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The map label for this gene is parC [H]

Identifier: 13507862

GI number: 13507862

Start: 158374

End: 160743

Strand: Direct

Name: parC [H]

Synonym: MPN123

Alternate gene names: 13507862

Gene position: 158374-160743 (Clockwise)

Preceding gene: 13507861

Following gene: 13507864

Centisome position: 19.4

GC content: 42.28

Gene sequence:

>2370_bases
ATGGAAAAGAATAAACAAGCGTTATTACTCCAGGCCATCGAAGATGTCTTTGCCTTTAGCTTTAGTAAGTATGCTAAGTA
CATTATCCAAGACCGGGCTTTACCTGATCTACGTGATGGGCTTAAACCAGTTCAACGCCGCATCCTCTATGGCATGTACC
AAATGGGCTTAAAACCCACTTCACCCTACAAAAAGTCAGCTCGGGCAGTCGGAGAAATTATGGGTAAGTACCACCCCCAT
GGCGATGCATCGATCTATGATGCGATTGTAAGGATGTCACAAGCCTGAAAGAACAACCTCACTACTATCTCCATTCACGG
GAATAATGGTTCCATAGATGGTGATAACGCTGCCGCGATGCGCTATACCGAAGCGCGTTTAAGTCCGTACGGGTTTGAAC
TACTCAAAGACATTGAAAAGCAGTTAGTACCGTTTGTGAATAACTTTGATGACAGTGAGGTCGAACCGAGCGTGTTACCA
ACCCTGTTACCTAACCTCTTTATTAACGGTACCAGTGGAATAGCGGCGGGTTATGCCACTAATATTGCACCCCATAATGT
CGGTGAACTGCTTGATGGTTTGAGTTACCGGATTGAAAACCCTGATTGTGATTTAAAGGCCATCTTAAAGATTGTTAAGG
GACCGGATTTTCCAACTGGGGGATTAGTGTACTTTGAGCAAGAGTTGGCGAACATCTACCAAACTGGGAAGGGTAAGTTT
GTGATTCAGGCCAAATATGAAACGAACACTGCGTTTGGCCAAAACCAGATTGTAATCACCGAAATCCCATACGAAACGGT
GAAGGCCAATATTGTTAAACAAATTGAAGAGTTAATTAGTGACAATAAACTCAGTGCCTTGGAAAGTGTGATTGACAGCT
CTGATCGTAGTGGTATTCGAATCATTATTAACCACAAGGACTTTTTGAGTGCTGACAAGATTATGGCGTTCTTGTTCAAA
CACACCCAACTCCAAGTAAACTTTAACCTCAACAATACGGTAATTGCCAACCGTTGTCCGGTACGGGTGGGGTTGTTAGC
TTACTTTGATCAGTTCCTAGCCTTTGCCCACGAATTGATCATTAACAGCGCCAAGTATGATTTAGCATTGGCCAATAAGC
GCTTGGAAATCATTAAGGGCTTAATTAAGGCGGTTTCCATGATTGATGAAATTATTCGTTTAATTCGCCGTGCTACTGAC
AAACAGGATGCGAAAACCAAGCTCATTGACAAGTATGCTTTTACCCTAAATCAAGCCGAAGCGATTGTGTCGTTGCGTTT
GTACCAGTTAACTAACACCGACATTAAGGTCCTGTTTGCCGAACAAAAAGAGTTAGAGCAAACGATCCAAACAGCCGAAC
GCTTAATTGCTAAACCGCAAGCACGAAACCAGTTGTTACAAGCACAGTTTTTCCAATACAAAAAGCAGTTTAACCAACCA
CGACGCGCACAAATAGTTGGTTTAATTGAAAAGCAAAAGGTACAAGACAGTGACTTCATCGAACACAAGGAAGTGGGCTT
ACTCATTAGTCACGATGGCATCTACTTTAAGTTTGAACCAGAACAGTTAGCGAAGCACCTAGTGGAATTTAAAAGTGAAC
AAGACCAACTGATTTTTGGAGGCGTAGTACAAAACTCCGATTACTTTTTTATGGTGACTTCACTCGGTAACATTATTACC
GTTCCCATTTACAAAACGTTAAGTAACACCAAAACCAAGATGAACGAGTTGTTGGCCAAAAAACCGATCCTAATGGAAGA
TGAAAAATTGGTACTAGCAGGGATTGTAAACCCAGACAAAATGGAACAACAGCTCTTGGTGTTAACGTCACAGTGCGGTA
TGGTCAAACGGGTCGAGTTGAGCAAAGTCATTAACACGAAGCAAATTAAGTCAAGCTGCTGCATGGCACTCCGGGAACGC
GACAAACTGGTCAACGCCTTTGTTCAAACTAAAGGGGAACCTAAACTAGTTTGTCTGGTGTCATCTTCCAACAGTTTTGC
TACCTTCTTAGCGGAAGAAATTCCAATTATTAGTAACAAGGGAATTGGGGTGAAGGGGATTAAACTCAAAGCTGAGGAAA
AGGTACGGTTTGCAATGCCGTTACAGGATAATGATGCCTTAGTAGTGATTAACAGTGATGGTGGTGTCTATAACTTTGAA
GTAGTGGAACTGGCAGTCGCTAGCCGCATGAGTGTTGGTAAAAAACTAATTCCCAAAACCAAAACCCCGGTAAGCTGTTT
TGCTGCTAATAAGCACAGTGAGATTATTGGTCATCGTGGTAAAAATGGTAGTGATCTGTTTACCCTAAATGAGTTAAACC
GTTTACCAAAGTCAACCGTTAGTCAAATGCGTTTGTTTAAGTGGAGCTAG

Upstream 100 bases:

>100_bases
TTATCCAAGCTGAAAAGCAAATTAATGTTTTTATGGGTGATAAAACCGAATTGCGTAAAAGCTGGATTGAAGCTAACATT
AACTTTAGTAGTGAGAACTA

Downstream 100 bases:

>100_bases
TGGTTTTACCACCGTGAAGTTGCTTATCGTACTCCTCGATCTCTTCTTTGAGGGTCAACAATAACGCTTTCACCTTTTGG
TAGTCCATCCGGGTGGGACC

Product: topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MEKNKQALLLQAIEDVFAFSFSKYAKYIIQDRALPDLRDGLKPVQRRILYGMYQMGLKPTSPYKKSARAVGEIMGKYHPH
GDASIYDAIVRMSQAWKNNLTTISIHGNNGSIDGDNAAAMRYTEARLSPYGFELLKDIEKQLVPFVNNFDDSEVEPSVLP
TLLPNLFINGTSGIAAGYATNIAPHNVGELLDGLSYRIENPDCDLKAILKIVKGPDFPTGGLVYFEQELANIYQTGKGKF
VIQAKYETNTAFGQNQIVITEIPYETVKANIVKQIEELISDNKLSALESVIDSSDRSGIRIIINHKDFLSADKIMAFLFK
HTQLQVNFNLNNTVIANRCPVRVGLLAYFDQFLAFAHELIINSAKYDLALANKRLEIIKGLIKAVSMIDEIIRLIRRATD
KQDAKTKLIDKYAFTLNQAEAIVSLRLYQLTNTDIKVLFAEQKELEQTIQTAERLIAKPQARNQLLQAQFFQYKKQFNQP
RRAQIVGLIEKQKVQDSDFIEHKEVGLLISHDGIYFKFEPEQLAKHLVEFKSEQDQLIFGGVVQNSDYFFMVTSLGNIIT
VPIYKTLSNTKTKMNELLAKKPILMEDEKLVLAGIVNPDKMEQQLLVLTSQCGMVKRVELSKVINTKQIKSSCCMALRER
DKLVNAFVQTKGEPKLVCLVSSSNSFATFLAEEIPIISNKGIGVKGIKLKAEEKVRFAMPLQDNDALVVINSDGGVYNFE
VVELAVASRMSVGKKLIPKTKTPVSCFAANKHSEIIGHRGKNGSDLFTLNELNRLPKSTVSQMRLFKWS

Sequences:

>Translated_789_residues
MEKNKQALLLQAIEDVFAFSFSKYAKYIIQDRALPDLRDGLKPVQRRILYGMYQMGLKPTSPYKKSARAVGEIMGKYHPH
GDASIYDAIVRMSQA*KNNLTTISIHGNNGSIDGDNAAAMRYTEARLSPYGFELLKDIEKQLVPFVNNFDDSEVEPSVLP
TLLPNLFINGTSGIAAGYATNIAPHNVGELLDGLSYRIENPDCDLKAILKIVKGPDFPTGGLVYFEQELANIYQTGKGKF
VIQAKYETNTAFGQNQIVITEIPYETVKANIVKQIEELISDNKLSALESVIDSSDRSGIRIIINHKDFLSADKIMAFLFK
HTQLQVNFNLNNTVIANRCPVRVGLLAYFDQFLAFAHELIINSAKYDLALANKRLEIIKGLIKAVSMIDEIIRLIRRATD
KQDAKTKLIDKYAFTLNQAEAIVSLRLYQLTNTDIKVLFAEQKELEQTIQTAERLIAKPQARNQLLQAQFFQYKKQFNQP
RRAQIVGLIEKQKVQDSDFIEHKEVGLLISHDGIYFKFEPEQLAKHLVEFKSEQDQLIFGGVVQNSDYFFMVTSLGNIIT
VPIYKTLSNTKTKMNELLAKKPILMEDEKLVLAGIVNPDKMEQQLLVLTSQCGMVKRVELSKVINTKQIKSSCCMALRER
DKLVNAFVQTKGEPKLVCLVSSSNSFATFLAEEIPIISNKGIGVKGIKLKAEEKVRFAMPLQDNDALVVINSDGGVYNFE
VVELAVASRMSVGKKLIPKTKTPVSCFAANKHSEIIGHRGKNGSDLFTLNELNRLPKSTVSQMRLFKWS
>Mature_789_residues
MEKNKQALLLQAIEDVFAFSFSKYAKYIIQDRALPDLRDGLKPVQRRILYGMYQMGLKPTSPYKKSARAVGEIMGKYHPH
GDASIYDAIVRMSQA*KNNLTTISIHGNNGSIDGDNAAAMRYTEARLSPYGFELLKDIEKQLVPFVNNFDDSEVEPSVLP
TLLPNLFINGTSGIAAGYATNIAPHNVGELLDGLSYRIENPDCDLKAILKIVKGPDFPTGGLVYFEQELANIYQTGKGKF
VIQAKYETNTAFGQNQIVITEIPYETVKANIVKQIEELISDNKLSALESVIDSSDRSGIRIIINHKDFLSADKIMAFLFK
HTQLQVNFNLNNTVIANRCPVRVGLLAYFDQFLAFAHELIINSAKYDLALANKRLEIIKGLIKAVSMIDEIIRLIRRATD
KQDAKTKLIDKYAFTLNQAEAIVSLRLYQLTNTDIKVLFAEQKELEQTIQTAERLIAKPQARNQLLQAQFFQYKKQFNQP
RRAQIVGLIEKQKVQDSDFIEHKEVGLLISHDGIYFKFEPEQLAKHLVEFKSEQDQLIFGGVVQNSDYFFMVTSLGNIIT
VPIYKTLSNTKTKMNELLAKKPILMEDEKLVLAGIVNPDKMEQQLLVLTSQCGMVKRVELSKVINTKQIKSSCCMALRER
DKLVNAFVQTKGEPKLVCLVSSSNSFATFLAEEIPIISNKGIGVKGIKLKAEEKVRFAMPLQDNDALVVINSDGGVYNFE
VVELAVASRMSVGKKLIPKTKTPVSCFAANKHSEIIGHRGKNGSDLFTLNELNRLPKSTVSQMRLFKWS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=297, Percent_Identity=23.9057239057239, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI19913406, Length=419, Percent_Identity=22.673031026253, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1788562, Length=769, Percent_Identity=31.4694408322497, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI1789396, Length=507, Percent_Identity=33.3333333333333, Blast_Score=293, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17535065, Length=300, Percent_Identity=27, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=293, Percent_Identity=26.2798634812287, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212645845, Length=173, Percent_Identity=31.2138728323699, Blast_Score=77, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=244, Percent_Identity=27.4590163934426, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136538, Length=255, Percent_Identity=23.1372549019608, Blast_Score=73, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 88466; Mature: 88466

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKNKQALLLQAIEDVFAFSFSKYAKYIIQDRALPDLRDGLKPVQRRILYGMYQMGLKPT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SPYKKSARAVGEIMGKYHPHGDASIYDAIVRMSQAKNNLTTISIHGNNGSIDGDNAAAMR
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHEE
YTEARLSPYGFELLKDIEKQLVPFVNNFDDSEVEPSVLPTLLPNLFINGTSGIAAGYATN
EHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCC
IAPHNVGELLDGLSYRIENPDCDLKAILKIVKGPDFPTGGLVYFEQELANIYQTGKGKFV
CCCCCHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCEE
IQAKYETNTAFGQNQIVITEIPYETVKANIVKQIEELISDNKLSALESVIDSSDRSGIRI
EEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEE
IINHKDFLSADKIMAFLFKHTQLQVNFNLNNTVIANRCPVRVGLLAYFDQFLAFAHELII
EEECHHHCCHHHHHHHHHHCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
NSAKYDLALANKRLEIIKGLIKAVSMIDEIIRLIRRATDKQDAKTKLIDKYAFTLNQAEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IVSLRLYQLTNTDIKVLFAEQKELEQTIQTAERLIAKPQARNQLLQAQFFQYKKQFNQPR
HHHEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RAQIVGLIEKQKVQDSDFIEHKEVGLLISHDGIYFKFEPEQLAKHLVEFKSEQDQLIFGG
HHHHHHHHHHHCCCCCCCCCHHCCEEEEECCCEEEEECHHHHHHHHHHHCCCCCCEEEEE
VVQNSDYFFMVTSLGNIITVPIYKTLSNTKTKMNELLAKKPILMEDEKLVLAGIVNPDKM
EEECCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCHHHH
EQQLLVLTSQCGMVKRVELSKVINTKQIKSSCCMALRERDKLVNAFVQTKGEPKLVCLVS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
SSNSFATFLAEEIPIISNKGIGVKGIKLKAEEKVRFAMPLQDNDALVVINSDGGVYNFEV
CCCCHHHHHHHHCCEECCCCCCEEEEEEECCCCEEEEECCCCCCEEEEEECCCCEEEHHH
VELAVASRMSVGKKLIPKTKTPVSCFAANKHSEIIGHRGKNGSDLFTLNELNRLPKSTVS
HHHHHHHHHHHCHHHCCCCCCCCEEEECCCCHHHHCCCCCCCCCEEEHHHHHHCCHHHHH
QMRLFKWS
HHHHHCCC
>Mature Secondary Structure
MEKNKQALLLQAIEDVFAFSFSKYAKYIIQDRALPDLRDGLKPVQRRILYGMYQMGLKPT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SPYKKSARAVGEIMGKYHPHGDASIYDAIVRMSQAKNNLTTISIHGNNGSIDGDNAAAMR
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHEE
YTEARLSPYGFELLKDIEKQLVPFVNNFDDSEVEPSVLPTLLPNLFINGTSGIAAGYATN
EHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCC
IAPHNVGELLDGLSYRIENPDCDLKAILKIVKGPDFPTGGLVYFEQELANIYQTGKGKFV
CCCCCHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCEE
IQAKYETNTAFGQNQIVITEIPYETVKANIVKQIEELISDNKLSALESVIDSSDRSGIRI
EEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEE
IINHKDFLSADKIMAFLFKHTQLQVNFNLNNTVIANRCPVRVGLLAYFDQFLAFAHELII
EEECHHHCCHHHHHHHHHHCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
NSAKYDLALANKRLEIIKGLIKAVSMIDEIIRLIRRATDKQDAKTKLIDKYAFTLNQAEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IVSLRLYQLTNTDIKVLFAEQKELEQTIQTAERLIAKPQARNQLLQAQFFQYKKQFNQPR
HHHEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RAQIVGLIEKQKVQDSDFIEHKEVGLLISHDGIYFKFEPEQLAKHLVEFKSEQDQLIFGG
HHHHHHHHHHHCCCCCCCCCHHCCEEEEECCCEEEEECHHHHHHHHHHHCCCCCCEEEEE
VVQNSDYFFMVTSLGNIITVPIYKTLSNTKTKMNELLAKKPILMEDEKLVLAGIVNPDKM
EEECCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCHHHH
EQQLLVLTSQCGMVKRVELSKVINTKQIKSSCCMALRERDKLVNAFVQTKGEPKLVCLVS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
SSNSFATFLAEEIPIISNKGIGVKGIKLKAEEKVRFAMPLQDNDALVVINSDGGVYNFEV
CCCCHHHHHHHHCCEECCCCCCEEEEEEECCCCEEEEECCCCCCEEEEEECCCCEEEHHH
VELAVASRMSVGKKLIPKTKTPVSCFAANKHSEIIGHRGKNGSDLFTLNELNRLPKSTVS
HHHHHHHHHHHCHHHCCCCCCCCEEEECCCCHHHHCCCCCCCCCEEEHHHHHHCCHHHHH
QMRLFKWS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]