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Identifier: 15678384

GI number: 15678384

Start: 297291

End: 298994

Strand: Direct

Name: Not Available

Synonym: MTH356

Alternate gene names: 15678384

Gene position: 297291-298994 (Clockwise)

Preceding gene: 15678383

Following gene: 15678389

Centisome position: 16.97

GC content: 52.0

Gene sequence:

>1704_bases
GTGCTAAACTTGGAACCTGATTCTGCAATCTTTGCAAGGAGACTCTCATTTTCATTTGCCCTTGCAGTTATAATCCTCTC
GGCCCTCACAATCACGGGCCACCTTATGGGGATCCCCCAGCTAAGGGGAGAGATCATGGGATCACCACACACGCAGCCGA
TGACCGCCGCAGTGTTCCTGATGCTGGGGTCCGCCATAATTCTTCTCTCAAAGCAGATCAGAACCCCAGCGCTCTACATT
GCAACCTTTCTACTTGTCTTCTACACCCTCACCGTCACCGGGTATCTTCAGACATCCATCACAGGGTACGGTTCAAACTC
TCGCTTCATATCATCAATCCTCTTCATCATCTACGCCATCATACTGATCCTCTTTTCGTCCTCAAGGTACACGGCACCCC
AGGTACTCGCCTTTTCAGCCGGGACAGTGGCCTACTGCGTGGCCACAGGATACCTTGGAGGTGTTGGAGTCTACGGCCAG
TACTTCCAGATGGCATTCTACACCGCCATCCTCCACCTCCTCACATCCACATCATTCCTTAGCCTCTACCCTGAGGAGGG
TATAGTTGCACCCATACACATGTCCTTCACCGGAGGGCATCTGGCCAGGCTGCTCATCCCCATCATGATAGCCAGCATAA
CCATCCTGGGCCTCTTCACCATGAAAATAAGTCAGAGGCTTTTCCCTGGATTCGGGGAGGTGTTCCTCATGGGGATGACA
GCCTCCCTCACCATAATAGTTGTTATCCTGGCATCGGATGAACTCAACAGGATAGATGAGAAGAGATCAGAATACCAGAG
GGACCTCCTCGAGGCCCAGAAGTTCTTCAGGGATGTTGTTGAAAACCTTGCAGAGGCTGTGGCGGTCTTTGACAAGGAGG
GGAGCATTATCTACAGGAACTCTGCCATGAAAAAACTGGGGATCATGGATCTTCCACGGCCATCATCCAGTGGCGAACCT
GTCATGATTGAACAGATGAAGGTGGGTGATGGCCACTACACGGGATGGATGGTTCCAAGGTTCTCTGACGGAAAATTCAC
AGGATACATCGTGTCACTCACAGATATCACGGACCTTATAGGGATACAGAGGTCCCTCGAGTCCACAGTGAGTGAGAGGG
ACGCTCTTCTTGCAGAGGTCCATCACAGGGTCAAGAATAACCTCCAGATAATCATGAGCCTCCTCAATATTCAGGCCATG
AATGCCAGTGAAGAGGCGCGTGAGGTCCTGAGGGATGCCCAGAGCCGTGTGCGGGCAATGGCTATCCTCCATGAGACAAT
CTATGATAGCGGAAACTTCACTGGTGTTGATATGGGGTCCTTCATAACAAGGCTCATTGAGAGACTTGTAAGCGCCTATG
GGGTCTACGGTATCCACTTCAGGGTGGATGCAGACGTCCGGGTGAACCTTGAAACCGCAATACCCCTGGGGCTCCTCATA
AATGAGGCGGTTACCAACTCAATCCGGCATGCCTTCCCCTCAGGGGAGGGCAGCATCACAGTGACGATGGAATCAGACGG
GCTACTCTACCTGCGGGTTGAGGATGATGGTACCGGCATGGAGGGTATACCCGATGGTACCGTTGGTCTGTCGCTCATGA
GGGCCCTTGCAGATCAGCTTGAGGGTGAACTTGAGATAGAATCAGATCAGGGTACTGTGGTGTCCCTAAGGTTCAGGGAA
CTCGAATACATGAAAAGAACCTAG

Upstream 100 bases:

>100_bases
TTAAGAGCGTCCAGGTCCACCCTTTACTGAAGATCAGGGATCAGCTGTGCTGCAAGTATCCGAAAGATTTTATTAACATG
ATCCCACAGAAGTTCTATGG

Downstream 100 bases:

>100_bases
TGCGGGACACGCTGTGCTGGTTTTCAATATCTGCAGTTATAGAGATCCGGTTTTTTGCGGATTTTAAGGGATCAGCTGTT
GAATGGGATCTTCCCGGTTA

Product: sensory transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MLNLEPDSAIFARRLSFSFALAVIILSALTITGHLMGIPQLRGEIMGSPHTQPMTAAVFLMLGSAIILLSKQIRTPALYI
ATFLLVFYTLTVTGYLQTSITGYGSNSRFISSILFIIYAIILILFSSSRYTAPQVLAFSAGTVAYCVATGYLGGVGVYGQ
YFQMAFYTAILHLLTSTSFLSLYPEEGIVAPIHMSFTGGHLARLLIPIMIASITILGLFTMKISQRLFPGFGEVFLMGMT
ASLTIIVVILASDELNRIDEKRSEYQRDLLEAQKFFRDVVENLAEAVAVFDKEGSIIYRNSAMKKLGIMDLPRPSSSGEP
VMIEQMKVGDGHYTGWMVPRFSDGKFTGYIVSLTDITDLIGIQRSLESTVSERDALLAEVHHRVKNNLQIIMSLLNIQAM
NASEEAREVLRDAQSRVRAMAILHETIYDSGNFTGVDMGSFITRLIERLVSAYGVYGIHFRVDADVRVNLETAIPLGLLI
NEAVTNSIRHAFPSGEGSITVTMESDGLLYLRVEDDGTGMEGIPDGTVGLSLMRALADQLEGELEIESDQGTVVSLRFRE
LEYMKRT

Sequences:

>Translated_567_residues
MLNLEPDSAIFARRLSFSFALAVIILSALTITGHLMGIPQLRGEIMGSPHTQPMTAAVFLMLGSAIILLSKQIRTPALYI
ATFLLVFYTLTVTGYLQTSITGYGSNSRFISSILFIIYAIILILFSSSRYTAPQVLAFSAGTVAYCVATGYLGGVGVYGQ
YFQMAFYTAILHLLTSTSFLSLYPEEGIVAPIHMSFTGGHLARLLIPIMIASITILGLFTMKISQRLFPGFGEVFLMGMT
ASLTIIVVILASDELNRIDEKRSEYQRDLLEAQKFFRDVVENLAEAVAVFDKEGSIIYRNSAMKKLGIMDLPRPSSSGEP
VMIEQMKVGDGHYTGWMVPRFSDGKFTGYIVSLTDITDLIGIQRSLESTVSERDALLAEVHHRVKNNLQIIMSLLNIQAM
NASEEAREVLRDAQSRVRAMAILHETIYDSGNFTGVDMGSFITRLIERLVSAYGVYGIHFRVDADVRVNLETAIPLGLLI
NEAVTNSIRHAFPSGEGSITVTMESDGLLYLRVEDDGTGMEGIPDGTVGLSLMRALADQLEGELEIESDQGTVVSLRFRE
LEYMKRT
>Mature_567_residues
MLNLEPDSAIFARRLSFSFALAVIILSALTITGHLMGIPQLRGEIMGSPHTQPMTAAVFLMLGSAIILLSKQIRTPALYI
ATFLLVFYTLTVTGYLQTSITGYGSNSRFISSILFIIYAIILILFSSSRYTAPQVLAFSAGTVAYCVATGYLGGVGVYGQ
YFQMAFYTAILHLLTSTSFLSLYPEEGIVAPIHMSFTGGHLARLLIPIMIASITILGLFTMKISQRLFPGFGEVFLMGMT
ASLTIIVVILASDELNRIDEKRSEYQRDLLEAQKFFRDVVENLAEAVAVFDKEGSIIYRNSAMKKLGIMDLPRPSSSGEP
VMIEQMKVGDGHYTGWMVPRFSDGKFTGYIVSLTDITDLIGIQRSLESTVSERDALLAEVHHRVKNNLQIIMSLLNIQAM
NASEEAREVLRDAQSRVRAMAILHETIYDSGNFTGVDMGSFITRLIERLVSAYGVYGIHFRVDADVRVNLETAIPLGLLI
NEAVTNSIRHAFPSGEGSITVTMESDGLLYLRVEDDGTGMEGIPDGTVGLSLMRALADQLEGELEIESDQGTVVSLRFRE
LEYMKRT

