573, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI55743073, Length=505, Percent_Identity=28.7128712871287, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI115529486, Length=419, Percent_Identity=26.9689737470167, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI48762689, Length=203, Percent_Identity=31.0344827586207, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48762685, Length=203, Percent_Identity=31.0344827586207, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48762691, Length=203, Percent_Identity=31.0344827586207, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48762687, Length=203, Percent_Identity=31.0344827586207, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI118498343, Length=217, Percent_Identity=30.4147465437788, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI153946397, Length=290, Percent_Identity=26.551724137931, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI22748667, Length=240, Percent_Identity=27.5, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1789879, Length=586, Percent_Identity=37.0307167235495, Blast_Score=318, Evalue=6e-88,
Organism=Escherichia coli, GI1786691, Length=609, Percent_Identity=32.512315270936, Blast_Score=257, Evalue=2e-69,
Organism=Escherichia coli, GI1786914, Length=508, Percent_Identity=27.1653543307087, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17556548, Length=567, Percent_Identity=30.1587301587302, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17557770, Length=189, Percent_Identity=31.7460317460317, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32566766, Length=189, Percent_Identity=31.7460317460317, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557486, Length=190, Percent_Identity=30.5263157894737, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193203354, Length=204, Percent_Identity=29.9019607843137, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193203356, Length=204, Percent_Identity=29.9019607843137, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=614, Percent_Identity=27.1986970684039, Blast_Score=213, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6319772, Length=526, Percent_Identity=28.1368821292776, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321430, Length=624, Percent_Identity=24.1987179487179, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325221, Length=620, Percent_Identity=24.8387096774194, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320245, Length=195, Percent_Identity=30.2564102564103, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320244, Length=195, Percent_Identity=30.2564102564103, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320243, Length=195, Percent_Identity=30.2564102564103, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321271, Length=203, Percent_Identity=30.5418719211823, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221329854, Length=438, Percent_Identity=25.5707762557078, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI281366617, Length=127, Percent_Identity=35.4330708661417, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668708, Length=127, Percent_Identity=35.4330708661417, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668704, Length=127, Percent_Identity=35.4330708661417, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668696, Length=127, Percent_Identity=35.4330708661417, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161085803, Length=127, Percent_Identity=35.4330708661417, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 63983; Mature: 63852

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCECSSCSPSGNGNEILVMAASAALLAAGILLDLQGSMISVPLLIAAVVAAGYRIFPAA
CCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHH
VRSVLRGHFTVHVLILIAVIGAIALGDYTEAALVTVLYHIAEYLEEYAHRRSHRSVESLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLRPRTARVLDGGERIMGVEDVEEGSTIGIKPGETVPLDGTVKSGTSQVDQSSITGESLP
HCCCCHHHHHCCCCCEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCE
VTVGEGDQVFAGTQNLDGYLEVKVTRTSEATVLAGVIETVRRSALRRSRRERFIERFASI
EEECCCCEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTPTVTGLAALTALIPVLTGGDPLTWIYRALVLLVISCPCALLISTPVAMVSGMTAAAGR
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHCCCHHHCCC
GILIKGSEFLEKMASTGCIIFDKTGTLTEGRPEVIAVEPEERRDEILRIAASLERKSGHP
CEEEECHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCH
IAEAIVNSYSGRTVDVTDFRSIPGRGVSGYIEGVRYTLGSPETGGGNPDRGTEVQLTGPE
HHHHHHHCCCCCEEEEHHCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCCEEEEECCC
GVIGVIRLRDSIRKSAGRITGRLRERGIGTLMLTGDTEDSAAAVAAEIGAERYRGGLLPE
CCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCH
DKMRIIRELSSRKITVMVGDGVNDAPALAAADVGIAMGVRGSDVAIETADITLVEDDLER
HHHHHHHHHHCCEEEEEECCCCCCCCCHHHHCCCEEECCCCCCEEEEECEEEEEHHHHHH
IDELIDISRRTMDIIRVNTGLTVAVKLSLAVLSVAGLVPLWVAVAVGDMGLSLFVITNSL
HHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
LLARF
HHHCC
>Mature Secondary Structure 
GCECSSCSPSGNGNEILVMAASAALLAAGILLDLQGSMISVPLLIAAVVAAGYRIFPAA
CCCCCCCCCCCCCCEEEEEECHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHH
VRSVLRGHFTVHVLILIAVIGAIALGDYTEAALVTVLYHIAEYLEEYAHRRSHRSVESLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLRPRTARVLDGGERIMGVEDVEEGSTIGIKPGETVPLDGTVKSGTSQVDQSSITGESLP
HCCCCHHHHHCCCCCEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCE
VTVGEGDQVFAGTQNLDGYLEVKVTRTSEATVLAGVIETVRRSALRRSRRERFIERFASI
EEECCCCEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTPTVTGLAALTALIPVLTGGDPLTWIYRALVLLVISCPCALLISTPVAMVSGMTAAAGR
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHCCCHHHCCC
GILIKGSEFLEKMASTGCIIFDKTGTLTEGRPEVIAVEPEERRDEILRIAASLERKSGHP
CEEEECHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCH
IAEAIVNSYSGRTVDVTDFRSIPGRGVSGYIEGVRYTLGSPETGGGNPDRGTEVQLTGPE
HHHHHHHCCCCCEEEEHHCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCCEEEEECCC
GVIGVIRLRDSIRKSAGRITGRLRERGIGTLMLTGDTEDSAAAVAAEIGAERYRGGLLPE
CCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCH
DKMRIIRELSSRKITVMVGDGVNDAPALAAADVGIAMGVRGSDVAIETADITLVEDDLER
HHHHHHHHHHCCEEEEEECCCCCCCCCHHHHCCCEEECCCCCCEEEEECEEEEEHHHHHH
IDELIDISRRTMDIIRVNTGLTVAVKLSLAVLSVAGLVPLWVAVAVGDMGLSLFVITNSL
HHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
LLARF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11302791 [H]