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Identifier: 15678263

GI number: 15678263

Start: 176500

End: 177150

Strand: Direct

Name: Not Available

Synonym: MTH235

Alternate gene names: 15678263

Gene position: 176500-177150 (Clockwise)

Preceding gene: 15678261

Following gene: 15678264

Centisome position: 10.08

GC content: 54.99

Gene sequence:

>651_bases
ATGAGACCCTACGTTATACTCAACGCAGCCATGACACTTGATGGTAAGATTGCAACGGCAACAGGGAGCTCTGAGATATC
TGGTGAGGAGGATCTCAGGAGGGTCCATGAACTCAGAAGGGAGTGTGACGCCATAATGGTGGGCATAAACACGGTGCTGG
CGGATGACCCGCGCCTCACAGTCCACAGGGTAGATGCAGCCCCCGGGGATAATCCGGTCAGGGTTGTGGTTGACAGCATG
GCCAGGACACCCCCCCATTTCAGGGTACTTAACGATGAGGCCCCGACGGTGATAGGTGTTTCAGAGAGCGCCCCGCCTGA
GAGGGTTGCTGAGCTCAGAAAAAGGGCTGAAGTGGTTGTTGCAGGGACCCGGCGGGTCGATCTCCATCTTTTACTTGAAC
GGCTGCATGGTATGGGGATAGAGAGACTTATGCTGGAGGGCGGATCGACACTCAACTACTCCATGCTGACCGGTGGCCTG
GTGGATGAGGTCCGGGTCTGCATAGCACCGATGATAGTTGGGGGCAGGGATGCCAGGACCCTTGTGGATGGTGAGGGTAT
AGATGAGATGGCAGATGCCATAAGACTTGAACTTAAACGGTCCTACACCCTGGGTGAGGACCTCATAGTGGAATACACTG
TAAAAGGTTAG

Upstream 100 bases:

>100_bases
TCTCCATGGTTCAACCTCCACTGGTTTCATCATTCTTCGACTTAAAATTCCACATTAATTTATAGGATGACATCTATAAA
TAGGTCGGAGGAGGAAGGCC

Downstream 100 bases:

>100_bases
ACGTGGTTTTCATGCTCGAGGACATATATGAGAGGATAGTAAGGATCAGGGAAGAGGGCTGCAGGGAATGCCTGAAGGTT
GTCTGCAGGATGGATGATTT

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: HTP reductase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRPYVILNAAMTLDGKIATATGSSEISGEEDLRRVHELRRECDAIMVGINTVLADDPRLTVHRVDAAPGDNPVRVVVDSM
ARTPPHFRVLNDEAPTVIGVSESAPPERVAELRKRAEVVVAGTRRVDLHLLLERLHGMGIERLMLEGGSTLNYSMLTGGL
VDEVRVCIAPMIVGGRDARTLVDGEGIDEMADAIRLELKRSYTLGEDLIVEYTVKG

Sequences:

>Translated_216_residues
MRPYVILNAAMTLDGKIATATGSSEISGEEDLRRVHELRRECDAIMVGINTVLADDPRLTVHRVDAAPGDNPVRVVVDSM
ARTPPHFRVLNDEAPTVIGVSESAPPERVAELRKRAEVVVAGTRRVDLHLLLERLHGMGIERLMLEGGSTLNYSMLTGGL
VDEVRVCIAPMIVGGRDARTLVDGEGIDEMADAIRLELKRSYTLGEDLIVEYTVKG
>Mature_216_residues
MRPYVILNAAMTLDGKIATATGSSEISGEEDLRRVHELRRECDAIMVGINTVLADDPRLTVHRVDAAPGDNPVRVVVDSM
ARTPPHFRVLNDEAPTVIGVSESAPPERVAELRKRAEVVVAGTRRVDLHLLLERLHGMGIERLMLEGGSTLNYSMLTGGL
VDEVRVCIAPMIVGGRDARTLVDGEGIDEMADAIRLELKRSYTLGEDLIVEYTVKG

Specific function: Converts 2,5-Diamino-6-(Ribosylamino)-4(3h)-Pyrimidinone 5'-Phosphate Into 5-Amino-6-(Ribosylamino)-2,4(1h,3h)- Pyrimidinedione 5'-Phosphate. [C]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTP reductase family

Homologues:

Organism=Escherichia coli, GI1786616, Length=223, Percent_Identity=32.7354260089686, Blast_Score=98, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIB7_METTH (O26337)

Other databases:

- EMBL:   AE000666
- PIR:   C69129
- RefSeq:   NP_275378.1
- ProteinModelPortal:   O26337
- SMR:   O26337
- STRING:   O26337
- GeneID:   1470196
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH235
- NMPDR:   fig|187420.1.peg.233
- eggNOG:   arNOG09581
- HOGENOM:   HBG668075
- OMA:   ISCEEDL
- PhylomeDB:   O26337
- ProtClustDB:   PRK05625
- BioCyc:   MTHE187420:MTH235-MONOMER
- BRENDA:   1.1.1.193
- InterPro:   IPR006401
- InterPro:   IPR011549
- InterPro:   IPR002734
- TIGRFAMs:   TIGR01508
- TIGRFAMs:   TIGR00227

Pfam domain/function: PF01872 RibD_C

EC number: =1.1.1.193

Molecular weight: Translated: 23577; Mature: 23577

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPYVILNAAMTLDGKIATATGSSEISGEEDLRRVHELRRECDAIMVGINTVLADDPRLT
CCCEEEEEEEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEHHHEECCCCCEE
VHRVDAAPGDNPVRVVVDSMARTPPHFRVLNDEAPTVIGVSESAPPERVAELRKRAEVVV
EEEECCCCCCCCCEEEEEHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHCEEEE
AGTRRVDLHLLLERLHGMGIERLMLEGGSTLNYSMLTGGLVDEVRVCIAPMIVGGRDART
ECCCCHHHHHHHHHHHCCCHHHHHHCCCCEEEEHHHHCCHHHHHHHHHHHHEECCCCCCE
LVDGEGIDEMADAIRLELKRSYTLGEDLIVEYTVKG
EECCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
>Mature Secondary Structure
MRPYVILNAAMTLDGKIATATGSSEISGEEDLRRVHELRRECDAIMVGINTVLADDPRLT
CCCEEEEEEEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEHHHEECCCCCEE
VHRVDAAPGDNPVRVVVDSMARTPPHFRVLNDEAPTVIGVSESAPPERVAELRKRAEVVV
EEEECCCCCCCCCEEEEEHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHCEEEE
AGTRRVDLHLLLERLHGMGIERLMLEGGSTLNYSMLTGGLVDEVRVCIAPMIVGGRDART
ECCCCHHHHHHHHHHHCCCHHHHHHCCCCEEEEHHHHCCHHHHHHHHHHHHEECCCCCCE
LVDGEGIDEMADAIRLELKRSYTLGEDLIVEYTVKG
EECCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463