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Identifier: 15678431

GI number: 15678431

Start: 341063

End: 341956

Strand: Direct

Name: Not Available

Synonym: MTH403

Alternate gene names: 15678431

Gene position: 341063-341956 (Clockwise)

Preceding gene: 15678430

Following gene: 15678432

Centisome position: 19.47

GC content: 56.6

Gene sequence:

>894_bases
ATGGAGATTAACGGAACACTGATTGAGGATACATTCTCTGAGGCCTTCACAGGGAGATGTGTGAGGGCCACCATAACGGC
CCGTGACATGGAGACCGTCAGGAGGGCGGCCCTTGATGCAACCGCAACCCCCGGTGCAGTCATAGGGAGGGTTGAGGGTG
GTGTTGAATCCTTCCTGGGAGGCGAGGACACCCCCGACGGCAGACCCGGGGCCGTGGTCCAGTTCTACTATGCCCTGGAT
GACATGGAGAAATTCCAGGTCGAATTATCCTACCGTATAAGGCAGGACATACTGGTGAAGCCCTTCACAGCCCTCTACAG
CTCCACCCCCGACCCGGATGGATACCTGGATATGATGAAGCATGTGGGACACTGCGGTGATGGCTATGAGTGGTTAGAGG
AGTTCAATGGCCGTGAAATGATCAACGTACCGGTAGCCGTCCCTGACTTCAAAATAGAATCAAGGATGGGCTACAGGGAG
GCCATCATGGGGGCCAACTTCTGGTACATGTGCAGGGATCCTGACACGGTACTGGAGGCAGGCAGGGCCGCCATAAGAGC
CATAGAGGAGGTTGAGGGTGTTGTGACGCCCTTTGATATCTGCTCCGCAGCATCAAAGCCAGAGACAAATTACCCCTGGA
TAGGCCCCACCACGAACCACCCCTACTGCCCGAGCCTGAAGGAGGTGCTCGGTGACGAGTCAAGGGTCCCGGAGGGCGTC
GGGTACATACCTGAGATAGTCATAAACGGCCTGACAATGGAGGCCCTTGAGGAGGCCATGAGGGCCGGGATAGAGGCTGT
CTGCAGGTACGATGGGGTCCTGAGGGTATCTGCAGGTAACTATGACGGTAAACTGGGGGACCACAGGATAGACCTACACG
GTGTTCTGGGATGA

Upstream 100 bases:

>100_bases
ACGCAAGCATGGAGGTCAGAAAGAACATCCGGGGAGAGGACGTCGGATCCCTCGGCTGAATCCCTGGATGTGCTTACATT
CAGCATGGTTGTGATGCTCA

Downstream 100 bases:

>100_bases
GGTTCGATGCGGTGGGCCTTGGAGCCCTCAACATGGACCAGCTCCACATGGTTGAGAGGATAGCAGGCCCGGATGAGGAG
ACCTTCGTGAGGGGGCTCGT

Product: formylmethanofuran--tetrahydromethanopterin formyltransferase

Products: methanofuran; 5-formyl-5,6,7,8-tetrahydromethanopterin

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MEINGTLIEDTFSEAFTGRCVRATITARDMETVRRAALDATATPGAVIGRVEGGVESFLGGEDTPDGRPGAVVQFYYALD
DMEKFQVELSYRIRQDILVKPFTALYSSTPDPDGYLDMMKHVGHCGDGYEWLEEFNGREMINVPVAVPDFKIESRMGYRE
AIMGANFWYMCRDPDTVLEAGRAAIRAIEEVEGVVTPFDICSAASKPETNYPWIGPTTNHPYCPSLKEVLGDESRVPEGV
GYIPEIVINGLTMEALEEAMRAGIEAVCRYDGVLRVSAGNYDGKLGDHRIDLHGVLG

Sequences:

>Translated_297_residues
MEINGTLIEDTFSEAFTGRCVRATITARDMETVRRAALDATATPGAVIGRVEGGVESFLGGEDTPDGRPGAVVQFYYALD
DMEKFQVELSYRIRQDILVKPFTALYSSTPDPDGYLDMMKHVGHCGDGYEWLEEFNGREMINVPVAVPDFKIESRMGYRE
AIMGANFWYMCRDPDTVLEAGRAAIRAIEEVEGVVTPFDICSAASKPETNYPWIGPTTNHPYCPSLKEVLGDESRVPEGV
GYIPEIVINGLTMEALEEAMRAGIEAVCRYDGVLRVSAGNYDGKLGDHRIDLHGVLG
>Mature_297_residues
MEINGTLIEDTFSEAFTGRCVRATITARDMETVRRAALDATATPGAVIGRVEGGVESFLGGEDTPDGRPGAVVQFYYALD
DMEKFQVELSYRIRQDILVKPFTALYSSTPDPDGYLDMMKHVGHCGDGYEWLEEFNGREMINVPVAVPDFKIESRMGYRE
AIMGANFWYMCRDPDTVLEAGRAAIRAIEEVEGVVTPFDICSAASKPETNYPWIGPTTNHPYCPSLKEVLGDESRVPEGV
GYIPEIVINGLTMEALEEAMRAGIEAVCRYDGVLRVSAGNYDGKLGDHRIDLHGVLG

Specific function: Unknown

COG id: COG2037

COG function: function code C; Formylmethanofuran:tetrahydromethanopterin formyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FTR family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTRL_METTH (O26503)

Other databases:

- EMBL:   AE000666
- PIR:   E69152
- RefSeq:   NP_275546.1
- ProteinModelPortal:   O26503
- STRING:   O26503
- GeneID:   1470364
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH403
- NMPDR:   fig|187420.1.peg.401
- eggNOG:   arNOG04986
- HOGENOM:   HBG373021
- OMA:   CGDGYEW
- ProtClustDB:   PRK02114
- BioCyc:   MTHE187420:MTH403-MONOMER
- HAMAP:   MF_00579
- InterPro:   IPR002770
- InterPro:   IPR022667
- InterPro:   IPR014053
- Gene3D:   G3DSA:3.30.70.520
- PIRSF:   PIRSF006414

Pfam domain/function: PF01913 FTR; PF02741 FTR_C; SSF55112 FTR_trans

EC number: 2.3.1.101

Molecular weight: Translated: 32693; Mature: 32693

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEINGTLIEDTFSEAFTGRCVRATITARDMETVRRAALDATATPGAVIGRVEGGVESFLG
CCCCCEEHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCEEEHHHCCHHHHCC
GEDTPDGRPGAVVQFYYALDDMEKFQVELSYRIRQDILVKPFTALYSSTPDPDGYLDMMK
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
HVGHCGDGYEWLEEFNGREMINVPVAVPDFKIESRMGYREAIMGANFWYMCRDPDTVLEA
HHCCCCCHHHHHHHCCCCEEEEECEECCCCCHHHHCCHHHHHHCCCEEEEECCHHHHHHH
GRAAIRAIEEVEGVVTPFDICSAASKPETNYPWIGPTTNHPYCPSLKEVLGDESRVPEGV
HHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCC
GYIPEIVINGLTMEALEEAMRAGIEAVCRYDGVLRVSAGNYDGKLGDHRIDLHGVLG
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MEINGTLIEDTFSEAFTGRCVRATITARDMETVRRAALDATATPGAVIGRVEGGVESFLG
CCCCCEEHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCEEEHHHCCHHHHCC
GEDTPDGRPGAVVQFYYALDDMEKFQVELSYRIRQDILVKPFTALYSSTPDPDGYLDMMK
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
HVGHCGDGYEWLEEFNGREMINVPVAVPDFKIESRMGYREAIMGANFWYMCRDPDTVLEA
HHCCCCCHHHHHHHCCCCEEEEECEECCCCCHHHHCCHHHHHHCCCEEEEECCHHHHHHH
GRAAIRAIEEVEGVVTPFDICSAASKPETNYPWIGPTTNHPYCPSLKEVLGDESRVPEGV
HHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCC
GYIPEIVINGLTMEALEEAMRAGIEAVCRYDGVLRVSAGNYDGKLGDHRIDLHGVLG
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formylmethanofuran; 5,6,7,8-tetrahydromethanopterin

Specific reaction: formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463