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Identifier: 15644999

GI number: 15644999

Start: 379640

End: 380110

Strand: Reverse

Name: Not Available

Synonym: HP0371

Alternate gene names: 15644999

Gene position: 380110-379640 (Counterclockwise)

Preceding gene: 15645002

Following gene: 15644998

Centisome position: 22.79

GC content: 43.1

Gene sequence:

>471_bases
ATGAACCTTTCTGAAATTGAAGAGTTGATCAAAGAATTTAAAGCTTCTGATTTGGGGCATTTGAAATTAAAGCATGAGCA
TTTTGAGTTGGTTTTGGATAAAGAATCCGCTTATGCGAAAAAAAGTGCGTTAAATCCCGCCCATTCTCCAGCCCCCATTA
TGGTAGAAGCGAGCATGCCAAGCGTCCAAACCCCTGTGCCTATGGTATGCACCCCTATTGTGGATAAAAAAGAAGATTTC
GTGCTTTCGCCTATGGTAGGCACTTTTTATCATGCACCCTCCCCTGGGGCTGAGCCTTATGTCAAAGCGGGCGATACGCT
TAAAAAAGGGCAAATCGTGGGCATTGTAGAAGCGATGAAAATCATGAATGAAATTGAAGTGGAATACCCTTGCAAGGTGG
TTTCTGTTGAAGTGGGAGACGCTCAACCGGTAGAATACGGCACAAAACTCATCAAAGTTGAAAAGCTTTAA

Upstream 100 bases:

>100_bases
ATTATGTTATTATAACAATAATTTTTTGCTAAAAACGCTTATGGCTAGTAAGATTATGTGTTTGTGGCATATTTTAAAAT
AATATAAGGAATAGATCGTT

Downstream 100 bases:

>100_bases
AATCCATGAATAAAGTGAATAAAGAAAATAAAAAGGTAGAAAAAAAAGAGCTTTCACGCATTTTGATCGCTAATAGAGGC
GAGATCGCTTTAAGAGCGAT

Product: biotin carboxyl carrier protein (fabE)

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MNLSEIEELIKEFKASDLGHLKLKHEHFELVLDKESAYAKKSALNPAHSPAPIMVEASMPSVQTPVPMVCTPIVDKKEDF
VLSPMVGTFYHAPSPGAEPYVKAGDTLKKGQIVGIVEAMKIMNEIEVEYPCKVVSVEVGDAQPVEYGTKLIKVEKL

Sequences:

>Translated_156_residues
MNLSEIEELIKEFKASDLGHLKLKHEHFELVLDKESAYAKKSALNPAHSPAPIMVEASMPSVQTPVPMVCTPIVDKKEDF
VLSPMVGTFYHAPSPGAEPYVKAGDTLKKGQIVGIVEAMKIMNEIEVEYPCKVVSVEVGDAQPVEYGTKLIKVEKL
>Mature_156_residues
MNLSEIEELIKEFKASDLGHLKLKHEHFELVLDKESAYAKKSALNPAHSPAPIMVEASMPSVQTPVPMVCTPIVDKKEDF
VLSPMVGTFYHAPSPGAEPYVKAGDTLKKGQIVGIVEAMKIMNEIEVEYPCKVVSVEVGDAQPVEYGTKLIKVEKL

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=157, Percent_Identity=30.5732484076433, Blast_Score=74, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 17133; Mature: 17133

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSEIEELIKEFKASDLGHLKLKHEHFELVLDKESAYAKKSALNPAHSPAPIMVEASMP
CCHHHHHHHHHHHCCCCCCEEEEECCEEEEEECCCHHHHHHHCCCCCCCCCCEEEECCCC
SVQTPVPMVCTPIVDKKEDFVLSPMVGTFYHAPSPGAEPYVKAGDTLKKGQIVGIVEAMK
CCCCCCCEEEECCCCCCCCEEECCCHHHEECCCCCCCCCEECCCCCCCCCCEEHHHHHHH
IMNEIEVEYPCKVVSVEVGDAQPVEYGTKLIKVEKL
HHHHCCCCCCEEEEEEECCCCCCHHHCCEEEEEECC
>Mature Secondary Structure
MNLSEIEELIKEFKASDLGHLKLKHEHFELVLDKESAYAKKSALNPAHSPAPIMVEASMP
CCHHHHHHHHHHHCCCCCCEEEEECCEEEEEECCCHHHHHHHCCCCCCCCCCEEEECCCC
SVQTPVPMVCTPIVDKKEDFVLSPMVGTFYHAPSPGAEPYVKAGDTLKKGQIVGIVEAMK
CCCCCCCEEEECCCCCCCCEEECCCHHHEECCCCCCCCCEECCCCCCCCCCEEHHHHHHH
IMNEIEVEYPCKVVSVEVGDAQPVEYGTKLIKVEKL
HHHHCCCCCCEEEEEEECCCCCCHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]