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The map label for this gene is hemA

Identifier: 15644867

GI number: 15644867

Start: 249297

End: 250646

Strand: Reverse

Name: hemA

Synonym: HP0239

Alternate gene names: 15644867

Gene position: 250646-249297 (Counterclockwise)

Preceding gene: 15644868

Following gene: 15644866

Centisome position: 15.03

GC content: 37.26

Gene sequence:

>1350_bases
ATGGAGTTAGAAACTCATTTGTCAAAATATTTCACCCTAGCCTTTACGCATAAAAGCATGAGCTTAGAAATGCGAGAAAA
ACTCGCTATTAATTCGAATGCAACGCTTAAAGAATTTTTACAAACCATTAAAAACCATTGCCCTAACATCAAAGAGTGCA
TGGTGTTATCCACATGCAATCGCTTTGAAATCTATGCGAGCCTAAAACACGGCGCTAATACTAATGAACAAAAAAACGCA
CTATTAAAGATTTTGGCTCAAAATAAAAAAATGAGCGTGTCTGATTTAGAAAAATGCGTTTTAATGAACACTGATGAAAG
CGCAGTCCATCATGTCTTTAGCGTGTGCAGCAGTTTGGATAGCTTGGTGGTTGGGGAAACTCAAATCACAGGGCAGATGA
AAAACGCTTATAAATTCGCTTTTGAAGAGAAATTTTGCTCTAAAGATTTAACCCGATTGCTCCATTTTGCTTTCAAATGC
GCCGCTAAAGTGCGCAATTTAACCGGCATTTCCAAGCAAGGGGTTTCCATCTCTTCAGTGGCGGTCAAAGAAGCGCTTAA
TATTTTTGAAAAAGAAAGGATTAAGGATAAAAAAGCCCTTGTGATAGGGCTTGGCGAGATGGCTCAATTAGTCATCAAGC
ACCTTTTAAACAAGCAATTTGAAGCGCTTATCTTAGGGCGTAATGCGGCTAAATTTGAAGATTTCATCAAAGAATTAGAA
GAACCTAAAAAAGTAAGCTTTCAAAATATAGAAAATTTAAACGCTTATATCAATGAATACGAACTGCTTTTTTGCGCCAC
TTCTTCGCCGCATTTTATCGTGCAAAATCGCATGTTAAAAGAAACGATTTTCAGGCGTTTTTGGTTTGATTTAGCCGTGC
CACGGAATATTGAAAAGCCGGTATTGGATAATATTTTCTTATACAGCGTTGATGATTTAGAGCCTATGGTGAGAGAAAAT
GTGGAAAACAGGCAAGAGAGCAGAATGAGAGCTTATGAGATTGTAGGGCTTGCCACAATGGAGTTTTACCAATGGATTCA
AAGTTTAGAAGTAGAGCCTGTGATTAAGGATTTAAGGGAATTGGCTAGGATTTCAGCCCAAAAAGAATTGCAAAAAGCGC
TTAAAAAACGCTATGTGCCTAAAGAATACGAAAACAACATTGAAAAGATCTTGCACAACGCTTTCAACACTTTTTTGCAT
AACCCTACCATCGCCTTAAAAAAGAACGCTCAAAAAGAAGAATCCGATGTGCTTGTGGGTGCGATTAAAAACTTGTTTAA
TTTAGACAAATCTAACGCTAACCATGCCCAGAATTTGAATCTCTATAAATGCGAATATTACGAGGAATAA

Upstream 100 bases:

>100_bases
TCGCTCAAGTTTATTCTAAAAAGGCCCTTGAAGCCATTAAAGGGGAGAACAATTTGATTTTAGAAAAACTAGCGCAAGAC
GTCATTTATAGGACTTTTTA

Downstream 100 bases:

>100_bases
TGCATGCTATTTTCAAAACTCTTTGCCCCCACTCTCAAAGAACCCCCTAAAGATGCCGTGTTAAAAAGCCATAAACACTT
AGCTCAAGCAGGATACATTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MELETHLSKYFTLAFTHKSMSLEMREKLAINSNATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLKHGANTNEQKNA
LLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNRMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVREN
VENRQESRMRAYEIVGLATMEFYQWIQSLEVEPVIKDLRELARISAQKELQKALKKRYVPKEYENNIEKILHNAFNTFLH
NPTIALKKNAQKEESDVLVGAIKNLFNLDKSNANHAQNLNLYKCEYYEE

Sequences:

>Translated_449_residues
MELETHLSKYFTLAFTHKSMSLEMREKLAINSNATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLKHGANTNEQKNA
LLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNRMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVREN
VENRQESRMRAYEIVGLATMEFYQWIQSLEVEPVIKDLRELARISAQKELQKALKKRYVPKEYENNIEKILHNAFNTFLH
NPTIALKKNAQKEESDVLVGAIKNLFNLDKSNANHAQNLNLYKCEYYEE
>Mature_449_residues
MELETHLSKYFTLAFTHKSMSLEMREKLAINSNATLKEFLQTIKNHCPNIKECMVLSTCNRFEIYASLKHGANTNEQKNA
LLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLDSLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKC
AAKVRNLTGISKQGVSISSVAVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNRMLKETIFRRFWFDLAVPRNIEKPVLDNIFLYSVDDLEPMVREN
VENRQESRMRAYEIVGLATMEFYQWIQSLEVEPVIKDLRELARISAQKELQKALKKRYVPKEYENNIEKILHNAFNTFLH
NPTIALKKNAQKEESDVLVGAIKNLFNLDKSNANHAQNLNLYKCEYYEE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=415, Percent_Identity=27.710843373494, Blast_Score=161, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 51903; Mature: 51903

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELETHLSKYFTLAFTHKSMSLEMREKLAINSNATLKEFLQTIKNHCPNIKECMVLSTCN
CCHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC
RFEIYASLKHGANTNEQKNALLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLD
HHHEEEEHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKCAAKVRNLTGISKQGVSISSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
HHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHC
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNRMLKETIFRRFWFDLAVPRNIEKP
CCHHCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VLDNIFLYSVDDLEPMVRENVENRQESRMRAYEIVGLATMEFYQWIQSLEVEPVIKDLRE
HHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LARISAQKELQKALKKRYVPKEYENNIEKILHNAFNTFLHNPTIALKKNAQKEESDVLVG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHH
AIKNLFNLDKSNANHAQNLNLYKCEYYEE
HHHHHHHCCCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MELETHLSKYFTLAFTHKSMSLEMREKLAINSNATLKEFLQTIKNHCPNIKECMVLSTCN
CCHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC
RFEIYASLKHGANTNEQKNALLKILAQNKKMSVSDLEKCVLMNTDESAVHHVFSVCSSLD
HHHEEEEHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SLVVGETQITGQMKNAYKFAFEEKFCSKDLTRLLHFAFKCAAKVRNLTGISKQGVSISSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AVKEALNIFEKERIKDKKALVIGLGEMAQLVIKHLLNKQFEALILGRNAAKFEDFIKELE
HHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHC
EPKKVSFQNIENLNAYINEYELLFCATSSPHFIVQNRMLKETIFRRFWFDLAVPRNIEKP
CCHHCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VLDNIFLYSVDDLEPMVRENVENRQESRMRAYEIVGLATMEFYQWIQSLEVEPVIKDLRE
HHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LARISAQKELQKALKKRYVPKEYENNIEKILHNAFNTFLHNPTIALKKNAQKEESDVLVG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHH
AIKNLFNLDKSNANHAQNLNLYKCEYYEE
HHHHHHHCCCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA