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The map label for this gene is parB [H]

Identifier: 13507861

GI number: 13507861

Start: 156467

End: 158374

Strand: Direct

Name: parB [H]

Synonym: MPN122

Alternate gene names: 13507861

Gene position: 156467-158374 (Clockwise)

Preceding gene: 13507860

Following gene: 13507862

Centisome position: 19.17

GC content: 42.82

Gene sequence:

>1908_bases
ATGAAAAATAATTACAGCGAAGCGAATATCAAAATTCTCAAGGGGCTAGATGCTGTAAAAAAACGCCCGGGAATGTACAT
CGGCTCAACCGATAGTCGCGGTTTTCACCACTTGCTGTGGGAAATTTTAGACAACTGTGTCGATGAAGTTTTATCGGGCT
TTGCTAATACTATTGCCGTTGTTTTACATGCCGAAAACCAGATAACTGTTAGTGACAACGGTCGTGGTATTCCCTTCGAA
ACACACTCCGATTCCAAGATTTCTACGATTGACACCGTCTTTACCTACCTCCATGCCGGTGGTAAGTTTGATAACGATTC
TTATAAGATTGCTGGAGGGTTGCACGGGGTGGGGGCTTCGGTGGTGAATGCCTTGAGTGACCAGTTACAAGTAACGGTTA
AACGTCAGGGCAAGGTGTACCGCTCGGTGTATGAAAATGGTGGTAAGATTAAGCAAAAAGCGCATTGCATTGGTAATGCC
AAAATTGACGAACACGGTACCAGTGTGACTTTTCGTCCTGACCCAAAGGTCTTTAAAAAGATCCACTTTGACAGCGAACT
AATTCGTGCGCGGTTAAAGGAATTAGCCTTCCTTTTCAAAAAGTTACAACTGACCTTCGTTGATGAAACCGGCAGTGGGG
AAAAAGAGGTGTTCTTTACCGAAGCCGGTATTAGTCAGTACTTGGACGAACTTAACGCTGATTCCAAACAAATTGCGCAA
AAGATCTTTGTTAGTGGCACTGAAGATGACATTGAACTGGAAGCCGTGTTTCAGTTTATTGATGGGGAGGATGAAAAACT
ACTTTCGTTTGCCAATTCGATTCGCACCAGCGAAGGGGGTAGTCATGAAGCGAGTTTTCGTCAATCTGTTGGTGATGTGA
TTAACAACTACTGCCGCAAGTACAACTTCCTAAAGGAGCGTGACAAGAACTTTGAGGCCAGTGAAATCCGTGAAGGCTTA
AACGGCATTATTAAGGTCAATCTCCCCGAAAAGATTATTGCCTTTGAAGGGCAAACGAAGAGCAAACTGTTCTCCAAGGA
AGTTAAAGCGGTAGTGCAAAAGCTAACCCAAAAGCACTTCTTCCAGTTCTTGGAACGTAACAGTGTTGATGCTAAATTAA
TTGTCGAAAAGCTGTTTTATAACCGCAAACTGCGCCAAGAACTCAAACAACAACGCCAAATTAAAAAGAACCTTTCTAAT
CCGAAGGCCGAGCGCATTTTGTTTGGTAAATTAGCACCGGCGCAGTCCAAAAAAGTGGCTGAACGCGAACTGTTTGTGGT
GGAAGGTGACAGTGCTGGTGGTACGGCTAAAATGGGACGAGATCGCTTTCTACAAGCCATCTTACCGTTACGCGGTAAGG
TGTTAAATGTGGAGAAAATTAACAACAAGAAGGAAGCGATTAACAACGAAGAGCTGTTAACACTCATCTTCTGTATCGGT
ACTGGTATTGGTAACAACTTCACCATTCGCGATCGTAAATACGACAAGATTATTATCATGACTGATGCTGACAATGACGG
TGCGCACATCCAGATTTTACTGCTCACCTTCTTCTACCGTTACATGAAACCCCTAATTGAAAAAGGACACATTTACCTAG
CACTTCCACCACTTTATAAGTTTGAAGGTCGTGATAAAAAAGCCCGTTATCTCTGAACCGAACAGGAATTGGAACAGTAC
CGTGCTAAGCATAGCCACTTTAATGTGCAACGGTACAAGGGTTTAGGGGAAATGAATGCTGATCAGCTCTGGGAAACCAC
GATGAACCCGATGACGCGTAAACTAATTCAGGTCAAATTGGATAACTTTATCCAAGCTGAAAAGCAAATTAATGTTTTTA
TGGGTGATAAAACCGAATTGCGTAAAAGCTGGATTGAAGCTAACATTAACTTTAGTAGTGAGAACTAA

Upstream 100 bases:

>100_bases
AATAACAGAGTCGAACTGTTCTCTGATCCTTACCATGGATCTGTTTTGCCCCTAAACTAATTCGGCTTCAAGGATAATTC
TAGTTTAAATTTGGACGGAG

Downstream 100 bases:

>100_bases
TGGAAAAGAATAAACAAGCGTTATTACTCCAGGCCATCGAAGATGTCTTTGCCTTTAGCTTTAGTAAGTATGCTAAGTAC
ATTATCCAAGACCGGGCTTT

Product: topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MKNNYSEANIKILKGLDAVKKRPGMYIGSTDSRGFHHLLWEILDNCVDEVLSGFANTIAVVLHAENQITVSDNGRGIPFE
THSDSKISTIDTVFTYLHAGGKFDNDSYKIAGGLHGVGASVVNALSDQLQVTVKRQGKVYRSVYENGGKIKQKAHCIGNA
KIDEHGTSVTFRPDPKVFKKIHFDSELIRARLKELAFLFKKLQLTFVDETGSGEKEVFFTEAGISQYLDELNADSKQIAQ
KIFVSGTEDDIELEAVFQFIDGEDEKLLSFANSIRTSEGGSHEASFRQSVGDVINNYCRKYNFLKERDKNFEASEIREGL
NGIIKVNLPEKIIAFEGQTKSKLFSKEVKAVVQKLTQKHFFQFLERNSVDAKLIVEKLFYNRKLRQELKQQRQIKKNLSN
PKAERILFGKLAPAQSKKVAERELFVVEGDSAGGTAKMGRDRFLQAILPLRGKVLNVEKINNKKEAINNEELLTLIFCIG
TGIGNNFTIRDRKYDKIIIMTDADNDGAHIQILLLTFFYRYMKPLIEKGHIYLALPPLYKFEGRDKKARYLWTEQELEQY
RAKHSHFNVQRYKGLGEMNADQLWETTMNPMTRKLIQVKLDNFIQAEKQINVFMGDKTELRKSWIEANINFSSEN

Sequences:

>Translated_635_residues
MKNNYSEANIKILKGLDAVKKRPGMYIGSTDSRGFHHLLWEILDNCVDEVLSGFANTIAVVLHAENQITVSDNGRGIPFE
THSDSKISTIDTVFTYLHAGGKFDNDSYKIAGGLHGVGASVVNALSDQLQVTVKRQGKVYRSVYENGGKIKQKAHCIGNA
KIDEHGTSVTFRPDPKVFKKIHFDSELIRARLKELAFLFKKLQLTFVDETGSGEKEVFFTEAGISQYLDELNADSKQIAQ
KIFVSGTEDDIELEAVFQFIDGEDEKLLSFANSIRTSEGGSHEASFRQSVGDVINNYCRKYNFLKERDKNFEASEIREGL
NGIIKVNLPEKIIAFEGQTKSKLFSKEVKAVVQKLTQKHFFQFLERNSVDAKLIVEKLFYNRKLRQELKQQRQIKKNLSN
PKAERILFGKLAPAQSKKVAERELFVVEGDSAGGTAKMGRDRFLQAILPLRGKVLNVEKINNKKEAINNEELLTLIFCIG
TGIGNNFTIRDRKYDKIIIMTDADNDGAHIQILLLTFFYRYMKPLIEKGHIYLALPPLYKFEGRDKKARYL*TEQELEQY
RAKHSHFNVQRYKGLGEMNADQLWETTMNPMTRKLIQVKLDNFIQAEKQINVFMGDKTELRKSWIEANINFSSEN
>Mature_635_residues
MKNNYSEANIKILKGLDAVKKRPGMYIGSTDSRGFHHLLWEILDNCVDEVLSGFANTIAVVLHAENQITVSDNGRGIPFE
THSDSKISTIDTVFTYLHAGGKFDNDSYKIAGGLHGVGASVVNALSDQLQVTVKRQGKVYRSVYENGGKIKQKAHCIGNA
KIDEHGTSVTFRPDPKVFKKIHFDSELIRARLKELAFLFKKLQLTFVDETGSGEKEVFFTEAGISQYLDELNADSKQIAQ
KIFVSGTEDDIELEAVFQFIDGEDEKLLSFANSIRTSEGGSHEASFRQSVGDVINNYCRKYNFLKERDKNFEASEIREGL
NGIIKVNLPEKIIAFEGQTKSKLFSKEVKAVVQKLTQKHFFQFLERNSVDAKLIVEKLFYNRKLRQELKQQRQIKKNLSN
PKAERILFGKLAPAQSKKVAERELFVVEGDSAGGTAKMGRDRFLQAILPLRGKVLNVEKINNKKEAINNEELLTLIFCIG
TGIGNNFTIRDRKYDKIIIMTDADNDGAHIQILLLTFFYRYMKPLIEKGHIYLALPPLYKFEGRDKKARYL*TEQELEQY
RAKHSHFNVQRYKGLGEMNADQLWETTMNPMTRKLIQVKLDNFIQAEKQINVFMGDKTELRKSWIEANINFSSEN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=628, Percent_Identity=27.2292993630573, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI19913406, Length=618, Percent_Identity=26.0517799352751, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI48994957, Length=653, Percent_Identity=38.43797856049, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789408, Length=636, Percent_Identity=35.8490566037736, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=628, Percent_Identity=23.5668789808917, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=609, Percent_Identity=24.4663382594417, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI212645657, Length=224, Percent_Identity=25.4464285714286, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=625, Percent_Identity=23.68, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136538, Length=636, Percent_Identity=26.4150943396226, Blast_Score=135, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72210; Mature: 72210

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNYSEANIKILKGLDAVKKRPGMYIGSTDSRGFHHLLWEILDNCVDEVLSGFANTIAV
CCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
VLHAENQITVSDNGRGIPFETHSDSKISTIDTVFTYLHAGGKFDNDSYKIAGGLHGVGAS
EEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHH
VVNALSDQLQVTVKRQGKVYRSVYENGGKIKQKAHCIGNAKIDEHGTSVTFRPDPKVFKK
HHHHHHHHHEEHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCEEEECCCHHHHHH
IHFDSELIRARLKELAFLFKKLQLTFVDETGSGEKEVFFTEAGISQYLDELNADSKQIAQ
HCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHH
KIFVSGTEDDIELEAVFQFIDGEDEKLLSFANSIRTSEGGSHEASFRQSVGDVINNYCRK
HHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
YNFLKERDKNFEASEIREGLNGIIKVNLPEKIIAFEGQTKSKLFSKEVKAVVQKLTQKHF
HHHHHHHCCCCCHHHHHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
FQFLERNSVDAKLIVEKLFYNRKLRQELKQQRQIKKNLSNPKAERILFGKLAPAQSKKVA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCHHHHHH
ERELFVVEGDSAGGTAKMGRDRFLQAILPLRGKVLNVEKINNKKEAINNEELLTLIFCIG
CCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHCCCHHHHCCCHHHHHHHHHHH
TGIGNNFTIRDRKYDKIIIMTDADNDGAHIQILLLTFFYRYMKPLIEKGHIYLALPPLYK
CCCCCCEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCEE
FEGRDKKARYLTEQELEQYRAKHSHFNVQRYKGLGEMNADQLWETTMNPMTRKLIQVKLD
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NFIQAEKQINVFMGDKTELRKSWIEANINFSSEN
HHHHHHHHEEEEECCHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure
MKNNYSEANIKILKGLDAVKKRPGMYIGSTDSRGFHHLLWEILDNCVDEVLSGFANTIAV
CCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
VLHAENQITVSDNGRGIPFETHSDSKISTIDTVFTYLHAGGKFDNDSYKIAGGLHGVGAS
EEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHH
VVNALSDQLQVTVKRQGKVYRSVYENGGKIKQKAHCIGNAKIDEHGTSVTFRPDPKVFKK
HHHHHHHHHEEHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCEEEECCCHHHHHH
IHFDSELIRARLKELAFLFKKLQLTFVDETGSGEKEVFFTEAGISQYLDELNADSKQIAQ
HCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHH
KIFVSGTEDDIELEAVFQFIDGEDEKLLSFANSIRTSEGGSHEASFRQSVGDVINNYCRK
HHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
YNFLKERDKNFEASEIREGLNGIIKVNLPEKIIAFEGQTKSKLFSKEVKAVVQKLTQKHF
HHHHHHHCCCCCHHHHHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
FQFLERNSVDAKLIVEKLFYNRKLRQELKQQRQIKKNLSNPKAERILFGKLAPAQSKKVA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCHHHHHH
ERELFVVEGDSAGGTAKMGRDRFLQAILPLRGKVLNVEKINNKKEAINNEELLTLIFCIG
CCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHCCCHHHHCCCHHHHHHHHHHH
TGIGNNFTIRDRKYDKIIIMTDADNDGAHIQILLLTFFYRYMKPLIEKGHIYLALPPLYK
CCCCCCEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCEE
FEGRDKKARYLTEQELEQYRAKHSHFNVQRYKGLGEMNADQLWETTMNPMTRKLIQVKLD
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NFIQAEKQINVFMGDKTELRKSWIEANINFSSEN
HHHHHHHHEEEEECCHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]