BacMap

Definition	Mycoplasma pneumoniae M129, complete genome.
Accession	NC_000912
Length	816,394

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The map label for this gene is gmk [H]

Identifier: 13507985

GI number: 13507985

Start: 297610

End: 298329

Strand: Direct

Name: gmk [H]

Synonym: MPN246

Alternate gene names: 13507985

Gene position: 297610-298329 (Clockwise)

Preceding gene: 13507983

Following gene: 13507986

Centisome position: 36.45

GC content: 38.06

Gene sequence:

>720_bases
ATGCAATCGAGACTCGCTTGGTCTAAGGGAAACTGAACTGGTTTAGTCGGTTCGTTAATTTCCTTAACATCGTCCAGCAC
TAGTCATGCTTTAGTTGGCAATAATTCCATATTAATTTGCGGTAAAATTAAAATTATTCTAAATATTGAAATGGTCGATA
CAGGGAGAATTTTTGTCATTACCGGACCGAGCGGTGTTGGCAAAAGTAGCCTTGTTAGATGCTTAATTGACCATTTCAAA
GATAAACTGCGCTACAGCATTTCCGCTACCACCCGTAAAATGCGTAACAGCGAAACTGAGGGTGTGGATTACTTCTTTAA
AGATAAAGCGGAGTTTGAAAAACTGATTGCTGCTGATGCCTTTGTGGAGTGAGCGATGTATAACGATAACTACTATGGTA
CCCTTAAATCCCAAGCTGAACAAATTATTCACAACGGTGGCAACTTGGTGTTAGAAATTGAATATCAAGGTGCTTTACAA
GTTAAGCAAAAGTATCCCAATGATGTGGTGCTAATTTTTATTAAACCACCTTCAATGGAAGAGTTGTTAGTGCGCTTAAA
GAAGCGTAATGACGAGGATGCAATAACAATTCAAAACCGATTGAAACAAGCTGAGAAGGAATGTCAACAAATTGGTCACT
TTAAGTATGTGGTTACCAACAACGAGTTTGACAAGACCTTAGCGGAGTTACAAGCAATTTTACTAGCTGAATTTAATTAA

Upstream 100 bases:

>100_bases
ATAACCAATTTGGTTAGCGGCAATCCCAATGCCGGGAATAATGCCATACTTCTCAGCATCACCGTTGTAAGATGCATCAA
CGTAAGCCATCATTTTGGCA

Downstream 100 bases:

>100_bases
TGGACAGCACCAACCAAAACCTGTTCGCGTCATTGTCCAAAAAAGGACCCGTTCGCAAAGAAAATCAGGACTTTAGTGTT
GTTACTTTCAACCGCTTTGG

Product: guanylate kinase homologue

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQSRLAWSKGNWTGLVGSLISLTSSSTSHALVGNNSILICGKIKIILNIEMVDTGRIFVITGPSGVGKSSLVRCLIDHFK
DKLRYSISATTRKMRNSETEGVDYFFKDKAEFEKLIAADAFVEWAMYNDNYYGTLKSQAEQIIHNGGNLVLEIEYQGALQ
VKQKYPNDVVLIFIKPPSMEELLVRLKKRNDEDAITIQNRLKQAEKECQQIGHFKYVVTNNEFDKTLAELQAILLAEFN

Sequences:

>Translated_239_residues
MQSRLAWSKGN*TGLVGSLISLTSSSTSHALVGNNSILICGKIKIILNIEMVDTGRIFVITGPSGVGKSSLVRCLIDHFK
DKLRYSISATTRKMRNSETEGVDYFFKDKAEFEKLIAADAFVE*AMYNDNYYGTLKSQAEQIIHNGGNLVLEIEYQGALQ
VKQKYPNDVVLIFIKPPSMEELLVRLKKRNDEDAITIQNRLKQAEKECQQIGHFKYVVTNNEFDKTLAELQAILLAEFN
>Mature_239_residues
MQSRLAWSKGN*TGLVGSLISLTSSSTSHALVGNNSILICGKIKIILNIEMVDTGRIFVITGPSGVGKSSLVRCLIDHFK
DKLRYSISATTRKMRNSETEGVDYFFKDKAEFEKLIAADAFVE*AMYNDNYYGTLKSQAEQIIHNGGNLVLEIEYQGALQ
VKQKYPNDVVLIFIKPPSMEELLVRLKKRNDEDAITIQNRLKQAEKECQQIGHFKYVVTNNEFDKTLAELQAILLAEFN

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=33.5106382978723, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=33.5106382978723, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=33.5106382978723, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=30.5084745762712, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI148539628, Length=191, Percent_Identity=29.8429319371728, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI148539578, Length=191, Percent_Identity=29.8429319371728, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI218156338, Length=175, Percent_Identity=33.7142857142857, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI218156340, Length=183, Percent_Identity=32.7868852459016, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI91199538, Length=175, Percent_Identity=33.7142857142857, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI218156270, Length=183, Percent_Identity=32.7868852459016, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI119943106, Length=182, Percent_Identity=29.1208791208791, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI262118259, Length=179, Percent_Identity=30.1675977653631, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI119943108, Length=202, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI192447426, Length=186, Percent_Identity=27.9569892473118, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4557529, Length=186, Percent_Identity=27.9569892473118, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI4505237, Length=179, Percent_Identity=30.1675977653631, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI262118255, Length=179, Percent_Identity=30.1675977653631, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI262118263, Length=179, Percent_Identity=30.1675977653631, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI261862237, Length=183, Percent_Identity=28.9617486338798, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI14780902, Length=190, Percent_Identity=27.8947368421053, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=187, Percent_Identity=39.0374331550802, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17508835, Length=183, Percent_Identity=31.1475409836066, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI193203132, Length=183, Percent_Identity=31.1475409836066, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988041, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17557440, Length=200, Percent_Identity=28, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=36.9565217391304, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356141, Length=186, Percent_Identity=37.6344086021505, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161077752, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281360700, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641282, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554818, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554804, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641280, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554791, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077754, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554813, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221330162, Length=127, Percent_Identity=34.6456692913386, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330166, Length=127, Percent_Identity=34.6456692913386, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330164, Length=127, Percent_Identity=34.6456692913386, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281362230, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648808, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281362232, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161078485, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24648810, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161078487, Length=180, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 26594; Mature: 26594

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSRLAWSKGNTGLVGSLISLTSSSTSHALVGNNSILICGKIKIILNIEMVDTGRIFVIT
CCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEEEEEEEEEEEEEECCCEEEEEE
GPSGVGKSSLVRCLIDHFKDKLRYSISATTRKMRNSETEGVDYFFKDKAEFEKLIAADAF
CCCCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHH
VEAMYNDNYYGTLKSQAEQIIHNGGNLVLEIEYQGALQVKQKYPNDVVLIFIKPPSMEEL
HHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEEECCCEEHHHCCCCCEEEEEECCCCHHHH
LVRLKKRNDEDAITIQNRLKQAEKECQQIGHFKYVVTNNEFDKTLAELQAILLAEFN
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQSRLAWSKGNTGLVGSLISLTSSSTSHALVGNNSILICGKIKIILNIEMVDTGRIFVIT
CCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEEEEEEEEEEEEEECCCEEEEEE
GPSGVGKSSLVRCLIDHFKDKLRYSISATTRKMRNSETEGVDYFFKDKAEFEKLIAADAF
CCCCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHH
VEAMYNDNYYGTLKSQAEQIIHNGGNLVLEIEYQGALQVKQKYPNDVVLIFIKPPSMEEL
HHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEEECCCEEHHHCCCCCEEEEEECCCCHHHH
LVRLKKRNDEDAITIQNRLKQAEKECQQIGHFKYVVTNNEFDKTLAELQAILLAEFN
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]