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Identifier: 15678281

GI number: 15678281

Start: 196257

End: 197477

Strand: Direct

Name: Not Available

Synonym: MTH253

Alternate gene names: 15678281

Gene position: 196257-197477 (Clockwise)

Preceding gene: 15678280

Following gene: 15678282

Centisome position: 11.21

GC content: 54.3

Gene sequence:

>1221_bases
ATGGATGGTGAATCTGTGATAAGGTGCATATCATGTGGTCGAGAGTATGACCTGGAGGAGATCATATACACCTGCAGGGA
GTGCGGGTCGGTACTTGAAGTTGAATGTGACGTGGAGGTCTCAAGGGACGTCTTCAGGGGCAGAAGGCAGAACATGTGGA
GGTACAGGGAGTTCATGCCTGTTGACCCCTCAAGGATAGTCAGCCTCGATGAGGGGGGAACACCCTTTGTCAGGTGTGAC
ACCATAGGATCTGAACTTGGTATTGAGCTCTATGTGAAGGTGGAGGGCTCCAACCCCACAGGGAGCTTCAAGGACAGGGG
GATGAGCGTGGGGATCACAAAGGCCCTTGAACTTGGCGTTGATACTGTGGGGTGCGCCTCAACCGGTAACACCTCAGCCT
CCCTTGCAGCCTACGCAGCCAGGGCTGGGCTGGGCTGCGTCGTTCTACTCCCATCAGGTAAGGTCGCCCTCGGTAAACTT
GCCCAGGCTATGTTCCATGGCGCCAGGGTCCTCTCGGTGAGGGGAAACTTTGACGAGGCCCTTGAGGCTGTCACGGAACT
TGCACTGATGGGTGAACTCTACCTCCTCAACTCCGTGAACCCCTTCAGGCTTGAGGGTCAGAAGTCAATAGGCTTTGAGA
TAGTGGATGACCTCGGCTGGGAGTCCCCTGACCGCATCATACTGCCTGTGGGGAATGCAGGTAATATCTCAGCCATCTGG
AAGGGTATATCAGAGTTTTACAGGGCTGGATTCATAGATGAGAGGCCGATGATGACCGGTATACAGGCCGAGGGCGCTTC
ACCGGTGGTAGAAGCCTTCAGGAAGGGCAGAACCGAGATTGAACCGGTCAGGGATCCTGAAACGGTTGCAACGGCCATAA
GGATAGGGGCCCCTGTTAGCTATCTCAAGGCCCTCCGGGCCATATATGAGTCAGATGGTTATGCTGAATCCGTGACCGAT
GAGGAGATACTCTCTGCCCAGAAACTCCTTGCAAGGAGGGAGGGTATAGGTGTTGAGCCCGCATCAGCGGCGTCCATAGC
GGGTCTCATCAAACTCGTTGATGAGGGTGTTGTTGACAGGGGTGAACGTGTGGTCTGTGTTGTCACTGGTCATGTACTCA
AGGACCCTGACACCGCCATAAAGGCATCAACGGAACCAGTTGAGGTAGAACCTGATATAAACCAGTTAAGATCCATTATA
AGGGGTACGGGGTCCTCCTAG

Upstream 100 bases:

>100_bases
CAGCTACATAAAGGGGTCCATCTAGACCCCGTTTAATTTCCCTGGTTAATTCAGGTACATATTGATAAGGTGAATCAGAA
ACTTTATTCTTACCGGTAAA

Downstream 100 bases:

>100_bases
CCCCCTGAATTCTTGAAGATACCTTTCTCTTTTTTAAGCTTTTCTATTTTTCATCGGACAACTTGAAGTTAATTTCTCAC
CCTCCAAGCACTCGTGGATA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MDGESVIRCISCGREYDLEEIIYTCRECGSVLEVECDVEVSRDVFRGRRQNMWRYREFMPVDPSRIVSLDEGGTPFVRCD
TIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGKL
AQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISAIW
KGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVSYLKALRAIYESDGYAESVTD
EEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLKDPDTAIKASTEPVEVEPDINQLRSII
RGTGSS

Sequences:

>Translated_406_residues
MDGESVIRCISCGREYDLEEIIYTCRECGSVLEVECDVEVSRDVFRGRRQNMWRYREFMPVDPSRIVSLDEGGTPFVRCD
TIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGKL
AQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISAIW
KGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVSYLKALRAIYESDGYAESVTD
EEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLKDPDTAIKASTEPVEVEPDINQLRSII
RGTGSS
>Mature_406_residues
MDGESVIRCISCGREYDLEEIIYTCRECGSVLEVECDVEVSRDVFRGRRQNMWRYREFMPVDPSRIVSLDEGGTPFVRCD
TIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGKL
AQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISAIW
KGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVSYLKALRAIYESDGYAESVTD
EEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLKDPDTAIKASTEPVEVEPDINQLRSII
RGTGSS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI2367138, Length=317, Percent_Identity=28.0757097791798, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 43717; Mature: 43717

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGESVIRCISCGREYDLEEIIYTCRECGSVLEVECDVEVSRDVFRGRRQNMWRYREFMP
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
VDPSRIVSLDEGGTPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGV
CCHHHEEEECCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCHHHCCCEECHHHHHHHCC
DTVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGKLAQAMFHGARVLSVRGNFDEA
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHH
LEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISAIW
HHHHHHHHHHHHHHEECCCCCEEECCCCCCCCEEHHHCCCCCCCEEEEECCCCCCHHHHH
KGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVS
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHH
YLKALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
GERVVCVVTGHVLKDPDTAIKASTEPVEVEPDINQLRSIIRGTGSS
CCEEEEEEECCEECCCCHHHCCCCCCEEECCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MDGESVIRCISCGREYDLEEIIYTCRECGSVLEVECDVEVSRDVFRGRRQNMWRYREFMP
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
VDPSRIVSLDEGGTPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGV
CCHHHEEEECCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCHHHCCCEECHHHHHHHCC
DTVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGKLAQAMFHGARVLSVRGNFDEA
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHH
LEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISAIW
HHHHHHHHHHHHHHEECCCCCEEECCCCCCCCEEHHHCCCCCCCEEEEECCCCCCHHHHH
KGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVS
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHH
YLKALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
GERVVCVVTGHVLKDPDTAIKASTEPVEVEPDINQLRSIIRGTGSS
CCEEEEEEECCEECCCCHHHCCCCCCEEECCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]