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Identifier: 15678261

GI number: 15678261

Start: 175193

End: 175963

Strand: Direct

Name: Not Available

Synonym: MTH233

Alternate gene names: 15678261

Gene position: 175193-175963 (Clockwise)

Preceding gene: 15678260

Following gene: 15678263

Centisome position: 10.0

GC content: 50.19

Gene sequence:

>771_bases
ATGGGAGGTATCATCATTATAGACGTTCACTGTCACCTTGACTTCAAGGACTTCAACAGGAACCGTGAAGAGGTCATCGA
AAGGGCCAGGAGTAAATTGAGGGCTGTTATAGATTCAGGGGTTGGTCTCGGGGGTAACAGGAGGGCCCTTGAACTTGCAT
CCCTCAACCCAGGTTTCATATGCCCTACAATGGGGTTCCACCCGGTTGATGCATCAAAGGCAAGACAGGACCTTATAGGG
GAGGTTGTCTCGCAGATAGAATCAAATATTGACCTTATAGTTGCAGTTGGGGAGACAGGCATGGACTTCCACCACACCCG
TGATGAGGAGGGTAGAAGAAGGCAGGAGGAGACCTTCAGGGTATTTGTGGAACTCGCAGCTGAACATGAAATGCCCCTGG
TGGTCCATGCAAGGGACGCTGAGGAGAGGGCCCTTGAAACTGTCCTTGAATACAGGGTACCCGAGGTAATCTTTCACTGC
TATGGTGGAAGCATTGAAACAGCCCGCAGGATACTGGATGAGGGATATTACATATCCATCTCGACACTTGTGGCATTTTC
AGAGCACCACATGGAACTTGTGAGGGCAATCCCCCTTGAGGGCATGTTAACGGAGACAGACAGCCCCTACCTTTCACCCT
TCAGGGGAAAACGTAACGAGCCAGCCTTCGTGGAGGAAGCTGTCAGGGCGATAGCCAGAATCAAGGACATGGACCTTGAG
GATGTTGACAGTATCACAACAGCAAATGCAGAAAGAGTGTTTGGTTTATAG

Upstream 100 bases:

>100_bases
CCATAAGGTCATATCAGCAGCGTGAGAGAAGGTTCGGCGTCTAGCACAGCCCCTTGATTCATGGGAGGTATGTAGACGTT
ATCCATATCAATCACTGATT

Downstream 100 bases:

>100_bases
GACTCCCGGGGCTGAGAGTCCCATTATTTTTTCTCTTTTAGAGTTCATCAGCTTTGAGTCTATTTTCAAACTTCAGCAGG
GTCATTCTCCGTGAAAACCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MGGIIIIDVHCHLDFKDFNRNREEVIERARSKLRAVIDSGVGLGGNRRALELASLNPGFICPTMGFHPVDASKARQDLIG
EVVSQIESNIDLIVAVGETGMDFHHTRDEEGRRRQEETFRVFVELAAEHEMPLVVHARDAEERALETVLEYRVPEVIFHC
YGGSIETARRILDEGYYISISTLVAFSEHHMELVRAIPLEGMLTETDSPYLSPFRGKRNEPAFVEEAVRAIARIKDMDLE
DVDSITTANAERVFGL

Sequences:

>Translated_256_residues
MGGIIIIDVHCHLDFKDFNRNREEVIERARSKLRAVIDSGVGLGGNRRALELASLNPGFICPTMGFHPVDASKARQDLIG
EVVSQIESNIDLIVAVGETGMDFHHTRDEEGRRRQEETFRVFVELAAEHEMPLVVHARDAEERALETVLEYRVPEVIFHC
YGGSIETARRILDEGYYISISTLVAFSEHHMELVRAIPLEGMLTETDSPYLSPFRGKRNEPAFVEEAVRAIARIKDMDLE
DVDSITTANAERVFGL
>Mature_255_residues
GGIIIIDVHCHLDFKDFNRNREEVIERARSKLRAVIDSGVGLGGNRRALELASLNPGFICPTMGFHPVDASKARQDLIGE
VVSQIESNIDLIVAVGETGMDFHHTRDEEGRRRQEETFRVFVELAAEHEMPLVVHARDAEERALETVLEYRVPEVIFHCY
GGSIETARRILDEGYYISISTLVAFSEHHMELVRAIPLEGMLTETDSPYLSPFRGKRNEPAFVEEAVRAIARIKDMDLED
VDSITTANAERVFGL

Specific function: Unknown

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI110349730, Length=263, Percent_Identity=29.277566539924, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI110349734, Length=263, Percent_Identity=29.277566539924, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI226061853, Length=270, Percent_Identity=28.5185185185185, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI226061614, Length=256, Percent_Identity=27.34375, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI226061595, Length=229, Percent_Identity=27.5109170305677, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI14042943, Length=263, Percent_Identity=25.0950570342205, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI225903439, Length=246, Percent_Identity=25.2032520325203, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI225903424, Length=176, Percent_Identity=29.5454545454545, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787342, Length=263, Percent_Identity=31.9391634980989, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI48994985, Length=267, Percent_Identity=30.7116104868914, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082439, Length=255, Percent_Identity=25.4901960784314, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71980746, Length=259, Percent_Identity=31.2741312741313, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17559024, Length=285, Percent_Identity=27.0175438596491, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17543026, Length=305, Percent_Identity=27.5409836065574, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17565396, Length=221, Percent_Identity=28.0542986425339, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648690, Length=295, Percent_Identity=26.1016949152542, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221330018, Length=201, Percent_Identity=31.8407960199005, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24586117, Length=201, Percent_Identity=31.8407960199005, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278
- InterPro:   IPR015991 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 28832; Mature: 28701

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS01090 TATD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGIIIIDVHCHLDFKDFNRNREEVIERARSKLRAVIDSGVGLGGNRRALELASLNPGFI
CCCEEEEEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEE
CPTMGFHPVDASKARQDLIGEVVSQIESNIDLIVAVGETGMDFHHTRDEEGRRRQEETFR
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
VFVELAAEHEMPLVVHARDAEERALETVLEYRVPEVIFHCYGGSIETARRILDEGYYISI
HHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEH
STLVAFSEHHMELVRAIPLEGMLTETDSPYLSPFRGKRNEPAFVEEAVRAIARIKDMDLE
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
DVDSITTANAERVFGL
HHHHHHCCCCHHHCCC
>Mature Secondary Structure 
GGIIIIDVHCHLDFKDFNRNREEVIERARSKLRAVIDSGVGLGGNRRALELASLNPGFI
CCEEEEEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEE
CPTMGFHPVDASKARQDLIGEVVSQIESNIDLIVAVGETGMDFHHTRDEEGRRRQEETFR
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
VFVELAAEHEMPLVVHARDAEERALETVLEYRVPEVIFHCYGGSIETARRILDEGYYISI
HHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEH
STLVAFSEHHMELVRAIPLEGMLTETDSPYLSPFRGKRNEPAFVEEAVRAIARIKDMDLE
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
DVDSITTANAERVFGL
HHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]