Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678170

GI number: 15678170

Start: 93308

End: 94762

Strand: Direct

Name: Not Available

Synonym: MTH142

Alternate gene names: 15678170

Gene position: 93308-94762 (Clockwise)

Preceding gene: 15678169

Following gene: 15678171

Centisome position: 5.33

GC content: 53.33

Gene sequence:

>1455_bases
ATGTACAGGAAAAAATTAACTGAAGCAGAAACAGGTTACACATTTGATGATTTTCTTCTTCTTCCCCAGGCATCATATGT
GGAACCCAGGGATGTGGAGACCGCTGGCAGGGTATCAAGGAATATAGAGCTCAAGATACCCGTAATCAGCTCCGCCATGG
ACACGGTAACAGAGTATGATATGGCCATTGCAATGGCACAGGAGGGTGGAATGGGGGTTATCCACAGGAACATGAGCATC
AGGGACCAGGTCGAACAGGTGAAGAAGGTTAAAAGATCCGGAGACATCACAATAAGGGACGTTATAACAATATCACCTGA
TTCAACCCTCAGGGAGGCCCATGAAATCATGGACCAGGAGGAGATAAGTGGTCTGCCGGTTGTTGAGGACGGTGTGCTCA
TAGGTATAATAAGCCGCAGGGACATTGAACCCATCTTCAACTCAGATGCGGACAAGAAGGTTGACCAGGTCATGACAAGG
GACGTTGTCACCGTGGACGAATCCATAACCCCCAACGAGGCCCTTGACATAGCCTACGAGAACAAGGTCGAAAGGCTCCC
TGTTGTGAAGGATGGAAGGATCGTCGGCATGCTCACAATGAAGGATATACTGGAGCGCAAGAGGTACCCCAACGCGTCCA
GGGACAGTGAAGGTTACCTCAGGGTCGCAGCCGCCACAGGCCCCTTTGATCTTGAAAGGGCCAGGGCACTGGATGAGGCT
GGCGCAGATGTGCTGGCAATCGACAGTGCCCATGGACACAACATGAACCTTGTGAAGAGTGCCGGGGCAATGAAGAAGGA
GATAGAGGCTGACCTCATAGTCGGCAACATAGCAACCAGGGAGGCTGCAGAGGACCTCATTGCACAGGACGTGGACGGTC
TAAAGGTGGGAATAGGGCCCGGTTCAATGTGCACAACAAGGATCATAGCAGGTGTCGGTGTCCCCCAGCTCACAGCCATA
GCAGAGGTGGCTGACGTGGCCGCAGAATATGGAGTGCCTGTCATCGCCGATGGAGGTATAAGGTACTCAGGGGACATTGC
AAAGGCAATAGCAGTGGGCGCCGACTGTGTGATGCTGGGTAATCTCCTTGCAGGTACCTATGAGGCCCCCGGTGATGTTG
TGGTTATGAACGGACGTAAATACAAACAGTACCGTGGAATGGGGTCCCTCGGTGCAATGACAGGGGGTATAGGTGCAGGC
ACGGATCGTTACTTCCAGGAACCCCGCGGGCACATGAAGCACACCAAGGTGGTGCCTGAGGGAGTGGAGGGTGTTGTCCC
GTACAGGGGCACGGTAAGTGAAGTTCTCTTCCAGCTCATAGGCGGTCTGAGAGCATCCATGGGCTACTGCGGTGCCGCTA
ACCTAAGTGAGATGAAGGAAAGGGCGAAGCTGGTCCGGATAACTTCAAGCGGGTATCAAGGAGAGCCACCCCCACGACCT
CCTCATAACCAATGA

Upstream 100 bases:

>100_bases
ATGTGTTGGCGGAGACCGCAACACAGGCAGAATCCACAGGGACGCTGTGAGGGAACTCAAGGAACTCCTGGACAGCTTCT
AAATTAGCTGAGGGATTTGA

Downstream 100 bases:

