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The map label for this gene is paaJ [C]

Identifier: 15669744

GI number: 15669744

Start: 1526422

End: 1527600

Strand: Direct

Name: paaJ [C]

Synonym: MJ1549

Alternate gene names: 15669744

Gene position: 1526422-1527600 (Clockwise)

Preceding gene: 15669743

Following gene: 15669745

Centisome position: 91.68

GC content: 40.46

Gene sequence:

>1179_bases
ATGAGAGATGTTGCCATTATCGGCTATGGACAGACAAAGTTTGGCGAGCTATGGGAAAGAAGTTTTAGAAGCTTGATTGT
TGAGGCTGGTGTTAAGGCAGTTGAAGCTGCAGGTATAGATGGGAAGGATATAGATGAGATGTATGTTGGAAACATGAGTG
CTGGTTTGTTTGTTGGACAGGAGCATATAGCCTCTTTAATAGCTGAGCATGCTGGTTTAAACCCAATTCCTTCAACAAGG
GTTGAAGCTGCTTGTGCATCTGGTAGCTTAGCTTTAAGACAAGCTGTTTTAAATGTAGCGAGCGGGGCAAGTGATGTTGT
TTTAGTTGGTGGAGTAGAAAAGATGACTGATGTTGTTGATGCAACCTCTGCAATATCATCAGCTTCAGACCAAGAATGGG
AGGCTTTGTTTGGAGCTACTTTTCCTTCACTGTATGCTATGATGGCTCAGAGGTATATGTATGAGTATGGCTTAACTTTA
GAGGAGTTATCAATGTGGAGCGTTATCATGCATGAAAACGCCTCAAAAAATAGATATGCACAATTCCCATTTAAGGTTAC
ATTGGAGCAGGTTCTCAACTCCTCACCAGTTGCTGAGCCTTTAAGATTACTACATTGCTCACCAGTTTCAGATGGTGCTG
CTGCCCTTATAGTATGTGAAGCAGAAAAGGCTAAAGAATTTGTAAATAAAGATGATATCATCTACATCAAAGCAAGTGTT
CAAGCATCAGATACAATTGCATTACACAGCAGAGAGAGCATAACAAGCTTAAAAGCTGCTAAAGTTGCAAGTGAAAAAGC
ATATAAAATGGCAAATATAGAACCAAAGGATGTGGATGTCGCTGAAGTTCATGACTGCTTTGCTATAAATGGTTTAATAT
TGATGGAGGAACTTGGTTTCTGTAAAAAGGGAGAGGCTGGAAAGATAGTTTATGATAAAAAGATAGCTATTGATTATGAT
GGCTTCCCAGCAGTAAATCCAAGTGGAGGGCTGAAAGCTGCTGGACATGCATTAGGGGCTACCGGTATAAGGCAGGTTGG
AGAGATTTACTGGCAGTTAAAGCAGGATAAGGAGGTTAAAGATAGGCAGGTAGAGATTAAAAATGGCTATGGAATTACTG
TAAATGTCGGAGGGACTGGAGGGACTGTATGCATCCATATATTGTCTGATAAGAGATAA

Upstream 100 bases:

>100_bases
AACTCTATGAAATCGCATACGAAAGTATGCGAGTAATGAAATGCGAAGCATTTCATCTGATAATAATTAAACTCATTGAA
TTCTATGAAAAGGTGGAAGA

Downstream 100 bases:

>100_bases
TTAGAGGATATTTATGGATAAAATTAAAAAGGAAGTGCTTACTATAGTAATTGGAAGCATTGGATTTGTGGTATTGGATT
TTATTATTTGGTATTATCTA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MRDVAIIGYGQTKFGELWERSFRSLIVEAGVKAVEAAGIDGKDIDEMYVGNMSAGLFVGQEHIASLIAEHAGLNPIPSTR
VEAACASGSLALRQAVLNVASGASDVVLVGGVEKMTDVVDATSAISSASDQEWEALFGATFPSLYAMMAQRYMYEYGLTL
EELSMWSVIMHENASKNRYAQFPFKVTLEQVLNSSPVAEPLRLLHCSPVSDGAAALIVCEAEKAKEFVNKDDIIYIKASV
QASDTIALHSRESITSLKAAKVASEKAYKMANIEPKDVDVAEVHDCFAINGLILMEELGFCKKGEAGKIVYDKKIAIDYD
GFPAVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKEVKDRQVEIKNGYGITVNVGGTGGTVCIHILSDKR

Sequences:

