Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678289

GI number: 15678289

Start: 201676

End: 202902

Strand: Direct

Name: Not Available

Synonym: MTH261

Alternate gene names: 15678289

Gene position: 201676-202902 (Clockwise)

Preceding gene: 15678288

Following gene: 15678290

Centisome position: 11.52

GC content: 54.52

Gene sequence:

>1227_bases
GTGAAAAATCAATCCGAAATAAACATTGGTCTTGTGGGGCACGTGGACCATGGTAAAACAACCCTTACAAAGGCACTTTC
AGGTGTCTGGACCGACACACACAGTGAGGAAACCAAGAGGGGCATCTCCATACGTCTGGGCTATGCCGACATAACCTTCA
GGAAGTGCCCGCAGTGCGAAGCCCCAATGTGCTATACAACGGCAGAGATATGTGAGAGGTGCGGCACAGAGACAGAGCTC
CTCAGGAAGGTTTCCTTTGTGGATGCCCCGGGCCATGAAACCCTCATGGCTACCATGCTCTCTGGAGCAGCCCTCATGGA
CGGCGCCATACTCGTGATAGCTGCAAACGAACCATGCCCCCAGCCCCAGACAAAGGAGCACCTCATGGCCCTTGATGTTA
TAGGGGTGAAGGATGTCATCGTCGTCCAGAACAAGATAGATATCGTTTCGAAGGAGAGGGCGCTTGAAAGCTACAGGGAG
ATCAAGGAGTTCGTGAAGGGTACCTGCGCTGAGGATGCACCTATAATACCGGTATCTGCTCAACAGGGCGCCAACATTGA
TATCCTCATTGAAACCATTGAGGAGAGAATCAAAACCCCCAAGAGGGACGTTGATAAACCTGCCAGGATGTACGTGGCCA
GGTCCTTTGACATAAACAAACCTGGCGCAGACCCCGAACACCTCGCAGGAGGAGTTATAGGGGGCTCACTGGTCCAGGGC
AGGCTCAGGGTTGGAGACGAGATAGAGATAAGACCGGGCATACAGGTCAAAAAGGACGGTAAGCAGACCTGGATGAGTCT
GCACTCCACAATCACGGGCCTGGTGGCCGGTGGAGAGGAGATGGAAGAAGTTGGACCCGGCGGACTCGTGGGTGTCGGGA
CACTCCTGGATCCAGCCCTCACCAAGGCGGACTCACTTTCAGGGTCAGTTGCCGGGGAACCAGGCACACTGCCACCTGTA
AGGCACTCATTCACCATGGAGACACACCTCCTGGAGAGGGTTGTCGGTACCAAGGAGGAGACCAAGGTCGAACCCATAAA
GACAGGGGAACCCCTGATGATAAACGTCGGTACCACAACCACGGTGGGTGTTGTCAAATCTGCCAGGGCAGATGATGCCG
ACGTGGTCCTCAAACTCCCTGCATGCGCAGAGGAGGGTCAGAGGATAGCCCTCTCCAGGCGTGTCGGTGCAAGATGGAGG
CTGATAGGATATGGTATCATCAAATAG

Upstream 100 bases:

>100_bases
AGTCCAGATAAACACCGTTGTCATTGAGAAGGGTGAGAAACCACTCGAAGAACTCCTTGGCGCCGATGAGGAATAATAAA
AGCGTTTATAGGTGTAATCT

Downstream 100 bases:

>100_bases
GGTGGTCATAGACACCAATTTTTTATGATACCCTACCAGTTCCGGGTCGACATCGTATCCGAGCTCCGGAGACTCTTCCC
AAAAAACGACCTTCTTGTCC

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETEL
LRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYRE
IKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQG
RLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPALTKADSLSGSVAGEPGTLPPV
RHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWR
LIGYGIIK

Sequences:

>Translated_408_residues
MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETEL
LRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYRE
IKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQG
RLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPALTKADSLSGSVAGEPGTLPPV
RHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWR
LIGYGIIK
>Mature_408_residues
MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETEL
LRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYRE
IKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQG
RLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPALTKADSLSGSVAGEPGTLPPV
RHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWR
LIGYGIIK

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

Homologues:

Organism=Homo sapiens, GI4503507, Length=431, Percent_Identity=45.4756380510441, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI34147630, Length=441, Percent_Identity=26.7573696145125, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI54607086, Length=290, Percent_Identity=29.6551724137931, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI223555963, Length=278, Percent_Identity=25.8992805755396, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI5729864, Length=278, Percent_Identity=25.8992805755396, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI2367247, Length=404, Percent_Identity=26.7326732673267, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1790412, Length=439, Percent_Identity=27.7904328018223, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789737, Length=439, Percent_Identity=27.7904328018223, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17509919, Length=425, Percent_Identity=45.6470588235294, Blast_Score=380, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17556456, Length=321, Percent_Identity=29.9065420560748, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25141371, Length=347, Percent_Identity=29.1066282420749, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506081, Length=270, Percent_Identity=29.2592592592593, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115532067, Length=196, Percent_Identity=30.6122448979592, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532065, Length=196, Percent_Identity=30.6122448979592, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320863, Length=424, Percent_Identity=47.1698113207547, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324761, Length=330, Percent_Identity=31.5151515151515, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6325337, Length=307, Percent_Identity=26.0586319218241, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319594, Length=307, Percent_Identity=26.0586319218241, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24647046, Length=424, Percent_Identity=46.6981132075472, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24647048, Length=424, Percent_Identity=46.6981132075472, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19922690, Length=254, Percent_Identity=34.6456692913386, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281363316, Length=328, Percent_Identity=30.1829268292683, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17864358, Length=328, Percent_Identity=30.1829268292683, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19921738, Length=223, Percent_Identity=32.7354260089686, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45550900, Length=419, Percent_Identity=25.5369928400955, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF2G_METTH (O26361)

Other databases:

- EMBL:   AE000666
- PIR:   H69132
- RefSeq:   NP_275404.1
- ProteinModelPortal:   O26361
- SMR:   O26361
- STRING:   O26361
- GeneID:   1470222
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH261
- NMPDR:   fig|187420.1.peg.259
- eggNOG:   arNOG04625
- HOGENOM:   HBG307581
- OMA:   IAANEPC
- PhylomeDB:   O26361
- ProtClustDB:   PRK04000
- BioCyc:   MTHE187420:MTH261-MONOMER
- HAMAP:   MF_00119
- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR03680

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF50465 Elong_init_C; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 43898; Mature: 43898

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCE
CCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEEECEEEECCCCCCCC
APMCYTTAEICERCGTETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCP
CCCEECHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCEEEEEECCCCCC
QPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYREIKEFVKGTCAEDAPIIPVSA
CCCCHHHEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
QQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQG
CCCCCEEEEHHHHHHHHCCCCCCCCCHHHEEEEEECCCCCCCCCHHHHHCCCCCHHHHHC
RLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPAL
CCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEHHHHHHHHH
TKADSLSGSVAGEPGTLPPVRHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTT
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCC
TVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWRLIGYGIIK
CHHHHHHCCCCCCCEEEECCCCCCCCCEEEEECCCCCEEEEEEEEECC
>Mature Secondary Structure
MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCE
CCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEEECEEEECCCCCCCC
APMCYTTAEICERCGTETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCP
CCCEECHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCEEEEEECCCCCC
QPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYREIKEFVKGTCAEDAPIIPVSA
CCCCHHHEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
QQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQG
CCCCCEEEEHHHHHHHHCCCCCCCCCHHHEEEEEECCCCCCCCCHHHHHCCCCCHHHHHC
RLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPAL
CCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEHHHHHHHHH
TKADSLSGSVAGEPGTLPPVRHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTT
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCC
TVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWRLIGYGIIK
CHHHHHHCCCCCCCEEEECCCCCCCCCEEEEECCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463