>100_bases
GAGTCCAAACTACCCGACCCTCAAATAATTATTTTTTTATGGAAATGAGTGAACTTGACTCTGTTGCTGTCCTCTGCGGT
GGCAGGGGAAGGCGGATGGG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MYRKKLTEAETGYTFDDFLLLPQASYVEPRDVETAGRVSRNIELKIPVISSAMDTVTEYDMAIAMAQEGGMGVIHRNMSI
RDQVEQVKKVKRSGDITIRDVITISPDSTLREAHEIMDQEEISGLPVVEDGVLIGIISRRDIEPIFNSDADKKVDQVMTR
DVVTVDESITPNEALDIAYENKVERLPVVKDGRIVGMLTMKDILERKRYPNASRDSEGYLRVAAATGPFDLERARALDEA
GADVLAIDSAHGHNMNLVKSAGAMKKEIEADLIVGNIATREAAEDLIAQDVDGLKVGIGPGSMCTTRIIAGVGVPQLTAI
AEVADVAAEYGVPVIADGGIRYSGDIAKAIAVGADCVMLGNLLAGTYEAPGDVVVMNGRKYKQYRGMGSLGAMTGGIGAG
TDRYFQEPRGHMKHTKVVPEGVEGVVPYRGTVSEVLFQLIGGLRASMGYCGAANLSEMKERAKLVRITSSGYQGEPPPRP
PHNQ

Sequences:

>Translated_484_residues
MYRKKLTEAETGYTFDDFLLLPQASYVEPRDVETAGRVSRNIELKIPVISSAMDTVTEYDMAIAMAQEGGMGVIHRNMSI
RDQVEQVKKVKRSGDITIRDVITISPDSTLREAHEIMDQEEISGLPVVEDGVLIGIISRRDIEPIFNSDADKKVDQVMTR
DVVTVDESITPNEALDIAYENKVERLPVVKDGRIVGMLTMKDILERKRYPNASRDSEGYLRVAAATGPFDLERARALDEA
GADVLAIDSAHGHNMNLVKSAGAMKKEIEADLIVGNIATREAAEDLIAQDVDGLKVGIGPGSMCTTRIIAGVGVPQLTAI
AEVADVAAEYGVPVIADGGIRYSGDIAKAIAVGADCVMLGNLLAGTYEAPGDVVVMNGRKYKQYRGMGSLGAMTGGIGAG
TDRYFQEPRGHMKHTKVVPEGVEGVVPYRGTVSEVLFQLIGGLRASMGYCGAANLSEMKERAKLVRITSSGYQGEPPPRP
PHNQ
>Mature_484_residues
MYRKKLTEAETGYTFDDFLLLPQASYVEPRDVETAGRVSRNIELKIPVISSAMDTVTEYDMAIAMAQEGGMGVIHRNMSI
RDQVEQVKKVKRSGDITIRDVITISPDSTLREAHEIMDQEEISGLPVVEDGVLIGIISRRDIEPIFNSDADKKVDQVMTR
DVVTVDESITPNEALDIAYENKVERLPVVKDGRIVGMLTMKDILERKRYPNASRDSEGYLRVAAATGPFDLERARALDEA
GADVLAIDSAHGHNMNLVKSAGAMKKEIEADLIVGNIATREAAEDLIAQDVDGLKVGIGPGSMCTTRIIAGVGVPQLTAI
AEVADVAAEYGVPVIADGGIRYSGDIAKAIAVGADCVMLGNLLAGTYEAPGDVVVMNGRKYKQYRGMGSLGAMTGGIGAG
TDRYFQEPRGHMKHTKVVPEGVEGVVPYRGTVSEVLFQLIGGLRASMGYCGAANLSEMKERAKLVRITSSGYQGEPPPRP
PHNQ

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=467, Percent_Identity=37.2591006423983, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI217035146, Length=467, Percent_Identity=37.2591006423983, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI156616279, Length=467, Percent_Identity=37.2591006423983, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI34328930, Length=467, Percent_Identity=37.2591006423983, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI34328928, Length=467, Percent_Identity=37.2591006423983, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI217035152, Length=454, Percent_Identity=37.6651982378855, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI217035148, Length=467, Percent_Identity=36.6167023554604, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI217035150, Length=467, Percent_Identity=35.7601713062098, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=38.8, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541954, Length=269, Percent_Identity=35.6877323420074, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI50541952, Length=269, Percent_Identity=35.6877323420074, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI50541948, Length=269, Percent_Identity=35.6877323420074, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI50541956, Length=270, Percent_Identity=35.5555555555556, Blast_Score=159, Evalue=8e-39,
Organism=Escherichia coli, GI1788855, Length=472, Percent_Identity=45.9745762711864, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1786293, Length=260, Percent_Identity=36.9230769230769, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=493, Percent_Identity=36.105476673428, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71994389, Length=439, Percent_Identity=37.5854214123007, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17560440, Length=225, Percent_Identity=38.6666666666667, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323585, Length=466, Percent_Identity=39.4849785407725, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6323464, Length=476, Percent_Identity=39.2857142857143, Blast_Score=295, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6322012, Length=464, Percent_Identity=38.5775862068966, Blast_Score=293, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=38.1231671554252, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319353, Length=121, Percent_Identity=39.6694214876033, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24641071, Length=467, Percent_Identity=38.3297644539615, Blast_Score=284, Evalue=8e-77,
Organism=Drosophila melanogaster, GI24641073, Length=467, Percent_Identity=38.3297644539615, Blast_Score=284, Evalue=8e-77,
Organism=Drosophila melanogaster, GI28571163, Length=418, Percent_Identity=39.4736842105263, Blast_Score=255, Evalue=5e-68,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52207; Mature: 52207

