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Identifier: 15645463

GI number: 15645463

Start: 895171

End: 895983

Strand: Reverse

Name: Not Available

Synonym: HP0844

Alternate gene names: 15645463

Gene position: 895983-895171 (Counterclockwise)

Preceding gene: 15645464

Following gene: 15645462

Centisome position: 53.72

GC content: 44.9

Gene sequence:

>813_bases
GTGGTGAAAATTTACCCGCAAGTTTTAAGCATTGCTGGCAGCGATAGCGGTGGGGGCTCTGGGATACAGGCCGATTTGAA
AGCGTTCCAAACTTTGGGCGTGTTTGGGACAAGCGTGATCACTTGCATCACCGCGCAAAACACACAGGGCGTGCATGGGG
TTTATCCGTTGAGCGTTGAGAGCGTGAAAGCGCAAATCTTAGCCATTAGAGATGATTTTTCTATCAAAGCGTTCAAAATG
GGAGCGTTATGTAACGCTCAAATCATTGAATGCGTGGCGGACACTTTAGAAACTTGCGATTTTGGGTTGTGCGTTTTAGA
TCCGGTGATGGTGGCAAAGAATGGGGCTTTGCTTTTAGAAGAAGAGGCGATTTTAAGCTTAAAAAAACGCCTTTTACCTA
CAACCCATTTACTAACCCCTAACCTCCCTGAAGTTTATGCGCTCACAGGCGTTCAAGTGCGAGATGATAAAAGCGCTTCA
AAAGCGATGGGCGTTTTAAGGGATTTAGGCGTTAAAAACGCTGTGATTAAAGGGGGGCATACAGAGCATTTTCAAGGGGA
ATATAGCAACGACTGGGTGTTTTTAGAAGACGCTGAATTTATCCTAAACGCCAAGCGCTTCAACACGAAAAACACGCATG
GCACGGGCTGCACTCTTTCTAGCTTGATTGTGGGCTTACTCGCTCAAGGGTTGGATTTAAAAAACGCTATTTCAAAGGCT
AAAGAGCTTTTAACCATCATCATTCAAAACCCTTTAAACATTGGGCATGGGCATGGGCCTTTGAATTTATGGAGTATCAA
AGAGCTTGTTTGA

Upstream 100 bases:

>100_bases
AGGTGTTGGAAAATAACGGCTCTAATGGTTCGTTCTTGTTTTATTTTTTAGATGCTCTAAGCTTGCCCATAGAGTTAGAA
AACAGCCTTATTAAGGAAGA

Downstream 100 bases:

>100_bases
TGCGGATTGTTTGAAACTCATGTTTGTGGCCGGATCGCAAGACTTCTACCACATAAAGGGCGGCAAAAACGATAGGATAA
ACGCGCTTTTAGACACTTTA

Product: thiamine biosynthesis protein (thi)

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MVKIYPQVLSIAGSDSGGGSGIQADLKAFQTLGVFGTSVITCITAQNTQGVHGVYPLSVESVKAQILAIRDDFSIKAFKM
GALCNAQIIECVADTLETCDFGLCVLDPVMVAKNGALLLEEEAILSLKKRLLPTTHLLTPNLPEVYALTGVQVRDDKSAS
KAMGVLRDLGVKNAVIKGGHTEHFQGEYSNDWVFLEDAEFILNAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAISKA
KELLTIIIQNPLNIGHGHGPLNLWSIKELV

Sequences:

>Translated_270_residues
MVKIYPQVLSIAGSDSGGGSGIQADLKAFQTLGVFGTSVITCITAQNTQGVHGVYPLSVESVKAQILAIRDDFSIKAFKM
GALCNAQIIECVADTLETCDFGLCVLDPVMVAKNGALLLEEEAILSLKKRLLPTTHLLTPNLPEVYALTGVQVRDDKSAS
KAMGVLRDLGVKNAVIKGGHTEHFQGEYSNDWVFLEDAEFILNAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAISKA
KELLTIIIQNPLNIGHGHGPLNLWSIKELV
>Mature_270_residues
MVKIYPQVLSIAGSDSGGGSGIQADLKAFQTLGVFGTSVITCITAQNTQGVHGVYPLSVESVKAQILAIRDDFSIKAFKM
GALCNAQIIECVADTLETCDFGLCVLDPVMVAKNGALLLEEEAILSLKKRLLPTTHLLTPNLPEVYALTGVQVRDDKSAS
KAMGVLRDLGVKNAVIKGGHTEHFQGEYSNDWVFLEDAEFILNAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAISKA
KELLTIIIQNPLNIGHGHGPLNLWSIKELV

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family

Homologues:

Organism=Escherichia coli, GI1788420, Length=257, Percent_Identity=40.8560311284047, Blast_Score=187, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6325378, Length=263, Percent_Identity=30.0380228136882, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324997, Length=281, Percent_Identity=33.8078291814947, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=31.6363636363636, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THID_HELPY (O25515)

Other databases:

- EMBL:   AE000511
- PIR:   D64625
- RefSeq:   NP_207637.1
- ProteinModelPortal:   O25515
- SMR:   O25515
- GeneID:   899373
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP0844
- NMPDR:   fig|85962.1.peg.835
- TIGR:   HP_0844
- HOGENOM:   HBG476673
- OMA:   LNIGHGH
- ProtClustDB:   CLSK477684
- BRENDA:   2.7.4.7
- InterPro:   IPR013749
- InterPro:   IPR004399
- TIGRFAMs:   TIGR00097

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.49; =2.7.4.7

Molecular weight: Translated: 28925; Mature: 28925

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: BINDING 46-46

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIYPQVLSIAGSDSGGGSGIQADLKAFQTLGVFGTSVITCITAQNTQGVHGVYPLSVE
CEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCEECCCHH
SVKAQILAIRDDFSIKAFKMGALCNAQIIECVADTLETCDFGLCVLDPVMVAKNGALLLE
HHEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEE
EEAILSLKKRLLPTTHLLTPNLPEVYALTGVQVRDDKSASKAMGVLRDLGVKNAVIKGGH
HHHHHHHHHHHCCHHHCCCCCCCCEEEECCEEEECCCHHHHHHHHHHHCCCCHHEECCCC
TEHFQGEYSNDWVFLEDAEFILNAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAISKA
CCCCCCCCCCCEEEEECHHHHEEHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
KELLTIIIQNPLNIGHGHGPLNLWSIKELV
HHHHHHHHHCCCCCCCCCCCCEEHHHHHCC
>Mature Secondary Structure
MVKIYPQVLSIAGSDSGGGSGIQADLKAFQTLGVFGTSVITCITAQNTQGVHGVYPLSVE
CEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCEECCCHH
SVKAQILAIRDDFSIKAFKMGALCNAQIIECVADTLETCDFGLCVLDPVMVAKNGALLLE
HHEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEE
EEAILSLKKRLLPTTHLLTPNLPEVYALTGVQVRDDKSASKAMGVLRDLGVKNAVIKGGH
HHHHHHHHHHHCCHHHCCCCCCCCEEEECCEEEECCCHHHHHHHHHHHCCCCHHEECCCC
TEHFQGEYSNDWVFLEDAEFILNAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAISKA
CCCCCCCCCCCEEEEECHHHHEEHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
KELLTIIIQNPLNIGHGHGPLNLWSIKELV
HHHHHHHHHCCCCCCCCCCCCEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185