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Identifier: 15646068

GI number: 15646068

Start: 1528141

End: 1528929

Strand: Reverse

Name: Not Available

Synonym: HP1459

Alternate gene names: 15646068

Gene position: 1528929-1528141 (Counterclockwise)

Preceding gene: 15646069

Following gene: 15646067

Centisome position: 91.67

GC content: 42.46

Gene sequence:

>789_bases
GTGGAGGGATTTAGCTTGAGGATCAACCAGTTTTTAGCCCATTACACCAAGCACTCCAGAAGAGAGGCTGAAAAATTGGT
TTTAGAAGGGCGGGTGAAAATCAACCATGAGCATGCCAAACTCGCTAGCGTGGTTAAAGAAAACGACAGGGTGTTTTTAG
ACAAACGACTCATCAAGCCCTTAAAAAACAAAAAATTCAGCGTGCTGGTCTATCACAAGCCAAAGGGCGAATTGGTGAGT
AAAGCCGATCCCTTAAAACGGCGCGTGATTTATGAAAGCTTGGAGAAAAAATACGCCCATTTTGCGCCGGTGGGGCGTTT
GGATTTTGCGAGTGAAGGGGTGTTATTATTGAGCGATAGTAAGGCGGTAGTGAGCGCTTTAATGCATGCGGATTTAGAAA
AAGAGTATCTCATTAAAATTCAAGGCTTTGTTACAAGAGAGATGGAAAACGCGATGCAAGAGGGCTTGAAATTAGAAAAC
GCTACTAAGGGAGCGCACCAAAAAACTCCCATTAAAAGCATGGAATTTGCCCCCTTTATTGGTTATGAAATCATCAAAAA
CCATGCCAAATACTCCAAACTGAGAGTCATTATCAATGAGGGGAAAAACAGAGAATTGAGGCGTTTTTTTGCGTTTTTTA
ACGCTGGAGTGTTGGATTTAAGGCGCGTTCGTTATGGTTTTGTGAATTTGAATGCCTTGCCGGTAGGGAAAATGCGTTTT
CTAAACCGCCAAGAATACAATGAGTTGCATGCGTTTATGGCTAATGCGGCTAATGTTAAAGGGGATTAG

Upstream 100 bases:

>100_bases
GCCCCTTGTATTTGATCATCAAAGATAAGGATAAGCAATTCAAAATCCAAAGCGATTTAATGGTAAATGAAAAGATTAAG
GACGATTTTAAAGGGTTAGA

Downstream 100 bases:

>100_bases
CTTACGAGTTATGCTATACTTCAAAGTTGGGGGAAATAAAAAATAAGGATTATCATGTCAGAAATGATTAACGGGAAGAA
TTACGCAGAGAAAATCGCTC

Product: hypothetical protein

Products: NA

Alternate protein names: RNA pseudouridylate synthase; RNA-uridine isomerase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MEGFSLRINQFLAHYTKHSRREAEKLVLEGRVKINHEHAKLASVVKENDRVFLDKRLIKPLKNKKFSVLVYHKPKGELVS
KADPLKRRVIYESLEKKYAHFAPVGRLDFASEGVLLLSDSKAVVSALMHADLEKEYLIKIQGFVTREMENAMQEGLKLEN
ATKGAHQKTPIKSMEFAPFIGYEIIKNHAKYSKLRVIINEGKNRELRRFFAFFNAGVLDLRRVRYGFVNLNALPVGKMRF
LNRQEYNELHAFMANAANVKGD

Sequences:

>Translated_262_residues
MEGFSLRINQFLAHYTKHSRREAEKLVLEGRVKINHEHAKLASVVKENDRVFLDKRLIKPLKNKKFSVLVYHKPKGELVS
KADPLKRRVIYESLEKKYAHFAPVGRLDFASEGVLLLSDSKAVVSALMHADLEKEYLIKIQGFVTREMENAMQEGLKLEN
ATKGAHQKTPIKSMEFAPFIGYEIIKNHAKYSKLRVIINEGKNRELRRFFAFFNAGVLDLRRVRYGFVNLNALPVGKMRF
LNRQEYNELHAFMANAANVKGD
>Mature_262_residues
MEGFSLRINQFLAHYTKHSRREAEKLVLEGRVKINHEHAKLASVVKENDRVFLDKRLIKPLKNKKFSVLVYHKPKGELVS
KADPLKRRVIYESLEKKYAHFAPVGRLDFASEGVLLLSDSKAVVSALMHADLEKEYLIKIQGFVTREMENAMQEGLKLEN
ATKGAHQKTPIKSMEFAPFIGYEIIKNHAKYSKLRVIINEGKNRELRRFFAFFNAGVLDLRRVRYGFVNLNALPVGKMRF
LNRQEYNELHAFMANAANVKGD

Specific function: Unknown

COG id: COG1187

COG function: function code J; 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787524, Length=258, Percent_Identity=29.8449612403101, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1790453, Length=256, Percent_Identity=28.515625, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1459_HELPY (P55986)

Other databases:

- EMBL:   AE000511
- PIR:   C64702
- RefSeq:   NP_208250.1
- ProteinModelPortal:   P55986
- SMR:   P55986
- DIP:   DIP-3572N
- MINT:   MINT-178262
- GeneID:   899834
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP1459
- NMPDR:   fig|85962.1.peg.1446
- TIGR:   HP_1459
- HOGENOM:   HBG754478
- OMA:   INHEHAK
- ProtClustDB:   CLSK872558
- InterPro:   IPR020103
- InterPro:   IPR006145
- InterPro:   IPR000748
- InterPro:   IPR018496
- InterPro:   IPR002942
- SMART:   SM00363
- TIGRFAMs:   TIGR00093

Pfam domain/function: PF00849 PseudoU_synth_2; PF01479 S4; SSF55120 PsdUridine_synth_cat_dom

EC number: NA

Molecular weight: Translated: 30229; Mature: 30229

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS01149 PSI_RSU; PS50889 S4

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGFSLRINQFLAHYTKHSRREAEKLVLEGRVKINHEHAKLASVVKENDRVFLDKRLIKP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECHHHHHHHHHHHCCCCEEHHHHHHHH
LKNKKFSVLVYHKPKGELVSKADPLKRRVIYESLEKKYAHFAPVGRLDFASEGVLLLSDS
HCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
KAVVSALMHADLEKEYLIKIQGFVTREMENAMQEGLKLENATKGAHQKTPIKSMEFAPFI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
GYEIIKNHAKYSKLRVIINEGKNRELRRFFAFFNAGVLDLRRVRYGFVNLNALPVGKMRF
HHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCEEEECCCCCHHHHH
LNRQEYNELHAFMANAANVKGD
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEGFSLRINQFLAHYTKHSRREAEKLVLEGRVKINHEHAKLASVVKENDRVFLDKRLIKP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECHHHHHHHHHHHCCCCEEHHHHHHHH
LKNKKFSVLVYHKPKGELVSKADPLKRRVIYESLEKKYAHFAPVGRLDFASEGVLLLSDS
HCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
KAVVSALMHADLEKEYLIKIQGFVTREMENAMQEGLKLENATKGAHQKTPIKSMEFAPFI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
GYEIIKNHAKYSKLRVIINEGKNRELRRFFAFFNAGVLDLRRVRYGFVNLNALPVGKMRF
HHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCEEEECCCCCHHHHH
LNRQEYNELHAFMANAANVKGD
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185