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Identifier: 15678405

GI number: 15678405

Start: 322532

End: 323278

Strand: Direct

Name: Not Available

Synonym: MTH377

Alternate gene names: 15678405

Gene position: 322532-323278 (Clockwise)

Preceding gene: 15678404

Following gene: 15678406

Centisome position: 18.42

GC content: 54.62

Gene sequence:

>747_bases
ATGAATGAGCATGATCCCACGAGGGGTGGTGATTACCTCAATGACTGTACCGCTGGAGGTGTCGCGATGAGGGTGGTCAC
AGTGATACCTGCATTCAATGAGGAGAGGACCGTCGAATCCGTTGTGAGGGGCGCCCTTGAACATGGTGACGTGATCCTGG
TGGACGATGGCAGCACAGACAGGACTGCAGCCCTTGGTGAGGAAGCAGGGGCAAGGGTCATCAGCCACCCCAAAAATCTC
GGGAAGGGGGCAGCCCTCAAGACAGGTATAAGGGAGGCCCTTGGAGGAGACTACGATGTCATAGTATTCATGGACGCCGA
TGGCCAGCACGACCCCTCCCTGATACCAGAACTTGCATCCGCGGTTAACGGTGGCGACTTCATCATAGGGTCAAGGTTCA
TAAGGAATAACCATGATAGCATGCCCCTCCACAGGCAGCTATCAAACCGGATAACCACCTGGATACTCAGACTGGCCACA
GGGTACCGGATAACAGATAGTCAGAGCGGCTTCAGGGCAATATCAGCCAGGTACGCCCACCTGATACTCGAAATACCCTA
CGACGACTATGTGTATGAATCAGAGGCAATATGTGAGACCTCAAGGCACCGGCTGAGGATAGCCGAGGTCCCCATCACCT
GCACCTATGGTGATGAGAAGTCCTACATCGGGGTCGGGGACGTCCTCCAGTACATCAGGTTCATAGTTAGGCTCTTCGTC
AGAAGGATATCCGGTGTCAGGGGCTGA

Upstream 100 bases:

>100_bases
AGGGAGGAGGGCCAGAAAGGGAGGCGCTTCGTGGAGTCAAATGACTGGGAAAGCATCACCGAAAGATTTGAGGAGACCCT
AAGGGAACTTGTGGAGAAGG

Downstream 100 bases:

>100_bases
TGTGGGAGCTGCTTCCCATCACCTTCACATCTGAGAGGAGATGGACTCCATGAAAAGGTTTTACTTCTTTGCACTGAGCA
TCCTTCTCATCCTGGCACTC

Product: dolichyl-phosphate mannose synthase related protein

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNEHDPTRGGDYLNDCTAGGVAMRVVTVIPAFNEERTVESVVRGALEHGDVILVDDGSTDRTAALGEEAGARVISHPKNL
GKGAALKTGIREALGGDYDVIVFMDADGQHDPSLIPELASAVNGGDFIIGSRFIRNNHDSMPLHRQLSNRITTWILRLAT
GYRITDSQSGFRAISARYAHLILEIPYDDYVYESEAICETSRHRLRIAEVPITCTYGDEKSYIGVGDVLQYIRFIVRLFV
RRISGVRG

Sequences:

>Translated_248_residues
MNEHDPTRGGDYLNDCTAGGVAMRVVTVIPAFNEERTVESVVRGALEHGDVILVDDGSTDRTAALGEEAGARVISHPKNL
GKGAALKTGIREALGGDYDVIVFMDADGQHDPSLIPELASAVNGGDFIIGSRFIRNNHDSMPLHRQLSNRITTWILRLAT
GYRITDSQSGFRAISARYAHLILEIPYDDYVYESEAICETSRHRLRIAEVPITCTYGDEKSYIGVGDVLQYIRFIVRLFV
RRISGVRG
>Mature_248_residues
MNEHDPTRGGDYLNDCTAGGVAMRVVTVIPAFNEERTVESVVRGALEHGDVILVDDGSTDRTAALGEEAGARVISHPKNL
GKGAALKTGIREALGGDYDVIVFMDADGQHDPSLIPELASAVNGGDFIIGSRFIRNNHDSMPLHRQLSNRITTWILRLAT
GYRITDSQSGFRAISARYAHLILEIPYDDYVYESEAICETSRHRLRIAEVPITCTYGDEKSYIGVGDVLQYIRFIVRLFV
RRISGVRG

Specific function: Unknown

COG id: COG0463

COG function: function code M; Glycosyltransferases involved in cell wall biogenesis

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4503363, Length=234, Percent_Identity=27.3504273504274, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585265, Length=234, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 27307; Mature: 27307

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEHDPTRGGDYLNDCTAGGVAMRVVTVIPAFNEERTVESVVRGALEHGDVILVDDGSTD
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
RTAALGEEAGARVISHPKNLGKGAALKTGIREALGGDYDVIVFMDADGQHDPSLIPELAS
CHHHHHHHHCCHHHHCCHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHH
AVNGGDFIIGSRFIRNNHDSMPLHRQLSNRITTWILRLATGYRITDSQSGFRAISARYAH
HCCCCCEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHEE
LILEIPYDDYVYESEAICETSRHRLRIAEVPITCTYGDEKSYIGVGDVLQYIRFIVRLFV
EEEECCCCCCEECCHHHHHHHHCEEEEEECCEEEEECCCCCEECHHHHHHHHHHHHHHHH
RRISGVRG
HHHHCCCC
>Mature Secondary Structure
MNEHDPTRGGDYLNDCTAGGVAMRVVTVIPAFNEERTVESVVRGALEHGDVILVDDGSTD
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
RTAALGEEAGARVISHPKNLGKGAALKTGIREALGGDYDVIVFMDADGQHDPSLIPELAS
CHHHHHHHHCCHHHHCCHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHH
AVNGGDFIIGSRFIRNNHDSMPLHRQLSNRITTWILRLATGYRITDSQSGFRAISARYAH
HCCCCCEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHEE
LILEIPYDDYVYESEAICETSRHRLRIAEVPITCTYGDEKSYIGVGDVLQYIRFIVRLFV
EEEECCCCCCEECCHHHHHHHHCEEEEEECCEEEEECCCCCEECHHHHHHHHHHHHHHHH
RRISGVRG
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]