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Identifier: 15646152

GI number: 15646152

Start: 1623814

End: 1624998

Strand: Reverse

Name: Not Available

Synonym: HP1545

Alternate gene names: 15646152

Gene position: 1624998-1623814 (Counterclockwise)

Preceding gene: 15646153

Following gene: 15646151

Centisome position: 97.43

GC content: 37.47

Gene sequence:

>1185_bases
ATGAAAAATAGCCCTTTGAATGGATTGAATGGACTAAAGGCGTTTTTAGAAACAAAGCCTAAGGAATACCATAAGTTTGA
CCCTAGCCGCTTCATTCAAATTTATAAAGATTTTAAAAACGCTTTTTTTGAGATTCAAGCGAAAGTCATTCATGTTGTAG
GGACTAATGGCAAGGGCAGCACGGGGCGGTTTTTAACCCTTTTATTAGCCGATCAAAATTTTAAGGTGTTGCATTTCACC
TCCCCTCATGTTTTTGAATTTAGGGAGCGCTTTTTTTTGAATGGTTCTGTTGTTGGAGAAAGCGTTTTAGAAAACGCCCA
CCAGCAATTACAATCGCACGCTTTCAGCAGCGCTTGCTCGTATTTTGAATACGCTACCTTACTGGCTGTCATGCTCGCTA
AAGATTGCGATTATTTGGTTTTAGAAGCAGGGCTTGGGGGGGAGTTTGACAGCACGAACGCTTTAAAAAAAACCCTAAGC
GTTTTCACCCCCATTGATTATGATCATAAGGAATTTTTAGGGGATAGTTTAGAAAGCATTGCGCAAACTAAATTAAAAGC
GATGGGCTCTCTTAGCATCATCGCTCCCCAACAAGAACTGGTTTTAAATGCGGCTCAAAAAATCGCTAAAGAAAAACACG
CAAAATTGATTGTGGTTCAAAATGAAATTTCAAAAGGAGTGAGGGATTATATTGAACGCTACCATTTAGCCCGTTTTTTA
GCGATGAATTTGGAAGTGGCTCTAAAAGCGTTTGAAACGCTTTTGCCATGCAATAAACAAGAAGTTTTAAAAAACCTAAA
GCCCCTAAATTTAATCGGCCGTTGCGAGCTTTTAAGCCCTAATATCTTAATAGATGTGGGGCATAACCCCCATAGCGCCA
AAGCCTTAAAAGAAGAAATCAAACGCATTTTTAACGCTAAAATCATTTTAATTTATAATTGCTATCAAGATAAAGACGCT
TTTTTGGTGCTAGAAATTTTAAAGCCTGTCATTAAAAAGGTTTTGATTTTAGAATTGCATGAAGAAAGGGTTATCAAGTT
AGAAAAGCTTAAAGGGATTTTAGAAACTTTAGGGTTAGAATACGCTTTGTTTGAAGATGTGGAAGAAAATGAAAATTATT
TGGTGTATGGCTCATTTCTGGTGGCCAACGCTTTTTATAAACGCTATCAAGAGAAGAGGGATTGA

Upstream 100 bases:

>100_bases
CTTAATACCTACCAGAACCGCTATTATGCTATCAATCAGGCTGTGGAACAGACTTTGACTAAATTTGTGGCTCAAATCGC
TTATGAGGGGAAATTCAATA

Downstream 100 bases:

>100_bases
TGCCGCAAAACCAGCTTGTGATCACCATCATTGATGAATCAGGCTCTAAACAGCTCAAATTTTCTAAAAATTTAAAACGC
AACCTCATCATTTCTGTTGT

Product: folylpolyglutamate synthase (folC)

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKNSPLNGLNGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFEIQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFT
SPHVFEFRERFFLNGSVVGESVLENAHQQLQSHAFSSACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALKKTLS
VFTPIDYDHKEFLGDSLESIAQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERYHLARFL
AMNLEVALKAFETLLPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFNAKIILIYNCYQDKDA
FLVLEILKPVIKKVLILELHEERVIKLEKLKGILETLGLEYALFEDVEENENYLVYGSFLVANAFYKRYQEKRD

Sequences:

>Translated_394_residues
MKNSPLNGLNGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFEIQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFT
SPHVFEFRERFFLNGSVVGESVLENAHQQLQSHAFSSACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALKKTLS
VFTPIDYDHKEFLGDSLESIAQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERYHLARFL
AMNLEVALKAFETLLPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFNAKIILIYNCYQDKDA
FLVLEILKPVIKKVLILELHEERVIKLEKLKGILETLGLEYALFEDVEENENYLVYGSFLVANAFYKRYQEKRD
>Mature_394_residues
MKNSPLNGLNGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFEIQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFT
SPHVFEFRERFFLNGSVVGESVLENAHQQLQSHAFSSACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALKKTLS
VFTPIDYDHKEFLGDSLESIAQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERYHLARFL
AMNLEVALKAFETLLPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFNAKIILIYNCYQDKDA
FLVLEILKPVIKKVLILELHEERVIKLEKLKGILETLGLEYALFEDVEENENYLVYGSFLVANAFYKRYQEKRD

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=177, Percent_Identity=31.0734463276836, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66932990, Length=177, Percent_Identity=31.0734463276836, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788654, Length=357, Percent_Identity=29.1316526610644, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17553150, Length=320, Percent_Identity=26.875, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71984923, Length=320, Percent_Identity=26.875, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17553148, Length=320, Percent_Identity=26.875, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323760, Length=324, Percent_Identity=25, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324815, Length=313, Percent_Identity=27.4760383386581, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641571, Length=183, Percent_Identity=32.7868852459016, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 44881; Mature: 44881

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSPLNGLNGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFEIQAKVIHVVGTNGKGS
CCCCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCC
TGRFLTLLLADQNFKVLHFTSPHVFEFRERFFLNGSVVGESVLENAHQQLQSHAFSSACS
CCCEEEEEEECCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALKKTLSVFTPIDYDHKEFLGDSLESI
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERYHLARFL
HHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHH
AMNLEVALKAFETLLPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEI
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHCCEEEECCCEEEECCCCCCHHHHHHHHH
KRIFNAKIILIYNCYQDKDAFLVLEILKPVIKKVLILELHEERVIKLEKLKGILETLGLE
HHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YALFEDVEENENYLVYGSFLVANAFYKRYQEKRD
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNSPLNGLNGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFEIQAKVIHVVGTNGKGS
CCCCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCC
TGRFLTLLLADQNFKVLHFTSPHVFEFRERFFLNGSVVGESVLENAHQQLQSHAFSSACS
CCCEEEEEEECCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALKKTLSVFTPIDYDHKEFLGDSLESI
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AQTKLKAMGSLSIIAPQQELVLNAAQKIAKEKHAKLIVVQNEISKGVRDYIERYHLARFL
HHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHH
AMNLEVALKAFETLLPCNKQEVLKNLKPLNLIGRCELLSPNILIDVGHNPHSAKALKEEI
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHCCEEEECCCEEEECCCCCCHHHHHHHHH
KRIFNAKIILIYNCYQDKDAFLVLEILKPVIKKVLILELHEERVIKLEKLKGILETLGLE
HHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YALFEDVEENENYLVYGSFLVANAFYKRYQEKRD
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]