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The map label for this gene is fabH [C]

Identifier: 15669741

GI number: 15669741

Start: 1524601

End: 1525638

Strand: Direct

Name: fabH [C]

Synonym: MJ1546

Alternate gene names: 15669741

Gene position: 1524601-1525638 (Clockwise)

Preceding gene: 15669740

Following gene: 15669742

Centisome position: 91.57

GC content: 39.69

Gene sequence:

>1038_bases
ATGGCGGGTATTGTTGGTTATGGAGCATACATCCCAAAATATAGGATAAAAGTTGAAGAAATAGCAAGAGTATGGAACAA
AGACCCGGAATCAATAAAAAAAGGACTTTTGGTATATGAGAAAGCAGTTCCAAGCTTGGATGAAGACACTGCAACTATTG
CAGTTGAAGCAGCAAGAAATGCATTAAAAAGAGCTGAAATAGACCCAAAAGACATTGGAGCTGTTTATGTTGGGAGTGAA
AGCCACCCTTATGCAGTTAAACCAACTGCTACAATAGTTGCTGAGGCTATAGATGCAACTCCAGACTTAACTGCAGCGGA
TTTAGAGTTTGCTTGCAAAGCTGGAACAGCAGGAATTCAGATGTGTATGGGATTGGTTGAGAGCGGCTTAATCAAATACG
GATTAGCTATTGGGGCAGATACTGCCCAAGGAGCTCCAGGAGATGCTTTGGAATACACGGCAGCAGCTGGAGGAGCTGCC
TATATAATAGGAAAATCAAACGTTATAGCTGAATTCAACGGCACTTATTCATACACAACAGACACCCCAGACTTCTGGAG
GAGAGAAGGAAAGCCATATCCAAGACATGGAGGAAGATTTACAGGAGAGCCAGCATACTTTAGACATGTAATTAATGCTG
CTAAAGGATTGATGGAAAAAATGGGAACAAAGCCAGAAGATTATGATTACTGCGTATTCCACCAACCAAACGGAAAATTC
TATATTAGGGTAGCTAAGATTTTGGGCTTTAAGGAAGAGCAATATAAAATAGGGCTATTAACCCCTTATATTGGAAACAC
TTACTCAGGAGCTGTTCCTTTAGGGTTATCAAATGTCTTAGATAATTGTGAAGGTGGAGAGAGAATTTTAGCAGTCTCCT
ATGGAAGTGGGGCTGGAAGTGATGCCTTCGACATAACAGTAACTGATAGAATAAATAAAGTCAAAGACAAAGCTCCAAAA
ACAGCCTATTACTTAGAGAGGAAAGAATATATCGACTATGCAATATATGCCAAATTTAGAAAGAAAATTAAGATGTGA

Upstream 100 bases:

>100_bases
TTAAAATTAGCTGAGATTGATAACATCCCACTAATAACAACCCATTTAGATACTAAAGAACTTATAAAAAGACTAAATGA
GATAAAATAAGGGGGAAATT

Downstream 100 bases:

>100_bases
GCAAAGTTTTTGGAATTCTGCTATATGGTTCTTATGCAAAGAATGAATACACAAAAAGGAGTGATATTGATATATGCTTA
GTAGGGGTTGATAGAAATAC

Product: hypothetical protein

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAGIVGYGAYIPKYRIKVEEIARVWNKDPESIKKGLLVYEKAVPSLDEDTATIAVEAARNALKRAEIDPKDIGAVYVGSE
SHPYAVKPTATIVAEAIDATPDLTAADLEFACKAGTAGIQMCMGLVESGLIKYGLAIGADTAQGAPGDALEYTAAAGGAA
YIIGKSNVIAEFNGTYSYTTDTPDFWRREGKPYPRHGGRFTGEPAYFRHVINAAKGLMEKMGTKPEDYDYCVFHQPNGKF
YIRVAKILGFKEEQYKIGLLTPYIGNTYSGAVPLGLSNVLDNCEGGERILAVSYGSGAGSDAFDITVTDRINKVKDKAPK
TAYYLERKEYIDYAIYAKFRKKIKM

Sequences:

