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Identifier: 15646112

GI number: 15646112

Start: 1574847

End: 1577213

Strand: Reverse

Name: Not Available

Synonym: HP1503

Alternate gene names: 15646112

Gene position: 1577213-1574847 (Counterclockwise)

Preceding gene: 15646113

Following gene: 15646110

Centisome position: 94.56

GC content: 40.35

Gene sequence:

>2367_bases
ATGAAATGTTCGCATTGCCAGTTGGAGTTTAAAGAAAGTGAGCTTTTTAAAGAGGTGATCAATCATAAAGAATTGCATTT
TTGCTGCACGGGGTGCGCTAGGGTGTATGCGTTATTGTTAGATTTGAATTTAGAGAGCTTTTATGACAAATTAAACGATT
CCACTTTAGCCCCCGTAACGCCCCAAGATTCAATGAGCGCTTTGGAATTAGAACAAGCCCTTGAAGAAAACAATAAGGGC
GATTTTATCCTTAATCTTTTGTTAGAAAAAACGCATTGTAACGCTTGCTTGTGGCTCAATCAAAAGGTTTTAGAACGTTT
AAGTGGGGTTAAAAAAGTGAGCGTGAATTTCACCACCCACCACTTGCAAATCGTGTTTGAGAAGTCCTTAAACCCTAAAG
AGATTATTCAAAAAATTGAGAGTTTGGGCTATGGGGCTAAAATTTATAATGCGCAAAATTACACCCTAAAAGCGCAAAAA
GAACAGCGCTCCTACTTGCTCACTTTGAGCGTGGGGTTTTTTGCCACTATGAATTTGATGTTTATCGCCATTGCCAAATA
CGCAAGTTATGGTGGCGCAAGTTATGGCGGTGCGAATTATGGCGCTGGCATGGATAAGCTTATGCAAAGGAATTTGGATC
TCGTATCGCTCTTTTTAAGCTTGTTGGTGTTAGTGGTTGTGGGGCGTTTTTTCATTAAGGGGGCGTTTTATGGGCTAAAA
AATGGCGTTTTGGGCATGGATTTGAGCGTGTCTTTTGGAGCGTTATCGGCGTTTGTTTATTCCGTTTATGCCATGTTGGT
GTCCCAAGAGACTTATTTTGAAGCGAGCAGCACGATTCTAACGCTTGTTTTTGGCTCTAAGTTTTTGGAATTAAAAGCCA
GGCTGTTTGCGAATGAAAAATGTCTGGCCCTAGAATCGCATGAAATCCATAGCGTGATCGTTGTAGAAAATGGCAAGCAA
ACAGAAAAACACCCTAAAGATGTGGCGATAGGCTCTGTTGTTTGGGTGCCAAGCGGGGCTAAAATCGCACTAGATGGCGT
GCTTTTAAATAATGCGAGCGTGGATGCGTCTTTGATCAGTGGGGAGTTTAAGCCTTTGGAATTGGGGGTTAATGATCCAA
TTTTAGGGGGTTATGTGAATGTGGGCGTGCCTTTTAGCTATCAAGTGAGCGCTAATTTTCAAAACTCACGCCTTTCTGGT
TTGTTAGAAACTTTAAAAAAGAGTTTTTTAGAAAAGCCCTTAATTGAGAGTAGCGCGAATCAAATTGCGGATATTTTTTC
TAAAGCGGTGTTGTTTTTAGCCTTTGTAAGCTTTTTGTTATGGCAATTTGGTTTGGGGGGTAATTTTGAAAAAGCCTTAA
TGGTGTGTATTAGCGTGCTAGTCATCAGCTGCCCTTGCGCGTTCGCTCTGGCTACGCCCATTGCGTTAGTGATAGGGGTG
TTTAAAAACCCTTTGATCGTGTTTAAAGAAGCGTTGTTTTTAGAAACTCTGGCTAAAGTGAAAAAAATCTTTATAGACAA
AACCGGCACGCTCACGCAAAAAGAAGTCCTTTTAAAAGAAAAAATCATTTATGAAGAATTTGATGGAAGGCTTTTGAAGA
GCCTTTTAAAAGTGAGAGAGCATTTAGCCCATAGCGCGATTCTTAAATCTCTAGATGGCGATGAGGTTAGTTTAGAAAAG
ATAGAGTTTTTCGCTCATGGTCTGAAAGCGAGCTATCAAAACGAAACCCTGCTAGTGGGGAGTTTGAAATTTTTGGGATC
TATGGGGGTGGATATACCAATGAAAGAGAGCGCTAATATCATGGTAGGCTTTGCGAAAAATGAGACTTTATGCGCGTTAT
TCATTTTAGAAGAGCGTTTGAAAGCTAACGCTAAAGAAGTCGTTCAGGCTTTACAAAATAAAGGCTTAGAATTAGAGATT
TTAAGCGGGGATAATGAAAGCTCGGTTAAGGAGTGCGCGAAAAAATTAGGGATTTCTAATTATCATGCCCATTTGACCCC
TGAAGATAAGGCTCAAACCATCAGCTCTTATAAGGGCGTTTGCGCGATGGTAGGCGATGGCAATAATGATGCGTTAGCCT
TAAAACAAGCGAGCGTTTCTTTAGGGTTTGAAAAAAGCGCTTTGAGTAAAAGCGCATGCGATATTTTGCTTTTAGAAGAG
GATTTGAGTTTGCTAAAAAAAGCGTTTGATAACGCTCAAAAAGTCTATCAAGTGGTGTTGCAAAACATTGTTTTGAGCTT
GATTTATAACGCTATTTTAATCCCGGTCGCTATGCTAGGATACATTAACCCTTTAATAGCGAGTTTGAGCATGAGCGCTA
GCTCACTCTTAGTGGTCTTAAATTCTTTGAGGTTGAAACGCTCTTAA

