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Identifier: 15644751

GI number: 15644751

Start: 132346

End: 134784

Strand: Reverse

Name: Not Available

Synonym: HP0121

Alternate gene names: 15644751

Gene position: 134784-132346 (Counterclockwise)

Preceding gene: 15644762

Following gene: 15644750

Centisome position: 8.08

GC content: 42.44

Gene sequence:

>2439_bases
GTGCGATATATCAAGTTTTTCAAAGAGTTGAACAATAAAAATGTGAATCTGGTTGGGGGCAAGAACGCTAGTATTGGTGA
AATGTTTCAAGAATTAGTGCCTATTGGTATTAAAGTGCCTGATGGCTTTGCGATCACCAGCGAAGCGTATTGGTATCTTT
TAGAGCAAGGAGGGGCTAAACAAAAAATCATAGAGCTTTTAGAAAATGTTGATGCCACCGAAATTGATGTGTTAAAAATC
CGCTCCAAACAAATCAGAGAGCTTATTTTTGGCACGCCTTTTCCTAGCGATTTGAGAGATGAGATTTTTCAAGCTTATGA
GATTTTAAGCCAGCAATACCACATGAAAGAAGCCGATGTGGCTGTAAGGAGTTCCGCTACTGCAGAAGATTTGCCGGACG
CTTCTTTTGCCGGGCAGCAAGACACTTATTTAAACATTAAGGGTAAAACCGAATTGATCCACTATATCAAATCCTGTTTA
GCGTCGCTTTTTACCGATAGAGCGATTAGCTATAGGGCGAGTCGTGGGTTTGATCATTTAAAAGTCGCGCTCAGCGTGGG
GGTGCAAAAAATGGTGCGAGCGGATAAAGGCAGCGCGGGCGTGATGTTTTCTATTGACACCGAAACCGGTTTTAAAGACG
CGGTGTTTATCACTTCAGCGTGGGGGTTAGGCGAAAATGTGGTGGGTGGCACGATAAACCCTGATGAATTTTATGTGTTT
AAGCCCACTTTAGAGCAAAACAAACGCCCCATTATCAAACGCCAACTCGGCAATAAAACGCAAAAAATGGTCTATGCCCC
AAGGGGTAGCGAACACCCCACCAGAAACATTAAAACCACCAAAAAAGAATGGCAATCCTTTTCATTGAGCGATGAAGACG
TGCTGATTTTAGCCAAATACGCCATTGAAATTGAAAAACACTACTCTAAAGAAGCCAAACAATACCGCCCTATGGATATA
GAATGGGCTAAAGATGGCGAGAGCGGGGAAATCTTTATCGTTCAAGCGCGCCCAGAAACCGTTCAAAGCCAAAAAAGTAA
AGAAGAAAGTCAAGTCTTTGAAAAATTCAAATTCAAAAACCCTAACGAAAAGAAAGAGATTATCTTACAAGGCAGAGCGA
TTGGGAGTAAAATTGGCTCAGGAAAAGTGCGCATCATCAATGATTTGGAGCACATGAATTCTTTTAAAGAGGGCGAAATT
TTAGTTACGGATAACACCGATCCGGACTGGGAGCCTTGCATGAAAAAAGCGAGCGCGGTTATCACTAATCGTGGAGGGCG
CACTTGCCATGCCGCTATTGTGGCGAGAGAAATTGGCGTGCCAGCTATCGTTGGGGTGAGCGGGGCGACTGATAGCCTTT
ATACCGGCATGGAAATCACGGTTTCTTGCGCTGAGGGCGAAGAGGGCTATGTGTATGCGGGCATTTATGAGCATGAAATT
GAAAGGGTGGAGCTTTCTAACATGCAAGAAACTCAAACAAAAATTTACATCAATATTGGAAACCCTGAAAAAGCCTTTGG
CTTTTCTCAACTCCCTAATCACGGCGTAGGGCTAGCCAGGATGGAAATGATTATTTTAAATCAAATCAAAGCCCACCCTT
TAGCTTTAGTGGATTTGCACCACAAAAAAAGCGTGAAAGAAAAAAATGAAATTGAAAACCTCATGGCAGGCTATGCTAAC
CCTAAAGATTTTTTTGTGAAAAAAATCGCTGAAGGCATTGGCATGATCAGTGCAGCGTTTTACCCTAAACCTGTCATTGT
GAGAACGAGCGATTTCAAATCCAATGAATACATGCGCATGCTTGGCGGCTCTAGCTATGAGCCTAATGAAGAAAACCCCA
TGCTTGGCTATAGGGGGGCTAGTCGGTATTATTCAGAGAGCTATAATGAAGCGTTTTCGTGGGAGTGTGAAGCCTTAGCG
TTAGTGAGGGAAGAAATGGGATTAACCAACATGAAAGTGATGATCCCTTTTTTGCGAACCATTGAAGAGGGTAAAAAAGT
CCTAGAAATCTTAAGAAAAAACAATTTAGAATCCGGTAAAAACGGGCTTGAAATTTATATCATGTGCGAATTGCCGGTGA
ATGTCATTTTGGCTGATGATTTCTTGAGCTTGTTTGATGGCTTTTCTATTGGATCAAACGATTTAACCCAGCTCACTTTA
GGCGTGGATAGAGACAGCGAATTGGTCAGCCATGTCTTTGATGAAAGGAATGAAGCGATGCTAAAGATGTTTAAAAAAGC
GATTGAAGCTTGCAAAAGGCACAACAAATATTGCGGGATTTGCGGGCAAGCCCCAAGCGATTACCCTGAAGTAACAGAGT
TTTTAGTCAAAGAGGGCATCACTTCCATTTCTTTAAACCCTGATAGCGTGATCCCCACTTGGAACGCTGTAGCCAAGTTA
GAAAAAGAACTAAAAGAACATGGCTTAACTGAACATTGA

Upstream 100 bases:

>100_bases
AAAGCTTAGTAATACAAACTAGCTAAAACTAAAGCTCTATCATGCTATCATTGTTATATTTTTGTTTTAAGAAACTTAAT
GATCATTTTAAGGGAGTTTT

Downstream 100 bases:

>100_bases
TAATAAATAAATCAATCTAACTTGAGTGGATTTTTCGTATTAGTTTCCATGATATRATTTTGWAAAGTAAGATTGTTTKT
TAAARAAAGGTTGGTAATGG

Product: phosphoenolpyruvate synthase

Products: NA

Alternate protein names: PEP synthase; Pyruvate, water dikinase [H]

Number of amino acids: Translated: 812; Mature: 812

Protein sequence:

>812_residues
MRYIKFFKELNNKNVNLVGGKNASIGEMFQELVPIGIKVPDGFAITSEAYWYLLEQGGAKQKIIELLENVDATEIDVLKI
RSKQIRELIFGTPFPSDLRDEIFQAYEILSQQYHMKEADVAVRSSATAEDLPDASFAGQQDTYLNIKGKTELIHYIKSCL
ASLFTDRAISYRASRGFDHLKVALSVGVQKMVRADKGSAGVMFSIDTETGFKDAVFITSAWGLGENVVGGTINPDEFYVF
KPTLEQNKRPIIKRQLGNKTQKMVYAPRGSEHPTRNIKTTKKEWQSFSLSDEDVLILAKYAIEIEKHYSKEAKQYRPMDI
EWAKDGESGEIFIVQARPETVQSQKSKEESQVFEKFKFKNPNEKKEIILQGRAIGSKIGSGKVRIINDLEHMNSFKEGEI
LVTDNTDPDWEPCMKKASAVITNRGGRTCHAAIVAREIGVPAIVGVSGATDSLYTGMEITVSCAEGEEGYVYAGIYEHEI
ERVELSNMQETQTKIYINIGNPEKAFGFSQLPNHGVGLARMEMIILNQIKAHPLALVDLHHKKSVKEKNEIENLMAGYAN
PKDFFVKKIAEGIGMISAAFYPKPVIVRTSDFKSNEYMRMLGGSSYEPNEENPMLGYRGASRYYSESYNEAFSWECEALA
LVREEMGLTNMKVMIPFLRTIEEGKKVLEILRKNNLESGKNGLEIYIMCELPVNVILADDFLSLFDGFSIGSNDLTQLTL
GVDRDSELVSHVFDERNEAMLKMFKKAIEACKRHNKYCGICGQAPSDYPEVTEFLVKEGITSISLNPDSVIPTWNAVAKL
EKELKEHGLTEH

Sequences:

