The gene/protein map for NC_000912 is currently unavailable.
Definition Mycoplasma pneumoniae M129, complete genome.
Accession NC_000912
Length 816,394

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The map label for this gene is ldh

Identifier: 13508413

GI number: 13508413

Start: 797819

End: 798757

Strand: Direct

Name: ldh

Synonym: MPN674

Alternate gene names: 13508413

Gene position: 797819-798757 (Clockwise)

Preceding gene: 13508408

Following gene: 13508415

Centisome position: 97.72

GC content: 42.39

Gene sequence:

>939_bases
ATGAAGAGTCTTAAAGTAGCACTCATTGGTTCTGGTGCAGTGGGCACCAGCTTTCTCTACGCTGCCATGAGCCGTGGTTT
AGCGAGTGAATACATGGTTATCGACATTAACGAAAAATCCCAAGTAGGGAATGTTTTTGACCTCCAAGATGCTGTACCAT
CATCACCGCAATACAGTAAGGTAATTGCTGGTGATTACAAACAACTCAAAGATTACGACTTTATCTTTATTGGTGCTGGT
CGACCCCAAAAGCAAGGTGGGGAAACCCGGTTACAACTCCTTGAAGGTAATGTCGAAATTATGAAGAACATTGCCAAAGC
CGTGAAGGAATCGGGCTTTAAGGGCATTACCTTAATTGCTTCCAACCCAGTCGACATTATGGCTTACACCTATTTAAAGG
TAACGGGGTTTGAACCGAATAAGGTAATTGGTTCTGGAACCTTACTAGACAGCGCCCGGTTAAAGTTTGCGATTGCTGAA
AAATATGGTATGAGCAGCAGGGATGTCCAAGCATATGTGTTAGGTGAACACGGGGATAGTTCAGTAAGTATTATTTCCTC
CGCTAAGATTGCTGGCTTACCACTCAAACACTTCTCGAAAGCAAGTGATATAGAAAAAGAATTTGCTGAAATTGACCACT
TTATTCGCCGTCGAGCTTATGAAATCATCGAACGCAAAGGAGCCACCTTTTATGGCATCGGGGAAGCAACTGCCGAAGTA
GCAGAATTAATTCTCCGCGACACTAAAGAAGTACGAGTAGTAGCATCGTTAATTAATGGCCAATATGGTGCTAAAGATGT
AATGTTTGGCACCCCTTGTGTCTTGGGACGCAATGGTGTGGAAAAGATCTTGGAAATTGAATTGTCTGCTACAGAAAAAG
CAGGCTTGGACAAATCAATCCAAGTATTGAAGGACAACATTAAGTTAGCTAAACTATAA

Upstream 100 bases:

>100_bases
TTGGCAGCAGGTTTTATTTAGATCAAATCTCAATTGGGAACAGTAAATGATTGGTGGCTTAAACCAAATTAAAATGAAGG
CAAGCTTGAATAAATTAGTT

Downstream 100 bases:

>100_bases
GAATTAGTTTAACTGTAGACATAAATAAACTAGTTAACTACTAGAACAAAACAAGCATGCTGACCCATTGGGGTTGATGT
GCTTGTTTTGTTTATTAAAA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKSLKVALIGSGAVGTSFLYAAMSRGLASEYMVIDINEKSQVGNVFDLQDAVPSSPQYSKVIAGDYKQLKDYDFIFIGAG
RPQKQGGETRLQLLEGNVEIMKNIAKAVKESGFKGITLIASNPVDIMAYTYLKVTGFEPNKVIGSGTLLDSARLKFAIAE
KYGMSSRDVQAYVLGEHGDSSVSIISSAKIAGLPLKHFSKASDIEKEFAEIDHFIRRRAYEIIERKGATFYGIGEATAEV
AELILRDTKEVRVVASLINGQYGAKDVMFGTPCVLGRNGVEKILEIELSATEKAGLDKSIQVLKDNIKLAKL

Sequences:

>Translated_312_residues
MKSLKVALIGSGAVGTSFLYAAMSRGLASEYMVIDINEKSQVGNVFDLQDAVPSSPQYSKVIAGDYKQLKDYDFIFIGAG
RPQKQGGETRLQLLEGNVEIMKNIAKAVKESGFKGITLIASNPVDIMAYTYLKVTGFEPNKVIGSGTLLDSARLKFAIAE
KYGMSSRDVQAYVLGEHGDSSVSIISSAKIAGLPLKHFSKASDIEKEFAEIDHFIRRRAYEIIERKGATFYGIGEATAEV
AELILRDTKEVRVVASLINGQYGAKDVMFGTPCVLGRNGVEKILEIELSATEKAGLDKSIQVLKDNIKLAKL
>Mature_312_residues
MKSLKVALIGSGAVGTSFLYAAMSRGLASEYMVIDINEKSQVGNVFDLQDAVPSSPQYSKVIAGDYKQLKDYDFIFIGAG
RPQKQGGETRLQLLEGNVEIMKNIAKAVKESGFKGITLIASNPVDIMAYTYLKVTGFEPNKVIGSGTLLDSARLKFAIAE
KYGMSSRDVQAYVLGEHGDSSVSIISSAKIAGLPLKHFSKASDIEKEFAEIDHFIRRRAYEIIERKGATFYGIGEATAEV
AELILRDTKEVRVVASLINGQYGAKDVMFGTPCVLGRNGVEKILEIELSATEKAGLDKSIQVLKDNIKLAKL

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family

Homologues:

Organism=Homo sapiens, GI15082234, Length=307, Percent_Identity=36.1563517915309, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI47059044, Length=312, Percent_Identity=34.9358974358974, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI221136809, Length=312, Percent_Identity=34.9358974358974, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI5031857, Length=306, Percent_Identity=37.9084967320261, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI260099723, Length=306, Percent_Identity=37.9084967320261, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI9257228, Length=306, Percent_Identity=36.6013071895425, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4504973, Length=306, Percent_Identity=36.6013071895425, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI291575128, Length=306, Percent_Identity=33.0065359477124, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI4557032, Length=306, Percent_Identity=33.0065359477124, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI207028494, Length=189, Percent_Identity=40.7407407407407, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI260099727, Length=222, Percent_Identity=36.9369369369369, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI260099725, Length=208, Percent_Identity=37.9807692307692, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI103472011, Length=310, Percent_Identity=26.4516129032258, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI103472015, Length=178, Percent_Identity=26.9662921348315, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1789632, Length=256, Percent_Identity=30.46875, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535107, Length=289, Percent_Identity=32.1799307958478, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17554310, Length=256, Percent_Identity=30.46875, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322765, Length=257, Percent_Identity=31.5175097276265, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136226, Length=308, Percent_Identity=35.7142857142857, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI45550422, Length=303, Percent_Identity=27.0627062706271, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): LDH_MYCPN (P78007)

Other databases:

- EMBL:   U00089
- PIR:   S73494
- RefSeq:   NP_110363.1
- ProteinModelPortal:   P78007
- SMR:   P78007
- GeneID:   877032
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN674
- HOGENOM:   HBG566126
- OMA:   GMSTARI
- ProtClustDB:   CLSK335359
- BioCyc:   MetaCyc:MONOMER-601
- BioCyc:   MPNE272634:MPN674-MONOMER
- BRENDA:   1.1.1.27
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0006096
- HAMAP:   MF_00488
- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.90.110.10
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000102
- PRINTS:   PR00086
- TIGRFAMs:   TIGR01771

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N; SSF56327 Lactate_DH/Glyco_hydro_4_C

EC number: =1.1.1.27

Molecular weight: Translated: 33889; Mature: 33889

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00064 L_LDH

Important sites: ACT_SITE 177-177 BINDING 90-90 BINDING 122-122 BINDING 153-153 BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKSLKVALIGSGAVGTSFLYAAMSRGLASEYMVIDINEKSQVGNVFDLQDAVPSSPQYSK
CCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEHHHCCCCCCCCHH
VIAGDYKQLKDYDFIFIGAGRPQKQGGETRLQLLEGNVEIMKNIAKAVKESGFKGITLIA
HHHCCHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEE
SNPVDIMAYTYLKVTGFEPNKVIGSGTLLDSARLKFAIAEKYGMSSRDVQAYVLGEHGDS
CCCCCEEEEEEEEEECCCCCCEECCCCEECCCCEEEEEHHHHCCCCCCEEEEEEECCCCC
SVSIISSAKIAGLPLKHFSKASDIEKEFAEIDHFIRRRAYEIIERKGATFYGIGEATAEV
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
AELILRDTKEVRVVASLINGQYGAKDVMFGTPCVLGRNGVEKILEIELSATEKAGLDKSI
HHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCEECCCHHHHHHEEEECCCHHCCCCHHH
QVLKDNIKLAKL
HHHHHCEEEECC
>Mature Secondary Structure
MKSLKVALIGSGAVGTSFLYAAMSRGLASEYMVIDINEKSQVGNVFDLQDAVPSSPQYSK
CCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEHHHCCCCCCCCHH
VIAGDYKQLKDYDFIFIGAGRPQKQGGETRLQLLEGNVEIMKNIAKAVKESGFKGITLIA
HHHCCHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEE
SNPVDIMAYTYLKVTGFEPNKVIGSGTLLDSARLKFAIAEKYGMSSRDVQAYVLGEHGDS
CCCCCEEEEEEEEEECCCCCCEECCCCEECCCCEEEEEHHHHCCCCCCEEEEEEECCCCC
SVSIISSAKIAGLPLKHFSKASDIEKEFAEIDHFIRRRAYEIIERKGATFYGIGEATAEV
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
AELILRDTKEVRVVASLINGQYGAKDVMFGTPCVLGRNGVEKILEIELSATEKAGLDKSI
HHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCEECCCHHHHHHEEEECCCHHCCCCHHH
QVLKDNIKLAKL
HHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633