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Identifier: 15645464

GI number: 15645464

Start: 895977

End: 896798

Strand: Reverse

Name: Not Available

Synonym: HP0845

Alternate gene names: 15645464

Gene position: 896798-895977 (Counterclockwise)

Preceding gene: 15645465

Following gene: 15645463

Centisome position: 53.77

GC content: 42.94

Gene sequence:

>822_bases
ATGGATTTTTGTAAAATAAAAGAAATTTTAAGGAGGCTTGTGGTGTTGAAAGAATTACGCCAAAAACGCCCTTTAGTGCA
TAATATCACCAATTATGTGGCGGCGCAATTTGTGGCTAATGGTTTGTTAGCTTTAGGGGCATCGCCTTTAATGAGCGATG
CGATTGATGAAATGCGAGATTTAGCGAAAATTTCTGACGCGCTCGCTATCAATATTGGCACCCTTAATGATCGCGCTATT
TTATGCGCTAAAGAGGCTATCAAGCATTACAAGGCTTTGAACAAACCCATTGTGTTAGATCCTGTGGGGTGTTCAGCGAG
CGCTTTGCGTCATGACACCAGTTTAGAGCTTTTGAAAAGTGGTGGGATTAGCGCGCTTAGGGGTAATGCTGCAGAATTAG
GCTCTTTAGTGGGGATTTCTTGCGAAAGTAAGGGGCTAGACTCTAATGATGCCGCCACGCCTGTAGAAATAATCAAATTA
GCGGCTCAAAAATATTCTGTGATAGCGGTAATGACGGGTAAAACAGATTACGTGAGCGATGGGAAAAAGGTTTTGAGTAT
TACTGGGGGGAGCGAGTATTTAGCGCTCATTACTGGGGCTGGGTGTTTGCATGCCGCAGCATGCGCGAGCTTTTTAAGTT
TGAAAAAAGACCCCTTAGATTCTATGGCGCAACTTTGCGCGCTCTATAAACAAGCCGCTTTTAACGCGCAAAAAAAGGTG
TTGGAAAATAACGGCTCTAATGGTTCGTTCTTGTTTTATTTTTTAGATGCTCTAAGCTTGCCCATAGAGTTAGAAAACAG
CCTTATTAAGGAAGAGTGGTGA

Upstream 100 bases:

>100_bases
CTAGCGCTATATTTAAGAAAAATGAGGTTAAAAAAGATGAGGTTAATGAAAAATAGTTCATGAACGCTTTTGCATTAAGG
CTCAAAAAAAGCGCCGTTTA

Downstream 100 bases:

>100_bases
AAATTTACCCGCAAGTTTTAAGCATTGCTGGCAGCGATAGCGGTGGGGGCTCTGGGATACAGGCCGATTTGAAAGCGTTC
CAAACTTTGGGCGTGTTTGG

Product: hydroxyethylthiazole kinase

Products: NA

Alternate protein names: 4-methyl-5-beta-hydroxyethylthiazole kinase; TH kinase; Thz kinase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MDFCKIKEILRRLVVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMRDLAKISDALAINIGTLNDRAI
LCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGSLVGISCESKGLDSNDAATPVEIIKL
AAQKYSVIAVMTGKTDYVSDGKKVLSITGGSEYLALITGAGCLHAAACASFLSLKKDPLDSMAQLCALYKQAAFNAQKKV
LENNGSNGSFLFYFLDALSLPIELENSLIKEEW

Sequences:

>Translated_273_residues
MDFCKIKEILRRLVVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMRDLAKISDALAINIGTLNDRAI
LCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGSLVGISCESKGLDSNDAATPVEIIKL
AAQKYSVIAVMTGKTDYVSDGKKVLSITGGSEYLALITGAGCLHAAACASFLSLKKDPLDSMAQLCALYKQAAFNAQKKV
LENNGSNGSFLFYFLDALSLPIELENSLIKEEW
>Mature_273_residues
MDFCKIKEILRRLVVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMRDLAKISDALAINIGTLNDRAI
LCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGSLVGISCESKGLDSNDAATPVEIIKL
AAQKYSVIAVMTGKTDYVSDGKKVLSITGGSEYLALITGAGCLHAAACASFLSLKKDPLDSMAQLCALYKQAAFNAQKKV
LENNGSNGSFLFYFLDALSLPIELENSLIKEEW

Specific function: Thiamine biosynthesis. [C]

COG id: COG2145

COG function: function code H; Hydroxyethylthiazole kinase, sugar kinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Thz kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788421, Length=244, Percent_Identity=38.5245901639344, Blast_Score=147, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6325042, Length=298, Percent_Identity=32.8859060402685, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000417 [H]

Pfam domain/function: PF02110 HK [H]

EC number: =2.7.1.50 [H]

Molecular weight: Translated: 29229; Mature: 29229

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFCKIKEILRRLVVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMRD
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAKISDALAINIGTLNDRAILCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKS
HHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCHHHHHHHC
GGISALRGNAAELGSLVGISCESKGLDSNDAATPVEIIKLAAQKYSVIAVMTGKTDYVSD
CCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCC
GKKVLSITGGSEYLALITGAGCLHAAACASFLSLKKDPLDSMAQLCALYKQAAFNAQKKV
CCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LENNGSNGSFLFYFLDALSLPIELENSLIKEEW
HHCCCCCCCCHHEEHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MDFCKIKEILRRLVVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMRD
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAKISDALAINIGTLNDRAILCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKS
HHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCHHHHHHHC
GGISALRGNAAELGSLVGISCESKGLDSNDAATPVEIIKLAAQKYSVIAVMTGKTDYVSD
CCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCC
GKKVLSITGGSEYLALITGAGCLHAAACASFLSLKKDPLDSMAQLCALYKQAAFNAQKKV
CCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LENNGSNGSFLFYFLDALSLPIELENSLIKEEW
HHCCCCCCCCHHEEHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA