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Identifier: 15678342

GI number: 15678342

Start: 248700

End: 250058

Strand: Direct

Name: Not Available

Synonym: MTH314

Alternate gene names: 15678342

Gene position: 248700-250058 (Clockwise)

Preceding gene: 15678341

Following gene: 15678343

Centisome position: 14.2

GC content: 60.19

Gene sequence:

>1359_bases
GTGGAGGTGAGCGAGGGAATCGAAATCATAAGGGGAGACCCCAGGAGGGCCCTCATCAAACTATCAGGGCCACTCATAGT
TGCAATGCTCCTCACATCCATCTACAACCTCGTGGACGCGGTATGGGTGGCAGGCCTTGGAGGCGAGGCCCTCGCAGCCA
TAGGATTCGTTACACCCATCTACATGATCCTCGTGGGCCTCTCCAACGGCCTAGGCGCCGGGGCAGCATCATCGGTCTCA
AGGTGCCTGGGTGCCGGTGATGAGGAGGGAATGAACAACAGCGCATCCCACACAATCATCATCACACTGGCGGTCTCAAT
AATCCTGACGGTGATAATCGAGATCCTCCTGAGGGACATCCTCCTCTCCCTGGGCGCCGCCGGGGCCCTGAAACCGGCAA
TGGAGTACGGTAGTGTGGTCTTTGCGGGTACCCTCTTCACCCTCTTCCCCGGGGCTGCCTACGGTATACTGAGGTCTGAG
GGTGATGCCAGGAGGCCCATGTATGCCATGGGTTTATCAGCTGTCCTCAACATGGTCCTGGACCCCATCCTCATCTACAC
GGCGGGCTGGGGGATAGCAGGGGCGGCCTGGGCCACGGTGATATCACAGCTCCTGGTGTCGCTCCTCATAATCTACTGGT
TCCTCGCAGGGAGGACCTTCACCTCCATAGGCTGGAGCCACTTCAGGGCCGACCGGGGGGTCGTCTGGTCCATCCTCTCG
GTCACCATACCCGCAAGTGCCGAGTTCCTGGTCATGTCCATGGTAACAGCCCTCCTCAACTGGATACTCACATCTGTGGC
CGGGACCTCGGCGGTGGCTGTATACTCCGCAGGGTGGAGGATAGTGATGCTCGCCATAGTCCCGGTGATATCGGTGGCAA
CAGCCCTTGTGAGCGTATCTGGCGTGGCATACGGGTCAAGGAACTTCGAAAACCTGGAGGTGGCCCACGGTTACTCAATA
AGGCTGGGCCTCCTGATAGCGGGGGCCACGGCGGCCCTCACATTCGTCCTGGCGCCATGGATAGCCTGGATATTCTCCTA
CTCCCAGGCATCATCCCATCTGGCCCCGAGGATAACCGGGTTCCTGAGGGTCATATGCCTCTTCTACATCTTCCTGCCCC
CGGGTATAATGTCAGGGTCCATATTCCAGGGCGCGGGGCGCGGGATGACGTCCCTCATGCTCTCGGTGATAAGGCAGGTC
CTCCTGGTCGCGGTCTTCGCATACCTCCTCGCCGTGACCCTGGGCCTCGGTGAGGTTGGTGTCTGGTGGGGTGTCGTTGC
AGGTGACATCGGGGGTAGCCTGGTGGCCTACCTGTGGGCCAGACTCTTCATCGGGAGGCTCCGGAGGTACGCTGCCTGA

Upstream 100 bases:

>100_bases
GGGAGGACCTCCTCTTCAGAGACTTCACAGAGGATGAGAGGAAACTCTTCAGGAAGATGTGCCGGAGACTGGCAGAGGAG
GCAGTCAGGATGAGGGGTGA

Downstream 100 bases:

>100_bases
TCATCTTAAAGTTCATATGAAGATCTCAGCCACTCTCCTAAGCGGATTATAAATTAGTCTCAGAAGCCTTTTTTCTTCAA
CGGCAGCGTGTGAGGTTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MEVSEGIEIIRGDPRRALIKLSGPLIVAMLLTSIYNLVDAVWVAGLGGEALAAIGFVTPIYMILVGLSNGLGAGAASSVS
RCLGAGDEEGMNNSASHTIIITLAVSIILTVIIEILLRDILLSLGAAGALKPAMEYGSVVFAGTLFTLFPGAAYGILRSE
GDARRPMYAMGLSAVLNMVLDPILIYTAGWGIAGAAWATVISQLLVSLLIIYWFLAGRTFTSIGWSHFRADRGVVWSILS
VTIPASAEFLVMSMVTALLNWILTSVAGTSAVAVYSAGWRIVMLAIVPVISVATALVSVSGVAYGSRNFENLEVAHGYSI
RLGLLIAGATAALTFVLAPWIAWIFSYSQASSHLAPRITGFLRVICLFYIFLPPGIMSGSIFQGAGRGMTSLMLSVIRQV
LLVAVFAYLLAVTLGLGEVGVWWGVVAGDIGGSLVAYLWARLFIGRLRRYAA

Sequences:

>Translated_452_residues
MEVSEGIEIIRGDPRRALIKLSGPLIVAMLLTSIYNLVDAVWVAGLGGEALAAIGFVTPIYMILVGLSNGLGAGAASSVS
RCLGAGDEEGMNNSASHTIIITLAVSIILTVIIEILLRDILLSLGAAGALKPAMEYGSVVFAGTLFTLFPGAAYGILRSE
GDARRPMYAMGLSAVLNMVLDPILIYTAGWGIAGAAWATVISQLLVSLLIIYWFLAGRTFTSIGWSHFRADRGVVWSILS
VTIPASAEFLVMSMVTALLNWILTSVAGTSAVAVYSAGWRIVMLAIVPVISVATALVSVSGVAYGSRNFENLEVAHGYSI
RLGLLIAGATAALTFVLAPWIAWIFSYSQASSHLAPRITGFLRVICLFYIFLPPGIMSGSIFQGAGRGMTSLMLSVIRQV
LLVAVFAYLLAVTLGLGEVGVWWGVVAGDIGGSLVAYLWARLFIGRLRRYAA
>Mature_452_residues
MEVSEGIEIIRGDPRRALIKLSGPLIVAMLLTSIYNLVDAVWVAGLGGEALAAIGFVTPIYMILVGLSNGLGAGAASSVS
RCLGAGDEEGMNNSASHTIIITLAVSIILTVIIEILLRDILLSLGAAGALKPAMEYGSVVFAGTLFTLFPGAAYGILRSE
GDARRPMYAMGLSAVLNMVLDPILIYTAGWGIAGAAWATVISQLLVSLLIIYWFLAGRTFTSIGWSHFRADRGVVWSILS
VTIPASAEFLVMSMVTALLNWILTSVAGTSAVAVYSAGWRIVMLAIVPVISVATALVSVSGVAYGSRNFENLEVAHGYSI
RLGLLIAGATAALTFVLAPWIAWIFSYSQASSHLAPRITGFLRVICLFYIFLPPGIMSGSIFQGAGRGMTSLMLSVIRQV
LLVAVFAYLLAVTLGLGEVGVWWGVVAGDIGGSLVAYLWARLFIGRLRRYAA

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=455, Percent_Identity=23.5164835164835, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47712; Mature: 47712

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVSEGIEIIRGDPRRALIKLSGPLIVAMLLTSIYNLVDAVWVAGLGGEALAAIGFVTPI
CCCHHCCHHHCCCCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
YMILVGLSNGLGAGAASSVSRCLGAGDEEGMNNSASHTIIITLAVSIILTVIIEILLRDI
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLSLGAAGALKPAMEYGSVVFAGTLFTLFPGAAYGILRSEGDARRPMYAMGLSAVLNMVL
HHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
DPILIYTAGWGIAGAAWATVISQLLVSLLIIYWFLAGRTFTSIGWSHFRADRGVVWSILS
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHCCCCHHHHHHH
VTIPASAEFLVMSMVTALLNWILTSVAGTSAVAVYSAGWRIVMLAIVPVISVATALVSVS
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GVAYGSRNFENLEVAHGYSIRLGLLIAGATAALTFVLAPWIAWIFSYSQASSHLAPRITG
HHCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLRVICLFYIFLPPGIMSGSIFQGAGRGMTSLMLSVIRQVLLVAVFAYLLAVTLGLGEVG
HHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VWWGVVAGDIGGSLVAYLWARLFIGRLRRYAA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEVSEGIEIIRGDPRRALIKLSGPLIVAMLLTSIYNLVDAVWVAGLGGEALAAIGFVTPI
CCCHHCCHHHCCCCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
YMILVGLSNGLGAGAASSVSRCLGAGDEEGMNNSASHTIIITLAVSIILTVIIEILLRDI
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLSLGAAGALKPAMEYGSVVFAGTLFTLFPGAAYGILRSEGDARRPMYAMGLSAVLNMVL
HHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
DPILIYTAGWGIAGAAWATVISQLLVSLLIIYWFLAGRTFTSIGWSHFRADRGVVWSILS
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHCCCCHHHHHHH
VTIPASAEFLVMSMVTALLNWILTSVAGTSAVAVYSAGWRIVMLAIVPVISVATALVSVS
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GVAYGSRNFENLEVAHGYSIRLGLLIAGATAALTFVLAPWIAWIFSYSQASSHLAPRITG
HHCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLRVICLFYIFLPPGIMSGSIFQGAGRGMTSLMLSVIRQVLLVAVFAYLLAVTLGLGEVG
HHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VWWGVVAGDIGGSLVAYLWARLFIGRLRRYAA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]