Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15644736

GI number: 15644736

Start: 113333

End: 114475

Strand: Reverse

Name: Not Available

Synonym: HP0106

Alternate gene names: 15644736

Gene position: 114475-113333 (Counterclockwise)

Preceding gene: 15644737

Following gene: 161353440

Centisome position: 6.86

GC content: 47.51

Gene sequence:

>1143_bases
ATGCGCATGCAAACCAAATTAATCCATGGGGGCATTAGTGAGGACGCAACAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCATAAGGGCTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CTTTAGAAGAACTCATCGCTGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGATTAGCTGGAATCCACGCC
GTTTTTTCCCTCTTGCAATCAGGCGATCATGTGTTATTGGGCGATGATGTTTATGGGGGGACTTTCCGCTTGTTTAATCA
AGTGCTTGTCAAAAACGGGCTTTCTTGCACCATTATAGACACTAGCGATATATCCCAAATTAAAAAGGCTATCAAGCCCA
ACACCAAAGCCCTTTATTTAGAAACCCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGCGCAATGCGCTAGTGTCGCT
AAAGATCATGGTTTGCTCACTATCGTGGATAACACCTTTGCCACCCCCTATTATCAAAACCCGCTTCTTTTGGGAGCGGA
CATTGTGGCACATAGCGGCACCAAATACTTAGGCGGGCATAGCGATGTGGTCGCCGGGCTTGTAACCACTAATAATGAAG
CGCTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTGGGATTGCGCATGGAAGCCCATCAAAAAAACGCTCTTTGTGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTGGAAAGGGTTTATTACCCGGGCCTTCCCACTCACCCTAATTACGAACTAGCTAAAAAACAGATGCGTGGCTTTA
GCGGGATGCTCTCTTTCACTCTCAAAAATGATAGCGAGGCGGTTGCTTTTGTAGAAAGCCTTAAACTATTCATTTTAGGC
GAGAGTTTGGGCGGGGTGGAAAGTTTGGTGGGGATTCCGGCATTTATGACCCATGCGTGCATCCCTAAAACGCAACGAGA
AGCTGCTGGGATTAGAGATGGCCTGGTGCGCTTGTCTGTAGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAGGCTAA

Upstream 100 bases:

>100_bases
CCCCGAAGGCAGCCAGGTTTTAACCATTTTCCCGGATGTTGCCGATCGTTATCTCTCAAAAGGTATTTATTTATAAAAAT
TCAATAAAAAAGGAAAAACC

Downstream 100 bases:

>100_bases
AGTTTCATTACAATTTATGAATAAAGGAGTTAAAAACATGAAAACACCAAAAATGAATGTAGAGAGTTTTAATTTGGATC
ACACCAAAGTCAAAGCCCCT

Product: cystathionine gamma-synthase/cystathionine beta-lyase

Products: NA

Alternate protein names: CGS; O-succinylhomoserine (thiol)-lyase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG

Sequences:

>Translated_380_residues
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG
>Mature_380_residues
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=360, Percent_Identity=50.2777777777778, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI299473759, Length=360, Percent_Identity=45.5555555555556, Blast_Score=311, Evalue=5e-85,
Organism=Homo sapiens, GI25453487, Length=359, Percent_Identity=45.125348189415, Blast_Score=295, Evalue=4e-80,
Organism=Escherichia coli, GI1790375, Length=377, Percent_Identity=41.3793103448276, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1789383, Length=399, Percent_Identity=31.328320802005, Blast_Score=194, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17560056, Length=364, Percent_Identity=49.1758241758242, Blast_Score=358, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17538055, Length=364, Percent_Identity=49.1758241758242, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=42.1621621621622, Blast_Score=292, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=46.5116279069767, Blast_Score=324, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=33.5820895522388, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321170, Length=330, Percent_Identity=35.7575757575758, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323333, Length=415, Percent_Identity=33.7349397590361, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321904, Length=395, Percent_Identity=29.3670886075949, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6322970, Length=363, Percent_Identity=26.7217630853994, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323557, Length=349, Percent_Identity=27.5071633237822, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322590, Length=257, Percent_Identity=29.9610894941634, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=50.5291005291005, Blast_Score=383, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =2.5.1.48 [H]

Molecular weight: Translated: 41119; Mature: 41119

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIA
CCCCHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
DLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIID
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEEEC
TSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQN
CCCHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
PLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
CEEEECHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFT
HHHHHCCEEEHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEE
LKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSV
ECCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCEEEEE
GIEHEQDLLEDLEQAFAKIG
CCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIA
CCCCHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
DLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIID
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEEEC
TSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQN
CCCHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
PLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
CEEEECHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFT
HHHHHCCEEEHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEE
LKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSV
ECCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCEEEEE
GIEHEQDLLEDLEQAFAKIG
CCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]