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRKKLTEAETGYTFDDFLLLPQASYVEPRDVETAGRVSRNIELKIPVISSAMDTVTEYD
CCCHHCCCCCCCCCHHHEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEHHHHHHHHHHHH
MAIAMAQEGGMGVIHRNMSIRDQVEQVKKVKRSGDITIRDVITISPDSTLREAHEIMDQE
HHEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCHH
EISGLPVVEDGVLIGIISRRDIEPIFNSDADKKVDQVMTRDVVTVDESITPNEALDIAYE
HCCCCCEECCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHHHEEECCCCCCCHHEEEHHH
NKVERLPVVKDGRIVGMLTMKDILERKRYPNASRDSEGYLRVAAATGPFDLERARALDEA
CCHHHCCEEECCCEEEEHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHC
GADVLAIDSAHGHNMNLVKSAGAMKKEIEADLIVGNIATREAAEDLIAQDVDGLKVGIGP
CCCEEEEECCCCCCCHHHHHCCHHHHHCCHHEEECCHHHHHHHHHHHHHCCCCEEEECCC
GSMCTTRIIAGVGVPQLTAIAEVADVAAEYGVPVIADGGIRYSGDIAKAIAVGADCVMLG
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCCHHHHHH
NLLAGTYEAPGDVVVMNGRKYKQYRGMGSLGAMTGGIGAGTDRYFQEPRGHMKHTKVVPE
HHHHCCCCCCCCEEEECCCHHHHHCCCCCHHHCCCCCCCCCHHHHHCCCCCCHHCCCCCC
GVEGVVPYRGTVSEVLFQLIGGLRASMGYCGAANLSEMKERAKLVRITSSGYQGEPPPRP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCC
PHNQ
CCCC
>Mature Secondary Structure
MYRKKLTEAETGYTFDDFLLLPQASYVEPRDVETAGRVSRNIELKIPVISSAMDTVTEYD
CCCHHCCCCCCCCCHHHEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEHHHHHHHHHHHH
MAIAMAQEGGMGVIHRNMSIRDQVEQVKKVKRSGDITIRDVITISPDSTLREAHEIMDQE
HHEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCHH
EISGLPVVEDGVLIGIISRRDIEPIFNSDADKKVDQVMTRDVVTVDESITPNEALDIAYE
HCCCCCEECCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHHHEEECCCCCCCHHEEEHHH
NKVERLPVVKDGRIVGMLTMKDILERKRYPNASRDSEGYLRVAAATGPFDLERARALDEA
CCHHHCCEEECCCEEEEHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHC
GADVLAIDSAHGHNMNLVKSAGAMKKEIEADLIVGNIATREAAEDLIAQDVDGLKVGIGP
CCCEEEEECCCCCCCHHHHHCCHHHHHCCHHEEECCHHHHHHHHHHHHHCCCCEEEECCC
GSMCTTRIIAGVGVPQLTAIAEVADVAAEYGVPVIADGGIRYSGDIAKAIAVGADCVMLG
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCCHHHHHH
NLLAGTYEAPGDVVVMNGRKYKQYRGMGSLGAMTGGIGAGTDRYFQEPRGHMKHTKVVPE
HHHHCCCCCCCCEEEECCCHHHHHCCCCCHHHCCCCCCCCCHHHHHCCCCCCHHCCCCCC
GVEGVVPYRGTVSEVLFQLIGGLRASMGYCGAANLSEMKERAKLVRITSSGYQGEPPPRP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCC
PHNQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]