>Translated_812_residues
MRYIKFFKELNNKNVNLVGGKNASIGEMFQELVPIGIKVPDGFAITSEAYWYLLEQGGAKQKIIELLENVDATEIDVLKI
RSKQIRELIFGTPFPSDLRDEIFQAYEILSQQYHMKEADVAVRSSATAEDLPDASFAGQQDTYLNIKGKTELIHYIKSCL
ASLFTDRAISYRASRGFDHLKVALSVGVQKMVRADKGSAGVMFSIDTETGFKDAVFITSAWGLGENVVGGTINPDEFYVF
KPTLEQNKRPIIKRQLGNKTQKMVYAPRGSEHPTRNIKTTKKEWQSFSLSDEDVLILAKYAIEIEKHYSKEAKQYRPMDI
EWAKDGESGEIFIVQARPETVQSQKSKEESQVFEKFKFKNPNEKKEIILQGRAIGSKIGSGKVRIINDLEHMNSFKEGEI
LVTDNTDPDWEPCMKKASAVITNRGGRTCHAAIVAREIGVPAIVGVSGATDSLYTGMEITVSCAEGEEGYVYAGIYEHEI
ERVELSNMQETQTKIYINIGNPEKAFGFSQLPNHGVGLARMEMIILNQIKAHPLALVDLHHKKSVKEKNEIENLMAGYAN
PKDFFVKKIAEGIGMISAAFYPKPVIVRTSDFKSNEYMRMLGGSSYEPNEENPMLGYRGASRYYSESYNEAFSWECEALA
LVREEMGLTNMKVMIPFLRTIEEGKKVLEILRKNNLESGKNGLEIYIMCELPVNVILADDFLSLFDGFSIGSNDLTQLTL
GVDRDSELVSHVFDERNEAMLKMFKKAIEACKRHNKYCGICGQAPSDYPEVTEFLVKEGITSISLNPDSVIPTWNAVAKL
EKELKEHGLTEH
>Mature_812_residues
MRYIKFFKELNNKNVNLVGGKNASIGEMFQELVPIGIKVPDGFAITSEAYWYLLEQGGAKQKIIELLENVDATEIDVLKI
RSKQIRELIFGTPFPSDLRDEIFQAYEILSQQYHMKEADVAVRSSATAEDLPDASFAGQQDTYLNIKGKTELIHYIKSCL
ASLFTDRAISYRASRGFDHLKVALSVGVQKMVRADKGSAGVMFSIDTETGFKDAVFITSAWGLGENVVGGTINPDEFYVF
KPTLEQNKRPIIKRQLGNKTQKMVYAPRGSEHPTRNIKTTKKEWQSFSLSDEDVLILAKYAIEIEKHYSKEAKQYRPMDI
EWAKDGESGEIFIVQARPETVQSQKSKEESQVFEKFKFKNPNEKKEIILQGRAIGSKIGSGKVRIINDLEHMNSFKEGEI
LVTDNTDPDWEPCMKKASAVITNRGGRTCHAAIVAREIGVPAIVGVSGATDSLYTGMEITVSCAEGEEGYVYAGIYEHEI
ERVELSNMQETQTKIYINIGNPEKAFGFSQLPNHGVGLARMEMIILNQIKAHPLALVDLHHKKSVKEKNEIENLMAGYAN
PKDFFVKKIAEGIGMISAAFYPKPVIVRTSDFKSNEYMRMLGGSSYEPNEENPMLGYRGASRYYSESYNEAFSWECEALA
LVREEMGLTNMKVMIPFLRTIEEGKKVLEILRKNNLESGKNGLEIYIMCELPVNVILADDFLSLFDGFSIGSNDLTQLTL
GVDRDSELVSHVFDERNEAMLKMFKKAIEACKRHNKYCGICGQAPSDYPEVTEFLVKEGITSISLNPDSVIPTWNAVAKL
EKELKEHGLTEH

Specific function: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate [H]

COG id: COG0574

COG function: function code G; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PEP-utilizing enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1787994, Length=800, Percent_Identity=52.5, Blast_Score=874, Evalue=0.0,
Organism=Escherichia coli, GI1788756, Length=428, Percent_Identity=26.6355140186916, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI48994992, Length=373, Percent_Identity=28.1501340482574, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1788726, Length=376, Percent_Identity=25.2659574468085, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1789193, Length=426, Percent_Identity=23.7089201877934, Blast_Score=93, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17564524, Length=239, Percent_Identity=27.6150627615063, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR008279
- InterPro:   IPR006318
- InterPro:   IPR006319
- InterPro:   IPR018274
- InterPro:   IPR023151
- InterPro:   IPR000121
- InterPro:   IPR002192
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00391 PEP-utilizers; PF02896 PEP-utilizers_C; PF01326 PPDK_N [H]

EC number: =2.7.9.2 [H]