Upstream 100 bases:

>100_bases
AGCGACAACACCAAAGAAGTTTTAAGCATCTATCAAACTTGTAACACTTATTCTATCAAAGCGCTTCTAAACTAGCGCCC
TTAAATTAAGGATTAAAAAA

Downstream 100 bases:

>100_bases
ACAAACCACATCGTTTTGGCTAAAATGGCGATTAAAAAGCCAAAAGTTAGAGCGATAGGGTGGATATATTTACCAATAGG
GTTTTTCTTGCCCAAAAACT

Product: cation-transporting ATPase, P-type (copA)

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 788

Protein sequence:

>788_residues
MKCSHCQLEFKESELFKEVINHKELHFCCTGCARVYALLLDLNLESFYDKLNDSTLAPVTPQDSMSALELEQALEENNKG
DFILNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTHHLQIVFEKSLNPKEIIQKIESLGYGAKIYNAQNYTLKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGGASYGGANYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQ
TEKHPKDVAIGSVVWVPSGAKIALDGVLLNNASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSANFQNSRLSG
LLETLKKSFLEKPLIESSANQIADIFSKAVLFLAFVSFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGV
FKNPLIVFKEALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKVREHLAHSAILKSLDGDEVSLEK
IEFFAHGLKASYQNETLLVGSLKFLGSMGVDIPMKESANIMVGFAKNETLCALFILEERLKANAKEVVQALQNKGLELEI
LSGDNESSVKECAKKLGISNYHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSACDILLLEE
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Sequences:

>Translated_788_residues
MKCSHCQLEFKESELFKEVINHKELHFCCTGCARVYALLLDLNLESFYDKLNDSTLAPVTPQDSMSALELEQALEENNKG
DFILNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTHHLQIVFEKSLNPKEIIQKIESLGYGAKIYNAQNYTLKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGGASYGGANYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQ
TEKHPKDVAIGSVVWVPSGAKIALDGVLLNNASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSANFQNSRLSG
LLETLKKSFLEKPLIESSANQIADIFSKAVLFLAFVSFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGV
FKNPLIVFKEALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKVREHLAHSAILKSLDGDEVSLEK
IEFFAHGLKASYQNETLLVGSLKFLGSMGVDIPMKESANIMVGFAKNETLCALFILEERLKANAKEVVQALQNKGLELEI
LSGDNESSVKECAKKLGISNYHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSACDILLLEE
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
>Mature_788_residues
MKCSHCQLEFKESELFKEVINHKELHFCCTGCARVYALLLDLNLESFYDKLNDSTLAPVTPQDSMSALELEQALEENNKG
DFILNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTHHLQIVFEKSLNPKEIIQKIESLGYGAKIYNAQNYTLKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGGASYGGANYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQ
TEKHPKDVAIGSVVWVPSGAKIALDGVLLNNASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSANFQNSRLSG
LLETLKKSFLEKPLIESSANQIADIFSKAVLFLAFVSFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGV
FKNPLIVFKEALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKVREHLAHSAILKSLDGDEVSLEK
IEFFAHGLKASYQNETLLVGSLKFLGSMGVDIPMKESANIMVGFAKNETLCALFILEERLKANAKEVVQALQNKGLELEI
LSGDNESSVKECAKKLGISNYHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSACDILLLEE
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=818, Percent_Identity=23.2273838630807, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI115529486, Length=538, Percent_Identity=23.4200743494424, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI55743073, Length=497, Percent_Identity=24.5472837022133, Blast_Score=115, Evalue=2e-25,
Organism=Escherichia coli, GI1786691, Length=843, Percent_Identity=25.5041518386714, Blast_Score=216, Evalue=5e-57,
Organism=Escherichia coli, GI1789879, Length=714, Percent_Identity=22.96918767507, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17556548, Length=441, Percent_Identity=25.3968253968254, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319772, Length=631, Percent_Identity=28.2091917591125, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320475, Length=765, Percent_Identity=24.8366013071895, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI221329854, Length=487, Percent_Identity=25.2566735112936, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86536; Mature: 86536

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCSHCQLEFKESELFKEVINHKELHFCCTGCARVYALLLDLNLESFYDKLNDSTLAPVT
CCCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PQDSMSALELEQALEENNKGDFILNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTH
CCCHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFEKSLNPKEIIQKIESLGYGAKIYNAQNYTLKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGGASYGGANYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEK
CCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHEEEEHHHHHHHHHHHHHHCCCC
CLALESHEIHSVIVVENGKQTEKHPKDVAIGSVVWVPSGAKIALDGVLLNNASVDASLIS
EEEEECCCCEEEEEEECCCCCCCCCCCEEECEEEEECCCCEEEEEEEEECCCCCCHHHHC
GEFKPLELGVNDPILGGYVNVGVPFSYQVSANFQNSRLSGLLETLKKSFLEKPLIESSAN
CCCCEEEECCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
QIADIFSKAVLFLAFVSFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FKNPLIVFKEALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKVRE
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
HLAHSAILKSLDGDEVSLEKIEFFAHGLKASYQNETLLVGSLKFLGSMGVDIPMKESANI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCCCCCE
MVGFAKNETLCALFILEERLKANAKEVVQALQNKGLELEILSGDNESSVKECAKKLGISN
EEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCC
YHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSACDILLLEE
CEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCCEEEEHH
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
NSLRLKRS
HHHHHCCC
>Mature Secondary Structure
MKCSHCQLEFKESELFKEVINHKELHFCCTGCARVYALLLDLNLESFYDKLNDSTLAPVT
CCCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PQDSMSALELEQALEENNKGDFILNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTH
CCCHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFEKSLNPKEIIQKIESLGYGAKIYNAQNYTLKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGGASYGGANYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEK
CCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHEEEEHHHHHHHHHHHHHHCCCC
CLALESHEIHSVIVVENGKQTEKHPKDVAIGSVVWVPSGAKIALDGVLLNNASVDASLIS
EEEEECCCCEEEEEEECCCCCCCCCCCEEECEEEEECCCCEEEEEEEEECCCCCCHHHHC
GEFKPLELGVNDPILGGYVNVGVPFSYQVSANFQNSRLSGLLETLKKSFLEKPLIESSAN
CCCCEEEECCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
QIADIFSKAVLFLAFVSFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FKNPLIVFKEALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKVRE
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
HLAHSAILKSLDGDEVSLEKIEFFAHGLKASYQNETLLVGSLKFLGSMGVDIPMKESANI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCCCCCE
MVGFAKNETLCALFILEERLKANAKEVVQALQNKGLELEILSGDNESSVKECAKKLGISN
EEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCC
YHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSACDILLLEE
CEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCCEEEEHH
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
NSLRLKRS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA