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Identifier: 15644718

GI number: 15644718

Start: 92952

End: 94967

Strand: Reverse

Name: Not Available

Synonym: HP0088

Alternate gene names: 15644718

Gene position: 94967-92952 (Counterclockwise)

Preceding gene: 15644719

Following gene: 15644717

Centisome position: 5.69

GC content: 39.09

Gene sequence:

>2016_bases
ATGAAAAAGAAAGCTAACGAAGAAAAAGCCCAAAAAAGAGCTAAAACAGAAGCCAAAGCAGAAGCCACACAAGAAAATAA
AACTAAAGAAAACAATAAAGCCAAAGAAAGCAAAATTAAAGAAAGCAAAATCAAAGAAGCTAAAGCGAAAGAACCTATTC
CTGTTAAAAAGCTTAGTTTTAATGAAGCGTTAGAAGAATTGTTCGCTAATTCCTTAAGCGATTGCGTTTCTTATGAGTCC
ATCATTCAAATCAGCGCGAAAGTCCCCACTCTAGCCCAAATCAAAAAAATCAAAGAATTGTGCCAAAAATACCAAAAGAA
ATTAGTCAGCTCTTCAGAATACGCTAAAAAACTCAATGCGATTGACAAGATTAAAAAAACCGAAGAAAAGCAAAAAGTTT
TAGATGAAGAATTAGAAGATGGCTATGACTTTTTGAAAGAAAAGGATTTTTTAGAGTGGAGCAGAAGCGATAGCCCAGTG
CGCATGTATTTGCGCGAAATGGGGGATATAAAACTTTTAAGCAAAGATGAAGAGATTGAATTGAGCAAGCAAATCCGCTT
GGGTGAAGACATTATTTTAGACGCGATCTGCTCGGTGCCGTATTTGATTGATTTTATCTATGCGTATAAAGACGCTTTAA
TCAATCGTGAAAGAAGGGTTAAAGAGCTTTTCAGGAGCTTTGATGATGACGATGAAAATAGCGTGAGCGATTCTAAAAAA
GATGAAGACAACGAAGAAGATGAAGAAAACGAAGAAAGGAAAAAAGTCGTTTCTGAAAAAGACAAGAAGCGTGTAGAAAA
GGTTCAAGAAAGCTTTAAAGCCCTAGACAAGGCTAAAAAAGAATGGCTTAAAGCCCTTGAAGCCCCCATAGATGAAAGAG
AAGACGAATTGGTGCGTTCATTGACCCTAGCTTACAAACGCCAAACACTCAAAGACAGACTCTATGATTTAGAACCTACC
AGCAAACTGATTAATGAATTAGTCAAAACGATGGAAACCACTTTAAAAAGCGGCGATGGGTTTGAAAAAGAGTTGAAACG
CTTGGAATACAAACTGCCCTTATTCAATGACACTCTCATCGCAAACCATAAAAAAATCCTTGCCAATATCACTAACATGA
CTAAAGAAGATATTATCGCTCAAGTGCCAGAAGCGACTATGGTGAGCGTGTATATGGATCTTAAAAAGCTTTTTTTGACT
AAAGAAGCGAGCGAAGAAGGCTTTGATCTAGCCCCCAACAAGCTAAAAGAAATTTTAGAGCAAATCAAAAGAGGGAAGTT
GATTTCCGATCGCGCTAAAAACAAAATGGCTAAATCCAATTTAAGGTTGGTGGTGAGCATCGCTAAACGATTCACGAGCA
GAGGCTTACCATTCTTGGATTTGATTCAAGAGGGCAATATTGGCTTGATGAAAGCGGTGGATAAGTTTGAGCATGAAAAG
GGCTTCAAGTTTTCTACCTATGCGACCTGGTGGATCAAACAAGCTATCAGCAGAGCCATAGCCGATCAGGCCCGCACTAT
CCGCATCCCCATTCACATGATTGATACGATTAATCGCATCAATAAAGTCATGCGCAAACACATTCAAGAAAACGGCAAAG
AGCCTGATTTAGAAGTGGTGGCTGAAGAAGTGGGGCTTTCGTTAGATAAAGTGAAGAATGTGATTAAGGTGACTAAAGAG
CCTATCAGTTTGGAAACCCCAGTCGGCAATGATGATGATGGCAAGTTTGGGGATTTCGTGGAAGATAAGAATATCGTCAG
CTCCATTGATCACATCATGCGAGAAGATTTGAAAGCACAAATTGAAAGCGTTTTGGATCAGTTGAATGAGCGAGAAAAAG
CGGTGATCCGCATGCGTTTTGGGCTTTTAGACGATGAAAGCGATCGAACTTTAGAAGAAATTGGCAAGGAATTGAATGTT
ACTAGAGAAAGGGTGCGCCAGATTGAAAGCTCTGCGATTAAAAAATTGAGAAGCCCGCAGTACGGGCGCATTTTAAGAAA
CTATTTGCGCATTTGA

Upstream 100 bases:

>100_bases
TAAGCTATTTTTTAGTAGAATAACAAAGGATTAGGTGTATCTTATCTTATGGATCTAGCTTTTGATTGAAAGCATGGGTT
CTTACTTTATGGAGTGTCCA

Downstream 100 bases:

>100_bases
TGTTAAGGTTTCTCTAAAGCATGCGTTATTTTCTTGTAGTTTTCTTGTTTTTGTTTGTGGGTTGCACAAAAAAGGATTTC
ACGCTCAAAGATTTATCCTT

Product: RNA polymerase sigma factor RpoD

Products: NA

Alternate protein names: Sigma-70 [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MKKKANEEKAQKRAKTEAKAEATQENKTKENNKAKESKIKESKIKEAKAKEPIPVKKLSFNEALEELFANSLSDCVSYES
IIQISAKVPTLAQIKKIKELCQKYQKKLVSSSEYAKKLNAIDKIKKTEEKQKVLDEELEDGYDFLKEKDFLEWSRSDSPV
RMYLREMGDIKLLSKDEEIELSKQIRLGEDIILDAICSVPYLIDFIYAYKDALINRERRVKELFRSFDDDDENSVSDSKK
DEDNEEDEENEERKKVVSEKDKKRVEKVQESFKALDKAKKEWLKALEAPIDEREDELVRSLTLAYKRQTLKDRLYDLEPT
SKLINELVKTMETTLKSGDGFEKELKRLEYKLPLFNDTLIANHKKILANITNMTKEDIIAQVPEATMVSVYMDLKKLFLT
KEASEEGFDLAPNKLKEILEQIKRGKLISDRAKNKMAKSNLRLVVSIAKRFTSRGLPFLDLIQEGNIGLMKAVDKFEHEK
GFKFSTYATWWIKQAISRAIADQARTIRIPIHMIDTINRINKVMRKHIQENGKEPDLEVVAEEVGLSLDKVKNVIKVTKE
PISLETPVGNDDDGKFGDFVEDKNIVSSIDHIMREDLKAQIESVLDQLNEREKAVIRMRFGLLDDESDRTLEEIGKELNV
TRERVRQIESSAIKKLRSPQYGRILRNYLRI

Sequences:

>Translated_671_residues
MKKKANEEKAQKRAKTEAKAEATQENKTKENNKAKESKIKESKIKEAKAKEPIPVKKLSFNEALEELFANSLSDCVSYES
IIQISAKVPTLAQIKKIKELCQKYQKKLVSSSEYAKKLNAIDKIKKTEEKQKVLDEELEDGYDFLKEKDFLEWSRSDSPV
RMYLREMGDIKLLSKDEEIELSKQIRLGEDIILDAICSVPYLIDFIYAYKDALINRERRVKELFRSFDDDDENSVSDSKK
DEDNEEDEENEERKKVVSEKDKKRVEKVQESFKALDKAKKEWLKALEAPIDEREDELVRSLTLAYKRQTLKDRLYDLEPT
SKLINELVKTMETTLKSGDGFEKELKRLEYKLPLFNDTLIANHKKILANITNMTKEDIIAQVPEATMVSVYMDLKKLFLT
KEASEEGFDLAPNKLKEILEQIKRGKLISDRAKNKMAKSNLRLVVSIAKRFTSRGLPFLDLIQEGNIGLMKAVDKFEHEK
GFKFSTYATWWIKQAISRAIADQARTIRIPIHMIDTINRINKVMRKHIQENGKEPDLEVVAEEVGLSLDKVKNVIKVTKE
PISLETPVGNDDDGKFGDFVEDKNIVSSIDHIMREDLKAQIESVLDQLNEREKAVIRMRFGLLDDESDRTLEEIGKELNV
TRERVRQIESSAIKKLRSPQYGRILRNYLRI
>Mature_671_residues
MKKKANEEKAQKRAKTEAKAEATQENKTKENNKAKESKIKESKIKEAKAKEPIPVKKLSFNEALEELFANSLSDCVSYES
IIQISAKVPTLAQIKKIKELCQKYQKKLVSSSEYAKKLNAIDKIKKTEEKQKVLDEELEDGYDFLKEKDFLEWSRSDSPV
RMYLREMGDIKLLSKDEEIELSKQIRLGEDIILDAICSVPYLIDFIYAYKDALINRERRVKELFRSFDDDDENSVSDSKK
DEDNEEDEENEERKKVVSEKDKKRVEKVQESFKALDKAKKEWLKALEAPIDEREDELVRSLTLAYKRQTLKDRLYDLEPT
SKLINELVKTMETTLKSGDGFEKELKRLEYKLPLFNDTLIANHKKILANITNMTKEDIIAQVPEATMVSVYMDLKKLFLT
KEASEEGFDLAPNKLKEILEQIKRGKLISDRAKNKMAKSNLRLVVSIAKRFTSRGLPFLDLIQEGNIGLMKAVDKFEHEK
GFKFSTYATWWIKQAISRAIADQARTIRIPIHMIDTINRINKVMRKHIQENGKEPDLEVVAEEVGLSLDKVKNVIKVTKE
PISLETPVGNDDDGKFGDFVEDKNIVSSIDHIMREDLKAQIESVLDQLNEREKAVIRMRFGLLDDESDRTLEEIGKELNV
TRERVRQIESSAIKKLRSPQYGRILRNYLRI

Specific function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium [H]

COG id: COG0568

COG function: function code K; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sigma-70 factor family [H]

Homologues:

Organism=Escherichia coli, GI1789448, Length=265, Percent_Identity=54.7169811320755, Blast_Score=309, Evalue=4e-85,
Organism=Escherichia coli, GI1789098, Length=234, Percent_Identity=43.1623931623932, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI1789871, Length=237, Percent_Identity=32.0675105485232, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788231, Length=201, Percent_Identity=26.3681592039801, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 700 (log & stationary phase) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014284
- InterPro:   IPR000943
- InterPro:   IPR009042
- InterPro:   IPR007627
- InterPro:   IPR007624
- InterPro:   IPR007630
- InterPro:   IPR013325
- InterPro:   IPR013324
- InterPro:   IPR012760
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00140 Sigma70_r1_2; PF04542 Sigma70_r2; PF04539 Sigma70_r3; PF04545 Sigma70_r4 [H]

EC number: NA

Molecular weight: Translated: 77738; Mature: 77738

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS00715 SIGMA70_1 ; PS00716 SIGMA70_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKANEEKAQKRAKTEAKAEATQENKTKENNKAKESKIKESKIKEAKAKEPIPVKKLSF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCH
NEALEELFANSLSDCVSYESIIQISAKVPTLAQIKKIKELCQKYQKKLVSSSEYAKKLNA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IDKIKKTEEKQKVLDEELEDGYDFLKEKDFLEWSRSDSPVRMYLREMGDIKLLSKDEEIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCHHH
LSKQIRLGEDIILDAICSVPYLIDFIYAYKDALINRERRVKELFRSFDDDDENSVSDSKK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DEDNEEDEENEERKKVVSEKDKKRVEKVQESFKALDKAKKEWLKALEAPIDEREDELVRS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LTLAYKRQTLKDRLYDLEPTSKLINELVKTMETTLKSGDGFEKELKRLEYKLPLFNDTLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
ANHKKILANITNMTKEDIIAQVPEATMVSVYMDLKKLFLTKEASEEGFDLAPNKLKEILE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
QIKRGKLISDRAKNKMAKSNLRLVVSIAKRFTSRGLPFLDLIQEGNIGLMKAVDKFEHEK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHC
GFKFSTYATWWIKQAISRAIADQARTIRIPIHMIDTINRINKVMRKHIQENGKEPDLEVV
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AEEVGLSLDKVKNVIKVTKEPISLETPVGNDDDGKFGDFVEDKNIVSSIDHIMREDLKAQ
HHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IESVLDQLNEREKAVIRMRFGLLDDESDRTLEEIGKELNVTRERVRQIESSAIKKLRSPQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YGRILRNYLRI
HHHHHHHHHCC
>Mature Secondary Structure
MKKKANEEKAQKRAKTEAKAEATQENKTKENNKAKESKIKESKIKEAKAKEPIPVKKLSF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCH
NEALEELFANSLSDCVSYESIIQISAKVPTLAQIKKIKELCQKYQKKLVSSSEYAKKLNA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IDKIKKTEEKQKVLDEELEDGYDFLKEKDFLEWSRSDSPVRMYLREMGDIKLLSKDEEIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCHHH
LSKQIRLGEDIILDAICSVPYLIDFIYAYKDALINRERRVKELFRSFDDDDENSVSDSKK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DEDNEEDEENEERKKVVSEKDKKRVEKVQESFKALDKAKKEWLKALEAPIDEREDELVRS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LTLAYKRQTLKDRLYDLEPTSKLINELVKTMETTLKSGDGFEKELKRLEYKLPLFNDTLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
ANHKKILANITNMTKEDIIAQVPEATMVSVYMDLKKLFLTKEASEEGFDLAPNKLKEILE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
QIKRGKLISDRAKNKMAKSNLRLVVSIAKRFTSRGLPFLDLIQEGNIGLMKAVDKFEHEK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHC
GFKFSTYATWWIKQAISRAIADQARTIRIPIHMIDTINRINKVMRKHIQENGKEPDLEVV
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AEEVGLSLDKVKNVIKVTKEPISLETPVGNDDDGKFGDFVEDKNIVSSIDHIMREDLKAQ
HHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IESVLDQLNEREKAVIRMRFGLLDDESDRTLEEIGKELNVTRERVRQIESSAIKKLRSPQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YGRILRNYLRI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]