>Translated_345_residues
MAGIVGYGAYIPKYRIKVEEIARVWNKDPESIKKGLLVYEKAVPSLDEDTATIAVEAARNALKRAEIDPKDIGAVYVGSE
SHPYAVKPTATIVAEAIDATPDLTAADLEFACKAGTAGIQMCMGLVESGLIKYGLAIGADTAQGAPGDALEYTAAAGGAA
YIIGKSNVIAEFNGTYSYTTDTPDFWRREGKPYPRHGGRFTGEPAYFRHVINAAKGLMEKMGTKPEDYDYCVFHQPNGKF
YIRVAKILGFKEEQYKIGLLTPYIGNTYSGAVPLGLSNVLDNCEGGERILAVSYGSGAGSDAFDITVTDRINKVKDKAPK
TAYYLERKEYIDYAIYAKFRKKIKM
>Mature_344_residues
AGIVGYGAYIPKYRIKVEEIARVWNKDPESIKKGLLVYEKAVPSLDEDTATIAVEAARNALKRAEIDPKDIGAVYVGSES
HPYAVKPTATIVAEAIDATPDLTAADLEFACKAGTAGIQMCMGLVESGLIKYGLAIGADTAQGAPGDALEYTAAAGGAAY
IIGKSNVIAEFNGTYSYTTDTPDFWRREGKPYPRHGGRFTGEPAYFRHVINAAKGLMEKMGTKPEDYDYCVFHQPNGKFY
IRVAKILGFKEEQYKIGLLTPYIGNTYSGAVPLGLSNVLDNCEGGERILAVSYGSGAGSDAFDITVTDRINKVKDKAPKT
AYYLERKEYIDYAIYAKFRKKIKM

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Catalyzes The First Condensation Reaction Which Initiates Fatty Acid Synthesis And May Therefore Play A Role In Governing The

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0219 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1546_METJA (Q58941)

Other databases:

- EMBL:   L77117
- PIR:   A64493
- RefSeq:   NP_248554.1
- ProteinModelPortal:   Q58941
- SMR:   Q58941
- GeneID:   1452454
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1546
- NMPDR:   fig|243232.1.peg.1591
- TIGR:   MJ1546
- HOGENOM:   HBG297330
- OMA:   RINTSDE
- ProtClustDB:   PRK04262
- BioCyc:   MJAN243232:MJ_1546-MONOMER
- HAMAP:   MF_01409
- InterPro:   IPR013747
- InterPro:   IPR004656
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00748

Pfam domain/function: PF08541 ACP_syn_III_C; PF01154 HMG_CoA_synt_N; SSF53901 Thiolase-like

EC number: 2.3.1.41

Molecular weight: Translated: 37549; Mature: 37418

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIVGYGAYIPKYRIKVEEIARVWNKDPESIKKGLLVYEKAVPSLDEDTATIAVEAARN
CCCEECCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHH
ALKRAEIDPKDIGAVYVGSESHPYAVKPTATIVAEAIDATPDLTAADLEFACKAGTAGIQ
HHHHCCCCHHHCCEEEECCCCCCEEECCHHHHHHHHHCCCCCCCHHCHHHHHCCCCHHHH
MCMGLVESGLIKYGLAIGADTAQGAPGDALEYTAAAGGAAYIIGKSNVIAEFNGTYSYTT
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCEEEEEECCCEEEEECCEEEECC
DTPDFWRREGKPYPRHGGRFTGEPAYFRHVINAAKGLMEKMGTKPEDYDYCVFHQPNGKF
CCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCE
YIRVAKILGFKEEQYKIGLLTPYIGNTYSGAVPLGLSNVLDNCEGGERILAVSYGSGAGS
EEEEEHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCC
DAFDITVTDRINKVKDKAPKTAYYLERKEYIDYAIYAKFRKKIKM
CEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGIVGYGAYIPKYRIKVEEIARVWNKDPESIKKGLLVYEKAVPSLDEDTATIAVEAARN
CCEECCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHH
ALKRAEIDPKDIGAVYVGSESHPYAVKPTATIVAEAIDATPDLTAADLEFACKAGTAGIQ
HHHHCCCCHHHCCEEEECCCCCCEEECCHHHHHHHHHCCCCCCCHHCHHHHHCCCCHHHH
MCMGLVESGLIKYGLAIGADTAQGAPGDALEYTAAAGGAAYIIGKSNVIAEFNGTYSYTT
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCEEEEEECCCEEEEECCEEEECC
DTPDFWRREGKPYPRHGGRFTGEPAYFRHVINAAKGLMEKMGTKPEDYDYCVFHQPNGKF
CCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCE
YIRVAKILGFKEEQYKIGLLTPYIGNTYSGAVPLGLSNVLDNCEGGERILAVSYGSGAGS
EEEEEHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCC
DAFDITVTDRINKVKDKAPKTAYYLERKEYIDYAIYAKFRKKIKM
CEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; DTT; EDTA [C]

Metal ions: Phosphate [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl -ACP-decarboxyl ation, [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087