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Identifier: 15645960

GI number: 15645960

Start: 1407180

End: 1407881

Strand: Reverse

Name: Not Available

Synonym: HP1347

Alternate gene names: 15645960

Gene position: 1407881-1407180 (Counterclockwise)

Preceding gene: 15645961

Following gene: 15645959

Centisome position: 84.41

GC content: 42.45

Gene sequence:

>702_bases
ATGAAGCTTTTTGACTACGCTCCTTTGAGTTTGGCTTGGCGGGAGTTTTTGCAAAGCGAATTTAAAAAGCCTTATTTTTT
AGAAATAGAAAAACGCTACCTAGAAGCCCTAAAAATCCCTAAAACCATTTTCCCTAAAAGCTCTAATCTGTTTTATGCGC
TCAATCTAACGCCCCCTTGTGCGGTTAAAATCATCCTTTTAGGGCAAGACCCCTACCATTCCACCTACCTAGAAAATGAT
CAAGAATTGCCGGTGGCGATGGGGTTGAGCTTTAGCGTGGAAAAAAACGCCCCTATTCCTCCAAGTTTAAAAAATATTTT
TAAAGAATTGCATGCGAATTTAGGCGTGCCTGTGCCTTGTTGTGGGGATTTGAGCGCATGGGCTAAAAGGGGCATGCTCT
TATTGAACGCCATTTTAAGCGTGGAAAAAAACCAAGCCGCTTCGCACCAATATATTGGCTGGGAAGCTTTTAGCGATCAA
ATACTGATGCGCCTTTTTGAAACGACCGCCCCTTTAATCGTGGTGTTACTAGGGAAAGTCGCCCAAAAAAAGATCGCGTT
AATCCCCAAAAACAAACACATCATCATCACAGCCCCTCACCCTAGCCCACTATCTAGGGGGTTTTTAGGGAGTGGGGTTT
TTACAAGCGTTCAAAAAGCTTATAGAGAGGTTTATCGCAAGGATTTTGATTTTAGTTTATGA

Upstream 100 bases:

>100_bases
ATACGCCTGATTTTAACTCGCCCACCTGGTATGAAGAATTACAAGAACGCATGCAAAAAGAGTATTTAAAACACTATCAT
GAATTAAACCCTAGCGAACA

Downstream 100 bases:

>100_bases
TTGATGCTTAATGAGACAGAACCCCTTAAGAATGCCTTTATTTAAGAGCATTTGTGATAGAATGGTGATTTTTAAATAAA
GGGAAAACATGCCAATTAGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKIPKTIFPKSSNLFYALNLTPPCAVKIILLGQDPYHSTYLEND
QELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVPVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHQYIGWEAFSDQ
ILMRLFETTAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSVQKAYREVYRKDFDFSL

Sequences:

>Translated_233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKIPKTIFPKSSNLFYALNLTPPCAVKIILLGQDPYHSTYLEND
QELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVPVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHQYIGWEAFSDQ
ILMRLFETTAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSVQKAYREVYRKDFDFSL
>Mature_233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKIPKTIFPKSSNLFYALNLTPPCAVKIILLGQDPYHSTYLEND
QELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVPVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHQYIGWEAFSDQ
ILMRLFETTAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSVQKAYREVYRKDFDFSL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=223, Percent_Identity=39.0134529147982, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI6224979, Length=223, Percent_Identity=39.0134529147982, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1788934, Length=207, Percent_Identity=40.0966183574879, Blast_Score=153, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17556304, Length=224, Percent_Identity=36.6071428571429, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323620, Length=241, Percent_Identity=34.0248962655602, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26297; Mature: 26297

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKIPKTIFPKSSNLFYALNLTPPC
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCCC
AVKIILLGQDPYHSTYLENDQELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVPVPC
CEEEEEECCCCCCCHHCCCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKNQAASHQYIGWEAFSDQILMRLFETTAPLIVVLLGKV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSVQKAYREVYRKDFDFSL
HHHHEEEECCCCEEEEECCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKIPKTIFPKSSNLFYALNLTPPC
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCCC
AVKIILLGQDPYHSTYLENDQELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVPVPC
CEEEEEECCCCCCCHHCCCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKNQAASHQYIGWEAFSDQILMRLFETTAPLIVVLLGKV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSVQKAYREVYRKDFDFSL
HHHHEEEECCCCEEEEECCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA