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Identifier: 15644868

GI number: 15644868

Start: 250646

End: 251569

Strand: Reverse

Name: Not Available

Synonym: HP0240

Alternate gene names: 15644868

Gene position: 251569-250646 (Counterclockwise)

Preceding gene: 15644869

Following gene: 15644867

Centisome position: 15.08

GC content: 36.15

Gene sequence:

>924_bases
ATGCAAGAAAAACAACTTAAAACCATTCAAAATAAGATCGCTTCCTGGATCAAAGAAATAGAAAGTGCCTTTATAGATGA
ATTATTTTCTAAGATTGGCCCTTCAAAAATGCTGCGCTCCAAACTCATGCTCGCTTTATTAAATGAAAAAACAGACGCTA
TTTTATTGGATAAAGCATTCAATTTGTGCGCGATTGTAGAAATGATACAGACCGCTTCTTTATTGCATGATGATGTGATT
GACAAAGCGGCCATGCGCCGAAAACTCCCCAGCATTAACGCTCTTTTTGGTAATTTTAACGCCGTGATGCTTGGGGATGT
GTTTTATTCTAAAGCCTTTTTTGAACTCTCTAAAATGGGTGAATCCATCGCCAAATCTCTCTCTAATGCGGTTTTAAGGC
TCTCTAGAGGCGAGATTGAAGATGTGTTTGTGGGGGGAAGTTTTAATAGCGACAAACAAAAATACTGGCGCATTTTAGAA
GACAAGACCGCTCATTTCATAGAAGCGAGTTTAAAGAGCATGGCGATTCTTTTAAATAAAGACGCAAAAATGTATGCGGA
TTTTGGATTAAATTTTGGCATGGCATTTCAAATCATTGATGATTTATTAGACATCACTCAAGACGCCAAAACTTTAGGTA
AGCCCAATTTTAGCGATTTTAAAGAGGGCAAAACCACTTTACCCTACTTGCTTTTATATGAAAAATTAAATCAGCGCGAT
CAAGGGCTTTTAATTTCTTATTTTAAACAAGATAGCCATGAAATCATAGAATGGACTAAGGAAAAATTCAAGCAATATGG
TACCATAGAAGAAACCCTTAAGATCGCTCAAGTTTATTCTAAAAAGGCCCTTGAAGCCATTAAAGGGGAGAACAATTTGA
TTTTAGAAAAACTAGCGCAAGACGTCATTTATAGGACTTTTTAA

Upstream 100 bases:

>100_bases
GTCGCTTGTGTTTAAAGATTTTAAAGAAGATAAAGCCGCTTTAAGGCTTTTAGCCCTTATGCCCCTTGTTTTTTCTCCTA
AAGAGCCTTAAGGAATTTGC

Downstream 100 bases:

>100_bases
TGGAGTTAGAAACTCATTTGTCAAAATATTTCACCCTAGCCTTTACGCATAAAAGCATGAGCTTAGAAATGCGAGAAAAA
CTCGCTATTAATTCGAATGC

Product: octaprenyl-diphosphate synthase (ispB)

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MQEKQLKTIQNKIASWIKEIESAFIDELFSKIGPSKMLRSKLMLALLNEKTDAILLDKAFNLCAIVEMIQTASLLHDDVI
DKAAMRRKLPSINALFGNFNAVMLGDVFYSKAFFELSKMGESIAKSLSNAVLRLSRGEIEDVFVGGSFNSDKQKYWRILE
DKTAHFIEASLKSMAILLNKDAKMYADFGLNFGMAFQIIDDLLDITQDAKTLGKPNFSDFKEGKTTLPYLLLYEKLNQRD
QGLLISYFKQDSHEIIEWTKEKFKQYGTIEETLKIAQVYSKKALEAIKGENNLILEKLAQDVIYRTF

Sequences:

>Translated_307_residues
MQEKQLKTIQNKIASWIKEIESAFIDELFSKIGPSKMLRSKLMLALLNEKTDAILLDKAFNLCAIVEMIQTASLLHDDVI
DKAAMRRKLPSINALFGNFNAVMLGDVFYSKAFFELSKMGESIAKSLSNAVLRLSRGEIEDVFVGGSFNSDKQKYWRILE
DKTAHFIEASLKSMAILLNKDAKMYADFGLNFGMAFQIIDDLLDITQDAKTLGKPNFSDFKEGKTTLPYLLLYEKLNQRD
QGLLISYFKQDSHEIIEWTKEKFKQYGTIEETLKIAQVYSKKALEAIKGENNLILEKLAQDVIYRTF
>Mature_307_residues
MQEKQLKTIQNKIASWIKEIESAFIDELFSKIGPSKMLRSKLMLALLNEKTDAILLDKAFNLCAIVEMIQTASLLHDDVI
DKAAMRRKLPSINALFGNFNAVMLGDVFYSKAFFELSKMGESIAKSLSNAVLRLSRGEIEDVFVGGSFNSDKQKYWRILE
DKTAHFIEASLKSMAILLNKDAKMYADFGLNFGMAFQIIDDLLDITQDAKTLGKPNFSDFKEGKTTLPYLLLYEKLNQRD
QGLLISYFKQDSHEIIEWTKEKFKQYGTIEETLKIAQVYSKKALEAIKGENNLILEKLAQDVIYRTF

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=230, Percent_Identity=32.1739130434783, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1789578, Length=255, Percent_Identity=31.3725490196078, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786623, Length=197, Percent_Identity=29.9492385786802, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17505681, Length=262, Percent_Identity=32.0610687022901, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319475, Length=282, Percent_Identity=29.7872340425532, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651612, Length=206, Percent_Identity=33.0097087378641, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281365769, Length=263, Percent_Identity=25.8555133079848, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24660002, Length=263, Percent_Identity=25.8555133079848, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 35048; Mature: 35048

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKQLKTIQNKIASWIKEIESAFIDELFSKIGPSKMLRSKLMLALLNEKTDAILLDKAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHH
NLCAIVEMIQTASLLHDDVIDKAAMRRKLPSINALFGNFNAVMLGDVFYSKAFFELSKMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ESIAKSLSNAVLRLSRGEIEDVFVGGSFNSDKQKYWRILEDKTAHFIEASLKSMAILLNK
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAKMYADFGLNFGMAFQIIDDLLDITQDAKTLGKPNFSDFKEGKTTLPYLLLYEKLNQRD
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
QGLLISYFKQDSHEIIEWTKEKFKQYGTIEETLKIAQVYSKKALEAIKGENNLILEKLAQ
CCHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DVIYRTF
HHHHHCC
>Mature Secondary Structure
MQEKQLKTIQNKIASWIKEIESAFIDELFSKIGPSKMLRSKLMLALLNEKTDAILLDKAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHH
NLCAIVEMIQTASLLHDDVIDKAAMRRKLPSINALFGNFNAVMLGDVFYSKAFFELSKMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ESIAKSLSNAVLRLSRGEIEDVFVGGSFNSDKQKYWRILEDKTAHFIEASLKSMAILLNK
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAKMYADFGLNFGMAFQIIDDLLDITQDAKTLGKPNFSDFKEGKTTLPYLLLYEKLNQRD
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
QGLLISYFKQDSHEIIEWTKEKFKQYGTIEETLKIAQVYSKKALEAIKGENNLILEKLAQ
CCHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DVIYRTF
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8312607; 9278503; 2670911; 8037730 [H]