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Identifier: 15678067

GI number: 15678067

Start: 19041

End: 19835

Strand: Direct

Name: Not Available

Synonym: MTH37

Alternate gene names: 15678067

Gene position: 19041-19835 (Clockwise)

Preceding gene: 15678066

Following gene: 15678068

Centisome position: 1.09

GC content: 50.19

Gene sequence:

>795_bases
ATGGATATTGCTCTTAAGGAAAAAACTGATACCGAAATGGTCTTTGTGGTCAGCGGCGTCACGGTTCCATTCATAAACGC
CATAAGGAGGATCTGCATGATGGAGGTCCCCAAACTGGCAATTGAGTACGTCAACATGTACAGGAACGACGCCAAGATGT
TCGATGAGGTACTGGCCCACAGGCTGGGGCTTGTACCCCTTGCAGCTGACCCTGAATTTGCTGAATCCCTTAAAATGCCT
GAGGAGTGCGACTGTGAGGAGTACTGCTCAGAGTGCAGTGTATCCCTCACCCTCAGGAAGAAGGGCCCGGGTGTTGTTTA
CTCAGGGGATCTTGTTTCAGAAACACCCGCAGTTAAACCGGTTTACCCTGACATTCCCCTTGTGAAGCTTGGAGATGATG
ATGAGCTTGAACTGGAGGCCGTCGCACAGCTGGGTGTGGGAAGGGAACATGCGAAATGGGAACCCACCACAGCATGCGCA
TACAAATACTACCCCAGGATAGAGTTCAGTGAAGACTGTGACGAGTGCCTTGAATGCATCGAGGCATGCCCGAGGGATGT
TCTTGGAGAGGAATCAGGTAAACCCGTGGTTGTTGACCTTGAAAACTGTTCAATGTGCAAGAGCTGTGTCAGGGCATGTG
ATAAGAGGGCCATAGATGTGGGATACGAGGAAGGCAAGTTCATATTCAGGATAGAGACCGACGGATCAGTTGACCCAAAG
GATGTTCTCCTTAAGGCCTGTGACATCCTCAGGGACAAGGCAGAGCAGGTAATAACATTTTGTGAAGGAGGCTAA

Upstream 100 bases:

>100_bases
GCAAGGGCTGGAATGAGGATAGGTAAAATTGAGGATGTAACTCCCATACCTCACGATGGAACAGGTAGACCTGGAGGTAA
GAGGGGAAGAAGGGTCTAAA

Downstream 100 bases:

>100_bases
CCAATGGTAAGGAAGATTACCAAGACGAATCCCAATCTTATAAAACTCATACGTAATCTCAGGAAAAAATCATCCCAGGA
AGGCGCAGCAATCTGGAAGG

Product: DNA-directed RNA polymerase subunit D

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MDIALKEKTDTEMVFVVSGVTVPFINAIRRICMMEVPKLAIEYVNMYRNDAKMFDEVLAHRLGLVPLAADPEFAESLKMP
EECDCEEYCSECSVSLTLRKKGPGVVYSGDLVSETPAVKPVYPDIPLVKLGDDDELELEAVAQLGVGREHAKWEPTTACA
YKYYPRIEFSEDCDECLECIEACPRDVLGEESGKPVVVDLENCSMCKSCVRACDKRAIDVGYEEGKFIFRIETDGSVDPK
DVLLKACDILRDKAEQVITFCEGG

Sequences:

>Translated_264_residues
MDIALKEKTDTEMVFVVSGVTVPFINAIRRICMMEVPKLAIEYVNMYRNDAKMFDEVLAHRLGLVPLAADPEFAESLKMP
EECDCEEYCSECSVSLTLRKKGPGVVYSGDLVSETPAVKPVYPDIPLVKLGDDDELELEAVAQLGVGREHAKWEPTTACA
YKYYPRIEFSEDCDECLECIEACPRDVLGEESGKPVVVDLENCSMCKSCVRACDKRAIDVGYEEGKFIFRIETDGSVDPK
DVLLKACDILRDKAEQVITFCEGG
>Mature_264_residues
MDIALKEKTDTEMVFVVSGVTVPFINAIRRICMMEVPKLAIEYVNMYRNDAKMFDEVLAHRLGLVPLAADPEFAESLKMP
EECDCEEYCSECSVSLTLRKKGPGVVYSGDLVSETPAVKPVYPDIPLVKLGDDDELELEAVAQLGVGREHAKWEPTTACA
YKYYPRIEFSEDCDECLECIEACPRDVLGEESGKPVVVDLENCSMCKSCVRACDKRAIDVGYEEGKFIFRIETDGSVDPK
DVLLKACDILRDKAEQVITFCEGG

Specific function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

COG id: COG0202

COG function: function code K; DNA-directed RNA polymerase, alpha subunit/40 kD subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal rpoD/eukaryotic RPB3 RNA polymerase subunit family

Homologues:

Organism=Homo sapiens, GI14702171, Length=292, Percent_Identity=30.8219178082192, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI42560246, Length=279, Percent_Identity=26.1648745519713, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4759046, Length=202, Percent_Identity=28.7128712871287, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI86560996, Length=280, Percent_Identity=27.1428571428571, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6325367, Length=281, Percent_Identity=30.9608540925267, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322168, Length=177, Percent_Identity=35.0282485875706, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137650, Length=278, Percent_Identity=28.4172661870504, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI20129237, Length=292, Percent_Identity=28.4246575342466, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPOD_METTH (O26144)

Other databases:

- EMBL:   AE000666
- PIR:   G69147
- RefSeq:   NP_275181.1
- ProteinModelPortal:   O26144
- SMR:   O26144
- STRING:   O26144
- GeneID:   1469999
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH37
- NMPDR:   fig|187420.1.peg.36
- eggNOG:   arNOG06868
- HOGENOM:   HBG539019
- OMA:   SFIFTVE
- PhylomeDB:   O26144
- ProtClustDB:   PRK00783
- BioCyc:   MTHE187420:MTH37-MONOMER
- BRENDA:   2.7.7.6
- HAMAP:   MF_00320
- InterPro:   IPR017896
- InterPro:   IPR001514
- InterPro:   IPR011261
- InterPro:   IPR011262
- InterPro:   IPR009025
- InterPro:   IPR011263
- InterPro:   IPR022842
- Gene3D:   G3DSA:2.170.120.12
- SMART:   SM00662

Pfam domain/function: PF01000 RNA_pol_A_bac; PF01193 RNA_pol_L; SSF56553 RNAP_insert; SSF55257 RNAP_RBP11-like

EC number: =2.7.7.6

Molecular weight: Translated: 29395; Mature: 29395

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2; PS00446 RNA_POL_D_30KD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
9.1 %Cys+Met (Translated Protein)
6.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
9.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIALKEKTDTEMVFVVSGVTVPFINAIRRICMMEVPKLAIEYVNMYRNDAKMFDEVLAH
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLGLVPLAADPEFAESLKMPEECDCEEYCSECSVSLTLRKKGPGVVYSGDLVSETPAVKP
HHCCCEECCCCHHHHHCCCCCCCCHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCC
VYPDIPLVKLGDDDELELEAVAQLGVGREHAKWEPTTACAYKYYPRIEFSEDCDECLECI
CCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCCCCCHHHHHHHH
EACPRDVLGEESGKPVVVDLENCSMCKSCVRACDKRAIDVGYEEGKFIFRIETDGSVDPK
HHCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCEECCCCCCEEEEEEECCCCCCHH
DVLLKACDILRDKAEQVITFCEGG
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIALKEKTDTEMVFVVSGVTVPFINAIRRICMMEVPKLAIEYVNMYRNDAKMFDEVLAH
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLGLVPLAADPEFAESLKMPEECDCEEYCSECSVSLTLRKKGPGVVYSGDLVSETPAVKP
HHCCCEECCCCHHHHHCCCCCCCCHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCC
VYPDIPLVKLGDDDELELEAVAQLGVGREHAKWEPTTACAYKYYPRIEFSEDCDECLECI
CCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCCCCCHHHHHHHH
EACPRDVLGEESGKPVVVDLENCSMCKSCVRACDKRAIDVGYEEGKFIFRIETDGSVDPK
HHCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCEECCCCCCEEEEEEECCCCCCHH
DVLLKACDILRDKAEQVITFCEGG
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463