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Identifier: 15645025

GI number: 15645025

Start: 407264

End: 408838

Strand: Reverse

Name: Not Available

Synonym: HP0397

Alternate gene names: 15645025

Gene position: 408838-407264 (Counterclockwise)

Preceding gene: 15645026

Following gene: 15645024

Centisome position: 24.51

GC content: 41.4

Gene sequence:

>1575_bases
ATGTATCAAGTAGCCATTTGCGACCCCATCCATGCTAAAGGCATTCAAATTTTAGAAGCTCAAAAAGACATTGTCTTGCA
TGATTATTCCAAATGCCCTAAAAAGGAGCTTTTAGAAAAACTCACTCCCATGGATGCGCTCATCACTCGCAGCATGACCC
CTATCACAAGCGATTTTTTAAAGCCCTTAACCCACTTAAAATCCATCGTGAGAGCGGGCGTGGGAGTGGATAATATTGAT
TTAGAAAGCTGCTCTCAAAAAGGGATTGTAGTGATGAATATCCCTACCGCTAACACGATTGCCGCTGTGGAATTGACCAT
GGCGCATTTGATCAATGCAGTGCGTTCGTTCCCTTGTGCAAACGATCAAATCAAACACCAAAGGTTATGGAAAAGAGAAG
ATTGGTATGGCACGGAATTGAAAAATAAAAAGCTGGGCATCATTGGTTTTGGGAATATTGGCTCTAGGGTGGGCATTAGA
GCAAAAGCCTTTGAAATGGAAGTTCTAGCCTATGATCCTTATATCCCTTCTTCAAAAGCCACTGATTTAGGAGTCATTTA
CACGAAAAATTTTGAAGACATTTTGCAATGCGATATGATCACTATCCACACCCCTAAAAATAAAGAAACGATTAACATGA
TAGGTGCTAAAGAGATTGAGCGCATGAAAAAAGGGGTTATTTTGCTCAATTGCGCTAGGGGTGGGCTTTATAATGAAGAC
GCTCTTTATGAGGCTTTAGAAACCAAAAAAGTGCGTTGGCTTGGCATTGATGTCTTTTCTAAAGAGCCTGGCATTCACAA
CAAGCTTTTAGACTTGCCCAATGTTTATGCGACCCCCCATATTGGCGCAAACACTTTAGAATCCCAAGAAGAAATTTCCA
AACAAGCCGCTCAAGGGGTTATGGAATCTTTAAGGGGTTCAAGCCACCCGCATGCTTTGAATTTACCCATGCAAGCTTTT
GACGCGAGCGCAAAAGCCTACTTGAATTTAGCGCAAAAATTGGGTTATTTTTCCAGTCAAATCCATAAGGGCGTGTGCCA
AAAAATTGAGCTCAGTCTTTGTGGGGAGATCAACCAATTTAAAGACGCTCTTGTAGCCTTTATGTTAGTGGGGGTGTTAA
AACCTGTTGTAGGGGATAAAATCAATTACATTAACGCCCCCTTTGTGGCCAAAGAAAGAGGTATTGAGATTAAGGTTAGC
CTTAAAGAAAGCGCTTCGCCCTATAAGAACATGCTCTCTTTAACCCTCAATGCGGCTAATGGCACAATCAGCGTGAGCGG
CACGGTGTTTGAAGAAGATATTTTAAAACTCACTGAGATTGATGGGTTTCATATTGATATAGAGCCAAAGGGTAAAATGC
TTTTATTCAGGAATACGGATATTCCAGGCGTTATTGGGAGTGTGGGGAATGCGTTCGCTAGGCATGGCATTAACATCGCT
GATTTTCGTTTGGGGCGTAACACGCAAAAAGAAGCCCTAGCACTCATTATTGTAGATGAAGAAGTTTCTTTGGAAGTTTT
AGAAGAGCTTAAAAACATTCCTGCGTGCTTAAGCGTTCATTATGTGGTTATTTAA

Upstream 100 bases:

>100_bases
CATCATCTATTTAGATGAAAATAAAAAAGAACGCTTGCTGGCTGATTTAGACTATTATAAAATACGCTATCATGCTGTTT
TTTAAATTCAAAGGATAAAA

Downstream 100 bases:

>100_bases
GGTAGTTGGATGCGAGATTTTTTAAAACTTTTAAAAAAGCATGATGAATTAAAAATCATTGACACCCCCCTTGAAGTGGA
TTTAGAAATCGCTCATCTAG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILLNCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQFKDALVAFMLVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGTISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Sequences:

>Translated_524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILLNCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQFKDALVAFMLVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGTISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
>Mature_524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILLNCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQFKDALVAFMLVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGTISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=398, Percent_Identity=33.6683417085427, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI61743967, Length=283, Percent_Identity=31.8021201413428, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI4557497, Length=283, Percent_Identity=31.8021201413428, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI145580578, Length=283, Percent_Identity=31.8021201413428, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI4557499, Length=283, Percent_Identity=31.8021201413428, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=32.2222222222222, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=30.1960784313725, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=32.7102803738318, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=28.9473684210526, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=28.2442748091603, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=29.277566539924, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081824, Length=246, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=307, Percent_Identity=37.785016286645, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=29.1338582677165, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=337, Percent_Identity=28.486646884273, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=28.1345565749235, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=30.8641975308642, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=298, Percent_Identity=28.1879194630872, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=33.1428571428571, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=285, Percent_Identity=23.5087719298246, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=313, Percent_Identity=36.4217252396166, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=31.2977099236641, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=31.2977099236641, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=31.2977099236641, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=31.2977099236641, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=31.2977099236641, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=306, Percent_Identity=30.3921568627451, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=29.073482428115, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=29.073482428115, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=29.073482428115, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=29.073482428115, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=29.073482428115, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=30.2547770700637, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=25.8785942492013, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57906; Mature: 57906

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFL
CEEEEECCCCCCCCEEEEECCCCEEEECHHCCCHHHHHHHHCCHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILLNCARGGLYNED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQF
HHHHCCCCCCCEEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KDALVAFMLVGVLKPVVGDKINYINAPFVAKERGIEIKVSLKESASPYKNMLSLTLNAAN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHEEEEEEEECC
GTISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
CEEEEECCCHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFL
CEEEEECCCCCCCCEEEEECCCCEEEECHHCCCHHHHHHHHCCHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILLNCARGGLYNED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQF
HHHHCCCCCCCEEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KDALVAFMLVGVLKPVVGDKINYINAPFVAKERGIEIKVSLKESASPYKNMLSLTLNAAN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHEEEEEEEECC
GTISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
CEEEEECCCHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]