Specific function: Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR [H]

COG id: COG3920

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR022066
- InterPro:   IPR011495
- InterPro:   IPR005467 [H]

Pfam domain/function: PF12282 H_kinase_N; PF02518 HATPase_c; PF07568 HisKA_2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62433; Mature: 62433

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50112 PAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLEPDSAIFARRLSFSFALAVIILSALTITGHLMGIPQLRGEIMGSPHTQPMTAAVFL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHH
MLGSAIILLSKQIRTPALYIATFLLVFYTLTVTGYLQTSITGYGSNSRFISSILFIIYAI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHH
ILILFSSSRYTAPQVLAFSAGTVAYCVATGYLGGVGVYGQYFQMAFYTAILHLLTSTSFL
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHE
SLYPEEGIVAPIHMSFTGGHLARLLIPIMIASITILGLFTMKISQRLFPGFGEVFLMGMT
EECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ASLTIIVVILASDELNRIDEKRSEYQRDLLEAQKFFRDVVENLAEAVAVFDKEGSIIYRN
HCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
SAMKKLGIMDLPRPSSSGEPVMIEQMKVGDGHYTGWMVPRFSDGKFTGYIVSLTDITDLI
CHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEECEEEEECCCCCEEEEEEEHHHHHHHH
GIQRSLESTVSERDALLAEVHHRVKNNLQIIMSLLNIQAMNASEEAREVLRDAQSRVRAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AILHETIYDSGNFTGVDMGSFITRLIERLVSAYGVYGIHFRVDADVRVNLETAIPLGLLI
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCEEEEEHHHCCHHHHH
NEAVTNSIRHAFPSGEGSITVTMESDGLLYLRVEDDGTGMEGIPDGTVGLSLMRALADQL
HHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
EGELEIESDQGTVVSLRFRELEYMKRT
CCCEEEECCCCCEEEEEHHHHHHHHCC
>Mature Secondary Structure
MLNLEPDSAIFARRLSFSFALAVIILSALTITGHLMGIPQLRGEIMGSPHTQPMTAAVFL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHH
MLGSAIILLSKQIRTPALYIATFLLVFYTLTVTGYLQTSITGYGSNSRFISSILFIIYAI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHH
ILILFSSSRYTAPQVLAFSAGTVAYCVATGYLGGVGVYGQYFQMAFYTAILHLLTSTSFL
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHE
SLYPEEGIVAPIHMSFTGGHLARLLIPIMIASITILGLFTMKISQRLFPGFGEVFLMGMT
EECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ASLTIIVVILASDELNRIDEKRSEYQRDLLEAQKFFRDVVENLAEAVAVFDKEGSIIYRN
HCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
SAMKKLGIMDLPRPSSSGEPVMIEQMKVGDGHYTGWMVPRFSDGKFTGYIVSLTDITDLI
CHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEECEEEEECCCCCEEEEEEEHHHHHHHH
GIQRSLESTVSERDALLAEVHHRVKNNLQIIMSLLNIQAMNASEEAREVLRDAQSRVRAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AILHETIYDSGNFTGVDMGSFITRLIERLVSAYGVYGIHFRVDADVRVNLETAIPLGLLI
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCEEEEEHHHCCHHHHH
NEAVTNSIRHAFPSGEGSITVTMESDGLLYLRVEDDGTGMEGIPDGTVGLSLMRALADQL
HHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
EGELEIESDQGTVVSLRFRELEYMKRT
CCCEEEECCCCCEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]