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The map label for this gene is secY

Identifier: 13507923

GI number: 13507923

Start: 227523

End: 228956

Strand: Direct

Name: secY

Synonym: MPN184

Alternate gene names: 13507923

Gene position: 227523-228956 (Clockwise)

Preceding gene: 13507922

Following gene: 13507924

Centisome position: 27.87

GC content: 45.96

Gene sequence:

>1434_bases
ATGCAAGCCAAACCAACAACTGCAGTTAAACAAAAACAGAATTTTGGGCAACGTTTGTTCACTTTGTTGCGCAACCGTGA
CTTCATGATCTCGTTTTTAATAACGGTCGTGCTGTTGGTTTTGTTTCGTGTTTTAGCGATTATTCCGCTCCCCGGCATCC
AAGTCAACCAAACCGGGCTAGACCAAAACTCAAACGATTTCTTCTCACTGTTTAACCTACTTGGTGGGGGTGGATTGAAC
CAACTATCGCTGTTTGCGGTGGGAATTAGTCCGTATATTTCGGCGCAAATTGTTATGCAGCTGTTGTCAACGGACTTAAT
TCCCCCGTTATCTAAACTGGTGAACAGTGGGGAAGTGGGTCGGCGTAAAATCGAGATGATTACGCGGATTATTACGCTAC
CGTTTGCGTTGGTGCAATCGTTTGCTGTGATCCAAATTGCCACTAATTCCGGTGGCGGTTCTTCACCTATTACCTTAAAA
AACAACGGTTCGGATTTTGTCGCGTTTTACATCATTGCCATGACTGCTGGCACCTACCTGTCGGTCTTTTTAGGTGACAC
CATTTCCAAAAAGGGAATTGGTAACGGGATCACCCTGTTAATTCTTTCGGGGATTTTAGCCCAGCTACCCGAAGGATTTA
TAGCTGCTTACAGCGTGTTATCAGGTGTAGTGGTAACCATTAACGCAACCTTAACCACTGCCATTAGCTTCTTCATTTAC
TTCATGGCGTTTGTGACATTACTGTTTGCCACTACCTTTATTACCCAAGAGACCCGGAAGATTCCGATTCAACAATCCGG
TCAGGGTTTAGTAACCGAATCCTCTGCGTTACCTTACCTCCCAATTAAGGTCAACTCCGCCGGGGTAATTCCGGTGATCT
TTGCGTCTTCGATTATGTCAATTCCGGTGACGATTGCCCAGTTCCAACCGCAAACCGAATCACGCTGGTTTGTGGAGGAC
TATCTTTCACTGTCCAAACCAACTGGCATTGTCCTGTATGGTATCTTGGTGATTCTCTTTAGCTTCTTTTACAGCTACAT
CCAGATCAATCCAGAACGGTTAGCCAAAAACTTCGAGAAGTCCGGGCGTTTTATCCCGGGTATTCGTCCCGGTAAGGATA
CTGAGAAACACATTGCCAGAGTACTCGTGCGGATTAACTTTATTGGCGCCCCTTTCCTAACGGTGATTGCCATTATTCCT
TACATAGTGTCAGCCTTAATCCACTTACCCAACTCCTTAAGTTTAGGGGGTACGGGGATTATTATCATTGTTACCGCTGT
GGTTGAGTTTATGTCAGCACTCCGCTCTGCAGCCACCGCTACTAACTACCAACAACTGCGCCGCAACTTGGCGATTGAAG
TGCAAAAAACAGCCCAACAAGACAAGGAGGAACAACTGCGCGCTGAAACCCCTGGTATTGGTAACCTATGGTAA

Upstream 100 bases:

>100_bases
AGCTCGAAAAGCCGTTGCACTTTGAGGTGCACAAGGTTTCCAAGCAAGCTTTGAAAGCGGTTGAAAACGCCAACGGTAGT
GTGAAGCTGTTAGAGAAATA

Downstream 100 bases:

>100_bases
TGGAAAATAAGTTCTTGTTTTTAGGCGCTCCGGGTGTGGGTAAGGGTACACTAGCTAAGCAAGTAGCCAACACCACCGGA
TTGTTTCACCTTTCCACTGG

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MQAKPTTAVKQKQNFGQRLFTLLRNRDFMISFLITVVLLVLFRVLAIIPLPGIQVNQTGLDQNSNDFFSLFNLLGGGGLN
QLSLFAVGISPYISAQIVMQLLSTDLIPPLSKLVNSGEVGRRKIEMITRIITLPFALVQSFAVIQIATNSGGGSSPITLK
NNGSDFVAFYIIAMTAGTYLSVFLGDTISKKGIGNGITLLILSGILAQLPEGFIAAYSVLSGVVVTINATLTTAISFFIY
FMAFVTLLFATTFITQETRKIPIQQSGQGLVTESSALPYLPIKVNSAGVIPVIFASSIMSIPVTIAQFQPQTESRWFVED
YLSLSKPTGIVLYGILVILFSFFYSYIQINPERLAKNFEKSGRFIPGIRPGKDTEKHIARVLVRINFIGAPFLTVIAIIP
YIVSALIHLPNSLSLGGTGIIIIVTAVVEFMSALRSAATATNYQQLRRNLAIEVQKTAQQDKEEQLRAETPGIGNLW

Sequences:

>Translated_477_residues
MQAKPTTAVKQKQNFGQRLFTLLRNRDFMISFLITVVLLVLFRVLAIIPLPGIQVNQTGLDQNSNDFFSLFNLLGGGGLN
QLSLFAVGISPYISAQIVMQLLSTDLIPPLSKLVNSGEVGRRKIEMITRIITLPFALVQSFAVIQIATNSGGGSSPITLK
NNGSDFVAFYIIAMTAGTYLSVFLGDTISKKGIGNGITLLILSGILAQLPEGFIAAYSVLSGVVVTINATLTTAISFFIY
FMAFVTLLFATTFITQETRKIPIQQSGQGLVTESSALPYLPIKVNSAGVIPVIFASSIMSIPVTIAQFQPQTESRWFVED
YLSLSKPTGIVLYGILVILFSFFYSYIQINPERLAKNFEKSGRFIPGIRPGKDTEKHIARVLVRINFIGAPFLTVIAIIP
YIVSALIHLPNSLSLGGTGIIIIVTAVVEFMSALRSAATATNYQQLRRNLAIEVQKTAQQDKEEQLRAETPGIGNLW
>Mature_477_residues
MQAKPTTAVKQKQNFGQRLFTLLRNRDFMISFLITVVLLVLFRVLAIIPLPGIQVNQTGLDQNSNDFFSLFNLLGGGGLN
QLSLFAVGISPYISAQIVMQLLSTDLIPPLSKLVNSGEVGRRKIEMITRIITLPFALVQSFAVIQIATNSGGGSSPITLK
NNGSDFVAFYIIAMTAGTYLSVFLGDTISKKGIGNGITLLILSGILAQLPEGFIAAYSVLSGVVVTINATLTTAISFFIY
FMAFVTLLFATTFITQETRKIPIQQSGQGLVTESSALPYLPIKVNSAGVIPVIFASSIMSIPVTIAQFQPQTESRWFVED
YLSLSKPTGIVLYGILVILFSFFYSYIQINPERLAKNFEKSGRFIPGIRPGKDTEKHIARVLVRINFIGAPFLTVIAIIP
YIVSALIHLPNSLSLGGTGIIIIVTAVVEFMSALRSAATATNYQQLRRNLAIEVQKTAQQDKEEQLRAETPGIGNLW

Specific function: Involved in protein export. Interacts with secA and secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family

Homologues:

Organism=Escherichia coli, GI1789696, Length=419, Percent_Identity=34.3675417661098, Blast_Score=202, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECY_MYCPN (Q59548)

Other databases:

- EMBL:   U34795
- EMBL:   U00089
- PIR:   S62824
- RefSeq:   NP_109872.1
- ProteinModelPortal:   Q59548
- GeneID:   876763
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN184
- HOGENOM:   HBG565931
- OMA:   VQDQANV
- ProtClustDB:   PRK09204
- BioCyc:   MPNE272634:MPN184-MONOMER
- InterPro:   IPR002208
- InterPro:   IPR023201
- PANTHER:   PTHR10906
- PIRSF:   PIRSF004557
- PRINTS:   PR00303
- TIGRFAMs:   TIGR00967

Pfam domain/function: PF00344 SecY; SSF103491 SecY

EC number: NA

Molecular weight: Translated: 51968; Mature: 51968

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00755 SECY_1; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbae8890)-; HASH(0xb899ca4)-; HASH(0xc21f678)-; HASH(0x96cf1b0)-; HASH(0xb76c394)-; HASH(0x406229c8)-; HASH(0xbfaa480)-; HASH(0x9698e50)-; HASH(0xc016cf0)-; HASH(0x960fdc0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAKPTTAVKQKQNFGQRLFTLLRNRDFMISFLITVVLLVLFRVLAIIPLPGIQVNQTGL
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
DQNSNDFFSLFNLLGGGGLNQLSLFAVGISPYISAQIVMQLLSTDLIPPLSKLVNSGEVG
CCCCHHHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHH
RRKIEMITRIITLPFALVQSFAVIQIATNSGGGSSPITLKNNGSDFVAFYIIAMTAGTYL
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
SVFLGDTISKKGIGNGITLLILSGILAQLPEGFIAAYSVLSGVVVTINATLTTAISFFIY
HHHHCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHH
FMAFVTLLFATTFITQETRKIPIQQSGQGLVTESSALPYLPIKVNSAGVIPVIFASSIMS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHH
IPVTIAQFQPQTESRWFVEDYLSLSKPTGIVLYGILVILFSFFYSYIQINPERLAKNFEK
CCCHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SGRFIPGIRPGKDTEKHIARVLVRINFIGAPFLTVIAIIPYIVSALIHLPNSLSLGGTGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
IIIVTAVVEFMSALRSAATATNYQQLRRNLAIEVQKTAQQDKEEQLRAETPGIGNLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MQAKPTTAVKQKQNFGQRLFTLLRNRDFMISFLITVVLLVLFRVLAIIPLPGIQVNQTGL
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
DQNSNDFFSLFNLLGGGGLNQLSLFAVGISPYISAQIVMQLLSTDLIPPLSKLVNSGEVG
CCCCHHHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHH
RRKIEMITRIITLPFALVQSFAVIQIATNSGGGSSPITLKNNGSDFVAFYIIAMTAGTYL
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
SVFLGDTISKKGIGNGITLLILSGILAQLPEGFIAAYSVLSGVVVTINATLTTAISFFIY
HHHHCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHH
FMAFVTLLFATTFITQETRKIPIQQSGQGLVTESSALPYLPIKVNSAGVIPVIFASSIMS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHH
IPVTIAQFQPQTESRWFVEDYLSLSKPTGIVLYGILVILFSFFYSYIQINPERLAKNFEK
CCCHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SGRFIPGIRPGKDTEKHIARVLVRINFIGAPFLTVIAIIPYIVSALIHLPNSLSLGGTGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
IIIVTAVVEFMSALRSAATATNYQQLRRNLAIEVQKTAQQDKEEQLRAETPGIGNLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8604303; 8948633