Click here to switch to the map view.

The map label for this gene is adk

Identifier: 13507924

GI number: 13507924

Start: 228950

End: 229597

Strand: Direct

Name: adk

Synonym: MPN185

Alternate gene names: 13507924

Gene position: 228950-229597 (Clockwise)

Preceding gene: 13507923

Following gene: 13507925

Centisome position: 28.04

GC content: 45.68

Gene sequence:

>648_bases
ATGGTAATGGAAAATAAGTTCTTGTTTTTAGGCGCTCCGGGTGTGGGTAAGGGTACACTAGCTAAGCAAGTAGCCAACAC
CACCGGATTGTTTCACCTTTCCACTGGTGACATCTTTCGCAGTGTGATGCAAGAGCAGGGTGCGTTGAGTCAAACGCTAG
CGCACTATATGAACCAGGGTTTGTATGTCCCTGATGAATTGACTAACCAAACCTTTTGGCACTTTGTCACTACCCACCAA
AATGAACTCCACAAGGGCTTTATCCTAGATGGGTATCCCCGTACCTTAAACCAACTCGAGTTTTTGCAAAGCAAGTTGCA
ATTAGACCAGGTGTTTCACCTTAAGCTAAGTGATCCCCAAGTGCTAGTAGCGCGGATCTTAAACCGTTTGGTTTGTCCTA
GTTGTGGTAGTGTATACAACAAGCAGAGCAAACCACCATTGAAGGCCAATCAGTGTGATCGTTGCCATGCTACGTTACAA
GCGCGCAATGATGACACGGAAGCGGTAATCTTAAAGCGTTTAACGCTTTACGAAGACACCGTTAAACCCTTAATTGAGGC
CTTCACCAAGCAGGGCATTCTCACCGTCATTGAAGCCCAATTACCGCTCGAACAACAGGTCAATTTGGTTCAACAGTTAG
TGCATTAA

Upstream 100 bases:

>100_bases
ACCAACAACTGCGCCGCAACTTGGCGATTGAAGTGCAAAAAACAGCCCAACAAGACAAGGAGGAACAACTGCGCGCTGAA
ACCCCTGGTATTGGTAACCT

Downstream 100 bases:

>100_bases
TGGTTTATTTAAAGTCTGCGCGTGAGGTCGAACAGATCCGCCAAGCATGTAAGATTTTCCAAGAAGCAAAGGCATATTTT
ACAATTGAAAGGCTACTTGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MVMENKFLFLGAPGVGKGTLAKQVANTTGLFHLSTGDIFRSVMQEQGALSQTLAHYMNQGLYVPDELTNQTFWHFVTTHQ
NELHKGFILDGYPRTLNQLEFLQSKLQLDQVFHLKLSDPQVLVARILNRLVCPSCGSVYNKQSKPPLKANQCDRCHATLQ
ARNDDTEAVILKRLTLYEDTVKPLIEAFTKQGILTVIEAQLPLEQQVNLVQQLVH

Sequences:

>Translated_215_residues
MVMENKFLFLGAPGVGKGTLAKQVANTTGLFHLSTGDIFRSVMQEQGALSQTLAHYMNQGLYVPDELTNQTFWHFVTTHQ
NELHKGFILDGYPRTLNQLEFLQSKLQLDQVFHLKLSDPQVLVARILNRLVCPSCGSVYNKQSKPPLKANQCDRCHATLQ
ARNDDTEAVILKRLTLYEDTVKPLIEAFTKQGILTVIEAQLPLEQQVNLVQQLVH
>Mature_215_residues
MVMENKFLFLGAPGVGKGTLAKQVANTTGLFHLSTGDIFRSVMQEQGALSQTLAHYMNQGLYVPDELTNQTFWHFVTTHQ
NELHKGFILDGYPRTLNQLEFLQSKLQLDQVFHLKLSDPQVLVARILNRLVCPSCGSVYNKQSKPPLKANQCDRCHATLQ
ARNDDTEAVILKRLTLYEDTVKPLIEAFTKQGILTVIEAQLPLEQQVNLVQQLVH

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=189, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI7524346, Length=200, Percent_Identity=34, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI4502013, Length=200, Percent_Identity=34, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI310110345, Length=189, Percent_Identity=31.2169312169312, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI53832003, Length=189, Percent_Identity=31.2169312169312, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI8051579, Length=189, Percent_Identity=31.2169312169312, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI53832001, Length=189, Percent_Identity=31.2169312169312, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4502011, Length=198, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI28144897, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI28144899, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786680, Length=187, Percent_Identity=32.0855614973262, Blast_Score=106, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17552384, Length=203, Percent_Identity=33.0049261083744, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=189, Percent_Identity=27.5132275132275, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17533833, Length=203, Percent_Identity=27.0935960591133, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17567503, Length=194, Percent_Identity=26.2886597938144, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=33.1683168316832, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=201, Percent_Identity=33.8308457711443, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=32.3076923076923, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=32.3076923076923, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI22026816, Length=197, Percent_Identity=32.994923857868, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MYCPN (Q50299)

Other databases:

- EMBL:   U34795
- EMBL:   U00089
- PIR:   S62823
- RefSeq:   NP_109873.1
- ProteinModelPortal:   Q50299
- SMR:   Q50299
- IntAct:   Q50299
- GeneID:   876756
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN185
- HOGENOM:   HBG630208
- OMA:   LEVYHEL
- ProtClustDB:   CLSK335171
- BioCyc:   MetaCyc:MONOMER-564
- BioCyc:   MPNE272634:MPN185-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24255; Mature: 24255

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMENKFLFLGAPGVGKGTLAKQVANTTGLFHLSTGDIFRSVMQEQGALSQTLAHYMNQG
CCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECHHHHHHHHHHHCCHHHHHHHHHHHCC
LYVPDELTNQTFWHFVTTHQNELHKGFILDGYPRTLNQLEFLQSKLQLDQVFHLKLSDPQ
CCCCHHHCCCHHHHHEECCHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHEEECCCHH
VLVARILNRLVCPSCGSVYNKQSKPPLKANQCDRCHATLQARNDDTEAVILKRLTLYEDT
HHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VKPLIEAFTKQGILTVIEAQLPLEQQVNLVQQLVH
HHHHHHHHHHCCHHEEHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MVMENKFLFLGAPGVGKGTLAKQVANTTGLFHLSTGDIFRSVMQEQGALSQTLAHYMNQG
CCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECHHHHHHHHHHHCCHHHHHHHHHHHCC
LYVPDELTNQTFWHFVTTHQNELHKGFILDGYPRTLNQLEFLQSKLQLDQVFHLKLSDPQ
CCCCHHHCCCHHHHHEECCHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHEEECCCHH
VLVARILNRLVCPSCGSVYNKQSKPPLKANQCDRCHATLQARNDDTEAVILKRLTLYEDT
HHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VKPLIEAFTKQGILTVIEAQLPLEQQVNLVQQLVH
HHHHHHHHHHCCHHEEHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8604303; 8948633