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Identifier: 15644858

GI number: 15644858

Start: 240354

End: 241085

Strand: Reverse

Name: Not Available

Synonym: HP0230

Alternate gene names: 15644858

Gene position: 241085-240354 (Counterclockwise)

Preceding gene: 15644863

Following gene: 15644857

Centisome position: 14.45

GC content: 39.89

Gene sequence:

>732_bases
ATGATTATCATTCCTGCTAGGTTAAAATCCAGTCGTTTTGAAAATAAAGTGCTAGAAGATATTTTTGGTTTGCCTATGGT
AGTGCGTTGCGCTAAAAATGCGAATCTAGTAGATGAATGCGTAGTCGCTTGCGATGATGAAAGCATCATGCAAACATGCC
AAAAATTCCACATTAAAGCGGTGCTCACCTCCAAACACCATAATAGTGGCACAGAACGCTGTTTGGAAGCGGCGCGAATT
TTAGGGTTAAAAAACGATGAAAGGGTTTTAAACTTGCAAGGCGATGAGCCTTTTTTAGAAAAAGAAGTCATTTTAGCCTT
ATTAGAAGCCACCAAAAACGCCCCTTTCATGGCGACTTGCGCTAAAGTTATTGATGAAGAGCAGGCCAAAAGCCCCAATT
TAGTCAAGGTGGTTTTAGATAGCCAAAATAACGCCTTGTATTTTTCGCGCTCCCTTATCCCCTTTTTACGAGATTTTGAT
GCGAAACGCCAAACCCCCCTTTTAGGGCATATCGGTATTTATGGCTTCCACAATAAAGAAATATTAGAAGAATTGTGCGC
TTTAAAACCTTGCGTTTTAGAGGAAATAGAAAAATTAGAGCAATTAAGGGCTTTGTATTACCAAAAAAAGATTGCAGTGA
AAATCGTTCAAAGTGAAAGCGTGGGCATTGACACCCAAGAAGATTTGCAAAACGCTTTGAAAATTTTTAGCCCCGATCTC
CTTGAGCGGTGA

Upstream 100 bases:

>100_bases
CCTAAAGTTCAATAGCCTAAATCCTTACAATAATAAGAAATAAGCTTTTAATGGGTATAATACCATAAAATCCCCTATTT
TGGCTTAAAAAGGTTTAAAG

Downstream 100 bases:

>100_bases
AATTTAAAAATACTCAAAACATTTTTCACTATCAAAAACCTTTTTTTTAAATCCAAAAAAAAAGCAAAATTTCTTAATTT
TTGCTCAATTTTATTAAAAA

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIIIPARLKSSRFENKVLEDIFGLPMVVRCAKNANLVDECVVACDDESIMQTCQKFHIKAVLTSKHHNSGTERCLEAARI
LGLKNDERVLNLQGDEPFLEKEVILALLEATKNAPFMATCAKVIDEEQAKSPNLVKVVLDSQNNALYFSRSLIPFLRDFD
AKRQTPLLGHIGIYGFHNKEILEELCALKPCVLEEIEKLEQLRALYYQKKIAVKIVQSESVGIDTQEDLQNALKIFSPDL
LER

Sequences:

>Translated_243_residues
MIIIPARLKSSRFENKVLEDIFGLPMVVRCAKNANLVDECVVACDDESIMQTCQKFHIKAVLTSKHHNSGTERCLEAARI
LGLKNDERVLNLQGDEPFLEKEVILALLEATKNAPFMATCAKVIDEEQAKSPNLVKVVLDSQNNALYFSRSLIPFLRDFD
AKRQTPLLGHIGIYGFHNKEILEELCALKPCVLEEIEKLEQLRALYYQKKIAVKIVQSESVGIDTQEDLQNALKIFSPDL
LER
>Mature_243_residues
MIIIPARLKSSRFENKVLEDIFGLPMVVRCAKNANLVDECVVACDDESIMQTCQKFHIKAVLTSKHHNSGTERCLEAARI
LGLKNDERVLNLQGDEPFLEKEVILALLEATKNAPFMATCAKVIDEEQAKSPNLVKVVLDSQNNALYFSRSLIPFLRDFD
AKRQTPLLGHIGIYGFHNKEILEELCALKPCVLEEIEKLEQLRALYYQKKIAVKIVQSESVGIDTQEDLQNALKIFSPDL
LER

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria [H]

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family [H]

Homologues:

Organism=Escherichia coli, GI1787147, Length=239, Percent_Identity=38.0753138075314, Blast_Score=145, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329
- InterPro:   IPR004528 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.38 [H]

Molecular weight: Translated: 27481; Mature: 27481

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIIPARLKSSRFENKVLEDIFGLPMVVRCAKNANLVDECVVACDDESIMQTCQKFHIKA
CEEECCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
VLTSKHHNSGTERCLEAARILGLKNDERVLNLQGDEPFLEKEVILALLEATKNAPFMATC
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
AKVIDEEQAKSPNLVKVVLDSQNNALYFSRSLIPFLRDFDAKRQTPLLGHIGIYGFHNKE
HHHHHHHHCCCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCCCCCCEECCCEECCCCHH
ILEELCALKPCVLEEIEKLEQLRALYYQKKIAVKIVQSESVGIDTQEDLQNALKIFSPDL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCHHH
LER
HCC
>Mature Secondary Structure
MIIIPARLKSSRFENKVLEDIFGLPMVVRCAKNANLVDECVVACDDESIMQTCQKFHIKA
CEEECCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
VLTSKHHNSGTERCLEAARILGLKNDERVLNLQGDEPFLEKEVILALLEATKNAPFMATC
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
AKVIDEEQAKSPNLVKVVLDSQNNALYFSRSLIPFLRDFDAKRQTPLLGHIGIYGFHNKE
HHHHHHHHCCCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCCCCCCEECCCEECCCCHH
ILEELCALKPCVLEEIEKLEQLRALYYQKKIAVKIVQSESVGIDTQEDLQNALKIFSPDL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCHHH
LER
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA