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Identifier: 15645410

GI number: 15645410

Start: 846877

End: 848937

Strand: Reverse

Name: Not Available

Synonym: HP0791

Alternate gene names: 15645410

Gene position: 848937-846877 (Counterclockwise)

Preceding gene: 15645411

Following gene: 15645409

Centisome position: 50.9

GC content: 42.6

Gene sequence:

>2061_bases
ATGCAAGAATACCACATTCATAATTTGGATTGCCCTGATTGTGCGTCTAAATTAGAAAGGGATTTAAACGAATTAGACTA
TGTGAAAAAAGCTCAAATCAATTTCAGCACCAGTAAGTTGTTTTTGGACACGAGCGATTTTGAAAAAGTTAAGGCTTTCA
TCAAGCAGAATGAACCGCATTTGAGCCTGTCTTTTAAAGAGGCTACAGAAAAGCCCTTGAGTTTTACGCCACTCATCATT
ACGATCATGGTTTTTTTGGGCGCGATTTTAATCTTGCACCTAAACCCTAGCCCTTTGATTGAAAAGGCTATGTTTTTCGT
GTTGGCTTTAGTGTATCTAGTGAGCGGTAAAGATGTGATTTTAGGGGCGTTTCGTGGGCTTAGGAAAGGGCAATTTTTTG
ATGAAAACGCTTTGATGCTCATTGCGACTATTGCGGCTTTTTTTGTGGGGGCTTATGAAGAGAGCGTGTCTATTATGGTG
TTTTATTCAGCGGGCGAATTTTTGCAAAAACTCGCTGTCTCTCGCTCTAAAAAATCCCTTAAGGCTTTAGTGGATGTCGC
TCCTAATTTGGCTTATTTGAAAAAGGGCGATGAATTAGTGAGCGTTGCGCCTGAAGATTTAAGAGTCAATGATATTGTGG
TGGTGAAAGTTGGCGAAAAAGTGCCTGTGGATGGCGTGGTAGTTAAGGGCGAAAGCTTGCTAGATGAAAGGGCGTTGAGT
GGGGAGTCTATGCCTGTTAATGTCAGCGAAAATTCTAAAGTTTTAGGGGGGAGCTTGAATTTAAAAGCGGTCCTTGAAAT
TCAAGTGGAAAAAATGTATAAAGATTCTTCTATCGCTAAAGTGGTGGATTTGGTCCAACAAGCCACGAATGAAAAGAGCG
AAACCGAGAAATTTATCACTAAATTTTCACGCTACTACACCCCAAGCGTTTTATTCATTGCTTTAATGATCGCTGTATTA
CCGCCCTTGTTTTCTATGGGGAGCTTTGATGAGTGGATTTATAGGGGGCTTGTGGCTTTAATGGTGAGCTGCCCTTGCGC
GTTAGTGATTTCTGTGCCTTTAGGGTATTTTGGGGGCGTGGGAGCAGCAAGCAGAAAGGGCATTTTAATGAAAGGCGTGC
ATGTTTTAGAGGTGCTTACCCAAGCTAAAAGCATCGCTTTTGATAAAACCGGCACTTTGACTAAAGGCGTTTTTAAAGTA
ACGGATATTGTGCCGCAAAATGGGCATTCTAAAGAAGAAGTTTTGCATTACGCTTCTTGTTCGCAGCTCTTATCCACGCA
CCCTATCGCTTTATCCATTCAAAAAGCATGCGAAGAAATGTTAAAGGACGATAAGCACCAACATGACATTAAAAATTACG
AAGAAGTGAGCGGGATGGGGGTTAAAGCGCAATGCCATACGGATTTAATCATCGCAGGGAATGAAAAAATGCTCGATCAA
TTCCATATCGCGCACAGCCCTTCCAAAGAAAACGGCACGATCGTGCATGTGGCTTTCAATCAAACTTATGTGGGCTATAT
CGTCATTAGCGATGAGATTAAAGATGACGCCATAGAGTGCTTAAGGGATTTAAAAGTGCAAGGGATAGAAAATTTTTGCA
TTTTGAGCGGGGACAGAAAGAGCGCGACTGAGAGCATCGCTCAAACCCTAGGCTGTGAATACCATGCGAGCTTGTTGCCT
GAAGAAAAAACGAGCGTGTTTAAAACCTTTAAAGAACGCTATAAAGCTCCGGCGATTTTTGTAGGCGATGGCATCAATGA
CGCTCCGACTCTAGCGAGTGCTGATGTGGGGATTGGCATGGGGAAAGGATCAGAATTGAGCAAGCAAAGCGCAGACATTG
TGATCACCAATGACTCTTTAAATTCGTTAGTGAAAGTTTTAGCGATCGCTAAAAAAACTAAAAGCATTATTTGGCAAAAT
ATCTTGTTCGCTTTAGGGATTAAAGCCGTTTTTATCGTGCTAGGGCTTATGGGGGTAGCGAGCTTGTGGGAAGCGGTCTT
TGGCGATGTGGGGGTTACGCTTTTAGCCTTAGCCAATTCCATGCGCGCGATGAGAGCTTAA

