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Identifier: 15678279

GI number: 15678279

Start: 194405

End: 195499

Strand: Direct

Name: Not Available

Synonym: MTH251

Alternate gene names: 15678279

Gene position: 194405-195499 (Clockwise)

Preceding gene: 15678278

Following gene: 15678280

Centisome position: 11.1

GC content: 53.15

Gene sequence:

>1095_bases
TTGATAGACCCTTGGGGATCAGCAAAGCTTGAATACCAGGATCTTATTGAGAACTTCGGCGTCAGACCCTTCAGTGAGGT
CCTTGACGAAGTACCCGAACCCAGCTGGCTCATGAGGCGGGGCATAATCTTCGGACACAGGGACTATGAGAGGATAATCA
GTGCCATGAAGAAGGGTGAGGACTTCGCGGTTGTAACAGGGATGATGCCAAGCGGAAGGATGCATATAGGCCACAAGATG
ATCGTGGACCAGCTCAGATGGTACGACAGGATGGGGGCCGAGATATTCATACCCATAGCAGACATGGAGGCCTACTCAGC
CAGGGGGGTGGACTTCGAGGACTCAAGGAGGATAGCCATTGAGGAGTACATCGCAGGGTACATTGCCCTCGGACTTGACC
TTGAGAAGGATAACATACACGTCTACCTCCAGTCAGAGAACCTCATGGTGGAGGACCTCGCCTATGTCCTTGCAGGGAAG
GTCAACTTCAATGAGCTCAGGGCGATCTATGGTTTCACAGGATCCACGAGCATGGCCCACATGTACGCCCCCATAATACA
GGTCTCAGACATCCTGCACCCCCAGCTGGATGAACTGGGGGGCCCCAGACCCGTAATTGTCCCTGTGGGCCCGGACCAGG
ACCCCCATATAAGGCTGACACGGGATATAGCAGCCAGGTTCAGGGACAGGTATGGCTTCATCCTCCCCTCATCAACATAC
CACAGATTCATGGGCGGCCTCACCGGGGGTAAGATGTCAAGCAACAGGCCCAAATCCGCCATATTCCTGAGCGACACACC
TGAGGAGGCAGAGGCGAAGATAAGGAACGCCAAGACCGGGGGGAGGGAGACCCTGAAGGAGCAAAGGGAACTTGGAGGAG
TGCCGGAGGAGTGCATAATATATGAGACACTCCTCTACCACATGTCAGGTTCAGACTCCAGGCTTGAGGAGATATATGAA
TCATGCAGAAACGGTACACTTATGTGCGGTGAGTGCAAAAATAATACTGCAGAGTTTATCAGGAAGTTCTTCGAGGAACT
TTCGGTGAAAAGGGAGAAGGCCCTTCCTGCTGCCAGAAGGATTCTTGAGGGATAA

Upstream 100 bases:

>100_bases
TGAGGAGGACATAACCTACTACCTTGTCGACTGGATAAGGCCATGATTTGGCTACTATGACGGCTTAAGCAACAGAAATG
ACTTAATAACGGTGATATGA

Downstream 100 bases:

>100_bases
AAATGAGAAATAAGAAGGTCAGATGGATTCTGATGGGGGTTCGAAGATGAGAAGGAAGGAGAAATATGAGGGCACACTGA
GTTACATCATAAGGAACAAT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MIDPWGSAKLEYQDLIENFGVRPFSEVLDEVPEPSWLMRRGIIFGHRDYERIISAMKKGEDFAVVTGMMPSGRMHIGHKM
IVDQLRWYDRMGAEIFIPIADMEAYSARGVDFEDSRRIAIEEYIAGYIALGLDLEKDNIHVYLQSENLMVEDLAYVLAGK
VNFNELRAIYGFTGSTSMAHMYAPIIQVSDILHPQLDELGGPRPVIVPVGPDQDPHIRLTRDIAARFRDRYGFILPSSTY
HRFMGGLTGGKMSSNRPKSAIFLSDTPEEAEAKIRNAKTGGRETLKEQRELGGVPEECIIYETLLYHMSGSDSRLEEIYE
SCRNGTLMCGECKNNTAEFIRKFFEELSVKREKALPAARRILEG

Sequences:

>Translated_364_residues
MIDPWGSAKLEYQDLIENFGVRPFSEVLDEVPEPSWLMRRGIIFGHRDYERIISAMKKGEDFAVVTGMMPSGRMHIGHKM
IVDQLRWYDRMGAEIFIPIADMEAYSARGVDFEDSRRIAIEEYIAGYIALGLDLEKDNIHVYLQSENLMVEDLAYVLAGK
VNFNELRAIYGFTGSTSMAHMYAPIIQVSDILHPQLDELGGPRPVIVPVGPDQDPHIRLTRDIAARFRDRYGFILPSSTY
HRFMGGLTGGKMSSNRPKSAIFLSDTPEEAEAKIRNAKTGGRETLKEQRELGGVPEECIIYETLLYHMSGSDSRLEEIYE
SCRNGTLMCGECKNNTAEFIRKFFEELSVKREKALPAARRILEG
>Mature_364_residues
MIDPWGSAKLEYQDLIENFGVRPFSEVLDEVPEPSWLMRRGIIFGHRDYERIISAMKKGEDFAVVTGMMPSGRMHIGHKM
IVDQLRWYDRMGAEIFIPIADMEAYSARGVDFEDSRRIAIEEYIAGYIALGLDLEKDNIHVYLQSENLMVEDLAYVLAGK
VNFNELRAIYGFTGSTSMAHMYAPIIQVSDILHPQLDELGGPRPVIVPVGPDQDPHIRLTRDIAARFRDRYGFILPSSTY
HRFMGGLTGGKMSSNRPKSAIFLSDTPEEAEAKIRNAKTGGRETLKEQRELGGVPEECIIYETLLYHMSGSDSRLEEIYE
SCRNGTLMCGECKNNTAEFIRKFFEELSVKREKALPAARRILEG

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI47419920, Length=375, Percent_Identity=28.2666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI47419918, Length=375, Percent_Identity=28.2666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI47419916, Length=375, Percent_Identity=28.2666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI47419914, Length=375, Percent_Identity=28.2666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI72001474, Length=370, Percent_Identity=28.1081081081081, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324475, Length=374, Percent_Identity=27.807486631016, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17864462, Length=373, Percent_Identity=28.9544235924933, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24645295, Length=373, Percent_Identity=28.9544235924933, Blast_Score=147, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_METTH (O26352)

Other databases:

- EMBL:   AE000666
- PIR:   E69131
- RefSeq:   NP_275394.1
- ProteinModelPortal:   O26352
- SMR:   O26352
- STRING:   O26352
- GeneID:   1470212
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH251
- NMPDR:   fig|187420.1.peg.249
- eggNOG:   arNOG04974
- HOGENOM:   HBG435805
- OMA:   ADILHPQ
- PhylomeDB:   O26352
- ProtClustDB:   PRK12285
- BioCyc:   MTHE187420:MTH251-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_A
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- InterPro:   IPR020653
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 41302; Mature: 41302

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPWGSAKLEYQDLIENFGVRPFSEVLDEVPEPSWLMRRGIIFGHRDYERIISAMKKGE
CCCCCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHCCC
DFAVVTGMMPSGRMHIGHKMIVDQLRWYDRMGAEIFIPIADMEAYSARGVDFEDSRRIAI
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCCCCCCCHHH
EEYIAGYIALGLDLEKDNIHVYLQSENLMVEDLAYVLAGKVNFNELRAIYGFTGSTSMAH
HHHHHHHHHCCEEEECCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHH
MYAPIIQVSDILHPQLDELGGPRPVIVPVGPDQDPHIRLTRDIAARFRDRYGFILPSSTY
HHHHHHHHHHHCCCCHHHCCCCCEEEEECCCCCCCCEEEHHHHHHHHHHHCCEECCCHHH
HRFMGGLTGGKMSSNRPKSAIFLSDTPEEAEAKIRNAKTGGRETLKEQRELGGVPEECII
HHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
YETLLYHMSGSDSRLEEIYESCRNGTLMCGECKNNTAEFIRKFFEELSVKREKALPAARR
HHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ILEG
HHCC
>Mature Secondary Structure
MIDPWGSAKLEYQDLIENFGVRPFSEVLDEVPEPSWLMRRGIIFGHRDYERIISAMKKGE
CCCCCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHCCC
DFAVVTGMMPSGRMHIGHKMIVDQLRWYDRMGAEIFIPIADMEAYSARGVDFEDSRRIAI
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCCCCCCCHHH
EEYIAGYIALGLDLEKDNIHVYLQSENLMVEDLAYVLAGKVNFNELRAIYGFTGSTSMAH
HHHHHHHHHCCEEEECCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHH
MYAPIIQVSDILHPQLDELGGPRPVIVPVGPDQDPHIRLTRDIAARFRDRYGFILPSSTY
HHHHHHHHHHHCCCCHHHCCCCCEEEEECCCCCCCCEEEHHHHHHHHHHHCCEECCCHHH
HRFMGGLTGGKMSSNRPKSAIFLSDTPEEAEAKIRNAKTGGRETLKEQRELGGVPEECII
HHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
YETLLYHMSGSDSRLEEIYESCRNGTLMCGECKNNTAEFIRKFFEELSVKREKALPAARR
HHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ILEG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463