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Identifier: 15645223

GI number: 15645223

Start: 632820

End: 633941

Strand: Reverse

Name: Not Available

Synonym: HP0598

Alternate gene names: 15645223

Gene position: 633941-632820 (Counterclockwise)

Preceding gene: 15645224

Following gene: 15645222

Centisome position: 38.01

GC content: 38.24

Gene sequence:

>1122_bases
ATGTTTTCTAAATCTTTAGAAGCCCTACACCATGCCAAACGCTACCGCAAAAGAGAGTTGTTTGACCCTTTATTAAAGGA
TTACGCTTCTAATGATTATTTGGGTTTGAGCGTTAAAAAAGACTTGCTTCAAAACGCTTTTAATAAGCTCCAATCCTTTG
TTTCTCATTCCCCCAAGGCTTCCATGCTAGTGAATGGCTACCACCCTTTGCATGCAGAATTGGAAGAGCGATTAGCCAAT
TTGTTGGGGTTTGAAAGCGCTCTTTTAGTGGGGAGTGGTTTTTTGGGCAATCTGGCTTTAATAGACACCCTTTTAGTCAA
AAACGCCCTCTTATTCATGGATGCACACTACCATGCGAGCGGGATCTTTAGCACCAAGATTAAGCCTAATCAAGTGATCT
TTTTTTCACACAATGATATTAAAGATTTGAAACAAAAACTCTTTAACGCCCCTAAAAATAAGATCAAATTCATCGCCATT
GAGGGGGTTTATTCTATGGATGCGAGCGTCGCTCCTTATGATTTTTATGCAATCATTCAAGAGATTCCTAACGCTTTTTT
AATCGTTGATGAAGCCCATAGTTTTGGGACTATCGGCGAGAATTTATTGGGTTTTTTAGAATATTATCGCATCAAAGAAA
AGGACAAAATCATTAAACTCAGCACTTTCTCTAAAGCGCTTGCGAGCTATGGGGCGTGTATTTTAGCCCCCTTACAAACC
ATAGAGTTTTTAACCAATCGCGCTAAAAGCGTGATTTACACCACCGCTTTAAGCCTGTTAGACACCGCTTTGACTTTGGC
CCATTTAGAATACTTTATTGTGCAAAAACAAGAATTAAAAAATGAGCTTAGCAAACACCAACAGATTATTTTTGAAACTT
TAGGTATTAGAACGCTCGCAGGATTTTTTACTTTAGAATTTGAAAGCAATCCCGCTCTTTTAAACGCTCATCATTTTTTG
AAAGAAAAGGGGTTTTTAGTGGGAGCTATCCGCCCTCCTACGGTTTCTAAACCCCTTTTACGAGTCTCTTTATCCCTCAA
AAACAGCTTAGAAGACACTAAAGAGCTTGCGAACACCCTTTTAAATTATTCTAAAATACAATCTTCTTTTAAGAGTGGTT
AA

Upstream 100 bases:

>100_bases
GAAAATATTGATAAGATGTTTTACGAAAAACAAGATGAACTCAATAAAATCATTGAAAAAATTCAAAAAGGCGAATGATT
TTATTCAATGAAGTGTTTTG

Downstream 100 bases:

>100_bases
ATGCTAAAAAAGATTTTTTATGGTTTTATCGTTTTATTTTTGATTGTCATGGGGTTATTAGCCATTCTTATCGCTCAAGT
TTGGGTAACTACGGATAAGG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MFSKSLEALHHAKRYRKRELFDPLLKDYASNDYLGLSVKKDLLQNAFNKLQSFVSHSPKASMLVNGYHPLHAELEERLAN
LLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHASGIFSTKIKPNQVIFFSHNDIKDLKQKLFNAPKNKIKFIAI
EGVYSMDASVAPYDFYAIIQEIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQT
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIVQKQELKNELSKHQQIIFETLGIRTLAGFFTLEFESNPALLNAHHFL
KEKGFLVGAIRPPTVSKPLLRVSLSLKNSLEDTKELANTLLNYSKIQSSFKSG

Sequences:

>Translated_373_residues
MFSKSLEALHHAKRYRKRELFDPLLKDYASNDYLGLSVKKDLLQNAFNKLQSFVSHSPKASMLVNGYHPLHAELEERLAN
LLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHASGIFSTKIKPNQVIFFSHNDIKDLKQKLFNAPKNKIKFIAI
EGVYSMDASVAPYDFYAIIQEIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQT
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIVQKQELKNELSKHQQIIFETLGIRTLAGFFTLEFESNPALLNAHHFL
KEKGFLVGAIRPPTVSKPLLRVSLSLKNSLEDTKELANTLLNYSKIQSSFKSG
>Mature_373_residues
MFSKSLEALHHAKRYRKRELFDPLLKDYASNDYLGLSVKKDLLQNAFNKLQSFVSHSPKASMLVNGYHPLHAELEERLAN
LLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHASGIFSTKIKPNQVIFFSHNDIKDLKQKLFNAPKNKIKFIAI
EGVYSMDASVAPYDFYAIIQEIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQT
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIVQKQELKNELSKHQQIIFETLGIRTLAGFFTLEFESNPALLNAHHFL
KEKGFLVGAIRPPTVSKPLLRVSLSLKNSLEDTKELANTLLNYSKIQSSFKSG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4758668, Length=240, Percent_Identity=29.5833333333333, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI284448556, Length=357, Percent_Identity=24.0896358543417, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7657118, Length=357, Percent_Identity=24.0896358543417, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=28.448275862069, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=28.448275862069, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=28.448275862069, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI119220554, Length=254, Percent_Identity=25.1968503937008, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4502025, Length=265, Percent_Identity=27.5471698113208, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI40316939, Length=265, Percent_Identity=27.5471698113208, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=29.1066282420749, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790046, Length=333, Percent_Identity=27.6276276276276, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32566772, Length=202, Percent_Identity=29.2079207920792, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560912, Length=198, Percent_Identity=30.3030303030303, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560914, Length=198, Percent_Identity=30.3030303030303, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994529, Length=240, Percent_Identity=27.5, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=180, Percent_Identity=26.1111111111111, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71982625, Length=180, Percent_Identity=26.1111111111111, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320438, Length=384, Percent_Identity=26.8229166666667, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320267, Length=256, Percent_Identity=27.34375, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24662918, Length=357, Percent_Identity=25.4901960784314, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17137420, Length=285, Percent_Identity=29.4736842105263, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17136286, Length=197, Percent_Identity=28.9340101522843, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24653280, Length=219, Percent_Identity=23.7442922374429, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24653276, Length=219, Percent_Identity=23.7442922374429, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24653278, Length=219, Percent_Identity=23.7442922374429, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41939; Mature: 41939

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKSLEALHHAKRYRKRELFDPLLKDYASNDYLGLSVKKDLLQNAFNKLQSFVSHSPKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCC
SMLVNGYHPLHAELEERLANLLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHAS
CEEECCCCCHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCC
GIFSTKIKPNQVIFFSHNDIKDLKQKLFNAPKNKIKFIAIEGVYSMDASVAPYDFYAIIQ
CEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEECEEECCCCCCCHHHHHHHH
EIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQT
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHHHHHHHHH
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIVQKQELKNELSKHQQIIFETLGIRTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFFTLEFESNPALLNAHHFLKEKGFLVGAIRPPTVSKPLLRVSLSLKNSLEDTKELANTL
HEEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LNYSKIQSSFKSG
HHHHHHHHHHCCC
>Mature Secondary Structure
MFSKSLEALHHAKRYRKRELFDPLLKDYASNDYLGLSVKKDLLQNAFNKLQSFVSHSPKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCC
SMLVNGYHPLHAELEERLANLLGFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHAS
CEEECCCCCHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCC
GIFSTKIKPNQVIFFSHNDIKDLKQKLFNAPKNKIKFIAIEGVYSMDASVAPYDFYAIIQ
CEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEECEEECCCCCCCHHHHHHHH
EIPNAFLIVDEAHSFGTIGENLLGFLEYYRIKEKDKIIKLSTFSKALASYGACILAPLQT
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHHHHHHHHH
IEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIVQKQELKNELSKHQQIIFETLGIRTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFFTLEFESNPALLNAHHFLKEKGFLVGAIRPPTVSKPLLRVSLSLKNSLEDTKELANTL
HEEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LNYSKIQSSFKSG
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]