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Identifier: 15645423

GI number: 15645423

Start: 858216

End: 859250

Strand: Reverse

Name: Not Available

Synonym: HP0804

Alternate gene names: 15645423

Gene position: 859250-858216 (Counterclockwise)

Preceding gene: 15645424

Following gene: 15645422

Centisome position: 51.52

GC content: 40.58

Gene sequence:

>1035_bases
ATGATCTTAAAACGAGTTACTGAAGCTTTAGAAGCGTATAAAAATGGCGAAATGCTCATTGTTATGGACGATGAAGACAG
AGAAAATGAGGGGGATTTGGTTTTAGCTGGGATTTTTTCTACCCCTGAGAAAATCAATTTCATGGCCACGCATGCTAGGG
GGTTGATTTGCGTGTCTTTGACCAAAGATTTAGCGAAAAAATTTGAATTACCCCCTATGGTTAGCGTGAATGATTCTAAC
CATGAGACCGCTTTCACGGTTTCCATTGACGCTAAAGAAGCCAGAACCGGGATTTCTGCTTTTGAAAGGCATTTAACGAT
TGAATTATTGTGTAAAGACACCACCAAACCGAGCGATTTTGTGCGCCCGGGGCATATTTTCCCTTTGATCGCCAAAGACG
GGGGCGTGTTAGCGCGCACGGGCCATACTGAAGCGAGCGTGGATTTGTGCAAATTAGCTGGATTAAAGCCCGTGAGCGTG
ATTTGTGAAATCATGAAAGAAGATGGCTCTATGGCGAGAAGGGGGGATAAATTTTTGAGCGATTTCGCCCTCAAACATAA
CCTTAAAACTCTCTATGTCTCTGATTTGATTAGCTATCGTTTGGAAAATGAAAGTTTGCTGAAAATGTTTTGTCAAGAAG
AAAGGGAATTTTTAAAACACCAAACGCAATGCTACACTTTTTTAGATCACCAGCAAAAAAACCATTACGCTTTTAAGTTT
AAAGGCGCAAAAACCCATGATTTAGCCCCTTTAGTGCGTTTCCACCCTATCAAAGAGGATTTTGATTTTTTAACGACTGA
TGCGTTTGAAGTGTTTTTTAAAGCGTTAGAATATTTAAAGCACGAAGGGGGCTATTTGATCTTTATGAACACCCATTCTA
AAGAAAACAATGTCGTTAAAGATTTTGGGATCGGGGCGTTGGTGTTAAAAAATTTGGGGATAAAGGATTTCAGGCTCTTA
AGCTCTTGTGAAGACAGGCAGTATAAGGCTTTGAGCGGGTTTGGGCTTAAGCTTGTAGAAACGATTAGCCTTTAA

Upstream 100 bases:

>100_bases
TGTATCTAAATAAAGCAATAAAGTAATAATCGTTATTAAACATGCTATATTTCTTTTTTCTATAAAACTCAATATTATTG
AATAAAACTAGGGAGTTAGA

Downstream 100 bases:

>100_bases
GAGGCTCGTTAAGTTTTATTGAATGTGTTGTAATGTTTTTAAGGTATAATAAACTCTTTTTAAGTCAAGCAATAAAGTTT
GCAACCTGATGAGAGTAATA

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLAKKFELPPMVSVNDSN
HETAFTVSIDAKEARTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTHDLAPLVRFHPIKEDFDFLTTDAFEVFFKALEYLKHEGGYLIFMNTHSKENNVVKDFGIGALVLKNLGIKDFRLL
SSCEDRQYKALSGFGLKLVETISL

Sequences:

>Translated_344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLAKKFELPPMVSVNDSN
HETAFTVSIDAKEARTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTHDLAPLVRFHPIKEDFDFLTTDAFEVFFKALEYLKHEGGYLIFMNTHSKENNVVKDFGIGALVLKNLGIKDFRLL
SSCEDRQYKALSGFGLKLVETISL
>Mature_344_residues
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSLTKDLAKKFELPPMVSVNDSN
HETAFTVSIDAKEARTGISAFERHLTIELLCKDTTKPSDFVRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSV
ICEIMKEDGSMARRGDKFLSDFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
KGAKTHDLAPLVRFHPIKEDFDFLTTDAFEVFFKALEYLKHEGGYLIFMNTHSKENNVVKDFGIGALVLKNLGIKDFRLL
SSCEDRQYKALSGFGLKLVETISL

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=45.5445544554455, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=41.871921182266, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 38972; Mature: 38972

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSL
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEH
TKDLAKKFELPPMVSVNDSNHETAFTVSIDAKEARTGISAFERHLTIELLCKDTTKPSDF
HHHHHHHCCCCCEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCCHHC
VRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSVICEIMKEDGSMARRGDKFLS
CCCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
DFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAKTHDLAPLVRFHPIKEDFDFLTTDAFEVFFKALEYLKHEGGYLIFMNTHSKENNVVK
CCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHH
DFGIGALVLKNLGIKDFRLLSSCEDRQYKALSGFGLKLVETISL
HHCCHHHHHHHCCCHHHHHHHHCCCCHHHHHHCCCHHHHHEECC
>Mature Secondary Structure
MILKRVTEALEAYKNGEMLIVMDDEDRENEGDLVLAGIFSTPEKINFMATHARGLICVSL
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEH
TKDLAKKFELPPMVSVNDSNHETAFTVSIDAKEARTGISAFERHLTIELLCKDTTKPSDF
HHHHHHHCCCCCEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCCHHC
VRPGHIFPLIAKDGGVLARTGHTEASVDLCKLAGLKPVSVICEIMKEDGSMARRGDKFLS
CCCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
DFALKHNLKTLYVSDLISYRLENESLLKMFCQEEREFLKHQTQCYTFLDHQQKNHYAFKF
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KGAKTHDLAPLVRFHPIKEDFDFLTTDAFEVFFKALEYLKHEGGYLIFMNTHSKENNVVK
CCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHH
DFGIGALVLKNLGIKDFRLLSSCEDRQYKALSGFGLKLVETISL
HHCCHHHHHHHCCCHHHHHHHHCCCCHHHHHHCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]