Upstream 100 bases:

>100_bases
TGCGGATTTAAACGCTTGCGAGGATATAGAAAAATCTCACATGCTTAAAGCGCTGAGTTTTAGAAAGATTTCTTAAAAGG
ATTTTTATAAGGGAGAAAAA

Downstream 100 bases:

>100_bases
AGCCTTGATCGTATCATTAGCCATTTAGAAAGGGGGGCAAAATGCATAAAATAGAGCGCTTACTCCAAACTCTAGCGCCT
AAGGGGGTGGAGTTTAAAAC

Product: cadmium-transporting ATPase, P-type (cadA)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MQEYHIHNLDCPDCASKLERDLNELDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEATEKPLSFTPLII
TIMVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMV
FYSAGEFLQKLAVSRSKKSLKALVDVAPNLAYLKKGDELVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
GESMPVNVSENSKVLGGSLNLKAVLEIQVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
TDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCHTDLIIAGNEKMLDQ
FHIAHSPSKENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKVQGIENFCILSGDRKSATESIAQTLGCEYHASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Sequences:

>Translated_686_residues
MQEYHIHNLDCPDCASKLERDLNELDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEATEKPLSFTPLII
TIMVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMV
FYSAGEFLQKLAVSRSKKSLKALVDVAPNLAYLKKGDELVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
GESMPVNVSENSKVLGGSLNLKAVLEIQVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
TDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCHTDLIIAGNEKMLDQ
FHIAHSPSKENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKVQGIENFCILSGDRKSATESIAQTLGCEYHASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA
>Mature_686_residues
MQEYHIHNLDCPDCASKLERDLNELDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEATEKPLSFTPLII
TIMVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMV
FYSAGEFLQKLAVSRSKKSLKALVDVAPNLAYLKKGDELVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
GESMPVNVSENSKVLGGSLNLKAVLEIQVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
TDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCHTDLIIAGNEKMLDQ
FHIAHSPSKENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKVQGIENFCILSGDRKSATESIAQTLGCEYHASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=798, Percent_Identity=24.6867167919799, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI115529486, Length=681, Percent_Identity=26.1380323054332, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI55743073, Length=524, Percent_Identity=26.9083969465649, Blast_Score=172, Evalue=1e-42,
Organism=Escherichia coli, GI1789879, Length=690, Percent_Identity=33.9130434782609, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1786691, Length=695, Percent_Identity=25.0359712230216, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1786914, Length=526, Percent_Identity=24.5247148288973, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17556548, Length=694, Percent_Identity=26.0806916426513, Blast_Score=176, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=27.5925925925926, Blast_Score=210, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6319772, Length=599, Percent_Identity=25.8764607679466, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221329854, Length=471, Percent_Identity=25.6900212314225, Blast_Score=122, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 75013; Mature: 75013

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEYHIHNLDCPDCASKLERDLNELDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEATEKPLSFTPLIITIMVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVI
EEEEEHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMVFYSAGEFLQKLAVSRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDELVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
HHHHHHCCCHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPVNVSENSKVLGGSLNLKAVLEIQVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCEEEECCCCEEECCCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAVLPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVTDIVPQNGHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCHTDLIIAGNEKMLDQ
HHHHHCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEECCHHHHHH
FHIAHSPSKENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKVQGIENFCILSGDRK
HHHCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH
SATESIAQTLGCEYHASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQEYHIHNLDCPDCASKLERDLNELDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEATEKPLSFTPLIITIMVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVI
EEEEEHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMVFYSAGEFLQKLAVSRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDELVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
HHHHHHCCCHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPVNVSENSKVLGGSLNLKAVLEIQVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCEEEECCCCEEECCCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAVLPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVTDIVPQNGHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCHTDLIIAGNEKMLDQ
HHHHHCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEECCHHHHHH
FHIAHSPSKENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKVQGIENFCILSGDRK
HHHCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH
SATESIAQTLGCEYHASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]