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The map label for this gene is nhaA

Identifier: 15646159

GI number: 15646159

Start: 1631260

End: 1632576

Strand: Reverse

Name: nhaA

Synonym: HP1552

Alternate gene names: 15646159

Gene position: 1632576-1631260 (Counterclockwise)

Preceding gene: 15646160

Following gene: 15646158

Centisome position: 97.88

GC content: 42.14

Gene sequence:

>1317_bases
ATGAATCTCAAAAAAACAGAAAACGCGCTCAGTTTGACGCTTAAGAACTTCATTAAAAGCGAGTCTTTTGGAGGGATTTT
CCTCTTTTTAAACGCTGTTTTAGCGATGGTGGTGGCTAATTCGTTTTTAAAAGAAAGTTATTTTGCACTATGGCACACCC
CTTTTGGGTTTCAAATAGGGGATTTTTTCATCGGCTTTAGTTTGCACAACTGGATTGATGATGTCTTAATGGCGTTATTC
TTTTTAATGATAGGCTTAGAAATCAAACGAGAATTGTTGTTTGGGGAATTATCCAGTTTCAAAAAAGCTTCTTTTCCTGT
GATTGCGGCCATAGGGGGCATGATAGCCCCAGGATTGATTTATTTTTTTCTTAACGCTAACACGCCTTCCCAGCATGGTT
TTGGGATCCCTATGGCGACGGATATTGCGTTCGCTTTAGGCGTGATCATGCTTTTAGGCAAGAGGGTGCCAACCGCTTTA
AAGGTTTTTTTAATCACTCTAGCGGTGGCTGATGACTTGGGGGCTATTGTGGTGATCGCGCTCTTTTATACCACGAATTT
AAAATTCGCATGGCTTTTAGGGGCTTTAGGGGTGGTTCTTGTTTTAGCCGTATTAAACCGCCTGAATATGCGCTCGCTCA
TCCCTTACTTGCTTTTAGGGGTGTTGCTTTGGTTTTGCGTGCATCAAAGCGGTATCCATGCGACGATTGCTGCAGTGATT
CTAGCTTTTATGATACCGGTGAAGATCCCTAAAGATTCTAAAAATGTAGAGCTTTTGGAACTAGGCAAACGATACGCAGA
AACGAGTTCAGGAGCGCTTTTGAGTAAAGAGCAGCAAGAAATCTTGCATTCTATTGAAGAAAAAGCGAGCGCCTTACAAA
GCCCCTTAGAAAGATTGGAGCATTTTCTAGCCCCCATTAGCGGGTATTTCATCATGCCCTTATTCGCGTTTGCAAACGCT
GGGGTGAGCGTTGATTCTAGCATCAATTTAGAAGTGGATAAGGTGCTTTTAGGGGTTATTTTAGGGCTTTGCTTGGGCAA
ACCTTTAGGGATTTTCTTAATCACTTTTATAAGCGAAAAGCTTAAAATCACCGCACGCCCTAAAGGCATCAGCTGGTGGC
ATATTTTAGGGGCTGGGCTTTTAGCAGGGATTGGCTTTACCATGTCTATGTTTATTTCTAATCTGGCCTTCACGAGCGAG
CATAAAGACGCTATGGAAGTGGCAAAAATTGCGATTTTACTCGGATCTTTGATTTCTGGGATCATAGGGGCTTTGTATTT
ATTTGCGCTAGACAAAAGAGCGGCTTTAAAGAAATAG

Upstream 100 bases:

>100_bases
CTCAAGCCCCCCATTTTAAGATACAAGCGGGCATTATTTACGCTCATAAAAGACTGCTTGAAAAATTATGGGTCTGAAAT
TAAAAATTTTAAGGTTGTCT

Downstream 100 bases:

>100_bases
CTAAAAATGCTATAATTTGAGATTAAAACATCTTTTAAGGAAATTAAATGGGACAAATTAAAGACATTCTAACGACGCTT
TTACCCCTTGTGGTGTTGTT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MNLKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNANTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIVVIALFYTTNLKFAWLLGALGVVLVLAVLNRLNMRSLIPYLLLGVLLWFCVHQSGIHATIAAVI
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLSKEQQEILHSIEEKASALQSPLERLEHFLAPISGYFIMPLFAFANA
GVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSE
HKDAMEVAKIAILLGSLISGIIGALYLFALDKRAALKK

Sequences:

>Translated_438_residues
MNLKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNANTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIVVIALFYTTNLKFAWLLGALGVVLVLAVLNRLNMRSLIPYLLLGVLLWFCVHQSGIHATIAAVI
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLSKEQQEILHSIEEKASALQSPLERLEHFLAPISGYFIMPLFAFANA
GVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSE
HKDAMEVAKIAILLGSLISGIIGALYLFALDKRAALKK
>Mature_438_residues
MNLKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNANTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIVVIALFYTTNLKFAWLLGALGVVLVLAVLNRLNMRSLIPYLLLGVLLWFCVHQSGIHATIAAVI
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLSKEQQEILHSIEEKASALQSPLERLEHFLAPISGYFIMPLFAFANA
GVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSE
HKDAMEVAKIAILLGSLISGIIGALYLFALDKRAALKK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=417, Percent_Identity=45.3237410071942, Blast_Score=288, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 47760; Mature: 47760

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DFFIGFSLHNWIDDVLMALFFLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YFFLNANTPSQHGFGIPMATDIAFALGVIMLLGKRVPTALKVFLITLAVADDLGAIVVIA
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFYTTNLKFAWLLGALGVVLVLAVLNRLNMRSLIPYLLLGVLLWFCVHQSGIHATIAAVI
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLSKEQQEILHSIEEKASALQSPLERLE
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFLAPISGYFIMPLFAFANAGVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSEHKDAMEVAKIAILLGSLISG
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IIGALYLFALDKRAALKK
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DFFIGFSLHNWIDDVLMALFFLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YFFLNANTPSQHGFGIPMATDIAFALGVIMLLGKRVPTALKVFLITLAVADDLGAIVVIA
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFYTTNLKFAWLLGALGVVLVLAVLNRLNMRSLIPYLLLGVLLWFCVHQSGIHATIAAVI
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLSKEQQEILHSIEEKASALQSPLERLE
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFLAPISGYFIMPLFAFANAGVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSEHKDAMEVAKIAILLGSLISG
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IIGALYLFALDKRAALKK
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA