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Identifier: 15646099

GI number: 15646099

Start: 1563068

End: 1564417

Strand: Reverse

Name: Not Available

Synonym: HP1490

Alternate gene names: 15646099

Gene position: 1564417-1563068 (Counterclockwise)

Preceding gene: 15646100

Following gene: 15646098

Centisome position: 93.8

GC content: 42.4

Gene sequence:

>1350_bases
ATGGGGAGGAATCAAGGAGCTTATTTGGATCCGTCTGAATCGATTTTGATGTTGATGGTTGCTTTTTTATTGGTGCTGTT
GAACGCTTTTTTTGTGCTTTCAGAGTTTGCCCTTGTGAAAGTGCGTAAAACCCGCTTAGAAGAGCTGGTTAAAATCGGTA
ATTCCAACGCTAAACTCGCTTTAAAGATGAGTCAAAGACTAGACACTTATTTGAGCGCGACGCAGTTAGGCATCACCCTT
TCTTCATTAGCTTTAGGCTGGGTGGGTGAGCCCGCTATCGCAAAATTGTTAGCCGCGCTGTTTGAGTCTATGGATTTGAG
AGAAAATCCTATTTTTATCCATTCAATGAGCGTGGTCATAGCGTTTTTAAGCATCACTTTTTTGCATGTCGTGTTGGGCG
AGATTGTGCCTAAATCTTTAGCGATCGCTAAATCTGAAAAAGCCACCCTTTTTGCCGCACGCCCTTTGCATGTGTTTTGG
GTGGTGTTTTATCCGGTGGTGCGTTTGTTTGATGTGATCGCTCATTTTTTTTTGAAAAAGATGGGCATCAATCCTAAAGA
GCATGACGGCACGCATTCTGAAGAAGAGTTAAAAATCATTGTGGGCGAGAGTTTGAGAGAGGGCATTATTGATTCAGTGG
AGGGCGAAATCATTAAAAACGCAGKGGATTTTTCTGACACGAGCGCTAAAGAAATCATGACCCCACGAAAAGACATGGTG
TGTTTGGATGAAGAAAACAGCTATGAAGAAAATATAGACATTGTTTTAAAAGGCCATTTCACGCGCTACCCTTATTGCAA
GGGTTCTAAGGATAACATTATCGGCATGGTGCATATTAGGGATTTGCTTTCGCGCTCTATTTTTACCCCCAAAATGCATG
ATTTCAATCAAATCGTTAGGAAAATGATCATCGTCCCCGAAAGCGCTTCCATTTCTCAAATCCTTATTAAAATGAAAAAA
GAGCAAATCCATACCGCTTTGGTGATTGATGAATACGGCGGCACAGCCGGGTTGCTCACTATGGAAGACATCATTGAAGA
GATCATGGGCGAGATTAGCGACGAATACGACTTAAAACAAGAGGGCATAAACAAGCTTGAAGAGGGCGTGTTTGAATTAG
AGGGCATGCTGGATTTAGAGAGCGTAGAAGAAGCGCTTCACATTGAATTTGATAAAGAATGCGAGCAGGTAACGCTTGGG
GGCTATGTTTTTAGCTTGTTAGAGCGCATGCCTATGGAGGGAGATACAATCGTTTCGCATGGGTATTCTTTTGAAGTCTT
AAGCGTGGATGGGGCTAGGATAAAACGCTTAAAAGCGGTTAAACAAGATCAGGGAGAAAATGAAGCATGA

Upstream 100 bases:

>100_bases
TTTTGAAGGCTTGATTTTTAAAGTTAGGCTTAATCTTTTATGTTAAAATTCTGAGATTTTATATATTTTATATTTATCGT
TAGGTTTTAGGTTTAAAGTT

Downstream 100 bases:

>100_bases
AAAAAACAACCCTCTTTGTATTGGGCTTATTATTTAATAGCTTTTTAAATGCTGTTGATGGGATTTCTAAAACCGATCTT
TCTTCTTTGAATTTGGCTGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MGRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLALKMSQRLDTYLSATQLGITL
SSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVIAFLSITFLHVVLGEIVPKSLAIAKSEKATLFAARPLHVFW
VVFYPVVRLFDVIAHFFLKKMGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAXDFSDTSAKEIMTPRKDMV
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFNQIVRKMIIVPESASISQILIKMKK
EQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQEGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLG
GYVFSLLERMPMEGDTIVSHGYSFEVLSVDGARIKRLKAVKQDQGENEA

Sequences:

>Translated_449_residues
MGRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLALKMSQRLDTYLSATQLGITL
SSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVIAFLSITFLHVVLGEIVPKSLAIAKSEKATLFAARPLHVFW
VVFYPVVRLFDVIAHFFLKKMGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAXDFSDTSAKEIMTPRKDMV
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFNQIVRKMIIVPESASISQILIKMKK
EQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQEGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLG
GYVFSLLERMPMEGDTIVSHGYSFEVLSVDGARIKRLKAVKQDQGENEA
>Mature_448_residues
GRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLALKMSQRLDTYLSATQLGITLS
SLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVIAFLSITFLHVVLGEIVPKSLAIAKSEKATLFAARPLHVFWV
VFYPVVRLFDVIAHFFLKKMGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAXDFSDTSAKEIMTPRKDMVC
LDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFNQIVRKMIIVPESASISQILIKMKKE
QIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQEGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLGG
YVFSLLERMPMEGDTIVSHGYSFEVLSVDGARIKRLKAVKQDQGENEA

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=409, Percent_Identity=40.3422982885086, Blast_Score=295, Evalue=5e-80,
Organism=Escherichia coli, GI1790664, Length=432, Percent_Identity=25.2314814814815, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786879, Length=248, Percent_Identity=28.2258064516129, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI145693175, Length=415, Percent_Identity=24.8192771084337, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87082033, Length=246, Percent_Identity=23.9837398373984, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788119, Length=245, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324512, Length=250, Percent_Identity=26.8, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 50381; Mature: 50250

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LKMSQRLDTYLSATQLGITLSSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVI
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
AFLSITFLHVVLGEIVPKSLAIAKSEKATLFAARPLHVFWVVFYPVVRLFDVIAHFFLKK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
MGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAXDFSDTSAKEIMTPRKDMV
HCCCCCCCCCCCCHHHEEEEECHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHCCCCCCEE
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFNQIVR
EECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHH
KMIIVPESASISQILIKMKKEQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQ
HHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
EGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLGGYVFSLLERMPMEGDTIVSH
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHCCCCCCEEEEC
GYSFEVLSVDGARIKRLKAVKQDQGENEA
CCEEEEEECCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LKMSQRLDTYLSATQLGITLSSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVI
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
AFLSITFLHVVLGEIVPKSLAIAKSEKATLFAARPLHVFWVVFYPVVRLFDVIAHFFLKK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
MGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAXDFSDTSAKEIMTPRKDMV
HCCCCCCCCCCCCHHHEEEEECHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHCCCCCCEE
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFNQIVR
EECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHH
KMIIVPESASISQILIKMKKEQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQ
HHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
EGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLGGYVFSLLERMPMEGDTIVSH
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHCCCCCCEEEEC
GYSFEVLSVDGARIKRLKAVKQDQGENEA
CCEEEEEECCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]