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The map label for this gene is lon [H]

Identifier: 13508071

GI number: 13508071

Start: 390328

End: 392715

Strand: Direct

Name: lon [H]

Synonym: MPN332

Alternate gene names: 13508071

Gene position: 390328-392715 (Clockwise)

Preceding gene: 13508070

Following gene: 13508072

Centisome position: 47.81

GC content: 41.58

Gene sequence:

>2388_bases
ATGCCAGCTGTAAAAAAACCACAAATTCTCGTTGTGCGTAACCAAGTTATCTTTCCGTACAACGGCTTTGAACTTGATGT
CGGTCGTGAACGCTCGAAAAAACTAATTAAAGCACTCAAAAACCTCAAAACCAAACGTTTGGTGTTAGTCACCCAAAAGA
ATTCAGATCAGCTCAACCCTGAGTTTGATGACATTTACCATTGCGGTACTTTATGTGACATTGATGAAATTATTGAAGTA
CCGAGTGAAGATGGCAAGACAGCTGACTATAAGATTAAGGGTAAAGGATTACAGCGCGTTGCCATTACAAGCTTCTCTGA
TGCTGATTTAACCAAGTACGACCATCACTTTCTCAACTCTACCCTAACAGAAAATAAAGCGTTAGATAAGTTGTTGGAAC
GGATCTTTCCCGATAAAGAAGACTTTGCTGAAATTTTAGACAGCTTAAACAGCTTCTTGGAACTGCAAGAGTTAAAGAAG
CTATCTAAGGTACCAAAAGACATAAAACGGTATGACATTATTACCTTCAAGCTTGCTAGCTTAATTTTCAAAGACATTAC
CCTCCAACAAGCCATTTTGGAAGAAAATGACATTGAAAAACGGTTACAGAAGATCATTGGTTCTGGCATCGAGGATTTAG
GTCACATCAGCGAAGAAGCCCGCGCTAAACAACGCGAAAGTGAGTTTGACAAGATTGACAACCGCATCACGCGCAAAGTT
AACGAACAGTTATCGCGCCAACAACGTGACTTTTACCTCCGGGAAAAACTCCGGGTTATCCGTGAAGAGATCGGGATGAC
TTCCAAGAAGGAAGATGAAGTATCCAACATTCGCAAAAAGCTAGAGGAAAACCCATATCCAGAGCACATTAAAAAACGGA
TTTTAAGTGAGTTAGATCACTTTGAAAACTCCTCCTCTTCATCACAAGAATCAACCTTAACCAAGACTTACATCGACACT
TTGATGAACTTGCCATGGTGACAGGAAAGCAAGGACAATGCTGATGTAAAAAACCTGATTAAGATCTTGAACAAGAACCA
CTCAGGACTAGATAAGGTAAAGGAACGAGTGGTTGAGTATTTAGCAGTACAGCTCCGTACCAAAAAGCTTAAGGGTCCGA
TTATGTGTTTAGTCGGTCCACCTGGAGTTGGTAAATCCAGTTTAGCCAAATCAATTGCTGAAGCGTTAAACAAGTGCTTT
GTTAAGGTTTCATTGGGCGGGGTGCATGATGAATCGGAAATCCGTGGTCACCGTAAAACCTATTTGGGTTCGATGCCAGG
ACGGATTTTAAAGGGCATGGTACGTGCTAAGGTTATTAACCCACTGTTCTTGTTAGATGAAATTGACAAGATGACATCCT
CCAATCAAGGTTACCCTTCCGGCGCTTTGTTAGAGGTATTAGATCCGGAGTTAAACAATAAGTTTAGCGATAACTATGTT
GAGGAGGATTATGACCTGTCTAAGGTAATGTTTGTAGCCACCGCTAACTATATCGAAGATATTCCGGAAGCCTTGTTAGA
CCGGATGGAAGTGATTGAACTTACCTCTTACACCGAACAGGAAAAGCTACAAATTACAAAGAGCCACTTAGTTAAGCGTT
GTTTAGATGACGCTGAGATTAAAACAGATGACCTCAAGTTTACCGATGAGGGTATTAGCTATATCATTAAGTTTTACACG
AGGGAAGCGGGGGTGAGACAGTTAGAACGCTTAATCCAGCAAATTGTGCGTAAGTACATTGTTAACTTGCAAAAAACCGG
CGAACAACAGGTAGTAGTTGATGTAGATTTGGTAAAGAAATACCTCAAGAAAGAAATCTTTGACTATACCGTGCGCGATG
AAGATGCACTTCCGGGAATTGTTAACGGCATGGCTTACACCCCAACTGGTGGTGATCTGTTACCAATTGAAGTAACCCAT
GTAGCTGGTAAGGGTGATTTAATTCTGACCGGCAATTTAAAGCAAACAATGCGTGAAAGTGCTAGCGTAGCGTTAGGTTA
TGTCAAGGCCAATGCGCAGAGCTTTAACATTAACCCTAACCTCTTTAAAAAGGTTGACATTAACATCCATGTTCCAGGTG
GTGGTATTCCCAAGGATGGCCCGAGTGCTGGCGCGGCTTTAGTTACTGCCATTATCTCGTCTTTAACTGGCAAAAAGGTT
GACCCTAAGATTGCCATGACCGGGGAGATTACCCTAAGGGGTAAAGTAATGACCATAGGCGGGGTGAAAGAAAAAACCAT
TTCCGCCTACCGCGGTGGAGTACGCACCATCTTTATGCCCGAAAAGAATGAGCGTTACTTAGATGAAGTGCCTAAAGACA
TCGTTAAGGACTTGGAGATTATCCTAGTAAAGGAATACAAGGACATCTACAACAAGATATTTAATTAA

Upstream 100 bases:

>100_bases
ACCAAGATAATTGAGTACTCCACTCATTAGCACTCAAAGTATTAGAGTGCTAAAAAATGTGTTACAATTTAGCATTCTTC
AACCTCTTATCTTAATAACT

Downstream 100 bases:

>100_bases
TTTTTACCAATTCAGGACTTCAAGGTGCCTAAGATCAGATAATTACCCTTTTTAAGGGTAAAATGGTCATCATTAAACTA
ATTCATTTCTTATAAGTGTT

Product: ATP-dependent protease Lon

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 795; Mature: 794

Protein sequence:

>795_residues
MPAVKKPQILVVRNQVIFPYNGFELDVGRERSKKLIKALKNLKTKRLVLVTQKNSDQLNPEFDDIYHCGTLCDIDEIIEV
PSEDGKTADYKIKGKGLQRVAITSFSDADLTKYDHHFLNSTLTENKALDKLLERIFPDKEDFAEILDSLNSFLELQELKK
LSKVPKDIKRYDIITFKLASLIFKDITLQQAILEENDIEKRLQKIIGSGIEDLGHISEEARAKQRESEFDKIDNRITRKV
NEQLSRQQRDFYLREKLRVIREEIGMTSKKEDEVSNIRKKLEENPYPEHIKKRILSELDHFENSSSSSQESTLTKTYIDT
LMNLPWWQESKDNADVKNLIKILNKNHSGLDKVKERVVEYLAVQLRTKKLKGPIMCLVGPPGVGKSSLAKSIAEALNKCF
VKVSLGGVHDESEIRGHRKTYLGSMPGRILKGMVRAKVINPLFLLDEIDKMTSSNQGYPSGALLEVLDPELNNKFSDNYV
EEDYDLSKVMFVATANYIEDIPEALLDRMEVIELTSYTEQEKLQITKSHLVKRCLDDAEIKTDDLKFTDEGISYIIKFYT
REAGVRQLERLIQQIVRKYIVNLQKTGEQQVVVDVDLVKKYLKKEIFDYTVRDEDALPGIVNGMAYTPTGGDLLPIEVTH
VAGKGDLILTGNLKQTMRESASVALGYVKANAQSFNINPNLFKKVDINIHVPGGGIPKDGPSAGAALVTAIISSLTGKKV
DPKIAMTGEITLRGKVMTIGGVKEKTISAYRGGVRTIFMPEKNERYLDEVPKDIVKDLEIILVKEYKDIYNKIFN

Sequences:

>Translated_795_residues
MPAVKKPQILVVRNQVIFPYNGFELDVGRERSKKLIKALKNLKTKRLVLVTQKNSDQLNPEFDDIYHCGTLCDIDEIIEV
PSEDGKTADYKIKGKGLQRVAITSFSDADLTKYDHHFLNSTLTENKALDKLLERIFPDKEDFAEILDSLNSFLELQELKK
LSKVPKDIKRYDIITFKLASLIFKDITLQQAILEENDIEKRLQKIIGSGIEDLGHISEEARAKQRESEFDKIDNRITRKV
NEQLSRQQRDFYLREKLRVIREEIGMTSKKEDEVSNIRKKLEENPYPEHIKKRILSELDHFENSSSSSQESTLTKTYIDT
LMNLPW*QESKDNADVKNLIKILNKNHSGLDKVKERVVEYLAVQLRTKKLKGPIMCLVGPPGVGKSSLAKSIAEALNKCF
VKVSLGGVHDESEIRGHRKTYLGSMPGRILKGMVRAKVINPLFLLDEIDKMTSSNQGYPSGALLEVLDPELNNKFSDNYV
EEDYDLSKVMFVATANYIEDIPEALLDRMEVIELTSYTEQEKLQITKSHLVKRCLDDAEIKTDDLKFTDEGISYIIKFYT
REAGVRQLERLIQQIVRKYIVNLQKTGEQQVVVDVDLVKKYLKKEIFDYTVRDEDALPGIVNGMAYTPTGGDLLPIEVTH
VAGKGDLILTGNLKQTMRESASVALGYVKANAQSFNINPNLFKKVDINIHVPGGGIPKDGPSAGAALVTAIISSLTGKKV
DPKIAMTGEITLRGKVMTIGGVKEKTISAYRGGVRTIFMPEKNERYLDEVPKDIVKDLEIILVKEYKDIYNKIFN
>Mature_794_residues
PAVKKPQILVVRNQVIFPYNGFELDVGRERSKKLIKALKNLKTKRLVLVTQKNSDQLNPEFDDIYHCGTLCDIDEIIEVP
SEDGKTADYKIKGKGLQRVAITSFSDADLTKYDHHFLNSTLTENKALDKLLERIFPDKEDFAEILDSLNSFLELQELKKL
SKVPKDIKRYDIITFKLASLIFKDITLQQAILEENDIEKRLQKIIGSGIEDLGHISEEARAKQRESEFDKIDNRITRKVN
EQLSRQQRDFYLREKLRVIREEIGMTSKKEDEVSNIRKKLEENPYPEHIKKRILSELDHFENSSSSSQESTLTKTYIDTL
MNLPW*QESKDNADVKNLIKILNKNHSGLDKVKERVVEYLAVQLRTKKLKGPIMCLVGPPGVGKSSLAKSIAEALNKCFV
KVSLGGVHDESEIRGHRKTYLGSMPGRILKGMVRAKVINPLFLLDEIDKMTSSNQGYPSGALLEVLDPELNNKFSDNYVE
EDYDLSKVMFVATANYIEDIPEALLDRMEVIELTSYTEQEKLQITKSHLVKRCLDDAEIKTDDLKFTDEGISYIIKFYTR
EAGVRQLERLIQQIVRKYIVNLQKTGEQQVVVDVDLVKKYLKKEIFDYTVRDEDALPGIVNGMAYTPTGGDLLPIEVTHV
AGKGDLILTGNLKQTMRESASVALGYVKANAQSFNINPNLFKKVDINIHVPGGGIPKDGPSAGAALVTAIISSLTGKKVD
PKIAMTGEITLRGKVMTIGGVKEKTISAYRGGVRTIFMPEKNERYLDEVPKDIVKDLEIILVKEYKDIYNKIFN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=37.4113475177305, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI21396489, Length=615, Percent_Identity=36.260162601626, Blast_Score=417, Evalue=1e-116,
Organism=Escherichia coli, GI1786643, Length=785, Percent_Identity=40.8917197452229, Blast_Score=577, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=37.7777777777778, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17505831, Length=619, Percent_Identity=35.702746365105, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319449, Length=625, Percent_Identity=35.52, Blast_Score=402, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24666867, Length=629, Percent_Identity=37.8378378378378, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI221513036, Length=629, Percent_Identity=37.8378378378378, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90001; Mature: 89870

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVKKPQILVVRNQVIFPYNGFELDVGRERSKKLIKALKNLKTKRLVLVTQKNSDQLNP
CCCCCCCCEEEEECCEEECCCCEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
EFDDIYHCGTLCDIDEIIEVPSEDGKTADYKIKGKGLQRVAITSFSDADLTKYDHHFLNS
CHHHHHHCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHH
TLTENKALDKLLERIFPDKEDFAEILDSLNSFLELQELKKLSKVPKDIKRYDIITFKLAS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LIFKDITLQQAILEENDIEKRLQKIIGSGIEDLGHISEEARAKQRESEFDKIDNRITRKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEQLSRQQRDFYLREKLRVIREEIGMTSKKEDEVSNIRKKLEENPYPEHIKKRILSELDH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FENSSSSSQESTLTKTYIDTLMNLPWQESKDNADVKNLIKILNKNHSGLDKVKERVVEYL
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
AVQLRTKKLKGPIMCLVGPPGVGKSSLAKSIAEALNKCFVKVSLGGVHDESEIRGHRKTY
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHH
LGSMPGRILKGMVRAKVINPLFLLDEIDKMTSSNQGYPSGALLEVLDPELNNKFSDNYVE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHCCCCCCCCCC
EDYDLSKVMFVATANYIEDIPEALLDRMEVIELTSYTEQEKLQITKSHLVKRCLDDAEIK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
TDDLKFTDEGISYIIKFYTREAGVRQLERLIQQIVRKYIVNLQKTGEQQVVVDVDLVKKY
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
LKKEIFDYTVRDEDALPGIVNGMAYTPTGGDLLPIEVTHVAGKGDLILTGNLKQTMRESA
HHHHHHCCCCCCCCCCCHHHCCEEECCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHH
SVALGYVKANAQSFNINPNLFKKVDINIHVPGGGIPKDGPSAGAALVTAIISSLTGKKVD
HHEEEEEEECCEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
PKIAMTGEITLRGKVMTIGGVKEKTISAYRGGVRTIFMPEKNERYLDEVPKDIVKDLEII
CCEEEEEEEEEEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
LVKEYKDIYNKIFN
HHHHHHHHHHHHCC
>Mature Secondary Structure 
PAVKKPQILVVRNQVIFPYNGFELDVGRERSKKLIKALKNLKTKRLVLVTQKNSDQLNP
CCCCCCCEEEEECCEEECCCCEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
EFDDIYHCGTLCDIDEIIEVPSEDGKTADYKIKGKGLQRVAITSFSDADLTKYDHHFLNS
CHHHHHHCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHH
TLTENKALDKLLERIFPDKEDFAEILDSLNSFLELQELKKLSKVPKDIKRYDIITFKLAS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LIFKDITLQQAILEENDIEKRLQKIIGSGIEDLGHISEEARAKQRESEFDKIDNRITRKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEQLSRQQRDFYLREKLRVIREEIGMTSKKEDEVSNIRKKLEENPYPEHIKKRILSELDH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FENSSSSSQESTLTKTYIDTLMNLPWQESKDNADVKNLIKILNKNHSGLDKVKERVVEYL
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
AVQLRTKKLKGPIMCLVGPPGVGKSSLAKSIAEALNKCFVKVSLGGVHDESEIRGHRKTY
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHH
LGSMPGRILKGMVRAKVINPLFLLDEIDKMTSSNQGYPSGALLEVLDPELNNKFSDNYVE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHCCCCCCCCCC
EDYDLSKVMFVATANYIEDIPEALLDRMEVIELTSYTEQEKLQITKSHLVKRCLDDAEIK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
TDDLKFTDEGISYIIKFYTREAGVRQLERLIQQIVRKYIVNLQKTGEQQVVVDVDLVKKY
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
LKKEIFDYTVRDEDALPGIVNGMAYTPTGGDLLPIEVTHVAGKGDLILTGNLKQTMRESA
HHHHHHCCCCCCCCCCCHHHCCEEECCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHH
SVALGYVKANAQSFNINPNLFKKVDINIHVPGGGIPKDGPSAGAALVTAIISSLTGKKVD
HHEEEEEEECCEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
PKIAMTGEITLRGKVMTIGGVKEKTISAYRGGVRTIFMPEKNERYLDEVPKDIVKDLEII
CCEEEEEEEEEEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
LVKEYKDIYNKIFN
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]