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Identifier: 15644737

GI number: 15644737

Start: 114500

End: 115420

Strand: Reverse

Name: Not Available

Synonym: HP0107

Alternate gene names: 15644737

Gene position: 115420-114500 (Counterclockwise)

Preceding gene: 15644739

Following gene: 15644736

Centisome position: 6.92

GC content: 46.58

Gene sequence:

>921_bases
ATGATGATTATCACCACAATGCAAGACGCCATAGGCCGCACTCCCGTTTTTAAATTCACTAACAAGGATTACCCCATTCC
GTTAAATTCCGCCATTTACGCCAAACTGGAGCATCTAAACCCAGGGGGGAGCGTTAAAGATCGCTTAGGCCAATACCTTA
TAGGAGAAGGGTTTAAAACGGGCAAAATCACTTCTAAAACAACCATCATTGAGCCTACCGCAGGCAATACCGGCATCGCT
CTAGCTTTAGTGGCAATCAAGCACCATCTCAAAACCATCTTTGTTGTCCCGGAAAAATTCAGCACAGAAAAACAACAAAT
CATGAGGGCTTTGGGGGCTTTAGTAATCAACACGCCTACTAGCGAGGGGATTTCTGGCGCCATTAAAAAAAGTAAAGAGT
TAGCCGAAAGTATCCCTGATAGCTATTTGCCCTTACAATTTGAAAACCCTGATAATCCCGCCGCTTACTACCACACCCTA
GCCCCTGAGATTGTCCAAGAATTAGGCACAAACCTTACGAGCTTTGTAGCCGGGATAGGGAGTGGTGGCACTTTTGCGGG
CACGGCTAGGTATTTGAAAGAACGCATCCCTGCGATTCGCTTGATTGGGGTGGAGCCGGAGGGTTCTATTTTGAATGGGG
GTGAGCCTGGGCCTCATGAGATTGAGGGCATTGGCGTGGAGTTCATCCCTCCTTTTTTTGAAAACTTGGATATTGATGGC
TTTGAAACGATCTCAGATGAAGAGGGTTTTAGCTACACTAGGAAGTTAGCCAAGAAAAACGGCTTATTAGTGGGGAGCTC
TAGCGGGGCAGCTTTTGTGGCAGCATTGAAAGAAGCGCAACGCCTCCCCGAAGGCAGCCAGGTTTTAACCATTTTCCCGG
ATGTTGCCGATCGTTATCTCTCAAAAGGTATTTATTTATAA

Upstream 100 bases:

>100_bases
TGATCGATCTTAATAAACCAACATTTTATCCTAAACTTATTCCATTTAACGAGTTTAGGCATAATCGCAAAATTGAATTT
TATTGTTTGTTATAGGAGAA

Downstream 100 bases:

>100_bases
AAATTCAATAAAAAAGGAAAAACCATGCGCATGCAAACCAAATTAATCCATGGGGGCATTAGTGAGGACGCAACAACGGG
GGCGGTGAGCGTGCCTATTT

Product: cysteine synthetase (cysK)

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MMIITTMQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKTGKITSKTTIIEPTAGNTGIA
LALVAIKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENPDNPAAYYHTL
APEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFENLDIDG
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLSKGIYL

Sequences:

>Translated_306_residues
MMIITTMQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKTGKITSKTTIIEPTAGNTGIA
LALVAIKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENPDNPAAYYHTL
APEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFENLDIDG
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLSKGIYL
>Mature_306_residues
MMIITTMQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKTGKITSKTTIIEPTAGNTGIA
LALVAIKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENPDNPAAYYHTL
APEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFENLDIDG
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYLSKGIYL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=40.1294498381877, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=40.1294498381877, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=40.1294498381877, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=36.1842105263158, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788754, Length=306, Percent_Identity=38.8888888888889, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=313, Percent_Identity=37.6996805111821, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=37.6623376623377, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=38.2838283828383, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=39.4648829431438, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=36.8253968253968, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=36.1022364217252, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=39.1447368421053, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=37.5586854460094, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321594, Length=312, Percent_Identity=38.4615384615385, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=32.0121951219512, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=38.1877022653722, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=38.1877022653722, Blast_Score=197, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSM_HELPY (P56067)

Other databases:

- EMBL:   AE000511
- PIR:   C64533
- RefSeq:   NP_206907.1
- ProteinModelPortal:   P56067
- SMR:   P56067
- DIP:   DIP-3738N
- MINT:   MINT-168918
- GeneID:   899978
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP0107
- NMPDR:   fig|85962.1.peg.105
- TIGR:   HP_0107
- HOGENOM:   HBG748215
- OMA:   INTPTSE
- ProtClustDB:   CLSK495864
- BRENDA:   2.5.1.47
- InterPro:   IPR001216
- InterPro:   IPR001926

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =2.5.1.47

Molecular weight: Translated: 32942; Mature: 32942

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: BINDING 76-76 BINDING 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIITTMQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKT
CEEEEECHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GKITSKTTIIEPTAGNTGIALALVAIKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPT
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHEEEECCC
SEGISGAIKKSKELAESIPDSYLPLQFENPDNPAAYYHTLAPEIVQELGTNLTSFVAGIG
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCC
SGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFENLDIDG
CCCCHHHHHHHHHHHCCEEEEEEECCCCCEECCCCCCCCCCCCCCEEECCHHHHCCCCCC
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYL
CCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHH
SKGIYL
HCCCCC
>Mature Secondary Structure
MMIITTMQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKT
CEEEEECHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GKITSKTTIIEPTAGNTGIALALVAIKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPT
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHEEEECCC
SEGISGAIKKSKELAESIPDSYLPLQFENPDNPAAYYHTLAPEIVQELGTNLTSFVAGIG
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCC
SGGTFAGTARYLKERIPAIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFENLDIDG
CCCCHHHHHHHHHHHCCEEEEEEECCCCCEECCCCCCCCCCCCCCEEECCHHHHCCCCCC
FETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYL
CCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHH
SKGIYL
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185