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Identifier: 15645304

GI number: 15645304

Start: 729049

End: 731415

Strand: Reverse

Name: Not Available

Synonym: HP0680

Alternate gene names: 15645304

Gene position: 731415-729049 (Counterclockwise)

Preceding gene: 15645305

Following gene: 15645303

Centisome position: 43.85

GC content: 41.19

Gene sequence:

>2367_bases
TTGATTACAGTGGTTAAACGAAACGGGCGCATTGAGCCTTTGGACATTACCAAAATCCAAAAATACACTAAGGACGCTAC
GGACAATTTAGAGGGCGTGAGCCAAAGTGAGCTGGAAGTGGATGCGAGGTTGCAATTCAGGGACAAGATCACTACTGAAG
AAATCCAACAAACTTTGATTAAAACCGCTGTGGATAAGATAGATATTGACACGCCTAATTGGAGTTTTGTCGCCTCAAGG
CTTTTTTTGTATGATTTATACCATAAAGTAAGTGGTTTTACAGGGTATAGGCATTTGAAAGAGTATTTTGAAAACGCTGA
AGAAAAGGGCCGCATCCTTAAGGGCTTTAAGGAAAAATTTGATCTAGAGTTTTTAAATAGCCAGATCAAGCCTGAAAGGG
ATTTCCAATTCAATTATTTAGGGATTAAAACCTTGTATGATCGCTATTTGTTAAAAGACGCTAACAACAACCCTATTGAA
TTGCCCCAACACATGTTTATGAGCATTGCGATGTTTTTAGCACAAAACGAACAAGAACCCAATAAAATCGCCTTAGAATT
TTATGAAGTTTTGAGCAAGTTTGAAGCGATGTGCGCGACCCCCACTCTAGCGAACGCCCGCACCACCAAACACCAGCTCA
GCTCATGCTATATTGGCAGCACGCCGGATAATATTGAGGGGATTTTTGACAGCTATAAGGAAATGGCGCTGTTGTCCAAA
TACGGCGGAGGGATTGGCTGGGATTTTTCTTTGGTGCGCTCTATTGGGAGTTATATTGATGGGCATAAAAATGCGAGCGC
TGGCACGATCCCTTTTTTAAAAATCGCTAACGATGTGGCGATTGCGGTGGATCAATTAGGCACACGAAAGGGCGCGATTG
CGGTGTATTTGGAAATTTGGCACATTGATGTGATGGAGTTCATTGATTTAAGGAAAAATAGCGGCGATGAAAGGCGAAGA
GCGCATGATTTATTCCCGGCTCTTTGGGTGTGCGATTTGTTTTTGAAAAGGGTTTTAGAAGATGCGATGTGGACTTTATT
TGACCCTTATGAGTGTAAGGATTTGACTGAGCTTTATGGGCAGGATTTTGAAAAACGCTATTTAGAGTATGAAAAAGATC
CCAAGATCATTAAGGAATACATTAACGCTAAAGATTTATGGAAAAAAATCTTAATGAATTATTTTGAAGCCGGTTTGCCT
TTCTTAGCCTTTAAAGATAACGCCAATCGGTGCAACCCAAACGCTCATGCAGGAATCATTCGATCCAGCAATCTATGCAC
GGAGATTTTCCAAAATACCGCGCCTAACCACTACTACATGCAAATAGAATACACCGACGGCACCATAGAGTTTTTTGAAG
AAAAAGAGTTGGTAACGACAGATAGTAATATCACTAAATGCGCTAACAAGCTCACTAGCACCGATATTCTAAAGGGCAAG
CCAATCTATATCGCTACTAAAGTCGCTAAAGACGGGCAAACGGCGGTGTGCAATCTGGCGAGCATCAATTTAAGCAAAAT
CAACACTGAAGAAGACATTAAAAGGGTTGTGCCGATCATGGTCAGGCTTTTAGACAATGTGATTGATTTGAATTTCTACC
CTAACCGCAAAGTCAAAGCCACTAATTTACAAAATAGGGCCATAGGGTTAGGGGTTATGGGTGAAGCGCAAATGCTCGCA
GAACACCAAATCGCTTGGGGGTCTAAAGAGCATTTAGAAAAAATTGACGCTTTAATGGAGCAAATCAGCTACCATGCGAT
TGACACGAGCGCGAATTTAGCGAAAGAAAAAGGGGTTTATAAGGATTTTGAAAATTCAGAATGGAGTAAGGGGATTTTCC
CCATTGATAAAGCCAATAATGAAGCCTTAAAGCTCACCGAAAAAGGGCTTTTTAATCACGCTTGCGATTGGCAAGGTTTG
AGGGAAAAAGTCAAAGCCAATGGCATGCGTAATGGCTATTTAATGGCGATCGCTCCCACAAGCTCCATTTCTATTTTAGT
AGGCACAACCCAAACGATTGAACCCATTTATAAGAAAAAATGGTTTGAAGAAAATTTGAGCGGGCTTATTCCTGTTGTGG
TGCCTAATTTGAATGTAGAAACCTGGAATTTTTACACATCAGCCTATGATATTGACGCTAAAGATTTGATTAAAGCAGCG
GCCGTGCGCCAAAAGTGGATTGATCAAGGCCAAAGCCTTAATGTGTTTTTACGCATAGAAAACGCCAGCGGTAAAACCTT
GCATGACATCTACACGCTCGCTTGGAAATTAGGACTCAAATCCACTTATTATTTGCGCAGCGAAAGCCCTAGCATAGATG
AAAAAAGCGTGTTGGATCGATCGGTGGAGTGTTTTAATTGCCAATAA

Upstream 100 bases:

>100_bases
AGAACAAATCCAACTTGAACTTTTCTTTTTCTTAAGTTTTTTATTGATACAATTCCAAATTTAAAAAACAAACGATTTAA
TTCAAATTTAAGGAAAAATT

Downstream 100 bases:

>100_bases
TATAAGCTTAAATAAGCTAATCTTTGCTAAAATGAGATTTAAAATTATTTAAGGAAGATGAATGCTTTTTGCGATGATTG
GTTCAGGGGGGTTTATCGCT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 788; Mature: 788

Protein sequence:

>788_residues
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR
LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE
LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR
AHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP
FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYYMQIEYTDGTIEFFEEKELVTTDSNITKCANKLTSTDILKGK
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA
EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL
REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
AVRQKWIDQGQSLNVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ

Sequences:

>Translated_788_residues
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR
LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE
LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR
AHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP
FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYYMQIEYTDGTIEFFEEKELVTTDSNITKCANKLTSTDILKGK
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA
EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL
REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
AVRQKWIDQGQSLNVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ
>Mature_788_residues
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR
LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE
LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR
AHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP
FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYYMQIEYTDGTIEFFEEKELVTTDSNITKCANKLTSTDILKGK
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA
EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL
REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
AVRQKWIDQGQSLNVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=813, Percent_Identity=33.5793357933579, Blast_Score=377, Evalue=1e-104,
Organism=Escherichia coli, GI2367133, Length=805, Percent_Identity=26.7080745341615, Blast_Score=286, Evalue=4e-78,
Organism=Escherichia coli, GI1789030, Length=671, Percent_Identity=29.6572280178838, Blast_Score=260, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17555242, Length=817, Percent_Identity=30.3549571603427, Blast_Score=335, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6320914, Length=830, Percent_Identity=33.1325301204819, Blast_Score=385, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322123, Length=822, Percent_Identity=31.7518248175182, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI17352481, Length=810, Percent_Identity=31.9753086419753, Blast_Score=350, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 90161; Mature: 90161

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLI
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHH
KTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHCCHHHHHHHHHH
DLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEP
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
NKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIW
HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEEH
HIDVMEFIDLRKNSGDERRRAHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
QDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLPFLAFKDNANRCNPNAHAGII
CCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEE
RSSNLCTEIFQNTAPNHYYMQIEYTDGTIEFFEEKELVTTDSNITKCANKLTSTDILKGK
ECCHHHHHHHHCCCCCEEEEEEEEECCCEEECCCCCEEECCCHHHHHHHHHCCCCCCCCC
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKA
CEEEEEEECCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
TNLQNRAIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVY
CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
KDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPT
CCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECC
SSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
CCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEECCCHHHHHHHH
AVRQKWIDQGQSLNVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDR
HHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHC
SVECFNCQ
CCHHCCCC
>Mature Secondary Structure
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLI
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHH
KTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHCCHHHHHHHHHH
DLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEP
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
NKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIW
HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEEH
HIDVMEFIDLRKNSGDERRRAHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
QDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLPFLAFKDNANRCNPNAHAGII
CCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEE
RSSNLCTEIFQNTAPNHYYMQIEYTDGTIEFFEEKELVTTDSNITKCANKLTSTDILKGK
ECCHHHHHHHHCCCCCEEEEEEEEECCCEEECCCCCEEECCCHHHHHHHHHCCCCCCCCC
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKA
CEEEEEEECCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
TNLQNRAIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVY
CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
KDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPT
CCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECC
SSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
CCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEECCCHHHHHHHH
AVRQKWIDQGQSLNVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDR
HHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHC
SVECFNCQ
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]