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Identifier: 15644762

GI number: 15644762

Start: 142227

End: 143594

Strand: Reverse

Name: Not Available

Synonym: HP0132

Alternate gene names: 15644762

Gene position: 143594-142227 (Counterclockwise)

Preceding gene: 15644763

Following gene: 15644751

Centisome position: 8.61

GC content: 43.27

Gene sequence:

>1368_bases
ATGGCTAGTTTTTCTATTTTATCTATTTTTAAAATCGGCGTGGGGCCTAGCTCTTCACACACTATAGGGCCTATGGAAGC
GGGAGCGAGATTTTGCGAGTCGTTAAAAGGCATTTTAGAGCAGGTTGTGCGCGTTCAAATCACCTTGCATGGCTCATTAG
CTTTAACCGGTAAAGGGCATTTGAGCGATGAGGCGGTTTTAATTGGCTTGCATGGCATTTACGCTAACGAATTAGAGGTA
ACAACCAAAAAAGCCTTATTGCATGAAGCGCTTGAGAATAAAGTTTTAAAACTCGCTAACCAGCATCATATCCCTTTTGA
TTATGCTAAAGATTTGATTTTTGACAACAAGCCTTTAACAAGACACCAAAACGCCCTCATTCTAAAAGCTTTTAACTCTA
AAAATGAGGTTTTAAAAGAAGAGACTTACTATTCTGTTGGTGGAGGGTTTGTCTATACTGAAAAAGAATTAGACAACTTG
TCTGAAGAGGATGGGAATGAAAGTATTGCCTATGATTTTTCAAGCGCTAAGGAGTTGCTAGAATTGTGCCAAAAACACCA
AAAAAGCATCGCTGAAATCGTGCGTTTGAGAGAAAACGCCCTGAAAAACCACCCTGATGCAACGATGGTTAAAATTTATC
ATGCGATGCTTGAGTGTTATGATAATGGGGCTAATTCTAAAGAAAGGTATCTGCCTGGTTCTTTGAAAGTAACACGATTG
GCCCCAAGCATTAAAACGCGCCTAGAAAAACACCCCACAAGCGGGAAAGACCCCTTAGCCTTGATTGATTACATTTCGCT
TTACGCTCGCGCCATTGCTGAAGAAAACGCTAGCGGAGGCAAGGTGGTAACCGCCCCCACTAATGGGGCGTGCGCGGTGG
TGCCAAGCGTGCTTTTATACGCTAAAAACCATTTGTTTGAAAATTTATCGCAAAAGGCTATCAATGATTTTTTACTCACT
AGTGCGGCGATTGGCTATCTTTACAAGAAAAACGCTTCCTTGAGTGGCGCAGAAGCCGGGTGTCAGGCTGAAATTGGCGT
GGCAAGCTCTATGGCTGCGGGGGGGTTAGCTCATTTGTGCCAAGCGACCACGCAACAGGTTTTGATCGCTAGTGAAATCG
CTATGGAACACCATTTAGGATTGACATGCGATCCGGTGGGGGGCTTGGTGCAAATCCCTTGCATTGAACGCAATGTTTTA
GGGGCGATTAAAGCGATCAGCGCTTCTAAACTAGCCTTAGAAGATGAATACAAGCCTAAAGTGAGTCTGGATGAAGTGAT
CGCTACAATGTATGCGACCGGAAAAGACATGAATGAAAAATACAAAGAGACTTCGTTAGGGGGGTTAGCCAAAACCTTAA
AATGCTAA

Upstream 100 bases:

>100_bases
GTGTTTCTAGTTTGAAGCGTTTTAGAAATTTCAAAGTGGATATTTTTGTGTTTGTCTTTGGGAGCTTGACGGCTTTGAGC
GTGTTTTTAGGACTATTTTA

Downstream 100 bases:

>100_bases
GGGATGAATCTAATCTTTAGGGGGCTTTAGGTTTCTAAAGAAAGTAAAAAGGTTTGTTTTTATCAAATATCAATAAGCCT
TATCTGCTTTGATATTCTTA

Product: L-serine deaminase (sdaA)

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MASFSILSIFKIGVGPSSSHTIGPMEAGARFCESLKGILEQVVRVQITLHGSLALTGKGHLSDEAVLIGLHGIYANELEV
TTKKALLHEALENKVLKLANQHHIPFDYAKDLIFDNKPLTRHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNL
SEEDGNESIAYDFSSAKELLELCQKHQKSIAEIVRLRENALKNHPDATMVKIYHAMLECYDNGANSKERYLPGSLKVTRL
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLYAKNHLFENLSQKAINDFLLT
SAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLAHLCQATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVL
GAIKAISASKLALEDEYKPKVSLDEVIATMYATGKDMNEKYKETSLGGLAKTLKC

Sequences:

>Translated_455_residues
MASFSILSIFKIGVGPSSSHTIGPMEAGARFCESLKGILEQVVRVQITLHGSLALTGKGHLSDEAVLIGLHGIYANELEV
TTKKALLHEALENKVLKLANQHHIPFDYAKDLIFDNKPLTRHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNL
SEEDGNESIAYDFSSAKELLELCQKHQKSIAEIVRLRENALKNHPDATMVKIYHAMLECYDNGANSKERYLPGSLKVTRL
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLYAKNHLFENLSQKAINDFLLT
SAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLAHLCQATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVL
GAIKAISASKLALEDEYKPKVSLDEVIATMYATGKDMNEKYKETSLGGLAKTLKC
>Mature_454_residues
ASFSILSIFKIGVGPSSSHTIGPMEAGARFCESLKGILEQVVRVQITLHGSLALTGKGHLSDEAVLIGLHGIYANELEVT
TKKALLHEALENKVLKLANQHHIPFDYAKDLIFDNKPLTRHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNLS
EEDGNESIAYDFSSAKELLELCQKHQKSIAEIVRLRENALKNHPDATMVKIYHAMLECYDNGANSKERYLPGSLKVTRLA
PSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLYAKNHLFENLSQKAINDFLLTS
AAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLAHLCQATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVLG
AIKAISASKLALEDEYKPKVSLDEVIATMYATGKDMNEKYKETSLGGLAKTLKC

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=458, Percent_Identity=45.4148471615721, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI48994925, Length=457, Percent_Identity=46.8271334792123, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1789161, Length=458, Percent_Identity=44.1048034934498, Blast_Score=386, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49242; Mature: 49111

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFSILSIFKIGVGPSSSHTIGPMEAGARFCESLKGILEQVVRVQITLHGSLALTGKGH
CCCCCEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECEEEEECCCC
LSDEAVLIGLHGIYANELEVTTKKALLHEALENKVLKLANQHHIPFDYAKDLIFDNKPLT
CCCCEEEEEEECEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCC
RHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNLSEEDGNESIAYDFSSAKELL
CCCCEEEEEECCCCHHHHHHHCEEECCCCEEEEHHHHHCCCCCCCCCCEEEEHHHHHHHH
ELCQKHQKSIAEIVRLRENALKNHPDATMVKIYHAMLECYDNGANSKERYLPGSLKVTRL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLY
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
AKNHLFENLSQKAINDFLLTSAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLAHLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
QATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVLGAIKAISASKLALEDEYKPK
HHHHHHHHHHHHHHHHHCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCC
VSLDEVIATMYATGKDMNEKYKETSLGGLAKTLKC
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASFSILSIFKIGVGPSSSHTIGPMEAGARFCESLKGILEQVVRVQITLHGSLALTGKGH
CCCCEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECEEEEECCCC
LSDEAVLIGLHGIYANELEVTTKKALLHEALENKVLKLANQHHIPFDYAKDLIFDNKPLT
CCCCEEEEEEECEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCC
RHQNALILKAFNSKNEVLKEETYYSVGGGFVYTEKELDNLSEEDGNESIAYDFSSAKELL
CCCCEEEEEECCCCHHHHHHHCEEECCCCEEEEHHHHHCCCCCCCCCCEEEEHHHHHHHH
ELCQKHQKSIAEIVRLRENALKNHPDATMVKIYHAMLECYDNGANSKERYLPGSLKVTRL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
APSIKTRLEKHPTSGKDPLALIDYISLYARAIAEENASGGKVVTAPTNGACAVVPSVLLY
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
AKNHLFENLSQKAINDFLLTSAAIGYLYKKNASLSGAEAGCQAEIGVASSMAAGGLAHLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
QATTQQVLIASEIAMEHHLGLTCDPVGGLVQIPCIERNVLGAIKAISASKLALEDEYKPK
HHHHHHHHHHHHHHHHHCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCC
VSLDEVIATMYATGKDMNEKYKETSLGGLAKTLKC
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]