Molecular weight: Translated: 91274; Mature: 91274

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00370 PEP_ENZYMES_PHOS_SITE ; PS00742 PEP_ENZYMES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYIKFFKELNNKNVNLVGGKNASIGEMFQELVPIGIKVPDGFAITSEAYWYLLEQGGAK
CHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEECCCCEEECCCCEEEEEECCCCH
QKIIELLENVDATEIDVLKIRSKQIRELIFGTPFPSDLRDEIFQAYEILSQQYHMKEADV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
AVRSSATAEDLPDASFAGQQDTYLNIKGKTELIHYIKSCLASLFTDRAISYRASRGFDHL
HHHCCCCHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KVALSVGVQKMVRADKGSAGVMFSIDTETGFKDAVFITSAWGLGENVVGGTINPDEFYVF
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEE
KPTLEQNKRPIIKRQLGNKTQKMVYAPRGSEHPTRNIKTTKKEWQSFSLSDEDVLILAKY
CCCCCCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHH
AIEIEKHYSKEAKQYRPMDIEWAKDGESGEIFIVQARPETVQSQKSKEESQVFEKFKFKN
HHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
PNEKKEIILQGRAIGSKIGSGKVRIINDLEHMNSFKEGEILVTDNTDPDWEPCMKKASAV
CCCCHHEEEECCHHHCCCCCCCEEEEECHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
ITNRGGRTCHAAIVAREIGVPAIVGVSGATDSLYTGMEITVSCAEGEEGYVYAGIYEHEI
EECCCCCEEHHHHHHHHCCCCEEEECCCCCCHHCCCEEEEEEECCCCCCEEEEEEEHHHH
ERVELSNMQETQTKIYINIGNPEKAFGFSQLPNHGVGLARMEMIILNQIKAHPLALVDLH
HHHHHCCCCCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEH
HKKSVKEKNEIENLMAGYANPKDFFVKKIAEGIGMISAAFYPKPVIVRTSDFKSNEYMRM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHH
LGGSSYEPNEENPMLGYRGASRYYSESYNEAFSWECEALALVREEMGLTNMKVMIPFLRT
HCCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
IEEGKKVLEILRKNNLESGKNGLEIYIMCELPVNVILADDFLSLFDGFSIGSNDLTQLTL
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEEHHHHHHHHCCCCCCCCCCEEEEE
GVDRDSELVSHVFDERNEAMLKMFKKAIEACKRHNKYCGICGQAPSDYPEVTEFLVKEGI
ECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCC
TSISLNPDSVIPTWNAVAKLEKELKEHGLTEH
CEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRYIKFFKELNNKNVNLVGGKNASIGEMFQELVPIGIKVPDGFAITSEAYWYLLEQGGAK
CHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEECCCCEEECCCCEEEEEECCCCH
QKIIELLENVDATEIDVLKIRSKQIRELIFGTPFPSDLRDEIFQAYEILSQQYHMKEADV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
AVRSSATAEDLPDASFAGQQDTYLNIKGKTELIHYIKSCLASLFTDRAISYRASRGFDHL
HHHCCCCHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KVALSVGVQKMVRADKGSAGVMFSIDTETGFKDAVFITSAWGLGENVVGGTINPDEFYVF
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEE
KPTLEQNKRPIIKRQLGNKTQKMVYAPRGSEHPTRNIKTTKKEWQSFSLSDEDVLILAKY
CCCCCCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHH
AIEIEKHYSKEAKQYRPMDIEWAKDGESGEIFIVQARPETVQSQKSKEESQVFEKFKFKN
HHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
PNEKKEIILQGRAIGSKIGSGKVRIINDLEHMNSFKEGEILVTDNTDPDWEPCMKKASAV
CCCCHHEEEECCHHHCCCCCCCEEEEECHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
ITNRGGRTCHAAIVAREIGVPAIVGVSGATDSLYTGMEITVSCAEGEEGYVYAGIYEHEI
EECCCCCEEHHHHHHHHCCCCEEEECCCCCCHHCCCEEEEEEECCCCCCEEEEEEEHHHH
ERVELSNMQETQTKIYINIGNPEKAFGFSQLPNHGVGLARMEMIILNQIKAHPLALVDLH
HHHHHCCCCCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEH
HKKSVKEKNEIENLMAGYANPKDFFVKKIAEGIGMISAAFYPKPVIVRTSDFKSNEYMRM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHH
LGGSSYEPNEENPMLGYRGASRYYSESYNEAFSWECEALALVREEMGLTNMKVMIPFLRT
HCCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
IEEGKKVLEILRKNNLESGKNGLEIYIMCELPVNVILADDFLSLFDGFSIGSNDLTQLTL
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEEHHHHHHHHCCCCCCCCCCEEEEE
GVDRDSELVSHVFDERNEAMLKMFKKAIEACKRHNKYCGICGQAPSDYPEVTEFLVKEGI
ECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCC
TSISLNPDSVIPTWNAVAKLEKELKEHGLTEH
CEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]