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The map label for this gene is apt

Identifier: 15669851

GI number: 15669851

Start: 1637708

End: 1638259

Strand: Direct

Name: apt

Synonym: MJ1655

Alternate gene names: 15669851

Gene position: 1637708-1638259 (Clockwise)

Preceding gene: 15669850

Following gene: 15669852

Centisome position: 98.36

GC content: 34.24

Gene sequence:

>552_bases
TTGTTATTAGAAGAAACATTAAAATCATGCCCAATTGTTAAAAGAGGGGAGTATCATTACTTTATTCATCCAATAAGTGA
CGGAGTTCCAGTTGTTGAGCCAAAGTTATTGAGAGAGGTAGCAACAAGAATAATAAAGATAGGAGACTTTGAAGGAGCTA
CCAAATTAGTTACAGCTGAAGCAATGGGTATTCCTTTGGTAACTACCCTCTCTTTATACACAGATATACCTTACGTGATT
ATGAGGAAAAGAGAATATAAATTACCAGGAGAGATTCCTGTCTTTCAATCTACTGGATATAGCAAAGGGCAACTCTATCT
AAACGGAATAGAGAAGGGAGATAAAGTTGTTATTATAGATGATGTCATCTCAACTGGGGGAACAATGATTGCAATAATAG
ATGCTTTAAAAAGGGCTGGAGCAGAGATAAAAGACATTATTTGCGTTATTGAAAGAGGAGAAGGGAAAAAGATAGTTGAA
GAAAAAACCGGATATAAGATAAAAACCTTGGTTAAAATTGATGTTGTAGATGGAAAGGTTGTTATTTTATAA

Upstream 100 bases:

>100_bases
AGGATTTAGAAAAATATTTATCTGAGTTGAAAGAATCAGGAGACATATTCGAACCAAGACCTGGTGTTTATAAGGTATTA
TAACCTTTGGAGGTGGAAGA

Downstream 100 bases:

>100_bases
TTAAGGATGGGGAATATGAAAAAGTCCTTAAAATCTCTATTAAAATCATTTTTTGAAAAACTGATAAAGAAAGCTTTTGA
AGTAAAATCAATCTGTGAGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLLEETLKSCPIVKRGEYHYFIHPISDGVPVVEPKLLREVATRIIKIGDFEGATKLVTAEAMGIPLVTTLSLYTDIPYVI
MRKREYKLPGEIPVFQSTGYSKGQLYLNGIEKGDKVVIIDDVISTGGTMIAIIDALKRAGAEIKDIICVIERGEGKKIVE
EKTGYKIKTLVKIDVVDGKVVIL

Sequences:

>Translated_183_residues
MLLEETLKSCPIVKRGEYHYFIHPISDGVPVVEPKLLREVATRIIKIGDFEGATKLVTAEAMGIPLVTTLSLYTDIPYVI
MRKREYKLPGEIPVFQSTGYSKGQLYLNGIEKGDKVVIIDDVISTGGTMIAIIDALKRAGAEIKDIICVIERGEGKKIVE
EKTGYKIKTLVKIDVVDGKVVIL
>Mature_183_residues
MLLEETLKSCPIVKRGEYHYFIHPISDGVPVVEPKLLREVATRIIKIGDFEGATKLVTAEAMGIPLVTTLSLYTDIPYVI
MRKREYKLPGEIPVFQSTGYSKGQLYLNGIEKGDKVVIIDDVISTGGTMIAIIDALKRAGAEIKDIICVIERGEGKKIVE
EKTGYKIKTLVKIDVVDGKVVIL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_METJA (Q59049)

Other databases:

- EMBL:   L77117
- PIR:   E64506
- RefSeq:   NP_248665.1
- ProteinModelPortal:   Q59049
- SMR:   Q59049
- GeneID:   1452564
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1655
- NMPDR:   fig|243232.1.peg.1702
- TIGR:   MJ1655
- HOGENOM:   HBG496859
- OMA:   TGYSKGE
- ProtClustDB:   PRK02304
- BioCyc:   MJAN243232:MJ_1655-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20218; Mature: 20218

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLEETLKSCPIVKRGEYHYFIHPISDGVPVVEPKLLREVATRIIKIGDFEGATKLVTAE
CCHHHHHHHCCCEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEEEH
AMGIPLVTTLSLYTDIPYVIMRKREYKLPGEIPVFQSTGYSKGQLYLNGIEKGDKVVIID
HCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEE
DVISTGGTMIAIIDALKRAGAEIKDIICVIERGEGKKIVEEKTGYKIKTLVKIDVVDGKV
HHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHHCCCCEEEEEEEEEEECCEE
VIL
EEC
>Mature Secondary Structure
MLLEETLKSCPIVKRGEYHYFIHPISDGVPVVEPKLLREVATRIIKIGDFEGATKLVTAE
CCHHHHHHHCCCEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEEEH
AMGIPLVTTLSLYTDIPYVIMRKREYKLPGEIPVFQSTGYSKGQLYLNGIEKGDKVVIID
HCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEE
DVISTGGTMIAIIDALKRAGAEIKDIICVIERGEGKKIVEEKTGYKIKTLVKIDVVDGKV
HHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHHCCCCEEEEEEEEEEECCEE
VIL
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087