>Translated_392_residues
MRDVAIIGYGQTKFGELWERSFRSLIVEAGVKAVEAAGIDGKDIDEMYVGNMSAGLFVGQEHIASLIAEHAGLNPIPSTR
VEAACASGSLALRQAVLNVASGASDVVLVGGVEKMTDVVDATSAISSASDQEWEALFGATFPSLYAMMAQRYMYEYGLTL
EELSMWSVIMHENASKNRYAQFPFKVTLEQVLNSSPVAEPLRLLHCSPVSDGAAALIVCEAEKAKEFVNKDDIIYIKASV
QASDTIALHSRESITSLKAAKVASEKAYKMANIEPKDVDVAEVHDCFAINGLILMEELGFCKKGEAGKIVYDKKIAIDYD
GFPAVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKEVKDRQVEIKNGYGITVNVGGTGGTVCIHILSDKR
>Mature_392_residues
MRDVAIIGYGQTKFGELWERSFRSLIVEAGVKAVEAAGIDGKDIDEMYVGNMSAGLFVGQEHIASLIAEHAGLNPIPSTR
VEAACASGSLALRQAVLNVASGASDVVLVGGVEKMTDVVDATSAISSASDQEWEALFGATFPSLYAMMAQRYMYEYGLTL
EELSMWSVIMHENASKNRYAQFPFKVTLEQVLNSSPVAEPLRLLHCSPVSDGAAALIVCEAEKAKEFVNKDDIIYIKASV
QASDTIALHSRESITSLKAAKVASEKAYKMANIEPKDVDVAEVHDCFAINGLILMEELGFCKKGEAGKIVYDKKIAIDYD
GFPAVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKEVKDRQVEIKNGYGITVNVGGTGGTVCIHILSDKR

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=390, Percent_Identity=30.5128205128205, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI302344760, Length=390, Percent_Identity=28.7179487179487, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI302344767, Length=312, Percent_Identity=30.4487179487179, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI302344762, Length=381, Percent_Identity=27.5590551181102, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI55956775, Length=348, Percent_Identity=27.5862068965517, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17537653, Length=374, Percent_Identity=29.9465240641711, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19921506, Length=390, Percent_Identity=31.5384615384615, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24585051, Length=388, Percent_Identity=30.6701030927835, Blast_Score=161, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1549_METJA (Q58944)

Other databases:

- EMBL:   L77117
- PIR:   D64493
- RefSeq:   NP_248557.1
- ProteinModelPortal:   Q58944
- SMR:   Q58944
- GeneID:   1452457
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1549
- NMPDR:   fig|243232.1.peg.1594
- TIGR:   MJ1549
- HOGENOM:   HBG567272
- OMA:   FTIAEIC
- ProtClustDB:   PRK06064
- BioCyc:   MJAN243232:MJ_1549-MONOMER
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: 2.3.1.16

Molecular weight: Translated: 42149; Mature: 42149

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVAIIGYGQTKFGELWERSFRSLIVEAGVKAVEAAGIDGKDIDEMYVGNMSAGLFVGQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHCCCCCCEEECH
EHIASLIAEHAGLNPIPSTRVEAACASGSLALRQAVLNVASGASDVVLVGGVEKMTDVVD
HHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHH
ATSAISSASDQEWEALFGATFPSLYAMMAQRYMYEYGLTLEELSMWSVIMHENASKNRYA
HHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEE
QFPFKVTLEQVLNSSPVAEPLRLLHCSPVSDGAAALIVCEAEKAKEFVNKDDIIYIKASV
ECCHHHHHHHHCCCCCHHHHHHHEECCCCCCCCEEEEEEECHHHHHHCCCCCEEEEEEEC
QASDTIALHSRESITSLKAAKVASEKAYKMANIEPKDVDVAEVHDCFAINGLILMEELGF
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEHHCCC
CKKGEAGKIVYDKKIAIDYDGFPAVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKEVK
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCCCC
DRQVEIKNGYGITVNVGGTGGTVCIHILSDKR
CCEEEEECCEEEEEEECCCCCEEEEEEECCCC
>Mature Secondary Structure
MRDVAIIGYGQTKFGELWERSFRSLIVEAGVKAVEAAGIDGKDIDEMYVGNMSAGLFVGQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHCCCCCCEEECH
EHIASLIAEHAGLNPIPSTRVEAACASGSLALRQAVLNVASGASDVVLVGGVEKMTDVVD
HHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHH
ATSAISSASDQEWEALFGATFPSLYAMMAQRYMYEYGLTLEELSMWSVIMHENASKNRYA
HHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEE
QFPFKVTLEQVLNSSPVAEPLRLLHCSPVSDGAAALIVCEAEKAKEFVNKDDIIYIKASV
ECCHHHHHHHHCCCCCHHHHHHHEECCCCCCCCEEEEEEECHHHHHHCCCCCEEEEEEEC
QASDTIALHSRESITSLKAAKVASEKAYKMANIEPKDVDVAEVHDCFAINGLILMEELGF
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEHHCCC
CKKGEAGKIVYDKKIAIDYDGFPAVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKEVK
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCCCC
DRQVEIKNGYGITVNVGGTGGTVCIHILSDKR
CCEEEEECCEEEEEEECCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087