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Identifier: 15645867

GI number: 15645867

Start: 1328909

End: 1329928

Strand: Reverse

Name: Not Available

Synonym: HP1253

Alternate gene names: 15645867

Gene position: 1329928-1328909 (Counterclockwise)

Preceding gene: 15645868

Following gene: 15645866

Centisome position: 79.74

GC content: 39.9

Gene sequence:

>1020_bases
GTGGTTACAATAACACTAACTAAAACAACGAGAAACAACATGCATAAAAAACGAGTCTTTTCAGGCATCCAACCTACTGG
GCAAATCCATTTGGGCAACTATTTAGGAGCGATCAAGCATTGGGTAGAGATGCAAGATGAATATGAAAACCTTTTTTGCG
TCGTCAATTCGCATGCGATCACCCTACCCATAGATCCTGCATTTTTAAAATCCCAAAGCTATGAGCTAGTCAAATTGCTT
TTGGCTTGCGGGATTGATCCTAAGCAATCGGGGTTATTCATTCAAAGTGAAGTGGATGAGCACCCGGCTTTAGCATGGCT
ATTAAATTGTCAGGTGTCTATGGGGGAAATGCAAAGAATGACGCAATTCAAAGACAAGTCTTTAAAAAACCCTAAAAGCG
TGAACGTGGGGCTTTTCAATTACCCTATTTTGATGGCGTCAGATATTTTGTTATACCAAAGCGATTTAGTGCCAGTGGGC
GAAGATCAAAAACAGCATTTAGAGCTCACGCGAAACATTGCAGAAAAATTTAACAGGGATTTTGGGAACTGCTTTAAAGT
GCCAGAGCCTTTGATCGCTAAAGTGGGGGCAAGGGTTATGGGGCTAGATGATCCAAAAGTGAAGATGAGTAAATCGCATC
AAGGGGCTAACCATGCGATTTTTCTTCTAGATGAGCCAGACATTATTGTAAAAAAAATCAAAAAAGCGGCCACTGATTCT
ATGGGCGTTATTGCATTTGATGAAAAAAGAGAGGGCATTTTTAACCTTTTAAATATCTACATGCTTTTGAGCAATGAAAG
CCCAGAAAACATAGAAGAGCGTTTTAAAAATAAGGGCTATGGGGATTTTAAAAAGGAATTGGCTGAAGTAATGATTCAGG
CTTTAAAACCCATCCAAGAAAGATACAAAGAAATCAGCGATGATGAAGTGAAAGCCATTTTAAATGGCGGAGCCGAAAAA
GCCAGGCCTTTAGCGAGAGCGACTTACCAAAAGGCTAAAGAATTGATGGGGTTAATTTGA

Upstream 100 bases:

>100_bases
TTTCAAAACATGGCGTTTGAAAAATTGAGCTATGAAGTGTTACTCTTTTCTGGGATCAAGCGTTCTTAAAAACTAAGATA
AATTAAAATATTAAAATTAG

Downstream 100 bases:

>100_bases
GTGGTCTTTAAAATTTTAGGTTTATGGTTAGGGGTGTTTTGTTTCCTTGAGGCTACGCCTTATTTATACTTGGGCGAAGA
GCCTAAATATAAAGACAATT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MVTITLTKTTRNNMHKKRVFSGIQPTGQIHLGNYLGAIKHWVEMQDEYENLFCVVNSHAITLPIDPAFLKSQSYELVKLL
LACGIDPKQSGLFIQSEVDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVG
EDQKQHLELTRNIAEKFNRDFGNCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVKKIKKAATDS
MGVIAFDEKREGIFNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVMIQALKPIQERYKEISDDEVKAILNGGAEK
ARPLARATYQKAKELMGLI

Sequences:

>Translated_339_residues
MVTITLTKTTRNNMHKKRVFSGIQPTGQIHLGNYLGAIKHWVEMQDEYENLFCVVNSHAITLPIDPAFLKSQSYELVKLL
LACGIDPKQSGLFIQSEVDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVG
EDQKQHLELTRNIAEKFNRDFGNCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVKKIKKAATDS
MGVIAFDEKREGIFNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVMIQALKPIQERYKEISDDEVKAILNGGAEK
ARPLARATYQKAKELMGLI
>Mature_339_residues
MVTITLTKTTRNNMHKKRVFSGIQPTGQIHLGNYLGAIKHWVEMQDEYENLFCVVNSHAITLPIDPAFLKSQSYELVKLL
LACGIDPKQSGLFIQSEVDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVG
EDQKQHLELTRNIAEKFNRDFGNCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVKKIKKAATDS
MGVIAFDEKREGIFNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVMIQALKPIQERYKEISDDEVKAILNGGAEK
ARPLARATYQKAKELMGLI

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=328, Percent_Identity=41.1585365853659, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=52.5139664804469, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI1789786, Length=331, Percent_Identity=48.3383685800604, Blast_Score=327, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI71982800, Length=337, Percent_Identity=34.1246290801187, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71982793, Length=337, Percent_Identity=34.1246290801187, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=41.6184971098266, Blast_Score=223, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24666151, Length=332, Percent_Identity=40.3614457831325, Blast_Score=256, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38311; Mature: 38311

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTITLTKTTRNNMHKKRVFSGIQPTGQIHLGNYLGAIKHWVEMQDEYENLFCVVNSHAI
CEEEEEECCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEECCEE
TLPIDPAFLKSQSYELVKLLLACGIDPKQSGLFIQSEVDEHPALAWLLNCQVSMGEMQRM
EEECCHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHH
TQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNIAEKFNRD
HHHHHHHCCCCCCCEEEHHHCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCC
FGNCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVKKIKKAATDS
HHHHCCCCCHHHHHHCCCEECCCCCCCHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCC
MGVIAFDEKREGIFNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVMIQALKPIQE
CCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RYKEISDDEVKAILNGGAEKARPLARATYQKAKELMGLI
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVTITLTKTTRNNMHKKRVFSGIQPTGQIHLGNYLGAIKHWVEMQDEYENLFCVVNSHAI
CEEEEEECCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEECCEE
TLPIDPAFLKSQSYELVKLLLACGIDPKQSGLFIQSEVDEHPALAWLLNCQVSMGEMQRM
EEECCHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHH
TQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNIAEKFNRD
HHHHHHHCCCCCCCEEEHHHCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCC
FGNCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVKKIKKAATDS
HHHHCCCCCHHHHHHCCCEECCCCCCCHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCC
MGVIAFDEKREGIFNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVMIQALKPIQE
CCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RYKEISDDEVKAILNGGAEKARPLARATYQKAKELMGLI
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]