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The map label for this gene is pgi

Identifier: 15669801

GI number: 15669801

Start: 1578731

End: 1579936

Strand: Reverse

Name: pgi

Synonym: MJ1605

Alternate gene names: 15669801

Gene position: 1579936-1578731 (Counterclockwise)

Preceding gene: 15669802

Following gene: 15669800

Centisome position: 94.89

GC content: 30.02

Gene sequence:

>1206_bases
ATGCTAAGTTATGATTACGAAAACGCTTTAAAAGTTGGAGAAATAAGCCTTGAAGATATCAATAAAGTAGATTTTGCAAA
TGCATATTCAAACTTGATGGAGAAATTGGATAATGGAGTTGTAGGATTTAGAGATGTTATTTATGATGAGAACTTAGATA
AATATAAATCTTTAAATGGATATGAAAATGTTGTAGTTATTGGAATGGGAGGCTCCATATTGGGAACAATGGCTATTTAT
TATGCAATTTCACCATTTAACAATAATGCCTATTTTATAGACAACAGCGACCCTGAAAAAACCCTCTCAATACTAAAAAA
AGTTGATTTAAACGAATCTATAATTTATATTATTAGTAAATCTGGCAACACATTGGAAACTTTGGTTAATTATTATCTAA
TTAAAAAAAGAATTGAAAAATTAAATTCATTTAAAGGAAAACTTGTTTTTATTACTAATGGTGGGAAATTAAAGAGAGAG
GCAGAGAAAAATAACTATGATATATTTTCAATTCCTGAAAATGTCCCTGGAAGGTTTTCAGTCTTTACTGCTGTTGGTTT
AGCTCCTTTATATTCTTTAGGAGTTGATATATCAAAAATATTAGAAGGAGCAAGAGAGATGGACAAAATCTGTCAAAATG
AAGATATTTTAAAAAATCCTGCACTTTTAAATGGGGTTATACACTACCTATATGATAAGAGAGGAAAGGACATCTCAGTT
ATTATGAGTTATGTTGAAAGCTTAAAATATTTTGGAGATTGGTATAAACAACTTATTGGAGAAAGTTTGGGAAAAAATAA
GCATGGAATAACTCCTTTATTATCAATTGGAGCCAAAGACCAACATTCTTTATTGCAGTTGTATATGGATGGGAAGAAAG
ACAAGATTATAACATTCATGGTTGCTAAAAAATATAGGTTAGATGAAGAAATAGAATTTGAAGACATAAATGATGAGAAA
ATTTCTTGCAGATATTCAGATATAATTAGGAGCCAACAAAAAGCTACAGAGATAGCTTTAACAAATAATGGAGTCCCAAA
TGTAAGAATAACCCTTGATGAAATAAATGAGATGGCTATGGGGGCTTTACTATACATGTATGAGATGCAAGTTGGTTTTA
TGGGGGAGCTTTACAATATAAACGCCTACAATCAACCAGCAGTTGAAGAGGAGAAAAAAATTTGCTGGAGATTGATTAAA
CAATAA

Upstream 100 bases:

>100_bases
TCTATAAGAAAGTATAAGGGCTTATTTGGAGGAGCAATTTATAATCACTATCTACAACCATAACTTTCCACTTTATGTAA
TAAAAGATTTGGGGGGAAAT

Downstream 100 bases:

>100_bases
ATAATATTTCTAATTCTTTTTCTTTATTAGTAGATATCTTAAAATGTGTGATATTATGGAAATAAAAAAATTTATTGAGA
CAATAAAAGGAACTAAGCTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLSYDYENALKVGEISLEDINKVDFANAYSNLMEKLDNGVVGFRDVIYDENLDKYKSLNGYENVVVIGMGGSILGTMAIY
YAISPFNNNAYFIDNSDPEKTLSILKKVDLNESIIYIISKSGNTLETLVNYYLIKKRIEKLNSFKGKLVFITNGGKLKRE
AEKNNYDIFSIPENVPGRFSVFTAVGLAPLYSLGVDISKILEGAREMDKICQNEDILKNPALLNGVIHYLYDKRGKDISV
IMSYVESLKYFGDWYKQLIGESLGKNKHGITPLLSIGAKDQHSLLQLYMDGKKDKIITFMVAKKYRLDEEIEFEDINDEK
ISCRYSDIIRSQQKATEIALTNNGVPNVRITLDEINEMAMGALLYMYEMQVGFMGELYNINAYNQPAVEEEKKICWRLIK
Q

Sequences:

>Translated_401_residues
MLSYDYENALKVGEISLEDINKVDFANAYSNLMEKLDNGVVGFRDVIYDENLDKYKSLNGYENVVVIGMGGSILGTMAIY
YAISPFNNNAYFIDNSDPEKTLSILKKVDLNESIIYIISKSGNTLETLVNYYLIKKRIEKLNSFKGKLVFITNGGKLKRE
AEKNNYDIFSIPENVPGRFSVFTAVGLAPLYSLGVDISKILEGAREMDKICQNEDILKNPALLNGVIHYLYDKRGKDISV
IMSYVESLKYFGDWYKQLIGESLGKNKHGITPLLSIGAKDQHSLLQLYMDGKKDKIITFMVAKKYRLDEEIEFEDINDEK
ISCRYSDIIRSQQKATEIALTNNGVPNVRITLDEINEMAMGALLYMYEMQVGFMGELYNINAYNQPAVEEEKKICWRLIK
Q
>Mature_401_residues
MLSYDYENALKVGEISLEDINKVDFANAYSNLMEKLDNGVVGFRDVIYDENLDKYKSLNGYENVVVIGMGGSILGTMAIY
YAISPFNNNAYFIDNSDPEKTLSILKKVDLNESIIYIISKSGNTLETLVNYYLIKKRIEKLNSFKGKLVFITNGGKLKRE
AEKNNYDIFSIPENVPGRFSVFTAVGLAPLYSLGVDISKILEGAREMDKICQNEDILKNPALLNGVIHYLYDKRGKDISV
IMSYVESLKYFGDWYKQLIGESLGKNKHGITPLLSIGAKDQHSLLQLYMDGKKDKIITFMVAKKYRLDEEIEFEDINDEK
ISCRYSDIIRSQQKATEIALTNNGVPNVRITLDEINEMAMGALLYMYEMQVGFMGELYNINAYNQPAVEEEKKICWRLIK
Q

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=408, Percent_Identity=24.2647058823529, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1790457, Length=379, Percent_Identity=25.8575197889182, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996708, Length=374, Percent_Identity=23.5294117647059, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71996703, Length=374, Percent_Identity=23.5294117647059, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319673, Length=364, Percent_Identity=24.1758241758242, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651916, Length=374, Percent_Identity=23.2620320855615, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651914, Length=374, Percent_Identity=23.2620320855615, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737445, Length=374, Percent_Identity=23.2620320855615, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_METJA (Q59000)

Other databases:

- EMBL:   L77117
- PIR:   D64500
- RefSeq:   NP_248615.1
- ProteinModelPortal:   Q59000
- SMR:   Q59000
- GeneID:   1452514
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1605
- NMPDR:   fig|243232.1.peg.1652
- TIGR:   MJ1605
- HOGENOM:   HBG615843
- OMA:   YVNDRAY
- ProtClustDB:   PRK00973
- BioCyc:   MJAN243232:MJ_1605-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 45675; Mature: 45675

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 261-261 ACT_SITE 282-282 ACT_SITE 392-392

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYDYENALKVGEISLEDINKVDFANAYSNLMEKLDNGVVGFRDVIYDENLDKYKSLNG
CCCCCCCCCCEECCEEHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCC
YENVVVIGMGGSILGTMAIYYAISPFNNNAYFIDNSDPEKTLSILKKVDLNESIIYIISK
CCCEEEEECCCHHHHHHHHHHEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEC
SGNTLETLVNYYLIKKRIEKLNSFKGKLVFITNGGKLKREAEKNNYDIFSIPENVPGRFS
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEHHHCCCCEEEECCCCCCCCCH
VFTAVGLAPLYSLGVDISKILEGAREMDKICQNEDILKNPALLNGVIHYLYDKRGKDISV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCCHHHH
IMSYVESLKYFGDWYKQLIGESLGKNKHGITPLLSIGAKDQHSLLQLYMDGKKDKIITFM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEE
VAKKYRLDEEIEFEDINDEKISCRYSDIIRSQQKATEIALTNNGVPNVRITLDEINEMAM
EHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHEEEEECCCCCEEEEEHHHHHHHHH
GALLYMYEMQVGFMGELYNINAYNQPAVEEEKKICWRLIKQ
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSYDYENALKVGEISLEDINKVDFANAYSNLMEKLDNGVVGFRDVIYDENLDKYKSLNG
CCCCCCCCCCEECCEEHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCC
YENVVVIGMGGSILGTMAIYYAISPFNNNAYFIDNSDPEKTLSILKKVDLNESIIYIISK
CCCEEEEECCCHHHHHHHHHHEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEC
SGNTLETLVNYYLIKKRIEKLNSFKGKLVFITNGGKLKREAEKNNYDIFSIPENVPGRFS
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEHHHCCCCEEEECCCCCCCCCH
VFTAVGLAPLYSLGVDISKILEGAREMDKICQNEDILKNPALLNGVIHYLYDKRGKDISV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCCHHHH
IMSYVESLKYFGDWYKQLIGESLGKNKHGITPLLSIGAKDQHSLLQLYMDGKKDKIITFM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEE
VAKKYRLDEEIEFEDINDEKISCRYSDIIRSQQKATEIALTNNGVPNVRITLDEINEMAM
EHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHEEEEECCCCCEEEEEHHHHHHHHH
GALLYMYEMQVGFMGELYNINAYNQPAVEEEKKICWRLIKQ
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087