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Identifier: 15644638

GI number: 15644638

Start: 1932

End: 2597

Strand: Reverse

Name: Not Available

Synonym: HP0004

Alternate gene names: 15644638

Gene position: 2597-1932 (Counterclockwise)

Preceding gene: 15646197

Following gene: 15644637

Centisome position: 0.16

GC content: 40.09

Gene sequence:

>666_bases
GTGAAAGCGTTTTTAGGAGCGTTAGAGTTTCAAGAGAATGAATATGAAGAGCTTAAAGAGCTTTATGAGAGCTTAAAAAC
CAAGCAAAAGCCCCACACTTTGTTCATTTCTTGTGTGGATTCACGAGTCGTGCCTAATTTAATCACTGGCACCAAACCGG
GCGAATTGTATGTGATTTGCAACATGGGCAATGTGAACCCCCCTAAAACAAGCTATAAAGAGTCCCTTTCTACCATTGCG
AGCATTGAATACGCTATCGCGCATGTGGGCGTTCAAAACTTAATCATTTGCGGGCATAGCGATTGTGGGGCTTGCGGGAG
CGTTCATTTAATCCATGATGAAACCACCAAAGCTAAAACCCCTTACATTGCAAACTGGATACAATTTTTAGAGCCTGTTA
AAGAAGAGTTAAAAAACCACCCGCAATTCAGCAACCATTTCGCCAAGCGTTCATGGCTTACAGAGCGTTTGAATGCGCGC
TTGCAACTCAACAACCTCTTAAGCTATGATTTCATTCAAGAGAAAGCGAGCAAGAATGAATTAAAAATTTTTGGTTGGCA
CTACATCATAGAAACAGGCAGGATTTATAATTATAATTTTGAAAGCCATTTTTTTGAGCCGATTGGAGAAACCATTAAAC
AAAGGAAAAGTCATGAAAACTTCTAA

Upstream 100 bases:

>100_bases
ATAACGCCATTATAACAAAAAGAAATGCAAGAATTTTAGCTATGATAAGCGTTTTAAAAACAAACGAATTTTAATCAAAA
TGAGATTTAAGGGTTAAAGA

Downstream 100 bases:

>100_bases
AACAAAAACCCCTAAATCCGTTTTAATCGCTGGGCCATGCGTCATTGAGAGCTTAGAAAATCTAAGAAGTATCGCCACTA
AATTGCAACCCCTAGCCAAC

Product: carbonic anhydrase (icfA)

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKAFLGALEFQENEYEELKELYESLKTKQKPHTLFISCVDSRVVPNLITGTKPGELYVICNMGNVNPPKTSYKESLSTIA
SIEYAIAHVGVQNLIICGHSDCGACGSVHLIHDETTKAKTPYIANWIQFLEPVKEELKNHPQFSNHFAKRSWLTERLNAR
LQLNNLLSYDFIQEKASKNELKIFGWHYIIETGRIYNYNFESHFFEPIGETIKQRKSHENF

Sequences:

>Translated_221_residues
MKAFLGALEFQENEYEELKELYESLKTKQKPHTLFISCVDSRVVPNLITGTKPGELYVICNMGNVNPPKTSYKESLSTIA
SIEYAIAHVGVQNLIICGHSDCGACGSVHLIHDETTKAKTPYIANWIQFLEPVKEELKNHPQFSNHFAKRSWLTERLNAR
LQLNNLLSYDFIQEKASKNELKIFGWHYIIETGRIYNYNFESHFFEPIGETIKQRKSHENF
>Mature_221_residues
MKAFLGALEFQENEYEELKELYESLKTKQKPHTLFISCVDSRVVPNLITGTKPGELYVICNMGNVNPPKTSYKESLSTIA
SIEYAIAHVGVQNLIICGHSDCGACGSVHLIHDETTKAKTPYIANWIQFLEPVKEELKNHPQFSNHFAKRSWLTERLNAR
LQLNNLLSYDFIQEKASKNELKIFGWHYIIETGRIYNYNFESHFFEPIGETIKQRKSHENF

Specific function: Reversible Hydration Of Carbon Dioxide. Carbon Dioxide Formed In The Bicarbonate-Dependent Decomposition Of Cyanate By Cyanase (Cyns) Diffuses Out Of The Cell Faster Than It Would Be Hydrated To Bicarbonate, So The Apparent Function Of This Enzyme Is To C

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=205, Percent_Identity=33.1707317073171, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786318, Length=208, Percent_Identity=27.8846153846154, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25147564, Length=238, Percent_Identity=24.3697478991597, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115532990, Length=113, Percent_Identity=30.0884955752212, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324292, Length=169, Percent_Identity=29.585798816568, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645213, Length=244, Percent_Identity=22.9508196721311, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 25515; Mature: 25515

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFLGALEFQENEYEELKELYESLKTKQKPHTLFISCVDSRVVPNLITGTKPGELYVIC
CCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCHHHCCCCCCCEEEEE
NMGNVNPPKTSYKESLSTIASIEYAIAHVGVQNLIICGHSDCGACGSVHLIHDETTKAKT
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHEEEECCCCCCCCCCEEEEECCCCCCCC
PYIANWIQFLEPVKEELKNHPQFSNHFAKRSWLTERLNARLQLNNLLSYDFIQEKASKNE
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
LKIFGWHYIIETGRIYNYNFESHFFEPIGETIKQRKSHENF
EEEEEEEEEEECCEEEEECHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKAFLGALEFQENEYEELKELYESLKTKQKPHTLFISCVDSRVVPNLITGTKPGELYVIC
CCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCHHHCCCCCCCEEEEE
NMGNVNPPKTSYKESLSTIASIEYAIAHVGVQNLIICGHSDCGACGSVHLIHDETTKAKT
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHEEEECCCCCCCCCCEEEEECCCCCCCC
PYIANWIQFLEPVKEELKNHPQFSNHFAKRSWLTERLNARLQLNNLLSYDFIQEKASKNE
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
LKIFGWHYIIETGRIYNYNFESHFFEPIGETIKQRKSHENF
EEEEEEEEEEECCEEEEECHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]