Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15645099

GI number: 15645099

Start: 492809

End: 494059

Strand: Reverse

Name: Not Available

Synonym: HP0471

Alternate gene names: 15645099

Gene position: 494059-492809 (Counterclockwise)

Preceding gene: 15645100

Following gene: 15645098

Centisome position: 29.62

GC content: 36.69

Gene sequence:

>1251_bases
ATGGAAAACAGCACACTTTATATTGTTATTGCTGGCTTATGGCTTGCTGTGGGCTTTGGAATCTTTTTAAAGAAATTAGA
CATGCCTGTTATCATTGGTTACATTTGCACAGGAACGGTCTTAGCGGCTTTTTTTAAAATTAATGATTTTGATTTGTTGT
CTGATATTGGCGAATTTGGTATCGTCTTTTTAATGTTTATGATAGGCATTGAGTTTAATTTTGACAAGCTCAAATCCATC
AAACAAGAAGTGCTGGTTTTTGGGCTTTTACAAGTGGTTTTATGCGCTTTAATCGCTTTTTTATTGGGGTATTTTGTTTT
GGGTCTTTCACCCATTTTTTCCCTTGTTTTAGGCATGGGGCTTTCGCTCTCTTCAACCGCTATTGTGCTGAAATTCTTTG
AAGATTCCAAACAGCTTAGCACGCCCATGGGAAAGAGCGCGGTGGGGATTTTGATTTTCCAAGATATTGCAGCCATTCCC
ATGCTTTTAATCCTCACTATTCTAGGTAGTAAAGATTCTAATGTTAATTTACTCATTCTTAAAACCTTTATTTCAGCAGG
GATTATTTTAGTTCTTTTATTATTGCCTGGAAAAAAAGGGGCTAATCTCATCTTAGAGCAAGCAAAAGACACGCGCCTGC
CTGAAATTTTTATAGGCACGATTTTAGTGATTGTTTGCAGCGCAGCAGGGTTGAGCCATTTTTTTGGGTTTTCTATGTCT
TTAGGAGCGTTCATTGTGGGCATGGCCATTTCTAAATCGCGCTATAAAATCAATGTCCAAGAAGAATTCGCGCAATTAAA
AAACCTCTTCTTGGCCCTTTTTTTCATTACGATAGGGATGCAAATTAATGTGAGTTTCTTTATGGAGAAATTCTTTGTTG
TCATCTTCTTACTCATTTTAGTGATGGGTTTTAAGACGGCTATCATTTATGCGCTTTTGCGTTTTTTTAGAGACGCTAAA
ACTGCCATAAAAACCGCTCTTTCTTTGGCGCAAATCGGGGAGTTTTCTTTTGTTATCTTTTTAAATTCAGGCTCGCACCA
GCTCTTTAATTTGCAAGAAAAAAAAGGGATTCTTGGTTTTTTGCACCAAAAAAATATCTTAAATATCGCTCAAAATGACA
TCCACCAACTCCTTATCCTCATGGTGGTCTTTTCTATGTTGGCAACCCCTTTTATTTTAAAATACCTAGAATCTATCGCT
CAATTTATTTTGCACCAAAAGAGCCAAGAAAATGAGCCGGCTAAAAAATAA

Upstream 100 bases:

>100_bases
TATTATTTTGTTCAATAGTGTTATTTAATGGATCAATTTAATAGGATAGTTTCGCTTTTATTTCTTTAAAACAAATTGAT
TCTACTGGGGAAAGGTTTTT

Downstream 100 bases:

>100_bases
TGGCGCAAAAACCAAATGATAAGTTTGCTTGTATTGTGAGTGTTATGTTAAAATACAAGCATATTTTAACTCCAAATTGA
TATAAAAAGGGGATTTCATG

Product: glutathione-regulated potassium-efflux system protein (kefB)

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFGIVFLMFMIGIEFNFDKLKSI
KQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMGLSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIP
MLLILTILGSKDSNVNLLILKTFISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
LGAFIVGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLILVMGFKTAIIYALLRFFRDAK
TAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIA
QFILHQKSQENEPAKK

Sequences:

>Translated_416_residues
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFGIVFLMFMIGIEFNFDKLKSI
KQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMGLSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIP
MLLILTILGSKDSNVNLLILKTFISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
LGAFIVGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLILVMGFKTAIIYALLRFFRDAK
TAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIA
QFILHQKSQENEPAKK
>Mature_416_residues
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFGIVFLMFMIGIEFNFDKLKSI
KQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMGLSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIP
MLLILTILGSKDSNVNLLILKTFISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
LGAFIVGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLILVMGFKTAIIYALLRFFRDAK
TAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIA
QFILHQKSQENEPAKK

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=359, Percent_Identity=28.4122562674095, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786232, Length=395, Percent_Identity=28.8607594936709, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789749, Length=392, Percent_Identity=27.0408163265306, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786685, Length=369, Percent_Identity=26.5582655826558, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 46097; Mature: 46097

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFG
CCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IVFLMFMIGIEFNFDKLKSIKQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIPMLLILTILGSKDSNVNLLIL
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHH
KTFISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAFIVGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLIL
HHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VMGFKTAIIYALLRFFRDAKTAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHCCCHHHCCHHHH
LHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIAQFILHQKSQENEPAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFG
CCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IVFLMFMIGIEFNFDKLKSIKQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIPMLLILTILGSKDSNVNLLIL
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHH
KTFISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAFIVGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLIL
HHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VMGFKTAIIYALLRFFRDAKTAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHCCCHHHCCHHHH
LHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIAQFILHQKSQENEPAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]