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Identifier: 15644719

GI number: 15644719

Start: 95191

End: 95886

Strand: Reverse

Name: Not Available

Synonym: HP0089

Alternate gene names: 15644719

Gene position: 95886-95191 (Counterclockwise)

Preceding gene: 15644720

Following gene: 15644718

Centisome position: 5.75

GC content: 42.82

Gene sequence:

>696_bases
ATGGTGCAAAAAATTGGCATTTTAGGGGCGATGAGAGAAGAAATAACCCCTATACTAGAATTGTTTGGCGTGGATTTTGA
AGAGATCCCTTTAGGGGGGAATGTCTTCCATAAAGGCGTTTATCACAACAAGGAAATCATTGTCGCTTATAGCAAGATTG
GCAAGGTGCATTCCACTTTAACCACAACGAGCATGATTTTAGCGTTTGGCGTTCAAAAGGTGCTTTTTAGCGGGGTGGCT
GGAAGCTTAGTTAAAGATTTAAAAATCAATGATTTACTAGTGGCTATTCAATTAGTCCAGCATGATGTGGATTTGAGCGC
GTTTGATCACCCTTTAGGGTTCATCCCAGAAAGCGCGATTTTTATTGAAACGAGCGAAAGTTTGAACGCTTTGGCTAAAG
AAGTCGCTAATGAACAGCATATCGTGCTCAAAGAAGGCGTCATCGCATCAGGCGATCAGTTTGTGCATAGCAAAGAAAGG
AAAGAGTTTTTAGTTAGCGAGTTTAAAGCGAGCGCGGTGGAAATGGAGGGGGCGAGCGTGGCGTTTGTGTGCCAAAAATT
TGGCGTGCCATGCTGTGTGTTAAGGAGCATTAGCGATAACGCTGATGAGGAAGCTAACATGAGCTTTGATGCGTTTTTAG
AAAAAAGCGCTCAAACTTCAGCGAAATTCTTAAAAAGCATGGTGGATGAGCTTTAG

Upstream 100 bases:

>100_bases
AACAAGCGATTAAGCAACAAACCCACCATAAGCGTGGGGGATAATAAAGGGCTTGATGAAGCGATTGAGTTTTTAGAAGA
ATACGTGTGATTGGGAGAAA

Downstream 100 bases:

>100_bases
GGTTTGTTTTTATAGAGGGGTGGAATGGAGGGGTGGAATGTAAAAAAGCTTTTTAGTATTTTTTACATTTTGTGATGAAT
ATTTAATAAAGCGGGGAAAA

Product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Products: NA

Alternate protein names: 5'-methylthioadenosine nucleosidase; S-adenosylhomocysteine nucleosidase

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVA
GSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAIFIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKER
KEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL

Sequences:

>Translated_231_residues
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVA
GSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAIFIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKER
KEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
>Mature_231_residues
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVA
GSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAIFIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKER
KEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL

Specific function: Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH)

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily

Homologues:

Organism=Escherichia coli, GI1786354, Length=233, Percent_Identity=34.3347639484979, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNN_HELPY (O24915)

Other databases:

- EMBL:   AE000511
- EMBL:   AF009177
- PIR:   A64531
- RefSeq:   NP_206889.1
- ProteinModelPortal:   O24915
- SMR:   O24915
- GeneID:   900251
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP0089
- NMPDR:   fig|85962.1.peg.87
- TIGR:   HP_0089
- HOGENOM:   HBG367723
- OMA:   YNISHVI
- ProtClustDB:   PRK05584
- BRENDA:   3.2.2.9
- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01704

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =3.2.2.9

Molecular weight: Translated: 25209; Mature: 25209

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTL
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHCCCCCCCEEEEEHHHHHHHHHHH
TTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEE
FIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASV
EEECHHHHHHHHHHHCCCCEEEEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
HHHHHHHCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTL
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHCCCCCCCEEEEEHHHHHHHHHHH
TTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEE
FIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASV
EEECHHHHHHHHHHHCCCCEEEEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
HHHHHHHCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185