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The map label for this gene is mtaD

Identifier: 15669736

GI number: 15669736

Start: 1517461

End: 1518723

Strand: Reverse

Name: mtaD

Synonym: MJ1541

Alternate gene names: 15669736

Gene position: 1518723-1517461 (Counterclockwise)

Preceding gene: 15669737

Following gene: 15669732

Centisome position: 91.22

GC content: 33.65

Gene sequence:

>1263_bases
GTGATATTGATAAAAAATGTATTTGTAAATGGGAAGAGACAGGATATACTAATTGAAGGAAATAAAATAAAAAAGATTGG
AGAGGTTAAAAAAGAAGAAATAGAGAATGCTGAAATTATAGATGGAAAGAACAAGATAGCAATCCCTGGGTTGATAAATA
CTCACACCCACATACCAATGACATTATTCAGAGGAGTTGCTGATGATTTACCTTTAATGGAGTGGTTAAACAACTACATC
TGGCCTATGGAGGCAAAGTTAAATGAAGAAATTGTTTATTGGGGAACACTATTAGGATGTATTGAGATGATTAGAAGTGG
AACTACTACTTTTAACGATATGTATTTCTTTTTGGAAGGGATTGCTAAGGCAGTTGATGAAAGTGGAATGAGGGCAGTTT
TAGCCTACGGAATGATTGATTTATTTGATGAGGAGAGAAGGGAGAGAGAGCTTAAAAATGCTGAGAAGTATATAAACTAC
ATAAACAGCTTAAATAATAGTAGAATAATGCCAGCTCTTGGCCCTCATGCTCCATACACTTGCTCCAAAGAGCTTTTAAT
GGAAGTTAATAACTTAGCTAAAAAATACAACGTCCCTATACATATACATCTAAATGAAACCTTAGATGAGATTAAAATGG
TTAAAGAGAAAACGGGTATGGAGCCGTTTATTTATTTAAACTCCTTTGGTTTCTTTGATGATGTTAGAGCTATAGCCGCT
CACTGCGTGCATTTAACAGATGAAGAAATCAAAATAATGAAACAAAAAAACATAAACGTCTCTCATAACCCAATTAGCAA
CTTAAAATTAGCTTCTGGAGTAGCTCCAATTCCAAAACTCTTGGCTGAGGGAATAAACGTTACCTTAGGAACTGATGGAT
GTGGAAGTAACAACAACTTAAACTTATTTGAGGAGATAAAGGTCTCTGCAATCTTACATAAGGGAGTTAATTTAAATCCA
ACTGTTGTTAAAGCTGAAGAGGCGTTTAACTTTGCCACTAAAAATGGGGCTAAAGCATTGAATATAAAAGCTGGAGAAAT
AAGAGAAGGATATTTAGCAGATATTGTTTTAATAAACTTGGATAAACCTTACTTGTATCCAAAAGAGAATATAATGTCCC
ATTTAGTTTATGCGTTTAATGGCTTTGTAGATGATGTCATCATAGATGGAAATATAGTTATGAGGGATGGAGAGATTTTA
ACTGTTGATGAAGAGAAAGTCTATGAAAAAGCTGAAGAAATGTATGAGATTTTGAGAAGCTAA

Upstream 100 bases:

>100_bases
ATAACTATATTGGTTACAGAAAAGATGTATTAAAGGAATTCAAAGAATTCTTTGATTACTTTGTTAAATTCCACAATTTA
CAGTAATACAAGGTGAAACA

Downstream 100 bases:

>100_bases
TTTTTGAATTCATTTAACATTTTTATCAAAGCTAATTTGTCAGTAATTTTTATATTTTTTAGAAATATTCCTCCTCTTGC
ATCATAACCAACAATTAAAA

Product: N-ethylammeline chlorohydrolase TrzA

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MILIKNVFVNGKRQDILIEGNKIKKIGEVKKEEIENAEIIDGKNKIAIPGLINTHTHIPMTLFRGVADDLPLMEWLNNYI
WPMEAKLNEEIVYWGTLLGCIEMIRSGTTTFNDMYFFLEGIAKAVDESGMRAVLAYGMIDLFDEERRERELKNAEKYINY
INSLNNSRIMPALGPHAPYTCSKELLMEVNNLAKKYNVPIHIHLNETLDEIKMVKEKTGMEPFIYLNSFGFFDDVRAIAA
HCVHLTDEEIKIMKQKNINVSHNPISNLKLASGVAPIPKLLAEGINVTLGTDGCGSNNNLNLFEEIKVSAILHKGVNLNP
TVVKAEEAFNFATKNGAKALNIKAGEIREGYLADIVLINLDKPYLYPKENIMSHLVYAFNGFVDDVIIDGNIVMRDGEIL
TVDEEKVYEKAEEMYEILRS

Sequences:

>Translated_420_residues
MILIKNVFVNGKRQDILIEGNKIKKIGEVKKEEIENAEIIDGKNKIAIPGLINTHTHIPMTLFRGVADDLPLMEWLNNYI
WPMEAKLNEEIVYWGTLLGCIEMIRSGTTTFNDMYFFLEGIAKAVDESGMRAVLAYGMIDLFDEERRERELKNAEKYINY
INSLNNSRIMPALGPHAPYTCSKELLMEVNNLAKKYNVPIHIHLNETLDEIKMVKEKTGMEPFIYLNSFGFFDDVRAIAA
HCVHLTDEEIKIMKQKNINVSHNPISNLKLASGVAPIPKLLAEGINVTLGTDGCGSNNNLNLFEEIKVSAILHKGVNLNP
TVVKAEEAFNFATKNGAKALNIKAGEIREGYLADIVLINLDKPYLYPKENIMSHLVYAFNGFVDDVIIDGNIVMRDGEIL
TVDEEKVYEKAEEMYEILRS
>Mature_420_residues
MILIKNVFVNGKRQDILIEGNKIKKIGEVKKEEIENAEIIDGKNKIAIPGLINTHTHIPMTLFRGVADDLPLMEWLNNYI
WPMEAKLNEEIVYWGTLLGCIEMIRSGTTTFNDMYFFLEGIAKAVDESGMRAVLAYGMIDLFDEERRERELKNAEKYINY
INSLNNSRIMPALGPHAPYTCSKELLMEVNNLAKKYNVPIHIHLNETLDEIKMVKEKTGMEPFIYLNSFGFFDDVRAIAA
HCVHLTDEEIKIMKQKNINVSHNPISNLKLASGVAPIPKLLAEGINVTLGTDGCGSNNNLNLFEEIKVSAILHKGVNLNP
TVVKAEEAFNFATKNGAKALNIKAGEIREGYLADIVLINLDKPYLYPKENIMSHLVYAFNGFVDDVIIDGNIVMRDGEIL
TVDEEKVYEKAEEMYEILRS

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=338, Percent_Identity=28.698224852071, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI87082177, Length=444, Percent_Identity=25.2252252252252, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789249, Length=368, Percent_Identity=26.9021739130435, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540282, Length=403, Percent_Identity=24.317617866005, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319963, Length=337, Percent_Identity=26.1127596439169, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24643849, Length=357, Percent_Identity=29.1316526610644, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_METJA (Q58936)

Other databases:

- EMBL:   L77117
- PIR:   D64492
- RefSeq:   NP_248549.1
- ProteinModelPortal:   Q58936
- SMR:   Q58936
- GeneID:   1452449
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1541
- NMPDR:   fig|243232.1.peg.1586
- TIGR:   MJ1541
- HOGENOM:   HBG668170
- OMA:   KENIESH
- ProtClustDB:   CLSK876616
- BioCyc:   MJAN243232:MJ_1541-MONOMER
- BRENDA:   3.5.4.28
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 47469; Mature: 47469

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: BINDING 84-84 BINDING 176-176 BINDING 206-206 BINDING 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIKNVFVNGKRQDILIEGNKIKKIGEVKKEEIENAEIIDGKNKIAIPGLINTHTHIPM
CEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEECCCCCEEECCEECCCCCCHH
TLFRGVADDLPLMEWLNNYIWPMEAKLNEEIVYWGTLLGCIEMIRSGTTTFNDMYFFLEG
HHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IAKAVDESGMRAVLAYGMIDLFDEERRERELKNAEKYINYINSLNNSRIMPALGPHAPYT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCC
CSKELLMEVNNLAKKYNVPIHIHLNETLDEIKMVKEKTGMEPFIYLNSFGFFDDVRAIAA
CCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
HCVHLTDEEIKIMKQKNINVSHNPISNLKLASGVAPIPKLLAEGINVTLGTDGCGSNNNL
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHCCCEEEECCCCCCCCCCC
NLFEEIKVSAILHKGVNLNPTVVKAEEAFNFATKNGAKALNIKAGEIREGYLADIVLINL
CHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEC
DKPYLYPKENIMSHLVYAFNGFVDDVIIDGNIVMRDGEILTVDEEKVYEKAEEMYEILRS
CCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEEECCCEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILIKNVFVNGKRQDILIEGNKIKKIGEVKKEEIENAEIIDGKNKIAIPGLINTHTHIPM
CEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEECCCCCEEECCEECCCCCCHH
TLFRGVADDLPLMEWLNNYIWPMEAKLNEEIVYWGTLLGCIEMIRSGTTTFNDMYFFLEG
HHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IAKAVDESGMRAVLAYGMIDLFDEERRERELKNAEKYINYINSLNNSRIMPALGPHAPYT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCC
CSKELLMEVNNLAKKYNVPIHIHLNETLDEIKMVKEKTGMEPFIYLNSFGFFDDVRAIAA
CCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
HCVHLTDEEIKIMKQKNINVSHNPISNLKLASGVAPIPKLLAEGINVTLGTDGCGSNNNL
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHCCCEEEECCCCCCCCCCC
NLFEEIKVSAILHKGVNLNPTVVKAEEAFNFATKNGAKALNIKAGEIREGYLADIVLINL
CHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEC
DKPYLYPKENIMSHLVYAFNGFVDDVIIDGNIVMRDGEILTVDEEKVYEKAEEMYEILRS
CCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEEECCCEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087